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1. 发明专利

HK1088019A1 用於非病毒基因送遞載體的陽離子接枝共聚物未知
公开(公告)号：HK1088019A1
公开(公告)日：2006-10-27
申请号：HK06104455
申请日：2006-04-12
申请人： YASUHIKO ONISHI
发明人： ONISHI YASUHIKO
IPC分类号： C08F20060101 , C12N15/09 , A61K47/48 , A61K48/00 , A61L20060101 , C07H21/04 , C08F251/00 , C08F261/04 , C08L20060101 , C08L51/02

2. 发明专利

JP2005036219A Chitosan copolymer 有权
标题翻译： CHOSOSAN共聚物
公开(公告)号：JP2005036219A
公开(公告)日：2005-02-10
申请号：JP2004192279
申请日：2004-06-29
申请人： Yasuhiko Onishi , 靖彦大西
发明人： ONISHI YASUHIKO
IPC分类号： C07H21/04 , C08B37/08 , C08F251/00
摘要： PROBLEM TO BE SOLVED: To obtain a vector that introduces DNA or RNA into a cell by preparing a surfactant-free latex solution by polymerizing an olefin compound in the presence of chitosan in water.
SOLUTION: The latex solution comprises a polymer obtained by polymerizing an olefin compound with chitosan in water. A complex is obtained by reacting the polymer with various DNA or RNA. Such a nonviral vector can be stably used since it, unlike a hazardous viral vector, is a safe artificial product. Selectivity for a cell membrane is important for a vector to have an enhanced transformation efficiency. It is necessary that a vector has hydrophobic and hydrophilic domains in order to enhance the transformation efficiency. In particular, it is important to form a latex comprising a copolymer material comprising chitosan and a vinyl monomer.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了获得通过在壳聚糖存在下在水中聚合烯烃化合物制备无表面活性剂的胶乳溶液来将DNA或RNA引入细胞的载体。解决方案：胶乳溶液包含通过在水中将壳聚糖与烯烃化合物聚合而获得的聚合物。通过使聚合物与各种DNA或RNA反应获得复合物。这种非病毒载体可以稳定地使用，因为它与危险的病毒载体不同，是一种安全的人造产品。细胞膜的选择性对于载体具有增强的转化效率是重要的。为了提高转化效率，载体必须具有疏水和亲水结构域。特别地，重要的是形成包含包含壳聚糖和乙烯基单体的共聚物材料的胶乳。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JPS61126101A Starch derivative and its copolymer 失效
标题翻译：淀粉衍生物及其共聚物
公开(公告)号：JPS61126101A
公开(公告)日：1986-06-13
申请号：JP24719184
申请日：1984-11-22
申请人： Yasuhiko Onishi
发明人： ONISHI YASUHIKO
IPC分类号： C08F251/00 , C08B31/12
摘要： PURPOSE: The titled derivative excellent in water solubility and characteristics as a hydrophilic colloid, obtained by reacting a starch with a halogenated alkanediol in the presence of an alkali.
CONSTITUTION: A starch (e.g., corn starch) is reacted with a halogenated alkanediol of formula I or II (wherein n is 0W7 and X is a halogen), e.g., 3- chloro-1,2-propanediol, in the presence of an alkali (e.g., NaOH) in a solvent (e.g., water) to obtain an alkanediol derivative of starch of formula III (wherein Y is a glycol compound of formula I or IV, 0≤n≤7, 0
摘要翻译：目的：通过在碱存在下使淀粉与卤代链烷二醇反应获得的水溶性和亲水胶体特性优异的标题衍生物。构成：在存在的情况下，将淀粉（例如玉米淀粉）与式I或II的卤代链烷二醇（其中n为0-7且X为卤素）反应，例如3-氯-1,2-丙二醇的碱（例如NaOH）在溶剂（例如水）中，得到式III的淀粉的链烷二醇衍生物（其中Y是式I或IV的二醇化合物，0 <= n <= 7,0 = 5）。该衍生物与丙烯酰胺共聚以获得接枝共聚物。所述衍生物和所述共聚物在水中的分散性和增稠和结块质量优异，因此它们可以应用于药物制剂领域，特别是以具有用于控制角膜水合作用的结构粘度的高粘度溶液形式使用在眼科中，洗涤隐形眼镜或作为润滑剂。

