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1. 发明申请

WO2006132476A1 DUAL-FUNCTION SURFACE PLASMON RESONANCE BIOSENSOR SYSTEM 审中-公开
标题翻译：双功能表面质谱共振生物传感器系统
公开(公告)号：WO2006132476A1
公开(公告)日：2006-12-14
申请号：PCT/KR2006/001724
申请日：2006-05-09
申请人： KNU-INDUSTRY COOPERATION FOUNDATION , YUK, Jong Seol , HA, Kwon-Soo
发明人： YUK, Jong Seol , HA, Kwon-Soo
IPC分类号： G01N33/52
CPC分类号： G01N21/253 , G01N21/553
摘要： The present invention relates to a dual-function surface plasmon resonance biosensor system. The system includes a light source, a polarizer for polarizing light output from the light source, an optical lens system for irradiating the light polarized by the polarizer, a X-Y linear stage having a plurality of protein chips on which the light irradiated by the optical lens system is incident, an optical detector for receiving light reflected from a protein chip and analyzing the received light, an X linear stage having the optical detector disposed thereon and adapted to move the optical detector, and a computer for displaying optical information received from the optical detector. Furthermore, in the case where the system operates in a wavelength interrogation-based SPR sensor mode, the light reflected from the protein chip is spectroscoped and analyzed by the spectrometer and the optical detector via the optical fiber and is displayed on the computer as optical data. Alternatively, in the case where the system operates in a surface plasmon microscope mode, as the X-Y linear stage is moved by given driving means, the irradiated light sequentially scans a protein chip having a plurality of protein spots, the reflected light is measured by the CCD camera and is displayed on a computer as optical data.
摘要翻译：本发明涉及双功能表面等离子体共振生物传感器系统。该系统包括光源，用于偏振从光源输出的光的偏振器，用于照射由偏振器偏振的光的光学透镜系统，具有多个蛋白质芯片的XY线性平台，其上由光学透镜照射的光系统入射，用于接收从蛋白质芯片反射的光并分析接收的光的光学检测器，具有设置在其上的光学检测器并适于移动光学检测器的X线性平台，以及用于显示从光学器件接收的光学信息的计算机探测器。此外，在系统以基于波长询问的SPR传感器模式工作的情况下，从蛋白质芯片反射的光通过光纤由光谱仪和光学检测器进行光谱分析和分析，并作为光学数据显示在计算机上。或者，在系统以表面等离子体显微镜模式工作的情况下，由于XY线性平台通过给定的驱动装置移动，所照射的光依次扫描具有多个蛋白点的蛋白质芯片，反射光由 CCD摄像机，作为光学数据显示在电脑上。

2. 发明申请

WO2003104775A1 METHOD FOR PROTEIN CHIP ANALYSIS BY USING SURFACE PLASMON RESONANCE SPECTROSCOPIC IMAGING TECHNOLOGY 审中-公开
标题翻译：使用表面等离子共振光谱成像技术的蛋白质芯片分析方法
公开(公告)号：WO2003104775A1
公开(公告)日：2003-12-18
申请号：PCT/KR2002/001659
申请日：2002-09-02
申请人： KOREA BASIC SCIENCE INSTITUTE , HA, Kwon, Soo , YUK, Jong, Seol , YI, Sun, Ju , LEE, Hyeon, Gon , KWON, Kyung, Hoon
发明人： HA, Kwon, Soo , YUK, Jong, Seol , YI, Sun, Ju , LEE, Hyeon, Gon , KWON, Kyung, Hoon
IPC分类号： G01N21/25
CPC分类号： G01N21/553
摘要： The present invention provides a method for protein chip analysis by using surface plasmon resonance spectroscopic image technology. A protein chip with a plurality of spots, arranged at a specific interval in vertical and horizontal directions, is mounted on a x-y stage, and p-polarized beams that passed through a prism are sequentially irradiated on each spot of the protein chip. The light signal reflected from each spot of the protein chip is collected into a spectrometer and its surface plasmon resonance wavelength is determined. This surface plasmon resonance wavelength value is represented by a color at the position of each protein spot to obtain a two dimensional image. Otherwise, the surface plasmon resonance wavelength value is allocated to a z-coordinate value to obtain a three-dimensional image.
摘要翻译：本发明提供了使用表面等离子体共振光谱图像技术进行蛋白质芯片分析的方法。将具有多个点的蛋白质芯片以垂直和水平方向的特定间隔安装在x-y平台上，并且通过棱镜的p偏振光束依次照射在蛋白质芯片的每个点上。从蛋白质芯片的每个点反射的光信号被收集到光谱仪中，并且确定其表面等离子体共振波长。该表面等离子体共振波长值由每个蛋白点的位置处的颜色表示，以获得二维图像。否则，将表面等离子体共振波长值分配给z坐标值以获得三维图像。

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