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    • 2. 发明申请
    • OXAZOLIDONE DERIVATIVE
    • 奥昔洛尔衍生物
    • WO1993008179A1
    • 1993-04-29
    • PCT/JP1992001257
    • 1992-09-30
    • EISAI CO., LTD.AKASAKA, KozoKAJIWARA, AkiharuNAGATO, SatoshiIIMURA, YouichiYOSHIDA, IchirouSASAKI, AtsushiMIZUNO, MasanoriKUBOTA, AtsuhikoKAGAYA, TakakiKOMATSU, Mariko
    • EISAI CO., LTD.
    • C07D263/56
    • C07D263/57C07D417/04C07D417/14
    • An oxazolidone derivative represented by general formula (I) and having a monoamine oxidase inhibitory activity, a pharmacologically acceptable salt thereof, and a drug containing the same as the active ingredient for preventing or treating diseases for which a monoamine oxidase inhibitory activity is efficacious. In formula (I) A and B represent each nitrogen, sulfur or oxygen provided that either A or B represents nitrogen; R represents a group of formula (a) wherein n and m represent each an integer of 0, 1 to 4; and R and R represent each hydrogen, hydroxy, lower alkyl, etc.; a group of formula (b) wherein p and q represent each an integer of 0, 1 to 4; and X represents oxygen, sulfur, etc.; a group of formula (c) wherein R and R represent each hydrogen, cyanoalkyl, etc., or alternatively R and R are bonded to each other to represent a ring together with the nitrogen atom to which they are bonded; and so forth; R represents hydrogen or lower alkyl; and the bond --- represents either a single or a double bond.
    • 由通式(I)表示的具有单胺氧化酶抑制活性的恶唑烷酮衍生物及其药理学可接受的盐,以及含有与用于预防或治疗单胺氧化酶抑制活性有效的疾病的活性成分相同的药物。 在式(I)中,A和B各自表示氮,硫或氧,只要A或B表示氮; R 1表示式(a)的基团,其中n和m各自表示0,1或4的整数; R 3和R 4各自代表氢,羟基,低级烷基等; 式(b)的基团,其中p和q各自表示0,1或4的整数; X表示氧,硫等; 式(c)的基团,其中R 5和R 6各自表示氢,氰基烷基等,或者R 5和R 6彼此键合以与氮一起代表环 它们结合的原子; 等等; R 2表示氢或低级烷基; 而债券---代表单一或双重债券。