4. 发明专利

JP2014001198A Anticancer agent deliver system of cationic polysaccharide copolymer 有权
标题翻译：阳离子多糖共聚物的反应物代理交付系统
公开(公告)号：JP2014001198A
公开(公告)日：2014-01-09
申请号：JP2013000134
申请日：2013-01-04
申请人： Yasuhiko Onishi , 靖彦大西
发明人： ONISHI YASUHIKO
IPC分类号： A61K47/36 , A61K31/337 , A61K38/00 , A61K45/00 , A61K47/48 , A61L31/00 , A61P35/00
CPC分类号： A61K47/36 , A61K31/337 , A61K38/13 , A61K47/32 , A61K47/61
摘要： PROBLEM TO BE SOLVED: To obtain a drug delivery material feeding a drug to a cell by polymerizing an olefin compound in water using a cationic derivative of polysaccharide to prepare latex solution containing no surfactant and forming a supermolecule complex with a drug.SOLUTION: A latex solution comprises a polymer obtained by polymerizing in water an olefin compound with a cationic derivative of polysaccharide. Further, a complex can be obtained by reacting the same with various kinds of drugs. The drug delivery material thus prepared can be used to achieve stable and safe usage of a drug that would otherwise have adverse effect. Selective permeability of the cell membrane and selective reactivity with substrate in the cell are critical for enhancing drug efficacy. It is also important for the supermolecule to have both hydrophobic and hydrophilic domains for enhancing selective permeability of the cell membrane and achieving the supermolecular property. Specifically, a latex is produced that is made of a copolymer material of cationic polysaccharide and vinyl monomer, and its complex with a drug is then produced. The supermolecular property of the complex is an important factor for selective permeability of the cell membrane and selective reactivity with substrate in the cell. Such drug delivery material is stable and expected to be used for coating, and so a very promising for the industry.
摘要翻译：要解决的问题：为了获得通过使用多糖的阳离子衍生物在水中使烯烃化合物聚合而将药物供给到细胞的药物递送材料，以制备不含表面活性剂并与药物形成超分子复合物的胶乳溶液。溶液：胶乳溶液包括通过在水中聚合烯烃化合物与多糖的阳离子衍生物而获得的聚合物。此外，可以通过使其与各种药物反应来获得复合物。如此制备的药物递送材料可用于实现否则将产生不利影响的药物的稳定和安全使用。细胞膜的选择性渗透性和细胞中底物的选择性反应性对于提高药物功效至关重要。超分子也具有疏水和亲水结构域，以增强细胞膜的选择性渗透性并达到超分子性质也是重要的。具体地说，制造由阳离子多糖和乙烯基单体的共聚物材料制成的胶乳，然后制备其与药物的复合物。复合物的超分子性质是细胞膜的选择性渗透性和细胞中与底物的选择性反应性的重要因素。这种药物输送材料是稳定的，预期用于涂层，因此对于行业来说是非常有希望的。

5. 发明专利

JPS61126119A Cationic polyelectrolyte copolymer 失效
标题翻译：阳离子聚电解质共聚物
公开(公告)号：JPS61126119A
公开(公告)日：1986-06-13
申请号：JP24847684
申请日：1984-11-24
申请人： Yasuhiko Onishi
发明人： ONISHI YASUHIKO
IPC分类号： C08F251/00 , C07K16/00 , C07K17/08 , C12N5/00 , C12N5/02 , G01N33/545 , G01N33/548 , G01N33/554
摘要： PURPOSE: The titled copolymer which can be firmly bonded to an antibody and is suitable in the production of an antibody adsorbing latex diagnostic agent, obtained by graft-polymerizing a vinyl monomer with a cationic partially substituted polysaccharide derived from a bacteria-produced water-soluble linear polysaccharide.
CONSTITUTION: A cationic partially substituted, bacteria-produced water-soluble linear polysaccharide (e.g., diethylaminoethyldextran or diethylaminoethylpullulan) is graft-polymerized with a vinyl monomer (e.g., methyl methacrylate or styrene) to obtain the purpose cationic polyelectrolyte copolymer. A latex obtained by dispersing this copolymer in water is firmly bonded to an antibody and is used in the reaction with an antigen as an anti body latex diagnostic agent. The bacteria-produced water-soluble linear polysac charide may be replaced with a hydroxyl group-containing high-molecular com pound (e.g., polypropylene glycol).
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：可以牢固地结合到抗体上并且适用于制备抗体吸附胶乳诊断剂的标题共聚物，其通过用衍生自细菌产生的水溶性的阳离子部分取代的多糖接枝聚合乙烯基单体而获得线性多糖。构成：阳离子部分取代的细菌生产的水溶性线性多糖（例如二乙基氨基乙基葡聚糖或二乙基氨基乙基普兰兰）与乙烯基单体（例如甲基丙烯酸甲酯或苯乙烯）接枝聚合，得到目的阳离子聚电解质共聚物。通过将该共聚物分散在水中得到的胶乳与抗体牢固结合，并与抗原作为抗体乳胶诊断剂进行反应。细菌产生的水溶性线性多糖可以用含羟基的高分子量（例如聚丙二醇）代替。

