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    • 3. 发明授权
    • Inhalation-type medicine delivery device
    • 吸入型药物输送装置
    • US5752505A
    • 1998-05-19
    • US820654
    • 1997-03-18
    • Hisatomo OhkiShigemi NakamuraKazunori IshizekiYoshiyuki YazawaAkira Yanagawa
    • Hisatomo OhkiShigemi NakamuraKazunori IshizekiYoshiyuki YazawaAkira Yanagawa
    • A61K9/72A61M15/00
    • A61M15/0028A61M15/0015A61M15/0036A61M2202/064
    • An inhalation type medication delivery device includes a dispenser body having a powder containment chamber at one axial side thereof and an inhalation port for drawing in a powder type medication on the another. An attached lid is provided on the dispenser body for opening and/or closing the powder containment chamber. In addition, an air passage is defined in the body allowing a powder type medication to be introduced into an airflow toward the inhalation port according to inhalation by a user. One end of the air passage opens through the lid towards the outside atmosphere and the other end communicates with the inhalation port while passing through the powder containment chamber. Also, a check valve is installed in the lid to prevent air drawn into said inhalation port from flowing in an outward direction opposite a medication delivery direction toward the inhalation port. Additional efficiency may be achieved by further providing a supplementary passage communicating between the inhalation port and the outside atmosphere independently of the air passage to generate additional suction force during inhalation.
    • 吸入型药物输送装置包括:分配器本体,其具有在其一个轴向侧的粉末容纳室和用于吸入粉末型药物的吸入口。 在分配器主体上设置附接的盖,用于打开和/或关闭粉末容纳室。 此外,空气通道被限定在体内,允许粉末型药物根据使用者的吸入被引入朝向吸入口的气流中。 空气通道的一端通过盖朝向外部大气开放,另一端在通过粉末容纳室的同时与吸入口连通。 此外,止回阀安装在盖中,以防止吸入所述吸入口的空气朝向与吸入口相反的药物输送方向的向外方向流动。 通过进一步提供在吸入口和外部气氛之间连通的补充通道,可独立于空气通道来实现额外的效率,以在吸入期间产生额外的吸力。
    • 4. 发明授权
    • Synchronizing signal generating circuit
    • 同步信号发生电路
    • US4827341A
    • 1989-05-02
    • US133971
    • 1987-12-16
    • Taizo AkimotoMikio NishiyamaYoshiyuki YazawaHirohumi Ohnishi
    • Taizo AkimotoMikio NishiyamaYoshiyuki YazawaHirohumi Ohnishi
    • H04N5/10H04N5/04H04N5/08
    • H04N5/10
    • A synchronizing signal generating circuit is incorporated in a digital image storing device. When a plurality of video signals composed of different numbers of scanning lines and issued from television cameras of different types of various diagnostic apparatus are converted from analog to digital signals and stored per frame in an image memory in the digital image storing apparatus, sampling pulses for an A/D converter which are synchronous with the horizontal synchronizing signals of the video signals and field discriminating signals relative to odd-numbered fields and even-numbered fields, among composite synchronizing signals, are generated by using an N-multiplier including an equalizing pulse remover controlled by an F/V converter and a field discriminating circuit with a field discriminating time constant being automatically controlled by the F/V converter. The video signals are stored per frame in the image memory on a real-time basis by utilizing the sampling pulses and the field discriminating signal.
    • 同步信号发生电路被并入数字图像存储装置中。 当将由不同类型的各种诊断装置的不同数目的扫描线组成的多个视频信号从模拟信号转换为数字信号并且每帧存储在数字图像存储装置中的图像存储器中时,采样脉冲用于 通过使用包括均衡脉冲的N倍乘器来生成与复合同步信号中的奇数场和偶数场的视频信号和场识别信号的水平同步信号同步的A / D转换器 由F / V转换器控制的去除器和具有由F / V转换器自动控制的场鉴别时间常数的场识别电路。 视频信号通过利用采样脉冲和场鉴别信号实时地按帧存储在图像存储器中。
    • 5. 发明授权
    • Inhalant medicator
    • 吸入药剂
    • US06810872B1
    • 2004-11-02
    • US09703794
    • 2000-11-02
    • Hisatomo OhkiShigemi NakamuraKazunori IshizekiYoshiyuki YazawaAkira Yanagawa
    • Hisatomo OhkiShigemi NakamuraKazunori IshizekiYoshiyuki YazawaAkira Yanagawa
    • A61M1500
    • A61M15/0045A61M11/002A61M15/0033A61M15/0035A61M15/0048A61M2202/064A61M2206/16
    • A blister pack for a inhalant medicator has a plurality of medical powder storage chambers spaced apart from each other in a circumferential direction. The inhalant medicator includes a pricking tool with a pair of parallel pins that prick inflow and outflow holes in one of the medical powder storage chambers during a preliminary operation of inhalant medication. The inflow and outflow holes are spaced apart from each other by a predetermined distance in a direction parallel to a lid panel of the blister pack to produce turbulent airflow within the medical powder storage chamber during inhalation during which the medical powder is inhaled by a patient's breathing. The medical powder storage chambers are dimensioned and designed to properly regulate or control properties of the airflow passing through the medical storage chamber, to ensure the airflow is suitable for the medical powder storage chamber.
