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1. 发明授权

US09012407B2 Therapies which act on neuropeptide S receptors 有权
标题翻译：作用于神经肽S受体的疗法
公开(公告)号：US09012407B2
公开(公告)日：2015-04-21
申请号：US11587444
申请日：2005-04-25
申请人： Olivier Civelli , Rainer K. Reinscheid , Yanling Xu
发明人： Olivier Civelli , Rainer K. Reinscheid , Yanling Xu
IPC分类号： A61K38/17 , A61K31/4985
CPC分类号： A61K31/4985 , A61K38/1709
摘要： Compositions and methods that act on Neuropeptide S receptors (NPSR) (also known as “TGR23” or “vasopressin receptor-related receptor 1 (VRR1)”) to cause desired effects in the bodies of human or animal subjects. Neuropeptide S (NPS) and other agonists of the NPSR may be administered to cause arousal, awakening, alertness, spontaneous movement, bronchoconstriction, contraction of bronchial smooth muscle or other effects. Antagonists of the NPSR may be administered to cause decreased arousal, decreased awakening, decreased alertness, decreased spontaneous movement, sleep, somnolence, sedation, anxiolytic effects, normalized sleep patterns, normalized sleep stages, increased duration of sleep, bronchodilation, relaxation of broncheal smooth muscle or other effects.
摘要翻译：作用于神经肽S受体（NPSR）（也称为“TGR23”或“加压素受体相关受体1（VRR1）”）的组合物和方法，以在人或动物受试者的身体中产生预期的效果。神经肽S（NPS）和NPSR的其它激动剂可以被施用以引起觉醒，觉醒，警觉，自发运动，支气管收缩，支气管平滑肌收缩或其它作用。可以施用NPSR的拮抗剂以引起觉醒降低，警觉性降低，自发运动降低，睡眠，嗜睡，镇静，抗焦虑作用，归一化睡眠模式，归一化睡眠阶段，睡眠增加持续时间，支气管扩张，放射支气管平滑肌肉或其他影响。

2. 发明申请

US20100056455A1 Therapies Which Act on Neuropeptide S Receptors 有权
标题翻译：对神经肽S受体的作用
公开(公告)号：US20100056455A1
公开(公告)日：2010-03-04
申请号：US11587444
申请日：2005-04-25
申请人： Olivier Civelli , Rainer K Reinscheld , Yanling Xu
发明人： Olivier Civelli , Rainer K Reinscheld , Yanling Xu
IPC分类号： A61K38/17 , A61P25/00 , C07K14/435
CPC分类号： A61K31/4985 , A61K38/1709
摘要： Compositions and methods that act on Neuropeptide S reseptors (NPSR) (also known as or “TGR23” or “vasopressin receptor-related receptor 1 (VRR1)”) to cause desired effects in the bodies of human or animal subjects. Neuropeptide S (NPS) and other agonists of the NPSR may be administered to cause arousal, awakening, alertness, spontaneous movement, bronchoconstriction, contraction of bronchial smooth muscle or other effects. Antagonists of the NPSR may be administered to cause decreased arousal, decreased awakening, decreased alertness, decreased spontaneous movement, sleep, somnolence, sedation, anxiolytic effects, normalized sleep patterns, normalized sleep stages, increased duration of sleep, bronchodilation, relaxation of broncheal smooth muscle or other effects.
摘要翻译：作用于神经肽S受体（NPSR）（也称为或“TGR23”或“加压素受体相关受体1（VRR1）”）的组合物和方法，以在人或动物受试者的身体中产生预期的效果。神经肽S（NPS）和NPSR的其它激动剂可以被施用以引起觉醒，觉醒，警觉，自发运动，支气管收缩，支气管平滑肌收缩或其它作用。可以施用NPSR的拮抗剂以引起觉醒降低，警觉性降低，自发运动降低，睡眠，嗜睡，镇静，抗焦虑作用，归一化睡眠模式，归一化睡眠阶段，睡眠增加持续时间，支气管扩张，放射支气管平滑肌肉或其他影响。

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