专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110300182A1 NUCLEIC ACID DRUG FOR TREATMENT OF ALLERGIC DISEASE 审中-公开
标题翻译：用于治疗过敏性疾病的核酸药物
公开(公告)号：US20110300182A1
公开(公告)日：2011-12-08
申请号：US13119080
申请日：2009-03-12
申请人： Hiroo Yokozeki , Kazuki Hosoya , Takahiro Satoh , Yasuhisa Nemoto
发明人： Hiroo Yokozeki , Kazuki Hosoya , Takahiro Satoh , Yasuhisa Nemoto
IPC分类号： A61K31/713 , C12N15/63 , A61P29/00 , A61P37/08 , A61P17/00 , A61P11/06 , C07H21/02 , A61K48/00
CPC分类号： C12N15/113 , C12N2310/14
摘要： This invention provides double-stranded (ds) RNA capable of suppressing the expression of STAT6 related to allergic diseases mediated by Th2-type cytokines via RNA interference and a pharmaceutical composition for prevention or treatment of allergic diseases comprising such dsRNA. Such dsRNA is a double-stranded RNA (dsRNA) molecule targeting mRNA of the STAT6 gene composed of (a) or (b): (a) a sense strand identical to a sequence having 15 to 50 continuous nucleotides in the STAT6 gene sequence represented by SEQ ID NO: 1 or 3 and an antisense strand comprising a nucleotide sequence complementary to the nucleotide sequence of the sense strand; or (b) a sense strand comprising a sequence derived from the sequence comprising 15 to 50 continuous nucleotides of the STAT6 gene sequence represented by SEQ ID NO: 1 or 3 by deletion, substitution, or addition of 1 or several nucleotides and capable of hybridizing to the STAT6 gene and an antisense strand comprising a nucleotide sequence complementary to the nucleotide sequence of the sense strand.
摘要翻译：本发明提供能够通过RNA干扰抑制由Th2型细胞因子介导的过敏性疾病的STAT6表达的双链（ds）RNA和用于预防或治疗包含这种dsRNA的过敏性疾病的药物组合物。这种dsRNA是靶向由（a）或（b）组成的STAT6基因mRNA的双链RNA（dsRNA）分子：（a）与在STAT6基因序列中具有15至50个连续核苷酸的序列相同的有义链代表通过SEQ ID NO：1或3和包含与有义链的核苷酸序列互补的核苷酸序列的反义链; 或（b）含有由SEQ ID NO：1或3表示的STAT6基因序列的15〜50个连续核苷酸的序列衍生的有义链，通过缺失，取代或添加1个或几个核苷酸并且能够杂交到STAT6基因和包含与有义链的核苷酸序列互补的核苷酸序列的反义链。

IPRDB

热门服务

关于我们

友情链接

联系方式