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2. 发明申请

WO1996017850A1 CEPHEM COMPOUNDS AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译： CEPHEM化合物及其药物用途
公开(公告)号：WO1996017850A1
公开(公告)日：1996-06-13
申请号：PCT/JP1995002505
申请日：1995-12-06
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YOSHIDA, Yoshiki , SASAKI, Hiroshi , MATSUDA, Keiji , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D501/36
CPC分类号： C07D501/00
摘要： This invention relates to a new use of a cephem compound of formula (I), wherein R is aryl(lower)alkyl which may have one or more suitable substituent(s), arylthio(lower)alkyl, lower alkenylthio(lower)alkyl which may have one or more suitable substituent(s), or a group of the formula: R -A- or R -S-A- in which R is heterocyclic group which may have one or more suitable substituent(s), and A is lower alkylene which may have one or more suitable substituent(s) or lower alkenylene, R is heterocyclic group which may have one or more suitable substituent(s), or heterocyclic(lower)-alkyl and R is carboxy or protected carboxy, and a pharmaceutically acceptable salt thereof, which have antimicrobial activity against Helicobacter pylori, and are useful as anti-Helicobacter pylori agents, anti-gastritis agents, antiulcer agents and anticancer agents.
摘要翻译：本发明涉及式（I）的头孢烯化合物的新用途，其中R 1为可具有一个或多个合适取代基的芳基（低级）烷基，芳硫基（低级）烷基，低级链烯硫基（低级））烷基，其可以具有一个或多个合适的取代基，或下式的基团：R 4 -A或R 4 -SA-，其中R 4是杂环基，其可以具有一个或多个更合适的取代基，并且A是可以具有一个或多个合适的取代基或低级亚烯基的低级亚烷基，R 2是可以具有一个或多个合适的取代基的杂环基或杂环（低级） - 烷基和R 3是对幽门螺杆菌具有抗微生物活性的羧基或被保护的羧基及其药学上可接受的盐，并且可用作抗幽门螺杆菌药，抗胃炎剂，抗溃疡剂和抗癌剂。

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