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1. 发明申请

WO2005044786A1 BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS 审中-公开
标题翻译：双酰胺酰胺，碳酸盐或尿素衍生物作为VANILLOID受体调节剂
公开(公告)号：WO2005044786A1
公开(公告)日：2005-05-19
申请号：PCT/EP2004/012050
申请日：2004-10-26
申请人： BAYER HEALTHCARE AG , MOGI, Muneto , FUJISHIMA, Hiroshi , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , URBAHNS, Klaus , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang , YUASA, Hiroaki
发明人： MOGI, Muneto , FUJISHIMA, Hiroshi , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , URBAHNS, Klaus , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang , YUASA, Hiroaki
IPC分类号： C07C275/28
CPC分类号： C07D295/155 , C07C235/38 , C07C275/32 , C07C2601/14 , C07C2602/08 , C07C2602/10
摘要： This invention relates to bicyclic amide, carbamate or urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The bicyclic amide, carbamate or urea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).
摘要翻译：本发明涉及可用作药物制剂活性成分的双环酰胺，氨基甲酸酯或脲衍生物及其盐。本发明的双环酰胺，氨基甲酸酯或尿素衍生物具有香草素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗泌尿系统疾病或病症，例如逼尿肌过度活动症（膀胱过度活动症），尿失禁，神经源性逼尿肌过敏反应（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

2. 发明申请

WO2010122384A9 ELECTRICITY METER 审中-公开
标题翻译：电度表
公开(公告)号：WO2010122384A9
公开(公告)日：2011-01-20
申请号：PCT/IB2010000583
申请日：2010-03-18
申请人： PANASONIC ELECTRIC WORKS DENRO , ICHIMURA SHOGO , NISIKAWA MAKOTO , KASAYA MASATO , YUASA HIROAKI , NAGATOSHI HIDEAKI , IHORI MASAKAZU , WATANABE TAKASHI
发明人： ICHIMURA SHOGO , NISIKAWA MAKOTO , KASAYA MASATO , YUASA HIROAKI , NAGATOSHI HIDEAKI , IHORI MASAKAZU , WATANABE TAKASHI
IPC分类号： G01R22/00
CPC分类号： G01R22/10
摘要： An electricity meter is provided which is capable of communicating assessment results as to whether integral power consumption is expected to exceed a target value, even to users who do not intentionally attempt to verify their power consumption. A calculation unit 9 is provided with a target setting means 22 for setting the target integral power consumption for a predetermined period of time, and an assessing means 23 which, on the basis of the current integral power consumption and the target integral power consumption, makes a judgment of a warning state in which the integral power consumption at the end of the predetermined period is expected to exceed the target integral power consumption, or a non-warning state in which the former is not expected to exceed the latter. A display block 3 is distinctly provided with a light-emitting display unit 20 comprising LEDs which continuously emit light, as a separate unit from a power consumption display 10, and the assessment results of the assessing means 23 as to whether the integral power consumption is expected to exceed a target integral power consumption are continuously notified by means of the light emitting state of the light-emitting display unit 20.
摘要翻译：提供了一种能够传达关于整体功耗是否超过目标值的评估结果的电表，即使是不故意尝试验证其功耗的用户。计算单元9设置有用于将目标积分功耗设定为预定时间段的目标设定装置22，以及评估装置23，其基于当前积分功耗和目标积分功耗，预测在预定期间结束时的积分功率消耗超过目标积分功率消耗的警告状态的判断，或者不预期前者不超过该预警状态的非警告状态。显示块3明显地设置有发光显示单元20，发光显示单元20包括连续发光的LED，作为与功耗显示器10分离的单元，以及评估装置23的评估结果，综合功耗是否为通过发光显示单元20的发光状态连续地通知目标积分功率消耗。

