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1. 发明申请

WO2004074313A8 METHODS FOR PREDICTION OF AMYLOID FIBRIL FORMATION AND IDENTIFICATION OF PEPTIDES USEFUL AS THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译：用于预测作为治疗和诊断试剂有效的肽的淀粉样蛋白形成和鉴定的方法
公开(公告)号：WO2004074313A8
公开(公告)日：2004-09-30
申请号：PCT/US2004004122
申请日：2004-02-13
申请人： UNIV NEW JERSEY MED , WELSH WILLIAM J , YOON SUKJOON
发明人： WELSH WILLIAM J , YOON SUKJOON
IPC分类号： C07K20060101 , C07K14/47 , G06F17/00 , G06F17/11 , G06F17/30 , G06F17/50 , G06F19/16 , G06F19/22 , G06F19/24 , C07K
CPC分类号： C07K14/4711 , G06F19/16 , G06F19/22 , G06F19/24
摘要： Protein misfolding is the underlying cause of many unrelated human diseases in which normal correctly folded proteins progressively aggregate after undergoing a conformational transformation from their proper native structure into an abnormal b-strand rich structure commonly known as amyloid fibril. The present invention provides methods for detecting hidden sequence propensity for amyloid fibril formation in any protein. This invention has applications for the discovery of agents that specifically target these sequences for the prevention, treatment, and diagnosis of amyloid diseases. The peptides provided by this invention are useful as potential therapeutic agents called "b-sheet breakers" capable of blocking and/or inhibiting amyloid fibril formation. These same peptides can be also used as diagnostic agents (or templates thereof) of amyloid plaque. This invention also has applications in protein engineering for the detection, and selective removal or replacement, of these offending sequences associated with strong b-strand propensity.
摘要翻译：蛋白质错误折叠是许多不相关的人类疾病的根本原因，其中正常正确折叠的蛋白质在经历从其适当的天然结构进入通常称为淀粉样蛋白原纤维的异常b-链富含结构的构象转化后逐渐聚集。本发明提供了用于检测任何蛋白质中淀粉样蛋白原纤维形成隐藏序列倾向的方法。本发明具有专门针对这些序列用于预防，治疗和诊断淀粉样蛋白病的药剂的发现的应用。本发明提供的肽可用作能够阻断和/或抑制淀粉样蛋白原纤维形成的称为“b-片断片”的潜在治疗剂。这些相同的肽也可以用作淀粉样斑块的诊断剂（或其模板）。本发明还在蛋白质工程中用于检测和选择性去除或替代与强b链倾向相关的这些违规序列。

2. 发明申请

WO2004074313A2 METHODS FOR PREDICTION OF AMYLOID FIBRIL FORMATION AND IDENTIFICATION OF PEPTIDES USEFUL AS THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译：预测淀粉样纤维蛋白形成和鉴定用作治疗剂和诊断剂的肽的方法
公开(公告)号：WO2004074313A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/004122
申请日：2004-02-13
申请人： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , WELSH, William J. , YOON, Sukjoon
发明人： WELSH, William J. , YOON, Sukjoon
IPC分类号： C07K
CPC分类号： C07K14/4711 , G06F19/16 , G06F19/22 , G06F19/24
摘要： Protein misfolding is the underlying cause of many unrelated human diseases in which normal correctly folded proteins progressively aggregate after undergoing a conformational transformation from their proper native structure into an abnormal b-strand rich structure commonly known as amyloid fibril. The present invention provides methods for detecting hidden sequence propensity for amyloid fibril formation in any protein. This invention has applications for the discovery of agents that specifically target these sequences for the prevention, treatment, and diagnosis of amyloid diseases. The peptides provided by this invention are useful as potential therapeutic agents called "b-sheet breakers" capable of blocking and/or inhibiting amyloid fibril formation. These same peptides can be also used as diagnostic agents (or templates thereof) of amyloid plaque. This invention also has applications in protein engineering for the detection, and selective removal or replacement, of these offending sequences associated with strong b-strand propensity.
摘要翻译：蛋白质错误折叠是许多不相关的人类疾病的根本原因，其中正常正确折叠的蛋白质在经历从它们的适当天然结构的构象转变后逐渐聚集成异常富含b链的结构，通常称为淀粉样蛋白原纤维。本发明提供了用于检测任何蛋白质中淀粉样蛋白原纤维形成的隐藏序列倾向的方法。本发明具有发现特异性靶向这些序列以预防，治疗和诊断淀粉样蛋白疾病的试剂的应用。本发明提供的肽可用作潜在的治疗剂，称为“b片破碎剂” 能够阻断和/或抑制淀粉状蛋白原纤维形成。这些相同的肽也可以用作淀粉样斑块的诊断剂（或其模板）。本发明还应用于蛋白质工程，用于检测和选择性去除或替换与强b链倾向相关的侵犯序列。

3. 发明申请

WO2004074313A3 METHODS FOR PREDICTION OF AMYLOID FIBRIL FORMATION AND IDENTIFICATION OF PEPTIDES USEFUL AS THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译：用于预测作为治疗和诊断试剂有效的肽的淀粉样蛋白形成和鉴定的方法
公开(公告)号：WO2004074313A3
公开(公告)日：2005-04-07
申请号：PCT/US2004004122
申请日：2004-02-13
申请人： UNIV NEW JERSEY MED , WELSH WILLIAM J , YOON SUKJOON
发明人： WELSH WILLIAM J , YOON SUKJOON
IPC分类号： C07K20060101 , C07K14/47 , G06F17/00 , G06F17/11 , G06F17/30 , G06F17/50 , G06F19/16 , G06F19/22 , G06F19/24 , G06F19/00
CPC分类号： C07K14/4711 , G06F19/16 , G06F19/22 , G06F19/24
摘要： Protein misfolding is the underlying cause of many unrelated human diseases in which normal correctly folded proteins progressively aggregate after undergoing a conformational transformation from their proper native structure into an abnormal b-strand rich structure commonly known as amyloid fibril. The present invention provides methods for detecting hidden sequence propensity for amyloid fibril formation in any protein. This invention has applications for the discovery of agents that specifically target these sequences for the prevention, treatment, and diagnosis of amyloid diseases. The peptides provided by this invention are useful as potential therapeutic agents called "b-sheet breakers" capable of blocking and/or inhibiting amyloid fibril formation. These same peptides can be also used as diagnostic agents (or templates thereof) of amyloid plaque. This invention also has applications in protein engineering for the detection, and selective removal or replacement, of these offending sequences associated with strong b-strand propensity.
摘要翻译：蛋白质错误折叠是许多不相关的人类疾病的根本原因，其中正常正确折叠的蛋白质在经历从其适当的天然结构到通常称为淀粉样蛋白原纤维的异常b-链富含结构的构象转化后逐渐聚集。本发明提供了用于检测任何蛋白质中淀粉样蛋白原纤维形成隐藏序列倾向的方法。本发明具有专门针对这些序列用于预防，治疗和诊断淀粉样蛋白病的药剂的发现的应用。本发明提供的肽可用作能够阻断和/或抑制淀粉样蛋白原纤维形成的称为“b-片断片”的潜在治疗剂。这些相同的肽也可以用作淀粉样斑块的诊断剂（或其模板）。本发明还在蛋白质工程中用于检测和选择性去除或替代与强b链倾向相关的这些违规序列。

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