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1. 发明申请

WO1996005819A1 REMEDY FOR PORTAL HYPERTENSION 审中-公开
标题翻译：补救门诊高血压
公开(公告)号：WO1996005819A1
公开(公告)日：1996-02-29
申请号：PCT/JP1995001605
申请日：1995-08-11
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YOSHIDA, Keizo , KITA, Yasuhiro
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/16
CPC分类号： A61K31/16
摘要： An excellent remedy for portal hypertension containing the compound represented by formula (I) or a medicinally acceptable salt thereof as the active ingredient.
摘要翻译：含有式（I）表示的化合物或其药学上可接受的盐作为活性成分的门静脉高压的优良补救方法。

2. 发明申请

WO9420102A3 MEDICAMENT FOR TREATING OR PREVENTING CEREBROVASCULAR DISEASES 审中-公开
标题翻译：用于治疗或预防脑血管疾病的药物
公开(公告)号：WO9420102A3
公开(公告)日：1994-10-27
申请号：PCT/JP9400249
申请日：1994-02-16
申请人： FUJISAWA PHARMACEUTICAL CO , KATSUTA KIYOTAKA , TAKAMATSU HIROYUKI , UEDA YOSHIKO , NAKANISHI HAJIME , YOSHIDA KEIZO
发明人： KATSUTA KIYOTAKA , TAKAMATSU HIROYUKI , UEDA YOSHIKO , NAKANISHI HAJIME , YOSHIDA KEIZO
IPC分类号： C07D487/04 , A61K31/40 , A61K31/415 , A61K31/435 , A61K31/437 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/505 , A61P9/00 , C07D401/06 , C07D403/06 , C07D471/04 , A61K
CPC分类号： A61K31/437 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505
摘要： A use of a compound of formula (I) wherein R1 is hydrogen, lower alkyl, lower alkenyl or N,N-di(lower)alkylaminomethyl, R2 is hydrogen, lower alkyl or halogen, R3 is imidazolyl or pyridyl, each of which may have suitable substituent(s), and R4 is hydrogen, lower alkyl, lower alkenyl or hydroxy(lower)alkyl and R5 is hydrogen, hydroxy or acyloxy, or R?4 and R5¿ are linked together to form an additional bond, or a pharmaceutically acceptable salt thereof (II) wherein R?1, R2, R3, R4 and R5¿ are each as defined above, or a pharmaceutically acceptable salt thereof, or (III) wherein R?6, R7 and R8¿ are each hydrogen, lower alkyl, lower alkenyl, aryl or ar(lower)alkyl, R9 is imidazolyl which may have suitable substituent(s) or pyridyl, A is lower alkylene, and -^_-^_-^_-^_ is single bond or double bond, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating of preventing cerebrovascular diseases.

3. 发明申请

WO1994020102A2 MEDICAMENT FOR TREATING OR PREVENTING CEREBROVASCULAR DISEASES 审中-公开
标题翻译：用于治疗或预防脑血管疾病的药物
公开(公告)号：WO1994020102A2
公开(公告)日：1994-09-15
申请号：PCT/JP1994000249
申请日：1994-02-16
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KATSUTA, Kiyotaka , TAKAMATSU, Hiroyuki , UEDA, Yoshiko , NAKANISHI, Hajime , YOSHIDA, Keizo
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/412
CPC分类号： A61K31/437 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505
摘要： A use of a compound of formula (I) wherein R is hydrogen, lower alkyl, lower alkenyl or N,N-di(lower)alkylaminomethyl, R is hydrogen, lower alkyl or halogen, R is imidazolyl or pyridyl, each of which may have suitable substituent(s), and R is hydrogen, lower alkyl, lower alkenyl or hydroxy(lower)alkyl and R is hydrogen, hydroxy or acyloxy, or R and R are linked together to form an additional bond, or a pharmaceutically acceptable salt thereof (II) wherein R , R , R , R and R are each as defined above, or a pharmaceutically acceptable salt thereof, or (III) wherein R , R and R are each hydrogen, lower alkyl, lower alkenyl, aryl or ar(lower)alkyl, R is imidazolyl which may have suitable substituent(s) or pyridyl, A is lower alkylene, and - &cir& _- &cir& _- &cir& _- &cir& _ is single bond or double bond, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating of preventing cerebrovascular diseases.
摘要翻译：其中R 1是氢，低级烷基，低级烯基或N，N-二（低级）烷基氨基甲基，R 2的式（I）化合物是氢，低级烷基或卤素，R 3，是咪唑基或吡啶基，其各自可以具有合适的取代基，R 4是氢，低级烷基，低级烯基或羟基（低级）烷基，R 5是氢，羟基或酰氧基， 4>和R 5连接在一起形成另外的键，或其药学上可接受的盐（II），其中R 1，R 2，R 3，R 4和R 5，或其药学上可接受的盐，或其中R 6，R 7和R 8各自为氢，低级烷基，低级烯基，芳基或芳（低级）烷基的（III） R 9是可以具有合适的取代基或吡啶基的咪唑基，A是低级亚烷基，并且其中R 1是单键或双键，或其药学上可接受的盐，用于制备用于治疗预防脑血管疾病的药物。

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