6. 发明专利

JP2010246563A Cationic polysaccharide copolymer vector 审中-公开
标题翻译：阳离子多糖共聚物载体
公开(公告)号：JP2010246563A
公开(公告)日：2010-11-04
申请号：JP2010166422
申请日：2010-07-23
申请人： Yasuhiko Onishi , 靖彦大西
发明人： ONISHI YASUHIKO
IPC分类号： C12N15/09 , C08F251/00
摘要： PROBLEM TO BE SOLVED: To obtain a non-viral vector for delivering a deoxyribonucleic acid (DNA), ribonucleic acid (RNA) into cells by preparing a latex solution without a surfactant by polymerizing an olefin compound in water using a cationic derivative of a polysaccharide.
SOLUTION: The latex solution prepared by polymerizing the olefin compound to the cationic derivative of a polysaccharide is provided. Complexes prepared by reacting various deoxyribonucleic acids (DNAs), ribonucleic acids (RNAs) to the latex solution are also provided. When such a non-viral vector is used, it can be safely and stably used, because it is an artificial product different from vectors of dangerous viruses. The selectivity of a cell membrane is important for enhancing transformation efficiency as a vector. Furthermore, it has been found that it is important to have a hydrophobic hydrophilic domains in order to enhance the transformation efficiency, concretely it is important to form the latex comprising a copolymer material of a cationic polysaccharide and a vinyl monomer.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：为了获得通过使用阳离子衍生物在水中聚合烯烃化合物而制备不含表面活性剂的胶乳溶液来获得用于将脱氧核糖核酸（DNA），核糖核酸（RNA）递送至细胞的非病毒载体的多糖。解决方案：提供通过将烯烃化合物聚合成多糖的阳离子衍生物而制备的胶乳溶液。还提供了通过使各种脱氧核糖核酸（DNA），核糖核酸（RNA）与胶乳溶液反应制备的配合物。当使用这种非病毒载体时，它可以安全和稳定地使用，因为它是与危险病毒载体不同的人造产品。细胞膜的选择性对于提高作为载体的转化效率是重要的。此外，已经发现，为了提高转化效率，具有疏水性亲水区域是重要的，具体地说，重要的是形成包含阳离子多糖和乙烯基单体的共聚物材料的胶乳。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2005102681A Cationic polysaccharide copolymer vector 有权
标题翻译：阳离子多糖共聚物载体
公开(公告)号：JP2005102681A
公开(公告)日：2005-04-21
申请号：JP2003434851
申请日：2003-12-26
申请人： Yasuhiko Onishi , 靖彦大西
发明人： ONISHI YASUHIKO
IPC分类号： C12N15/09 , A61K47/48 , A61K48/00 , C07H21/04 , C08F251/00 , C08F261/04 , C08L51/02
CPC分类号： C08L51/02 , C08F251/00 , C08F261/04
摘要： PROBLEM TO BE SOLVED: To obtain a non-viral vector capable of introducing a deoxyribonucleic acid (DNA) or a ribonucleic acid (RNA) into a cell, by using a cationic derivative of a polysaccharide, polymerizing the derivative with an olefin compound in water, and preparing a latex solution without containing a surfactant.
SOLUTION: The latex solution comprises a polymer which is given by polymerizing the cationic derivative of the polysaccharide with the olefin compound in the water. Complexes are obtained by reacting the latex solution with various kinds of the DNA's or the RNA's. The non-viral vector comprising the complex thus obtained is safely and stably used, because the vector is different from vectors derived from dangerous viruses and comprises an artificial product. Selectivity of a cell membrane is important, for the purpose of enhancing transformation efficiency as the vector. The vector is required to have hydrophobic and hydrophilic domains, for the purpose of more enhancing the transformation efficiency than ever, so that it is concretely important to form a latex which comprises a copolymer material formed out of a cationic polysaccharide and a vinyl monomer.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了获得能够将脱氧核糖核酸（DNA）或核糖核酸（RNA）引入细胞的非病毒载体，通过使用多糖的阳离子衍生物，将该衍生物与烯烃聚合在水中复合，并制备不含表面活性剂的胶乳溶液。解决方案：胶乳溶液包含通过在水中聚合多糖的阳离子衍生物与烯烃化合物而得到的聚合物。通过使胶乳溶液与各种DNA或RNA的反应获得复合物。包含由此获得的复合物的非病毒载体是安全和稳定地使用的，因为载体不同于衍生自危险病毒的载体，并且包含人造产品。细胞膜的选择性是重要的，目的是提高作为载体的转化效率。为了更有效地提高转化效率，载体需要具有疏水性和亲水性的区域，因此形成包含由阳离子多糖和乙烯基单体形成的共聚物材料的胶乳具有特别重要的意义。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JPS61133214A Matrix polymer 失效
标题翻译： MATRIX聚合物
公开(公告)号：JPS61133214A
公开(公告)日：1986-06-20
申请号：JP25449184
申请日：1984-11-30
申请人： Yasuhiko Onishi
发明人： ONISHI YASUHIKO
IPC分类号： A61L27/16 , C08F251/00 , G02B1/04
CPC分类号： C08B37/0021 , A61F2/16 , A61L27/16 , C08F251/00 , G02B1/04 , G02C7/04 , A61F2/28 , A61F2/06 , C08L51/02 , C08L51/00
摘要： PURPOSE: To obtain the titled polymer useful for contact lens, artificial blood vessel, artificial kidney, artificial lens, etc., by polymerization of unsaturated acid to cationic derivative from polysaccharide (except dextran).
CONSTITUTION: The objective polymer or formed article therefrom can be obtained by polymerization or pref. copolymerization or bulk polymerization of an unsaturated acid (e.g., acrylic acid) or pref. another vinyl monomer in combination therewith, to a cationic derivative from polysaccharide (except edxtran). The formed article is pref. contact lens.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过将不饱和酸与多糖（葡聚糖除外）的阳离子衍生物聚合，得到可用于隐形眼镜，人造血管，人造肾，人造晶状体等的标题聚合物。构成：可以通过聚合或优选获得目标聚合物或其成型制品。不饱和酸（例如丙烯酸）的共聚合或本体聚合或优选。另外与其组合的乙烯基单体，与多糖（葡聚糖除外）的阳离子衍生物。形成的文章是pref。隐形眼镜。