3. 发明申请

WO2005040119A1 TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES 审中-公开
标题翻译：四氢萘和尿素衍生物
公开(公告)号：WO2005040119A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/010606
申请日：2004-09-22
申请人： BAYER HEALTHCARE AG , BOUCHON, Axel , DIEDRICHS, Nicole , HERMANN, Achim , LUSTIG, Klemens , MEIER, Heinrich , PERNERSTORFER, Josef , REISSMÜLLER, Elke , DE VRY, Jean , MOGI, Muneto , URBAHNS, Klaus , YURA, Takeshi , FUJISHIMA, Hiroshi , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , YUASA, Hiroaki , GUPTA, Jang , TSUKIMI, Yasuhiro , HAYASHI, Fumihiko
发明人： BOUCHON, Axel , DIEDRICHS, Nicole , HERMANN, Achim , LUSTIG, Klemens , MEIER, Heinrich , PERNERSTORFER, Josef , REISSMÜLLER, Elke , DE VRY, Jean , MOGI, Muneto , URBAHNS, Klaus , YURA, Takeshi , FUJISHIMA, Hiroshi , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , YUASA, Hiroaki , GUPTA, Jang , TSUKIMI, Yasuhiro , HAYASHI, Fumihiko
IPC分类号： C07D211/62
CPC分类号： C07D295/215 , C07D211/62 , C07D401/04
摘要： This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q 1a , Q 2a , Q 3a and Q 4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q 1b , Q 2b , Q 3b , Q 4b , Q 5b , R 1b , na, ma, X a and R a are defined.
摘要翻译：本发明涉及用作药物制剂活性成分的羟基 - 四氢 - 萘或脲衍生物式（I）及其盐，其中A表示式（II）或（III），其中＃表示与分子和Q1a，Q2a，Q3a和Q4a，E表示式（IV）或（V），其中＃表示与分子的连接位置，Q1b，Q2b，Q3b，Q4b，Q5b，R 1b，na， ma，Xa和Ra。

4. 发明申请

WO2014020402A1 INLET ASSEMBLY BODY 审中-公开
标题翻译：入口装配体
公开(公告)号：WO2014020402A1
公开(公告)日：2014-02-06
申请号：PCT/IB2013/001627
申请日：2013-07-26
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , YUASA, Hiroaki
发明人： YUASA, Hiroaki
IPC分类号： H01R13/52
CPC分类号： H01R13/5227 , H01R2201/26
摘要： A hollow space that is surrounded by an inlet base that fixes an inlet, which is coupled to a connector, to a vehicle, a sleeve portion that sticks out on a back face side of the inlet base, and a retainer that covers a back face side of the sleeve portion is formed on the back face side of the inlet base. A drainage hole that penetrates the inlet base to establish communication between the hollow space and a front side of the inlet base is formed at a lowermost portion of the sleeve portion. The retainer includes a protrusion portion that protrudes on the inlet base side. The protrusion portion has a tapered face whose distance from the inlet base decreases downward in a vertical direction.
摘要翻译：一个中空空间，被一个入口基座围绕，该入口基座将一个连接到一个连接器上的入口固定在一个车辆上，一个套筒部分伸出入口底座的背面，套筒部分的一侧形成在入口底座的背面侧。穿过入口底座的排水孔形成在套筒部分的最下部分处，以在中空空间与入口底座的前侧之间建立连通。保持器包括在入口基座侧突出的突出部分。突起部具有与入口底座的距离在垂直方向上向下方减小的锥面。

5. 发明申请

WO2005103018A1 UREA DERIVATIVES AS ANTAGONISTS OF THE VANILLOID RECEPTOR (VR1) 审中-公开
标题翻译：尿素衍生物作为VANILLOID受体（VR1）的拮抗剂
公开(公告)号：WO2005103018A1
公开(公告)日：2005-11-03
申请号：PCT/EP2005/003632
申请日：2005-04-07
申请人： BAYER HEALTHCARE AG , FUJISHIMA, Hiroshi , MOGI, Muneto , YUASA, Hiroaki , TAIJIMI, Masaomi , YAMAMOTO, Noriyuki , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang
发明人： FUJISHIMA, Hiroshi , MOGI, Muneto , YUASA, Hiroaki , TAIJIMI, Masaomi , YAMAMOTO, Noriyuki , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang
IPC分类号： C07D265/36
CPC分类号： C07D265/36 , C07D215/227
摘要： This invention relates to urea derivatives according to general formula I and salts thereof which are useful as active ingredients of pharmaceutical preparations. The urea derivatives of the present invention have an excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke; and respiratory diseases and inflammatory disorders such as asthma, chronic obstructive pulmonary (or airways) disease (COPD), common cold, cough, sneeze, bronchitis including acute and chronic bronchitis, bronchiolitis, rhinitis, allergic rhinitis, vasomotor rhinitis, mucositis, sinusitis, allergy, disorders associated with exogenous irritants such as tobacco smoke, smog, high levels of atmospheric SO2 and noxious gases in the workplace, and airways hyperreactivity, milk product intolerance, Loffler's pneumonia, emphysema, cystic fibrosis, bronchiectasis, pulmonary fibrosis, pneumoconiosis, collagen vascular disease, granulomatous disease, laryngitis, pharyngitis, pneumonia, pleuritis, persistent asthma and chronic asthmatic bronchitis. Formula I Wherein n represents 0, 1, 2, 3, or 4; X represents O, CH 2 , S, or N(R 10 ), Wherein R 10 respresents hydrogen or C 1-6 alkyl
摘要翻译：本发明涉及可用作药物制剂活性成分的通式Ⅰ的脲衍生物及其盐。本发明的尿素衍生物作为VR1拮抗剂具有优异的活性，并且可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗泌尿系统疾病或疾病，例如逼尿肌过度活动症（膀胱过度活动症），尿失禁，神经源性逼尿肌反应性（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经退行性卒中; 呼吸系统疾病和哮喘，慢性阻塞性肺（或气道）疾病（COPD），感冒，咳嗽，打喷嚏，支气管炎，包括急性和慢性支气管炎，细支气管炎，鼻炎，过敏性鼻炎，血管舒缩性鼻炎，粘膜炎，鼻窦炎，过敏，与外来刺激物如烟草烟雾，烟雾，工作场所大气中二氧化硫和有毒气体高度相关的疾病，气道高反应性，乳制品不耐受，霍夫勒氏肺炎，肺气肿，囊性纤维化，支气管扩张，肺纤维化，肺尘埃沉着病，胶原蛋白血管疾病，肉芽肿病，喉炎，咽炎，肺炎，胸膜炎，持续性哮喘和慢性哮喘性支气管炎。其中n表示0,1,2,3或4; X表示O，CH 2，S或N（R 10），其中R 10表示氢或C 1-6烷基

