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1. 发明授权

US06428770B1 Solid preparation for oral hygiene 失效
标题翻译：口腔卫生的固体制剂
公开(公告)号：US06428770B1
公开(公告)日：2002-08-06
申请号：US09554621
申请日：2000-06-02
申请人： Shigeto Kayane , Yoshitaka Yano , Shinji Kiji , Keiko Masuki , Hidetake Fujinaka , Yasuteru Eguchi , Mitsuyoshi Kashiwagi
发明人： Shigeto Kayane , Yoshitaka Yano , Shinji Kiji , Keiko Masuki , Hidetake Fujinaka , Yasuteru Eguchi , Mitsuyoshi Kashiwagi
IPC分类号： A61K716
CPC分类号： A61Q11/00 , A61K8/02 , A61K9/0007 , A61K2800/222
摘要： The present invention relates to a solid preparation for oral hygiene, which comprises (a) 15 to 90 wt. % of a bubbling component and (b) 0.001 to 10 wt. % of an orally-usable medicinal component at an (a):(b) ratio ranging from 10:1 to 1000:1. Use of the preparation brings about a drastic improvement in the drug efficacy and moreover, breath is freshened by bubbling.
摘要翻译：本发明涉及口腔卫生用固体制剂，其包含（a）15〜90重量％％的起泡组分和（b）0.001至10wt。（a）:( b）比例为10:1-1000:1的口服药物组分的％。使用这种制剂可大大提高药物的疗效，而且呼吸也因气泡而变得清新。

2. 发明授权

US5244651A Method of desensitizing hypersensitive dentin 失效
标题翻译：脱敏敏感性牙本质的方法
公开(公告)号：US5244651A
公开(公告)日：1993-09-14
申请号：US941242
申请日：1992-09-04
申请人： Shigeto Kayane , Katsumi Kita , Ryozo Nakai , Yoshiaki Fujikura , Yasuteru Eguchi
发明人： Shigeto Kayane , Katsumi Kita , Ryozo Nakai , Yoshiaki Fujikura , Yasuteru Eguchi
IPC分类号： A61K8/26 , A61K8/27 , A61K8/60 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/26 , A61K8/27 , A61K8/60
摘要： A method of desensitizing hypersensitive dentin is disclosed. The method comprises treating teeth of patients suffering from hypersensitive dentin with a colloid produced by mixing (a) a salt of polyvalent metal and (b) a polyol phosphate and/or a water-soluble salt thereof. The colloid can constrict or occlude dentinal tubules in the tooth dentin, exhibiting a continuous effect on the desensitization of hypersensitive dentin owing to the very high absorptivity of the colloid to teeth. The colloid does not impair taste, and does not produce precipitate near the neutral region, enabling it to be used safely.
摘要翻译：公开了一种使过敏性牙本质脱敏的方法。该方法包括用通过混合（a）多价金属盐和（b）多元醇磷酸盐和/或其水溶性盐产生的胶体来治疗患有过敏性牙本质的患者的牙齿。胶体可以收缩或阻塞牙质牙本质中的牙质小管，由于胶体对牙齿的吸收性非常高，对过敏性牙本质的脱敏具有持续的作用。胶体不损害味道，并且在中性区域附近不会产生沉淀物，使其能够安全使用。

3. 发明授权

US4859696A Precutaneous absorption accelerator and preparation containing same 失效
标题翻译：皮肤吸收促进剂及其制备方法
公开(公告)号：US4859696A
公开(公告)日：1989-08-22
申请号：US227777
申请日：1988-08-03
申请人： Tetsuro Kamiya , Takeshi Inoue , Hidenori Yorozu , Yasuteru Eguchi , Kaoru Tsujii
发明人： Tetsuro Kamiya , Takeshi Inoue , Hidenori Yorozu , Yasuteru Eguchi , Kaoru Tsujii
IPC分类号： A61K9/08 , A61K9/00 , A61K9/06 , A61K9/107 , A61K9/70 , A61K47/08 , A61K47/10
CPC分类号： A61K9/0014 , A61K47/10 , Y10S514/946 , Y10S514/947 , Y10S514/969
摘要： A percutaneous absorption accelerator and a precutaneous absorbent preparation containing the same and, more particularly, a percutaneous absorption accelerator containing ether derivatives of specific glycerols or polyglycerols and alcohols as effective components and a percutaneous absorbent preparation containing the percutaneous absorption accelerators and pharmaceutically effective components.
摘要翻译：一种经皮吸收促进剂和含有该吸收促进剂的皮肤吸收制剂，特别是含有特定甘油或聚甘油和醇的醚衍生物作为有效成分的经皮吸收促进剂和含有经皮吸收促进剂和药学上有效成分的经皮吸收制剂。

