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1. 发明申请

US20060189943A1 Two-chamber-type pre-filled syringe 有权
标题翻译：两室式预灌注注射器
公开(公告)号：US20060189943A1
公开(公告)日：2006-08-24
申请号：US10543139
申请日：2004-02-18
申请人： Masahiko Kato , Yasaburo Akagi
发明人： Masahiko Kato , Yasaburo Akagi
IPC分类号： A61M5/00 , A61M37/00
CPC分类号： A61M5/284 , A61M2005/3132
摘要： A dual-chamber type prefilled syringe comprises a cylindrical body within which a front plug member, a middle plug member and an end plug member are hermetically fitted to form a first chamber and a second chamber. The cylindrical body (2) has an inner surface formed with a bypass (14). When the middle plug member (7) moves to a position where the bypass (14) is formed, the first chamber (9) is communicated with the second chamber (10) for the first time via the bypass (14). In this beginning state of liquid transfer (S), an inner volume (VS) of the cylindrical body (2) between a leading end (2a) of the cylindrical body (2) and a rear end (6b) of the front plug member (6) is set to be at least 60% of a volume (VC) of a second component (12). When liquid component within the second chamber flows into the first chamber, it is possible to prevent part of the liquid component from passing through the first chamber to reach a portion for attaching an injection needle at a leading end of the cylindrical body.
摘要翻译：双室型预充式注射器包括圆柱形主体，其中前插塞构件，中塞构件和端塞构件气密地配合在其中以形成第一腔室和第二腔室。圆柱体（2）具有形成有旁路（14）的内表面。当中间塞构件（7）移动到形成旁路（14）的位置时，第一室（9）经由旁路（14）首次与第二室（10）连通。在液体转移（S）的开始状态下，筒状体（2）的前端部（2a）与前端部的后端（6b）之间的筒体（2）的内部体积（VS）插塞构件（6）被设定为第二构件（12）的体积（VC）的至少60％。当第二室内的液体成分流入第一室时，可以防止液体成分的一部分通过第一室到达在筒体的前端附着注射针的部分。

2. 发明授权

US07311692B2 Two-chamber-type pre-filled syringe 有权
标题翻译：两室式预灌注注射器
公开(公告)号：US07311692B2
公开(公告)日：2007-12-25
申请号：US10543139
申请日：2004-02-18
申请人： Masahiko Kato , Yasaburo Akagi
发明人： Masahiko Kato , Yasaburo Akagi
IPC分类号： A61M37/00
CPC分类号： A61M5/284 , A61M2005/3132
摘要： A dual-chamber type prefilled syringe comprises a cylindrical body within which a front plug member, a middle plug member and an end plug member are hermetically fitted to form a first chamber and a second chamber. The cylindrical body has an inner surface formed with a bypass. When the middle plug member moves to a position where the bypass is formed, the first chamber is communicated with the second chamber for the first time via the bypass. In this beginning state of liquid transfer (S), an inner volume (VS) of the cylindrical body between a leading end of the cylindrical body and a rear end of the front plug member is set to be at least 60% of a volume (VC) of a second component. When liquid component within the second chamber flows into the first chamber, it is possible to prevent part of the liquid component from passing through the first chamber to reach a portion for attaching an injection needle at a leading end of the cylindrical body.
摘要翻译：双室型预充式注射器包括圆柱形主体，其中前插塞构件，中塞构件和端塞构件气密地配合在其中以形成第一腔室和第二腔室。圆柱体具有形成有旁路的内表面。当中间塞构件移动到形成旁路的位置时，第一室经由旁路第一次与第二室连通。在液体转移（S）的这种开始状态下，圆柱体的前端与前塞子构件的前端之间的筒体的内体积（VS）设定为体积的至少60％ VC）的第二组件。当第二室内的液体成分流入第一室时，可以防止液体成分的一部分通过第一室到达在筒体的前端附着注射针的部分。

3. 发明授权

US5723269A Microparticle preparation and production thereof 失效
标题翻译：微粒制备及其制备
公开(公告)号：US5723269A
公开(公告)日：1998-03-03
申请号：US612071
申请日：1996-03-07
申请人： Yasaburo Akagi , Nobuyuki Takechi , Muneo Nonomura
发明人： Yasaburo Akagi , Nobuyuki Takechi , Muneo Nonomura
IPC分类号： A61K9/16 , A61K9/50 , A61K9/58
CPC分类号： A61K9/1694 , A61K9/1647 , A61K9/501 , A61K9/5015 , Y10S514/963 , Y10T428/2985
摘要： A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are at least partially or wholly coated with a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid, which acts as an agent for preventing aggregation of the microparticle preparation is disclosed. The preparation is produced by spraying a polymer solution containing a drug and a solution or dispersion of a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid from different nozzles and contacting them with each other in a spray dryer. In this procedure, if desired, a non-ionic surfactant may be added to the solution of the water-soluble inorganic salt, the water-soluble organic acid or the water-soluble salt of organic acid, or a solution of non-ionic surfactant may be sprayed from the other nozzle simultaneously.
摘要翻译：一种新颖的微粒制剂，其包含含有药物并且至少部分或全部被水溶性无机盐，水溶性有机酸或有机酸的水溶性盐的聚合物的微粒，其作为公开了防止微粒制剂聚集的试剂。该制剂通过从不同喷嘴喷射含有药物的聚合物溶液和水溶性无机盐，水溶性有机酸或有机酸的水溶性盐的溶液或分散体并将它们彼此接触来制备在喷雾干燥器中。在该方法中，如果需要，可以将非离子表面活性剂加入到水溶性无机盐，水溶性有机酸或有机酸的水溶性盐溶液或非离子表面活性剂可以同时从另一个喷嘴喷射。

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