6. 发明申请

WO2005039569A1 5-SUBSTITUTED 2-(PHENYLMETHYL) THIO-4-PHENYL-4H-1,2,4-TRIAZOLE DERIVATIVES AND RELATED COMPOUNDS AS GABA-AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE AND RELATED DISEASES 审中-公开
标题翻译： 5-取代的2-（苯基甲基）硫代-4-苯基-4H-1,2,4-三唑衍生物及相关化合物作为用于治疗尿失禁和相关疾病的GABA-AGONISTS
公开(公告)号：WO2005039569A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011101
申请日：2004-10-05
申请人： BAYER HEALTHCARE AG , BAUSER, Marcus , KRÜGER, Joachim , MEIER, Heinrich , VÖHRINGER, Verena , BEYREUTHER, Bettina , MOGI, Muneto , MARUMO, Makiko , TSUNO, Naoki , SHIMIZU, Haruka , FUJISHIMA, Hiroshi , YUASA, Hiroaki , HAYASHI, Mayumi , UMEDA, Masaomi , IWATA, Atsuko
发明人： BAUSER, Marcus , KRÜGER, Joachim , MEIER, Heinrich , VÖHRINGER, Verena , BEYREUTHER, Bettina , MOGI, Muneto , MARUMO, Makiko , TSUNO, Naoki , SHIMIZU, Haruka , FUJISHIMA, Hiroshi , YUASA, Hiroaki , HAYASHI, Mayumi , UMEDA, Masaomi , IWATA, Atsuko
IPC分类号： A61K31/4196
CPC分类号： C07D401/10 , C04B35/632 , C07D249/12 , C07D401/12 , C07D403/10
摘要： This invention relates to phenyltriazole derivatives of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations : (I) wherein R 1 represents alkyl optionally substituted or 3-8 membered saturated or unsaturated ring optionally substituted, R 2 represents -COR 21 , -(CH 2 ) n -R 21 or tert-butyl, X represents CR 10 R 11 , NR 12 , S, O, SO 2 , or SO wherein R 10 , R 11 and R 12 independently represent hydrogen or methyl. The other substituents are as defined in the claims. The phenyltriazole derivatives of the present invention have an excellent activity as GABAb agonist and are useful for the prophylaxis and treatment of diseases associated with GABAb activity, in particular for the treatment of overactive bladder, urinary incontinence such as urge urinary incontinence, benign prostatic hyperplasia (BPH), chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, or nerve injury.
摘要翻译：本发明涉及式（I）的苯基三唑衍生物及其盐，其可用作药物制剂的活性成分：（I）其中R 1表示任选取代的烷基或任选取代的3-8元饱和或不饱和环， R 2表示-COR 21， - （CH 2）n R 21或叔丁基，X表示CR 10 R 11，NR 12，S，O，SO 2或SO，其中R R 10和R 12独立地表示氢或甲基。其它取代基如权利要求中所定义。本发明的苯基三唑衍生物作为GABAb激动剂具有优异的活性，并且可用于预防和治疗与GABAb活性相关的疾病，特别是用于治疗膀胱过度活动症，尿失禁例如急迫性尿失禁，良性前列腺增生（ BPH），慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉或神经损伤。

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