9. 发明授权

US09577087B2 Semiconductor apparatus 有权
标题翻译：半导体装置
公开(公告)号：US09577087B2
公开(公告)日：2017-02-21
申请号：US13313583
申请日：2011-12-07
申请人： Yasuhiko Onishi , Akio Sugi
发明人： Yasuhiko Onishi , Akio Sugi
IPC分类号： H01L29/78 , H01L29/08 , H01L29/06 , H01L29/40 , H01L29/417
CPC分类号： H01L29/7811 , H01L29/0619 , H01L29/0634 , H01L29/0638 , H01L29/0696 , H01L29/0878 , H01L29/402 , H01L29/404 , H01L29/41741
摘要： A semiconductor apparatus that has a first parallel pn-layer formed between an active region and an n+-drain region. A peripheral region is provided with a second parallel pn-layer, which has a repetition pitch narrower than the repetition pitch of the first parallel pn-layer. An n−-surface region is formed between the second parallel pn-layer and a first main surface. On the first main surface side of the n−-surface region, a plurality of p-guard ring regions are formed to be separated from each other. A field plate electrode is connected electrically to the outermost p-guard ring region among the p-guard ring regions. A channel stopper electrode is connected electrically to an outermost peripheral p-region of the peripheral region.
摘要翻译：一种半导体装置，其具有在有源区域和n + - 划分区域之间形成的第一并联pn层。外围区域设置有第二平行pn层，其具有比第一并联pn层的重复间距窄的重复间距。在第二平行pn层和第一主表面之间形成n表面区域。在n面区域的第一主表面侧，形成多个p保护环区域以彼此分离。场板电极电连接到保护环区域中的最外侧保护环区域。通道阻挡电极电连接到周边区域的最外周边p区域。

10. 发明授权

US09339549B2 Cationic graft-copolymer for drug delivery system 有权
标题翻译：用于药物输送系统的阳离子接枝共聚物
公开(公告)号：US09339549B2
公开(公告)日：2016-05-17
申请号：US14378974
申请日：2013-02-21
申请人： Yasuhiko Onishi
发明人： Yasuhiko Onishi
IPC分类号： A61K31/337 , A61K38/13 , A61K47/36 , A61K47/32 , A61K47/48
CPC分类号： A61K47/36 , A61K31/337 , A61K38/13 , A61K47/32 , A61K47/61
摘要： A cationic graft-copolymer for a drug delivery system comprising a unit derived from a having a hydroxyl groups, namely, a cationic polysaccharide of the following formula (1) (C6H7O2(OH)3-a (OX)a)xH2O (1) and a unit derived from a polymerizable olefin compound of the following formula (2) (a, x, X, R4, R5, R6, and R7 are defined in claim 1-8); a process for preparing the same and a transfection reagent made therefrom.
摘要翻译：一种用于药物递送系统的阳离子接枝共聚物，其包含衍生自具有羟基的单元，即下式（1）的阳离子多糖（C6H7O2（OH）3-a（OX）a）xH2O（1）和由下式（2）（a，x，X，R4，R5，R6和R7定义）的可聚合烯烃化合物衍生的单元定义在权利要求1-8中。其制备方法和由其制备的转染试剂。

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