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1. 发明授权

US09442282B2 Organism sample observation device 有权
标题翻译：有机体样品观察装置
公开(公告)号：US09442282B2
公开(公告)日：2016-09-13
申请号：US13251673
申请日：2011-10-03
申请人： Hideo Kuroda , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Ryuji Koshiba , Takayuki Uozumi
发明人： Hideo Kuroda , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Ryuji Koshiba , Takayuki Uozumi
IPC分类号： G02B21/36 , G01N21/64 , G02B21/16
CPC分类号： G02B21/367 , G01N21/6486 , G02B21/16 , G02B21/365 , G06K9/00134 , G06K9/0014
摘要： A biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image, a micro observation point corresponding to an extracted biological change region is registered, and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point, and the registered micro observation point is updated on the basis of this judgment result. It is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and to carry out accurate observation of a biological specimen.
摘要翻译：可以准确地进行生物样本的观察的生物样本观察装置。在宏观观察中，从宏观图像提取生物变化区域，登记与提取的生物体变化区域对应的微观观察点，并且识别跟踪对象。在微观观察中，从微观图像判断微观察点处的生物变化区域的生物变化是否持续，并且基于该判断结果来更新登记的微观察点。可以进行用于检测生物变化区域的宏观观察和用于观察已经显示生物学变化的部分微小区域的生长进展的微观察，并进行生物样本的准确观察。

2. 发明授权

US09404074B2 Incubation apparatus 有权
标题翻译：孵化器
公开(公告)号：US09404074B2
公开(公告)日：2016-08-02
申请号：US11991401
申请日：2006-11-10
申请人： Yasujiro Kiyota
发明人： Yasujiro Kiyota
IPC分类号： C12M3/00 , C12M1/00 , C12M1/36 , C12M1/34
CPC分类号： C12M41/14 , C12M23/50 , C12M41/00 , C12M41/36 , C12M41/44 , C12M41/46 , C12M41/48
摘要： An incubation apparatus, including a temperature-controlled room adjusted to be a predetermined environment condition, and incubating a sample of an incubation container inside the temperature-controlled room, includes a carrying apparatus, an imaging section, and an image analyzing section. The carrying apparatus carries the incubation container in the temperature-controlled room. The imaging section photographs a whole of the incubation container inside the temperature-controlled room. The image analyzing section analyzes an operation state of the incubation apparatus or an incubating environment state of the sample based on a total observing image of the incubation container photographed at the imaging section, and outputs an error signal notifying an abnormality of the operation state or the incubating environment state in accordance with the analysis result.
摘要翻译：包括调节为预定环境条件的温度控制室和在温度控制室内孵育孵育容器的样品的培养装置包括携带装置，成像部分和图像分析部分。携带装置在温度控制室内携带培养容器。成像部分将温室内的整个孵化容器拍摄。图像分析部基于在摄像部拍摄的孵育容器的全部观察图像，分析培养装置的动作状态或样本的孵育环境状态，并输出通知操作状态异常的误差信号或根据分析结果孵化环境状态。