4. 发明授权

US07125573B2 Preventive, alleviative or remedy for hypertension 有权
公开(公告)号：US07125573B2
公开(公告)日：2006-10-24
申请号：US10192075
申请日：2002-07-11
申请人： Wataru Okawa , Yuki Mitsui , Takuya Watanabe , Yasuteru Eguchi , Hirokazu Takahashi , Atsushi Suzuki
发明人： Wataru Okawa , Yuki Mitsui , Takuya Watanabe , Yasuteru Eguchi , Hirokazu Takahashi , Atsushi Suzuki
IPC分类号： A61K35/78
CPC分类号： A61K36/74 , A23F5/02 , A23F5/24 , A23L23/00 , A61K2300/00
摘要： Provided is a preventive, ameliorant or remedy for hypertension excellent in both blood pressure lowering action and blood pressure-rise suppressing action and having high safety.This preventive, ameliorant or remedy for hypertension comprises a coffee bean extract.

5. 发明授权

US5370865A Composition for use in oral cavity 失效
标题翻译：口腔用组合物
公开(公告)号：US5370865A
公开(公告)日：1994-12-06
申请号：US16233
申请日：1993-02-11
申请人： Atsushi Yamagishi , Kazushi Oshino , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
发明人： Atsushi Yamagishi , Kazushi Oshino , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
IPC分类号： A61K8/34 , A61K8/43 , A61K8/44 , A61K8/49 , A61K8/55 , A61K8/63 , A61K8/67 , A61Q11/00 , A61K7/16 , A61K7/22
CPC分类号： A61K8/43 , A61K8/347 , A61K8/44 , A61K8/4926 , A61K8/556 , A61K8/63 , A61K8/678 , A61Q11/00
摘要： A composition for use in the oral cavity comprising a monophosphate represented by the following general formula (1), ##STR1## wherein R.sup.1 is a linear or branched alkyl or alkenyl group with 6 to 20 carbon atoms, and may have a substituted fluorine atom; one of X.sup.1 or X.sup.2 is a basic amino acid residual group, while the other is a hydrogen atom, an alkali metal, an ammonium, an alkyl amine, an alkanol amine, or a basic amino acid residual group; and n is an integer from 0 to 4. The composition exhibits a superior action in protecting the tooth surface, is stable, and has a pleasant taste.
摘要翻译：一种用于口腔的组合物，其包含由以下通式（1）表示的单磷酸酯，其中R 1是具有6至20个碳原子的直链或支链烷基或烯基，并且可以具有取代基氟原子 X1或X2中的一个是碱性氨基酸残基，而另一个是氢原子，碱金属，铵，烷基胺，链烷醇胺或碱性氨基酸残基; n为0〜4的整数。该组合物在保护牙齿表面方面表现出优异的作用，稳定，味道好。

