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1. 发明专利

IL256744B Pyrazine derivatives, and preparation method and medical application thereof 未知
公开(公告)号：IL256744B
公开(公告)日：2022-12-01
申请号：IL25674418
申请日：2018-01-04
申请人： GUANGZHOU MAGPIE PHARMACEUTICALS CO LTD , YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , PENG YI
发明人： YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , PENG YI
IPC分类号： A61K31/4965 , A61K31/497 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/06
摘要： The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and treatment of cardiovascular and cerebrovascular diseases, neurodegenerative diseases and other related diseases.

3. 发明专利

IL256744D0 New pyrazine derivative, and preparation method and medical application thereof 未知
公开(公告)号：IL256744D0
公开(公告)日：2018-03-29
申请号：IL25674418
申请日：2018-01-04
申请人： GUANGZHOU MAGPIE PHARMACEUTICALS CO LTD , YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , PENG YI
发明人： YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , PENG YI
IPC分类号： A61K20060101
摘要： The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and treatment of cardiovascular and cerebrovascular diseases, neurodegenerative diseases and other related diseases.

5. 发明申请

US20120115874A1 PYRAZINE DERIVATIVES, PROCESS FOR MANUFACTURE AND USE THEREOF 有权
标题翻译：吡嗪衍生物，其制备方法及其用途
公开(公告)号：US20120115874A1
公开(公告)日：2012-05-10
申请号：US13254653
申请日：2011-07-01
申请人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
发明人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
IPC分类号： A61K31/498 , A61K31/4965 , C07D241/42 , C07D403/12 , A61K31/497 , C07D495/04 , A61P25/00 , A61P9/00 , A61P29/00 , A61P27/02 , A61P35/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P9/10 , A61P1/00 , A61P3/10 , A61P11/06 , A61P1/16 , A61P37/06 , A61P1/18 , A61P13/12 , A61P3/04 , A61P27/06 , C07D241/12
CPC分类号： C07D241/12 , C07D241/24 , C07D241/42 , C07D495/04
摘要： The present invention provides pyrazine derivatives of formula I and pharmaceutically acceptable salts thereof, wherein the designation of R1, R2, R3 and R4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.
摘要翻译：本发明提供式I的吡嗪衍生物及其药学上可接受的盐，其中R1，R2，R3和R4的名称在本文中提供。本发明还提供了用于制备这些化合物的合成。本发明还提供了使用这些化合物和含有它们的药物组合物用于治疗和/或预防疾病和制备药物的方法。这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由局部缺血引起的脑卒中，并用于制备用于治疗和/或预防由过度引起的神经系统疾病的药物自由基和/或血栓形成的数量，传染病，代谢系统疾病，心血管和脑血管疾病以及年龄相关的退行性疾病。

6. 发明申请

US20110034485A1 NITRONE COMPOUNDS, PROCESS OF PREPARATION THEREOF, AND USE THEREOF IN MEDICAMENT MANUFACTURE 有权
标题翻译：硝基化合物，其制备方法及其在药物制造中的应用
公开(公告)号：US20110034485A1
公开(公告)日：2011-02-10
申请号：US12937405
申请日：2009-04-16
申请人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
发明人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
IPC分类号： A61K31/505 , C07D239/30 , A61P25/00 , A61P9/00 , A61P27/02 , A61P29/00 , A61P35/00
CPC分类号： C07D241/12
摘要： The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus.
摘要翻译：本发明提供新的硝酮，其制备和用途。该化合物具有以下结构式：I本发明化合物具有较强的抗氧化活性，且具有血栓溶解作用。这些化合物可用于治疗和/或预防由过度产生自由基和/或形成血栓引起的疾病。