3. 发明授权

US08947518B2 Cell observing apparatus and cell incubation method 有权
标题翻译：细胞观察装置和细胞培养方法
公开(公告)号：US08947518B2
公开(公告)日：2015-02-03
申请号：US13552839
申请日：2012-07-19
申请人： Yasujiro Kiyota , Takayuki Uozumi
发明人： Yasujiro Kiyota , Takayuki Uozumi
IPC分类号： H04N9/47 , H04N7/18 , C12M1/34 , G02B21/00 , G02B21/32 , G02B21/36
CPC分类号： C12M41/36 , G02B21/0088 , G02B21/32 , G02B21/36
摘要： User's time and labor required for performing manipulations with respect to cells which exist in an incubation container, are reduced. To achieve the above, a cell observing apparatus includes an observation stage supporting an incubation container that houses cells, a micro imaging optical system forming, on an imaging device for micro imaging, an image of the cell in the incubation container disposed at an observing position of the observation stage, a macro imaging optical system forming, on an imaging device for macro imaging, an image of an area wider than that captured by the micro imaging optical system in the incubation container, and a controlling unit controlling an operation of a manipulation needle that manipulates the cells in the incubation container, in which the micro imaging optical system is disposed on a side facing the macro imaging optical system with the observation stage being located therebetween.
摘要翻译：对于存在于孵育容器中的细胞进行操作所需的用户时间和劳动力减少。为了实现上述目的，细胞观察装置包括：支持容纳细胞的培养容器的观察台，在微成像用成像装置上形成在设置在观察位置的培养容器中的细胞的图像的微成像光学系统在宏观成像装置上形成比由培养容器中的微成像光学系统捕获的区域宽的区域的图像的宏观成像光学系统，以及控制操作的控制单元操纵培养容器中的细胞的针，其中微成像光学系统设置在面向宏观成像光学系统的一侧，观察台位于其间。

4. 发明授权

US08917347B2 Focus control method and culture observation apparatus 有权
标题翻译：聚焦控制方法和文化观察装置
公开(公告)号：US08917347B2
公开(公告)日：2014-12-23
申请号：US13290565
申请日：2011-11-07
申请人： Yasujiro Kiyota , Yoichi Wada , Hiroaki Kii
发明人： Yasujiro Kiyota , Yoichi Wada , Hiroaki Kii
IPC分类号： G03B13/00 , H04N5/232 , G02B21/24 , G02B7/38
CPC分类号： G02B21/244 , C12M21/06 , C12M25/01 , C12M41/14 , C12M41/36 , G02B7/38
摘要： The focus control culture observation apparatus enable simple and reliable detection of a focusing position of an objective lens on a subject and with certainty. When a focusing position is detected, an area, which includes an edge portion of the culture medium drop is selected as an AF area which is to be a target of detecting the focusing position of the objective lens on the culture medium drop. The apparatus detects the focusing position on the culture medium drop based on an observation image of the AF area. By detecting the focusing position as a targeting area that is different from an area which is near the edge of the culture container and where illumination unevenness is generated, the detection accuracy can be improved.
摘要翻译：聚焦控制文化观察装置能够确实地对被摄体上的物镜的聚焦位置进行简单可靠的检测。当检测到聚焦位置时，选择包括培养基液滴的边缘部分的区域作为将物镜在培养基液滴上检测聚焦位置的对象的AF区域。该装置基于AF区域的观察图像来检测培养基落下的聚焦位置。通过将聚焦位置检测为与培养容器的边缘附近的区域不同的目标区域，并且产生照明不均匀，可以提高检测精度。

5. 发明授权

US08541228B2 Cell observation apparatus, cell observation method, and program 有权
标题翻译：细胞观察装置，细胞观察方法和程序
公开(公告)号：US08541228B2
公开(公告)日：2013-09-24
申请号：US12451384
申请日：2008-06-20
申请人： Yasujiro Kiyota
发明人： Yasujiro Kiyota
IPC分类号： C12M1/00
CPC分类号： G02B21/34 , C12M41/14 , C12M41/36 , C12M41/48 , G01N35/0092 , G02B21/365
摘要： The present invention relates to a cell observation apparatus that facilitates the setting of schedules. An observation schedule that has already been registered is presented to a user by a time schedule display unit of a schedule setting screen, and a new observation schedule is acquired in response to an input of set values of photographic conditions by the user. Then determination is made whether the photographing time of this observation schedule and the photographing time of the already registered observation schedule overlap, and when the photographing times are determined to overlap, the photographic conditions including the photographing time of one or both of the observation schedules are changed and the observation schedule is registered. The invention can be applied, for example, to incubators for culturing cells.
摘要翻译：本发明涉及便于设定时间表的细胞观察装置。已经登记的观测时间表通过时间表设置画面的时间表显示单元呈现给用户，并且响应于用户对摄影条件的设定值的输入而获取新的观察时间表。然后确定该观察时间表的拍摄时间和已登记的观察时间表的拍摄时间是否重叠，并且当确定拍摄时间重叠时，包括观察时间表中的一个或两个的拍摄时间的拍摄条件是改变了观察进度表。本发明可以应用于例如培养细胞的培养箱。