6. 发明授权

US5026551A Bath additive composition 失效
标题翻译：浴添加剂组成
公开(公告)号：US5026551A
公开(公告)日：1991-06-25
申请号：US1461
申请日：1987-01-08
申请人： Hidenori Yorozu , Yasuteru Eguchi , Wataru Ohkawa , Yasunobu Matsumoto
发明人： Hidenori Yorozu , Yasuteru Eguchi , Wataru Ohkawa , Yasunobu Matsumoto
IPC分类号： A61K8/04 , A61K8/19 , A61Q19/10
CPC分类号： A61Q19/10 , A61K8/046 , A61K8/19 , A61K2800/22 , A61K2800/56
摘要： A novel weakly acidic bath additive composition comprises carbon dioxide gas or a substance capable of producing carbon dioxide gas and an oily ingredient.The composition promotes the blood circulation due to the effect of carbon dioxide gas present in the bath water. Further, because of an oily ingredient, the skin is supplied by an oil and provided moistened feel after bathing.
摘要翻译：一种新颖的弱酸性浴添加剂组合物包含二氧化碳气体或能够产生二氧化碳气体和油性成分的物质。该组合物由于存在于浴水中的二氧化碳气体的作用促进血液循环。此外，由于油性成分，皮肤由油提供并且在洗澡后提供润湿的感觉。

7. 发明授权

US4613447A Composition for cleansing and wiping the circumanal region 失效
标题翻译：用于清洁和擦拭环境区域的组成
公开(公告)号：US4613447A
公开(公告)日：1986-09-23
申请号：US615759
申请日：1984-05-31
申请人： Kenji Hara , Yasuteru Eguchi
发明人： Kenji Hara , Yasuteru Eguchi
IPC分类号： A61K8/00 , A61H35/00 , A61K8/31 , A61K8/37 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/97 , A61K8/98 , A61Q19/10 , C08L83/04 , C11D7/22 , C11D17/00
CPC分类号： A61Q19/10 , A61K8/31 , A61K8/375 , A61K8/891 , A61K8/922
摘要： A composition of cleansing and wiping skin in the circumanal region which comprises at least one oil selected from the group consisting of vegetable oils, animal oils and synthetic oils, and a silicone oil and has a viscosity of not more than 30 cs as measured at 5.degree.0 C.The composition according to the invention is preferably used after excrement is wiped off with usual toilet paper and facilitates removal of excrement residues on the skin of circumanal region. Besides, when the composition is applied to the circumanal skin prior to defecation, it prevents excrement from sticking to the skin or makes excrement easy to be wiped off.The composition may be sprayed on conventional toilet paper or impregnated into nonwoven fabric, cloth, paper etc. on application.Such materials containing the composition according to the invention is effective in preventing any aggravation to hemorrhoids or the like.
摘要翻译：包含至少一种选自植物油，动物油和合成油组成的组的油和氧化硅油的清洁和擦拭皮肤的组合物，其粘度不超过30cs，如在5 DEG 0℃。根据本发明的组合物优选在排泄物用通常的卫生纸擦除之后使用，并有利于去除人类区域皮肤上的粪便残留物。此外，当组合物在排便之前应用于人造皮肤时，其防止排泄物粘附到皮肤上或使排泄物容易被擦去。组合物可以喷洒在常规卫生纸上，或者在施用时浸渍到无纺织物，布，纸等中。含有根据本发明的组合物的这种材料有效地防止对痔疮等的加重。

8. 发明授权

US5374418A Composition for use in oral cavity 失效
标题翻译：口腔用组合物
公开(公告)号：US5374418A
公开(公告)日：1994-12-20
申请号：US16234
申请日：1993-02-11
申请人： Kazushi Oshino , Atsushi Yamagishi , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
发明人： Kazushi Oshino , Atsushi Yamagishi , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
IPC分类号： A61K8/41 , A61K8/43 , A61K8/44 , A61K8/49 , A61K8/55 , A61K8/63 , A61K8/66 , A61Q11/00 , A61K7/16 , A61K7/22
CPC分类号： A61K8/43 , A61K8/416 , A61K8/44 , A61K8/4926 , A61K8/55 , A61K8/63 , A61K8/66 , A61Q11/00
摘要： A composition for use in the oral cavity is disclosed. The composition comprises (A) an antibacterial compound represented by the following general formula (1),A.sup.m+ .multidot.X.sub.m.sup.- (1)wherein A.sup.m+ is a nitrogen-containing antibacterial cation and the counter anion X.sup.- represents a monoalkyl phosphate ion, a monoalkenyl phosphate ion, a monoalkyl phosphonate ion, or a monoalkenyl phosphonate ion having a linear or branched alkyl or alkenyl group with 8 to 20 carbon atoms, and m is a valence of the cation A, and (B) a vehicle for use in the oral cavity. It exhibits a remarkablely rapid and continued disinfection effect action against oral cavity bacteria, while providing a good taste. Its disinfection effect is not reduced in the presence of surfactants. In addition, it does not color the tooth.
摘要翻译：公开了一种用于口腔中的组合物。该组合物包含（A）由以下通式（1）表示的抗菌化合物，Am + xXm-（1）其中Am +为含氮抗菌阳离子，抗衡阴离子X为磷酸单烷基酯离子，单链烯基磷酸酯离子，单烷基膦酸根离子或具有碳原子数为8〜20的直链或支链烷基或烯基的单烯基膦酸酯离子，m为阳离子A的化合价，（B）在口腔中使用的载体。它对口腔细菌表现出非常快速和持续的消毒效果，同时提供了良好的口味。在表面活性剂存在下，其消毒效果不会降低。此外，它不会使牙齿变色。