    • 用于吸入剂的吸塑包装具有沿圆周方向彼此隔开的多个医用粉末储存室。 吸入剂包括具有一对平行销的穿刺工具,其在吸入药物的初步操作期间刺入一个医疗粉末储存室中的流入和流出孔。 流入和流出孔在平行于泡罩包装的盖板的方向上彼此隔开预定距离,以在吸入期间在医用粉末储存室内产生湍流气流,在此期间医疗粉末被患者的呼吸吸入 。 医疗粉末储存室的尺寸设计为适当地调节或控制通过医疗储存室的气流的特性,以确保气流适合于医用粉末储存室。
    • 6. 发明授权
    • Inhalation type drug dispenser
    • 吸入式药物分配器
    • US06408846B1
    • 2002-06-25
    • US09623457
    • 2000-09-11
    • Hisatomo OhkiKazunori IshizekiShigemi NakamuraYoshiyuki YazawaAkira Yanagawa
    • Hisatomo OhkiKazunori IshizekiShigemi NakamuraYoshiyuki YazawaAkira Yanagawa
    • A61M1500
    • A61M15/0028A61M15/0033A61M15/0086A61M2202/064A61M2206/16
    • A diffusion chamber block 14 is provided in a block mounting hole 13A of an inhalant port 13, and a granular medicine diffusion chamber 17 is formed in the diffusion chamber block 14. The granular medicine diffusion chamber 17 is formed at a side of the inhalant port 13 with a granular medicine inflow opening 17A and at a side of a capsule housing hole 9 with a granular medicine outflow opening 17B. A diffusion chamber in flow passage 18 is provided to communicate an outflow air passageway 12 with the granular medicine inflow opening 17A, whereas a diffusion chamber outflow passage is provided to communicate the granular medicine outflow opening 17B with the inhalant port 13. When inhaling granular medicines in the capsule housing hole 9 via the inhalant port 13 by way of breathing action, there results in counter-flow vortex within the granular medicine diffusion chamber 17. The counter-flow cortex acts to finely break and atomize massive granular medicines, thus promoting atomization of the granular medicines.
    • 扩散室块14设置在吸入口13的块安装孔13A中,并且在扩散室块14中形成有粒状药物扩散室17.粒状药物扩散室17形成在吸入口侧 13,其具有粒状药物流入口17A,并且在具有粒状药物流出口17B的胶囊容纳孔9的一侧。 设置流路18的扩散室,使流出空气通路12与粒状药剂流入口17A连通,设置扩散室流出通路,使粒状药物流出口17B与吸入口13连通。吸入粒状药物时 通过呼吸作用经由吸入口13在胶囊容纳孔9中,在颗粒状药物扩散室17内产生逆流涡流。逆流皮层用于细粒化颗粒状药物,从而促进雾化 的颗粒状药物。
    • 8. 发明授权
    • Inhalant medicator
    • 吸入药剂
    • US06273086B1
    • 2001-08-14
    • US09355759
    • 1999-08-04
    • Hisatomo OhkiYoshiyuki YazawaShigemi NakamuraKazunori IshizekiAkira Yanagawa
    • Hisatomo OhkiYoshiyuki YazawaShigemi NakamuraKazunori IshizekiAkira Yanagawa
    • A61M1500
    • A61M15/0028A61M15/002A61M15/0033A61M2202/064A61M2206/16
    • An inhalant medicator comprises a medicator body having a granular medicine accommodation chamber and an inhalant port, and air passageways disposed in the medicator body and communicating the inhalant port via the granular medicine accommodation chamber to the atmosphere for supplying granular medicines into the inhalant port. Also provided is a granular medicine diffusion means located downstream of the granular medicine accommodation chamber for efficiently diffusing the granular medicines. A cylindrical adapter 10 is detachably installed in the inhalant port 9. The granular medicine diffusion means comprises a granular medicine diffusion chamber 11 formed in the adapter, an adapter inlet passageway tangentially radially extending from the circumference of the diffusion chamber 11 for creating turbulent flow in the diffusion chamber, and an adapter outlet passageway intercommunicating the diffusion chamber and the inhalant port and having a diametrically-enlarged outlet passage portion, for good dispersion of the granulated medicines flowing out of the diffusion chamber into the inhalant port.
