专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5292754A Treatment for hypertension or glaucoma in eyes 失效
标题翻译：治疗眼内高血压或青光眼
公开(公告)号：US5292754A
公开(公告)日：1994-03-08
申请号：US948179
申请日：1992-09-21
申请人： Morio Kishi , Kimio Takahashi , Kenji Kawada , Yasumasa Goh
发明人： Morio Kishi , Kimio Takahashi , Kenji Kawada , Yasumasa Goh
IPC分类号： C07C405/00 , A61K31/557
CPC分类号： C07C405/00 , Y10S206/828 , Y10S514/913
摘要： The present invention relates to a method for treating hypertension or glaucoma in the eye comprising contacting the surface of the eye with a therapeutic amount of a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R.sup.1 is hydrogen or lower alkyl; R.sup.2 is C.sub.6 -C.sub.12 alkyl, C.sub.6 -C.sub.12 alkenyl or C.sub.6 -C.sub.12 alkadienyl or a pharmaceutically acceptable salt thereof. The invention also relates to a kit for delivery of a topical solution for treatment of glaucoma which comprises (a) container having a solution including a compound of the formula (I), and (b) means for topical delivery of said solution to the eye in a controlled dosage.
摘要翻译：本发明涉及一种用于治疗眼睛中的高血压或青光眼的方法，包括使眼表面与治疗量的式（I）的15-脱氧前列腺素衍生物接触：（*化学结构*）（I），其中（*化学结构*）是选自（*化学结构*）R 1为氢或低级烷基的5元环; R2是C6-C12烷基，C6-C12链烯基或C6-C12链二烯基或其药学上可接受的盐。本发明还涉及一种用于递送用于治疗青光眼的局部用溶液的试剂盒，其包含（a）具有包含式（I）化合物的溶液的容器，和（b）将所述溶液局部递送至眼睛的装置以受控剂量。

2. 发明授权

US4824857A Use of prostaglandin D.sub.2 -active substances 失效
标题翻译：使用前列腺素D2活性物质
公开(公告)号：US4824857A
公开(公告)日：1989-04-25
申请号：US45965
申请日：1987-05-04
申请人： Yasumasa Goh , Osamu Hayaishi
发明人： Yasumasa Goh , Osamu Hayaishi
IPC分类号： A61K31/40 , A61K31/415 , A61K31/557 , A61P9/12 , A61P27/02 , A61P27/06 , C07D233/78 , A61K31/19 , A61K31/215
CPC分类号： C07D233/78 , A61K31/40 , A61K31/415 , A61K31/557 , Y10S514/913
摘要： Method of treatment of ocular hypertension and glaucoma which comprises administering an effective amount of prostaglandin D.sub.2 -active substance to a subject in need of such treatment.
摘要翻译：治疗高眼压症和青光眼的方法，其包括将有效量的前列腺素D2活性物质给予需要这种治疗的受试者。

3. 发明授权

US5599837A Treatment for hypertension or glaucoma in eyes 失效
标题翻译：治疗眼内高血压或青光眼
公开(公告)号：US5599837A
公开(公告)日：1997-02-04
申请号：US395642
申请日：1995-02-28
申请人： Morio Kishi , Kimio Takahashi , Kenji Kawada , Yasumasa Goh
发明人： Morio Kishi , Kimio Takahashi , Kenji Kawada , Yasumasa Goh
IPC分类号： A61K31/557 , A61P27/06 , C07C405/00
CPC分类号： C07C405/00
摘要： The present invention relates to a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R.sup.1 is hydrogen or lower alkyl; R.sup.2 is C.sub.6 -C.sub.12 alkyl, C.sub.6 -C.sub.12 alkenyl or C.sub.6 -C.sub.12 alkadienyl;provided that the compound of the following formula is excluded: ##STR4## wherein R' is hydrogen or methyl; or pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical formulation comprising a 15-deoxyprostaglandin derivative as an active ingredient, which is useful as an intraocular pressure reducing agent.
摘要翻译：本发明涉及式（I）的15-脱氧前列腺素衍生物：其中是一种5元环，其选自由下列组成的组：R1是氢或低级烷基; R2是C6-C12烷基，C6-C12链烯基或C6-C12链二烯基; 条件是排除下列化学式的化合物：其中R'是氢或甲基; 或其药学上可接受的盐。本发明还涉及含有作为活性成分的15-脱氧前列腺素衍生物的药物制剂，其可用作眼内压降低剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式