9. 发明授权

US5206010A Composition for use in oral cavity 失效
标题翻译：用于口腔的组合物
公开(公告)号：US5206010A
公开(公告)日：1993-04-27
申请号：US810117
申请日：1991-12-19
申请人： Takeshi Inoue , Kouji Maeda , Yasuteru Eguchi
发明人： Takeshi Inoue , Kouji Maeda , Yasuteru Eguchi
IPC分类号： A61K8/00 , A61K8/04 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/0245 , A61K8/025 , A61K8/0275 , A61K8/24 , A61K8/25 , A61K8/26 , A61K8/29 , A61K8/361 , A61K8/731 , A61K8/8117 , A61K8/8152
摘要： A composition for use in the oral cavity comprising granules composed of a water-insoluble powders and a water-insoluble organic binder; and which granules have an apparent density of from 0.1 to 1.5 and collapse at a deformation rate of from 0.1 to 20% at a load of from 0.1 to 50 g per granule. The granules of the composition have a proper hardness so that the presence of the granules can be felt when used in the oral cavity. The composition makes users feel the cleaning effect of the composition by the tactual sense, while giving a pleasant feeling to users. The composition is particularly suitable as a dentifrice.
摘要翻译：一种用于口腔的组合物，其包含由水不溶性粉末和水不溶性有机粘合剂组成的颗粒; 并且哪个颗粒的表观密度为0.1至1.5，并且在每个颗粒0.1至50g的负载下以0.1至20％的变形速率塌陷。组合物的颗粒具有适当的硬度，使得当在口腔中使用时可以感觉到颗粒的存在。该组合使用户通过触觉感觉到组合物的清洁效果，同时给用户带来愉快的感觉。该组合物特别适合作为洁齿剂。

10. 发明授权

US4948588A Percutaneous absorption accelerator and preparation containing same 失效
标题翻译：经皮吸收促进剂及含有其的制剂
公开(公告)号：US4948588A
公开(公告)日：1990-08-14
申请号：US361489
申请日：1989-06-02
申请人： Tetsuro Kamiya , Takeshi Inoue , Hidenori Yorozu , Yasuteru Eguchi , Kaoru Tsujii
发明人： Tetsuro Kamiya , Takeshi Inoue , Hidenori Yorozu , Yasuteru Eguchi , Kaoru Tsujii
IPC分类号： A61K9/08 , A61K9/00 , A61K9/06 , A61K9/107 , A61K9/70 , A61K47/08 , A61K47/10
CPC分类号： A61K9/0014 , A61K47/10 , Y10S514/946 , Y10S514/947 , Y10S514/969
摘要： A percutaneous absorption accelerator and a percutaneous absorbent preparation containing the same and, more particularly, a percutaneous absorption accelerator containing either derivatives of specific glycerols or polyglycerols and alcohols as effective components and a percutaneous absorbent preparation containing the percutaneous absorption accelerators and pharmaceutically effective components.

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