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1. 发明授权

US5639664A Method for producing human nerve growth factor 2 失效
标题翻译：人类神经生长因子2的制备方法
公开(公告)号：US5639664A
公开(公告)日：1997-06-17
申请号：US376296
申请日：1995-01-23
申请人： Makoto Iwane , Yoshihiko Kaisho , Koichi Igarashi
发明人： Makoto Iwane , Yoshihiko Kaisho , Koichi Igarashi
IPC分类号： C12N15/09 , C07K14/475 , C07K14/48 , C07K14/71 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/16 , C12N15/67 , C12P21/02 , C12R1/91 , C12N15/79 , C12N1/16 , C12N21/00
CPC分类号： C07K14/48 , C07K14/475 , C07K2319/00 , C07K2319/036 , C07K2319/75
摘要： A transformant, which harbors a recombinant vector containing a DNA which codes for human nerve growth factor 2 and a DNA which codes for the pro-region of a nerve growth factor at 5'-terminal of said DNA, produces human nerve factor 2 in stable and large amount in a culture medium.
摘要翻译：含有编码人神经生长因子2的DNA的重组载体和编码所述DNA的5'末端的神经生长因子的前区的DNA的转化体产生稳定的人神经因子2 并且在培养基中大量存在。

2. 发明授权

US06709837B1 Polypeptide and production thereof 失效
标题翻译：多肽及其生产
公开(公告)号：US06709837B1
公开(公告)日：2004-03-23
申请号：US07488696
申请日：1990-03-05
申请人： Kazuo Nakahama , Yoshihiko Kaisho , Koji Yoshimura , Reiko Sasada
发明人： Kazuo Nakahama , Yoshihiko Kaisho , Koji Yoshimura , Reiko Sasada
IPC分类号： C12N500
CPC分类号： C07K16/22 , A61K38/00 , C07K14/475 , C07K14/48
摘要： Disclosed are (1) a polypeptide (I) including the following amino acid sequence (II) in a molecule thereof: TyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys (II) AspSerGluSerLeuTrpValThrAspLysSerSerAlaIle spIleArgGlyHisGlnValThrValLeuGlyGluIleLys ThrGlyAsnSerProValLysGlnTyrPheTyrGluThrArg CysLysGluAlaArgProValLysAsnGlyCysArgGlyIle AspAspLysHisTrpAsnSerGlnCysLysThrSerGlnThr TyrValArgAlaLeuThrSerGluAsnAsnLysLeuValGly TrpArgTrpIleArgIleAspThrSerCysValCysAlaLeu SerArgLysIleGlyArg (2) a DNA sequence coding for the polypeptide described in (1), (3) a vector including the DNA described in (2), (4) a transformant transformed by the vector described in (3), and (5) a process for producing the polypeptide (I) which comprises cultivating the transformant described in (4) in a culture medium to produce and accumulate the polypeptide described in (1) in a culture. The polypeptide is useful as a reagent for studies relating to the differentiation, growth and survival of animal cells, and may also be useful as a drug.
摘要翻译：公开了（1）在其分子中包含以下氨基酸序列（II）的多肽（I）：（2）编码（1），（3）中描述的多肽的DNA序列，包含在（2）中，（4）由（3）中描述的载体转化的转化体，和（5）生产多肽（I）的方法，其包括在培养基中培养（4）中描述的转化体以产生和积累（1）中所述的多肽在培养物中。该多肽可用作用于与动物细胞的分化，生长和存活相关的研究的试剂，并且也可用作药物。

3. 发明授权

US5182195A Method for increasing gene expression using protease deficient yeasts 失效
标题翻译：使用蛋白酶缺乏症增加基因表达的方法
公开(公告)号：US5182195A
公开(公告)日：1993-01-26
申请号：US269140
申请日：1988-11-09
申请人： Kazuo Nakahama , Yoshihiko Kaisho , Koji Yoshimura
发明人： Kazuo Nakahama , Yoshihiko Kaisho , Koji Yoshimura
IPC分类号： C07K14/485 , C12N1/19 , C12N9/36 , C12N15/81
CPC分类号： C12N9/2462 , C07K14/485 , C12N15/81 , C12R1/865 , C07K2319/00 , C07K2319/02 , Y10S435/942
摘要： Disclosed are respiratory-deficient yeast except Saccharomyces cerevisiae AH22R.sup.-, said respiratory-deficient yeast being transformed with a DNA containing a gene encoding a protein foreign to yeast and a method for preparing a protein foreign to yeast described above, which comprises culturing the yeast, and producing and accumulating the protein in a culture. The respiratory-deficient yeast of the present invention can produce a higher amount of protein than its parent strain.

4. 发明申请

US20090313709A1 Genetically Modified Animal and Use Thereof 审中-公开
标题翻译：转基因动物及其使用
公开(公告)号：US20090313709A1
公开(公告)日：2009-12-17
申请号：US12223355
申请日：2007-01-30
申请人： Yoshihiko Kaisho , Shigehisa Taketomi
发明人： Yoshihiko Kaisho , Shigehisa Taketomi
IPC分类号： G01N33/00 , A01K67/027 , C12Q1/02 , A01K67/00 , C12N5/06
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0362 , C07K14/705 , C12N15/8509 , C12N2830/008
摘要： The present invention provides a transgenic mouse retaining a DNA that encodes an exogenous GPR40 in an expressible state, wherein (1) the insulin secretion capacity has been increased, and/or (2) the glucose tolerance has been improved, compared with the corresponding non-transgenic mouse, or a portion of the living body thereof, a screening method for a prophylactic/therapeutic drug for diabetes mellitus and metabolic syndrome using the transgenic mouse, and the like.
摘要翻译：本发明提供了保持编码可表达状态的外源性GPR40的DNA的转基因小鼠，其中（1）胰岛素分泌能力已经增加，和/或（2）葡萄糖耐量已经提高，与相应的非 - 转基因小鼠或其活体的一部分，使用转基因小鼠的糖尿病预防/治疗药物和代谢综合征的筛选方法等。

5. 发明授权

US5625123A Neurotrophin-3-deficient embryonic stem cells and mice and their use 失效
标题翻译：神经营养因子缺陷型胚胎干细胞和小鼠及其用途
公开(公告)号：US5625123A
公开(公告)日：1997-04-29
申请号：US268020
申请日：1994-06-29
申请人： Osamu Shiho , Yoshihiko Kaisho , Hideaki Tojo
发明人： Osamu Shiho , Yoshihiko Kaisho , Hideaki Tojo
IPC分类号： A01K67/027 , C12N5/10 , C12N15/09 , C12N15/85 , A61K49/00 , C12N15/00 , C12N15/06 , G01N31/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393
摘要： The present invention provides mouse embryonic stem cells and homozygous mutant mice carrying disruptions in the neurotrophin-3 (NT-3) gene generated by homologous recombination which results in the insertion of a reporter gene or a drug-resistance gene into an exon of the neurotrophin-3 gene. The mice harboring such homozygous mutations have a reduced number of sensory neurons compared with the number of sensory neurons present in a mouse lacking such mutations. These mice may be used to screen for substances that enhance the transcriptional activity of the NT-3 gene.
摘要翻译：本发明提供小鼠胚胎干细胞和纯合突变体小鼠，其通过同源重组产生的神经营养因子-3（NT-3）基因中携带破坏，导致将报道基因或药物抗性基因插入神经营养蛋白的外显子 -3基因。与缺乏这种突变的小鼠中存在的感觉神经元的数量相比，携带这种纯合突变的小鼠具有减少的感觉神经元数量。这些小鼠可用于筛选增强NT-3基因转录活性的物质。

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