7. 发明专利

IL253204A Trifluoroacetyl hydrazide compounds and methods of preparation and uses thereof 未知
公开(公告)号：IL253204A
公开(公告)日：2020-05-31
申请号：IL25320417
申请日：2017-06-27
申请人： GUANGZHOU MAGPIE PHARMACEUTICALS CO LTD , YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , HAIYUN CHEN , LIANG TAO
发明人： YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , HAIYUN CHEN , LIANG TAO
IPC分类号： A61K31/4965
摘要： The present invention relates to trifluoroacetyl hydrazide compounds and methods of preparation and uses thereof. The compounds have a structure of the following formula: The compounds showed multifunctional mechanisms, including inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, clearance of free radicals, and promotion of nerve differentiation, and has a better protective effect on cells especially nerve cells.. The compound can be used to prepare prophylactic or therapeutic medicaments with cytoprotective effects, for the prevention or treatment of diseases related to glutamate receptor activation, MEF2 disorders or excessive free radicals generation. The diseases include neurodegenerative diseases such as Alzheimer's disease, Parkinson and stroke, and the free radicals related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.

8. 发明专利

IL253204D0 Trifluoroacetyl hydrazide compounds and methods of preparation and uses thereof 未知
公开(公告)号：IL253204D0
公开(公告)日：2017-08-31
申请号：IL25320417
申请日：2017-06-27
申请人： GUANGZHOU MAGPIE PHARMACEUTICALS CO LTD , YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , HAIYUN CHEN , LIANG TAO
发明人： YUQIANG WANG , PEI YU , YEWEI SUN , ZAIJUN ZHANG , GAOXIAO ZHANG , LUCHEN SHAN , HAIYUN CHEN , LIANG TAO
IPC分类号： A61K20060101
摘要： The present invention relates to trifluoroacetyl hydrazide compounds and methods of preparation and uses thereof. The compounds have a structure of the following formula: The compounds showed multifunctional mechanisms, including inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, clearance of free radicals, and promotion of nerve differentiation, and has a better protective effect on cells especially nerve cells.. The compound can be used to prepare prophylactic or therapeutic medicaments with cytoprotective effects, for the prevention or treatment of diseases related to glutamate receptor activation, MEF2 disorders or excessive free radicals generation. The diseases include neurodegenerative diseases such as Alzheimer's disease, Parkinson and stroke, and the free radicals related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.

9. 发明授权

US08796281B2 Lighting device having at least one heat sink 有权
标题翻译：吡嗪衍生物，其制备方法和用途
公开(公告)号：US08796281B2
公开(公告)日：2014-08-05
申请号：US13254653
申请日：2011-07-01
申请人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
发明人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
IPC分类号： A61K31/4965 , C07D241/26
CPC分类号： C07D241/12 , C07D241/24 , C07D241/42 , C07D495/04
摘要： The present invention provides pyrazine derivatives of formula I and pharmaceutically acceptable salts thereof, wherein the designation of R1, R2, R3 and R4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.
摘要翻译：本发明提供式I的吡嗪衍生物及其药学上可接受的盐，其中R1，R2，R3和R4的名称在本文中提供。本发明还提供了用于制备这些化合物的合成。本发明还提供了使用这些化合物和含有它们的药物组合物用于治疗和/或预防疾病和制备药物的方法。这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由局部缺血引起的脑卒中，并用于制备用于治疗和/或预防由过度引起的神经系统疾病的药物自由基和/或血栓形成的数量，传染病，代谢系统疾病，心血管和脑血管疾病以及年龄相关的退行性疾病。

10. 发明授权

US08404688B2 Nitrone compounds, process of preparation thereof, and use thereof in medicament manufacture 有权
标题翻译：硝基化合物，其制备方法及其在药物制备中的应用
公开(公告)号：US08404688B2
公开(公告)日：2013-03-26
申请号：US12937405
申请日：2009-04-16
申请人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
发明人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
IPC分类号： A61K31/4965
CPC分类号： C07D241/12
摘要： The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus.
摘要翻译：本发明提供新的硝酮，其制备和用途。该化合物具有以下结构式：I本发明化合物具有较强的抗氧化活性，且具有血栓溶解作用。这些化合物可用于治疗和/或预防由过度产生自由基和/或形成血栓引起的疾病。

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