6. 发明授权

US08159675B2 Observation device and wavelength limiting filter 有权
标题翻译：观察装置和波长限制滤波器
公开(公告)号：US08159675B2
公开(公告)日：2012-04-17
申请号：US12461013
申请日：2009-07-29
申请人： Yasujiro Kiyota
发明人： Yasujiro Kiyota
IPC分类号： G01J3/51 , G02B21/00
CPC分类号： G02B21/14 , G01N21/25 , Y10S435/808
摘要： An observation device observing a sample cultured in a culture vessel includes an illuminating unit including an illumination optical system and illuminating the sample, an image-capturing unit including an imaging sensor and generating an image by capturing an image of the sample illuminated by the illuminating unit, and a wavelength limiting filter being placed on an optical axis of the illumination optical system and between the illuminating unit and the image-capturing unit, and limiting a part of wavelengths of an illumination light from the illumination optical system in accordance with optical absorption properties of an additive contained in a culture medium used for culturing the sample. Accordingly, it is possible to suppress a change of the image resulting from the additive and to enable to generate an appropriate image in an automatic observation.
摘要翻译：观察在培养容器中培养的样本的观察装置包括：照明单元，包括照明光学系统和照射样本;图像捕获单元，包括成像传感器，并且通过拍摄由照明单元照射的样本的图像来产生图像; 以及波长限制滤光器，其被放置在照明光学系统的光轴上，并且在照明单元和图像捕获单元之间，并且根据光吸收特性限制来自照明光学系统的照明光的一部分波长包含在用于培养样品的培养基中的添加剂。因此，可以抑制由添加剂产生的图像的变化，并且能够在自动观察中产生适当的图像。

7. 发明申请

US20090068728A1 Cell incubator 审中-公开
标题翻译：细胞培养箱
公开(公告)号：US20090068728A1
公开(公告)日：2009-03-12
申请号：US12230258
申请日：2008-08-26
申请人： Yasujiro KIYOTA , Takayuki Uozumi
发明人： Yasujiro KIYOTA , Takayuki Uozumi
IPC分类号： C12M3/00
CPC分类号： C12M41/14 , C12M41/36 , G02B7/38
摘要： A cell incubator having an observation unit to observe a cell incubation process comprises: a focus detecting unit to detect a focus position of an imaging optical system of the observation unit; an optimum focus selecting unit to select an optimum focus position based upon a plurality of images taken by moving the imaging optical system stepwise at a fine pitch along an optical axis direction from the focus position, based upon the focus position detected by the focus detecting unit; and a fluorescence observation unit to shoot a fluorescence image of the cells by moving the imaging optical system to the optimum focus position thus detected by the optimum focus selecting unit.
摘要翻译：具有用于观察细胞培养过程的观察单元的细胞培养箱包括：焦点检测单元，用于检测观察单元的成像光学系统的焦点位置; 最佳焦点选择单元，基于由焦点检测单元检测到的对焦位置，基于通过沿着光轴方向以微小间距逐渐地从聚焦位置逐步移动成像光学系统而获取的多个图像来选择最佳聚焦位置; ; 以及荧光观察单元，通过将成像光学系统移动到由最佳聚焦选择单元检测到的最佳聚焦位置来拍摄细胞的荧光图像。