    • 吸入药剂包括具有粒状药物容纳室和吸入口的药剂体,以及设置在药剂体内的空气通路,并且经由粒状药物容纳室将吸入口连通到用于向吸入口供给粒状药剂的气氛。 还提供了一种位于粒状药物容纳室下游的用于有效扩散颗粒状药物的颗粒状药物扩散装置。 圆柱形适配器10可拆卸地安装在吸入口9中。颗粒状药物扩散装置包括形成在适配器中的颗粒状药物扩散室11,从扩散室11的圆周切向径向延伸的适配器入口通道,用于产生湍流 扩散室和将扩散室和吸入口相互连通并具有径向扩大的出口通道部分的适配器出口通道,用于将从扩散室流出的粒状药物良好分散到吸入口中。
    • 9. 发明授权
    • Medicine administering device for nasal cavities
    • 鼻腔用药管理装置
    • US5989217A
    • 1999-11-23
    • US823314
    • 1997-03-21
    • Hisatomo OhkiShigemi NakamuraKazunori IshizekiYoshiyuki YazawaAkira Yanagawa
    • Hisatomo OhkiShigemi NakamuraKazunori IshizekiYoshiyuki YazawaAkira Yanagawa
    • A61K9/00A61K9/14A61M13/00A61M15/00A61M15/08A61M31/00A61M11/00
    • A61M15/0028A61M15/0033A61M2202/064A61M2205/075A61M31/00
    • A medicine administering device for nasal cavities, comprising a capsule holding section formed with a capsule containing powder-state medicine. An air supply section is connected to the lower end of the capsule holding section and formed with an air supply passage which is in communication with the capsule accommodating chamber. A branched passage section is connected to the upper end of the capsule holding section and has an air flow passage in communication with the capsule accommodating chamber. The air flow passage is bifurcated to form first and second outlet passage portions which are arranged to form a generally Y-shape. First and second medicine passages are formed such that air from the branched passage section flows therethrough to carry the medicine in the capsule into right-side and left-side nasal cavities of a patient. The first and second passages are respectively in communication with the first and second outlet passages of the branched passage section. First and second spraying holes are respectively in communication with the first and second medicine passages, the medicine from the first medicine passage and the medicine from the second medicine passage being sprayed respectively from the first and second spraying holes. The first and second spraying holes respectively have first and second axes which are separate from each other by a distance ranging from 12 to 25 mm.
    • 一种用于鼻腔的给药装置,包括形成有包含粉末状药物的胶囊的胶囊保持部。 空气供应部分连接到胶囊保持部分的下端,并且形成有与胶囊容纳室连通的供气通道。 分支通道部分连接到胶囊保持部分的上端,并且具有与胶囊容纳室连通的空气流动通道。 气流通道分叉形成第一和第二出口通道部分,它们被布置为形成大致Y形。 第一和第二药物通道形成为使得来自分支通道部分的空气流过其中以将胶囊中的药物运送到患者的右侧和左侧鼻腔中。 第一通道和第二通道分别与分支通道部分的第一和第二出口通道连通。 第一和第二喷孔分别与第一和第二药物通道连通,来自第一药物通道的药物和来自第二药物通道的药物分别从第一和第二喷射孔喷洒。 第一和第二喷孔分别具有彼此分离距离为12至25mm的第一和第二轴。
    • 10. 发明授权
    • Inhalation type drug dispenser
    • 吸入式药物分配器
    • US06371111B1
    • 2002-04-16
    • US09623478
    • 2000-09-13
    • Hisatomo OhkiYoshiyuki YazawaShigemi NakamuraKazunori IshizekiAkira Yanagawa
    • Hisatomo OhkiYoshiyuki YazawaShigemi NakamuraKazunori IshizekiAkira Yanagawa
    • A61M1500
    • A61M15/0028A61M15/003A61M2202/064A61M2206/16
    • An inhalant medicator includes a medicator body 1 which is formed therein with a cylindrical fit hole 2, an inhalant port 3, an inflow air passageway 5, and an outflow air passageway 6, and a medical powder storage cylindrical member 8 which is installed or fitted into the cylindrical fit hole 2 in a manner so as to open or close the air passageways 5 and 6 with respect to a medical powder storage chamber 12. The inhalant medicator is constructed by two component parts, namely the medicator body 1 and the medical powder storage cylindrical member 8, thus ensuring simplified structure and reduced production costs. Additionally, powder-and-granular medicine or medical powder 16 is tightly encapsulated within the medical powder storage chamber 12 by means of the medical powder storage cylindrical member 8, thus preventing loss of flow of the medical powder 16.
    • 吸入药剂包括形成有圆筒形配合孔2,吸入口3,流入空气通路5和流出空气通路6的药剂主体1,以及安装或安装的医疗用粉末储存筒状构件8 以相对于医用粉末储存室12打开或关闭空气通道5和6的方式进入圆柱形配合孔2中。吸入剂由两部分构成,即药物体1和医用粉末 从而确保了简化的结构并降低了生产成本。 此外,粉末状药物或医用粉末16通过医用粉末储存筒状构件8紧密地包封在医疗粉末储存室12内,从而防止药物粉末16的流失。