8. 发明授权

US09296982B2 Cell picking-assisting device, display device and culture container 有权
标题翻译：细胞采摘辅助装置，显示装置和培养容器
公开(公告)号：US09296982B2
公开(公告)日：2016-03-29
申请号：US13344038
申请日：2012-01-05
申请人： Yasujiro Kiyota
发明人： Yasujiro Kiyota
IPC分类号： H04N7/18 , C12M1/00 , C12M1/34 , C12M1/36
CPC分类号： C12M47/04 , C12M23/50 , C12M41/46 , C12M41/48 , G06F19/00
摘要： A cell picking support device, a display device and a culture container that can enhance work efficiency. An adapter fixes a well plate that holds cells cultured in a cell culture observation device. A control unit reads culture observation information that includes cell information and coordinate information, from a memory card that is fitted to an external memory I/F. A display unit is provided on a placing surface side of the well plate that is fixed by the adapter, and in response to control by the control unit, displays the cell information, read from the memory card, at display positions corresponding to positions on the bottom face of the well plate, as specified by the coordinate information. Embodiments can be used, for instance, as a cell picking support device that supports a picking operation that is performed in a clean bench.
摘要翻译：可提高工作效率的细胞采集支持装置，显示装置和培养容器。适配器固定保持在细胞培养观察装置中培养的细胞的孔板。控制单元从安装到外部存储器I / F的存储卡中读取包括单元信息和坐标信息的文化观察信息。显示单元设置在由适配器固定的孔板的放置表面侧上，并且响应于控制单元的控制，将从存储卡读取的单元信息显示在对应于位置的显示位置井板底面，由坐标信息指定。实施例可以用作例如支持在洁净工作台中执行的拾取操作的细胞采集支持装置。

9. 发明授权

US08447092B2 Observation device for observing cells or the like 有权
标题翻译：用于观察细胞等的观察装置
公开(公告)号：US08447092B2
公开(公告)日：2013-05-21
申请号：US12292623
申请日：2008-11-21
申请人： Hiroaki Kii , Yasujiro Kiyota
发明人： Hiroaki Kii , Yasujiro Kiyota
IPC分类号： G06K9/00
CPC分类号： C12M41/36 , G02B21/06 , G02B21/365
摘要： An observation device that observes a test specimen such as cultured cells or the like includes: an illumination device that illuminates the test specimen; an image-capturing device that acquires an image of the test specimen illuminated by the illumination device; a storage unit that stores correlation data manifesting a correlation relationship between an occupation ratio of the test specimen within a culture vessel, and statistically processed data regarding to luminance information of the test specimen; and a calculation unit that obtains the statistically processed data based upon luminance information in a specified color of the test specimen captured by the image-capturing device, and calculates the occupation ratio of the test specimen within the culture vessel using the correlation data in the storage unit.
摘要翻译：观察诸如培养细胞等的测试样本的观察装置包括：照射测试样本的照明装置; 获取由所述照明装置照射的所述试验片的图像的摄像装置; 存储单元，存储表示培养容器内的检体的占有率与统计处理的关于检体的亮度信息的数据之间的相关关系的相关数据; 以及计算单元，其基于由图像捕获装置捕获的测试样本的指定颜色的亮度信息获得统计处理的数据，并且使用存储器中的相关数据来计算培养容器内的测试样本的占有率单元。

10. 发明授权

US08445266B2 Apparatus for judging cell detachment, method of judging cell detachment, and cell culture apparatus 有权
公开(公告)号：US08445266B2
公开(公告)日：2013-05-21
申请号：US12289595
申请日：2008-10-30
申请人： Yasujiro Kiyota , Hiroaki Kii
发明人： Yasujiro Kiyota , Hiroaki Kii
IPC分类号： C12Q1/70 , C12Q1/06 , C12C1/02 , C12M1/34 , C12M3/00
CPC分类号： C12M41/14 , C12M41/46 , C12M41/48 , C12Q1/02
摘要： An apparatus for judging cell detachment that judges a state of detachment of cells that have been cultured within a cell culture container (cultured cells), includes: an image-capturing unit that captures an image of the cultured cells; and a detachment state judging unit that determines luminance information within the cell culture container based upon image capture data from the image-capturing unit, and judges that the culture cells are detached when the luminance information exceeds a predetermined luminance level.

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