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    • 4. 发明申请
    • BACK CALIBRATION OF SENSOR DATA
    • 传感器数据的后校准
    • WO2012155032A2
    • 2012-11-15
    • PCT/US2012/037487
    • 2012-05-11
    • BAYER HEALTHCARE LLCYAO, Simin
    • YAO, Simin
    • G06F19/00A61B5/145
    • A61B5/7275A61B5/14532A61B5/1495A61B2560/0238G06F19/00
    • Methods, apparatuses and systems for back calibration of data from a continuous sensor are provided. The continuous sensor may be calibrated periodically by comparing raw sensor values from the sensor to sensor values obtained from a second sensor, such as a blood glucose meter (BGM). Each calibration may produce a calibration factor. In an aspect, the calibration factor may be applied to sensor values acquired prior to the calibration (i.e., back calibration). In a further aspect, a first calibration and a second calibration may be applied to raw sensor values acquired at a time point between the first calibration and the second calibration. The first and second calibrations may be applied to the raw sensor values by weighted averaging according to the proximity of the first and second calibrations to the acquisition time of the raw sensor value.
    • 提供了用于从连续传感器反向校准数据的方法,装置和系统。 可以通过将来自传感器的原始传感器值与从诸如血糖仪(BGM)的第二传感器获得的传感器值进行比较来周期性地校准连续传感器。 每个校准都可能产生校准因子。 在一方面,校准因子可以应用于在校准之前获取的传感器值(即,反向校准)。 在另一方面,可以将第一校准和第二校准应用于在第一校准和第二校准之间的时间点获取的原始传感器值。 可以根据第一和第二校准的接近度与原始传感器值的获取时间进行加权平均,将第一和第二校准应用于原始传感器值。
    • 5. 发明申请
    • BACK CALIBRATION OF SENSOR DATA
    • 传感器数据的后校准
    • WO2012155032A3
    • 2013-01-10
    • PCT/US2012037487
    • 2012-05-11
    • BAYER HEALTHCARE LLCYAO SIMIN
    • YAO SIMIN
    • G06F19/00A61B5/145
    • A61B5/7275A61B5/14532A61B5/1495A61B2560/0238
    • Methods, apparatuses and systems for back calibration of data from a continuous sensor are provided. The continuous sensor may be calibrated periodically by comparing raw sensor values from the sensor to sensor values obtained from a second sensor, such as a blood glucose meter (BGM). Each calibration may produce a calibration factor. In an aspect, the calibration factor may be applied to sensor values acquired prior to the calibration (i.e., back calibration). In a further aspect, a first calibration and a second calibration may be applied to raw sensor values acquired at a time point between the first calibration and the second calibration. The first and second calibrations may be applied to the raw sensor values by weighted averaging according to the proximity of the first and second calibrations to the acquisition time of the raw sensor value.
    • 提供了用于从连续传感器反向校准数据的方法,装置和系统。 可以通过将来自传感器的原始传感器值与从诸如血糖仪(BGM)的第二传感器获得的传感器值进行比较来周期性地校准连续传感器。 每个校准都可能产生校准因子。 在一方面,校准因子可以应用于在校准之前获取的传感器值(即,反向校准)。 在另一方面,可以将第一校准和第二校准应用于在第一校准和第二校准之间的时间点获取的原始传感器值。 可以根据第一和第二校准的接近度与原始传感器值的获取时间进行加权平均,将第一和第二校准应用于原始传感器值。
    • 7. 发明申请
    • TORSIONALLY FLEXIBLE SEALED DRIVE
    • 扭转弹性密封驱动
    • WO2008144089A1
    • 2008-11-27
    • PCT/US2008/054653
    • 2008-02-22
    • NEW BRUNSWICK SCIENTIFIC COMPANY, INC.WATKINS, JeffYAO, Simin
    • WATKINS, JeffYAO, Simin
    • C12M1/12
    • C12M23/26B01F7/00675B01F11/0088B01F15/00831B01F15/0085C12M27/08
    • A simple, robust and low-cost torsionally flexible, sealed drive that allows external drives to provide agitation within a container. A torsionally flexible tube is sealed to a torsionally rigid portion of a container. A second end of the tube is sealed to a driven element within the container. The driven element is coupled to a drive- shaft that is partly contained within the tube. Motion of the protruding end of the drive shaft imparts a corresponding motion to the driven element, while maintaining a water-tight seal between container and drive-shaft. One useful motion is a rotary oscillation. A stepper motor may operate via such a drive to impart a rotary oscillation to an impellor in a bioreactor, or mixing container, suitable for agitating a cell culture in a nutrient medium or hydrating a powdered media in water. The drive is suited to use in disposable bioreactors and mixers.
    • 一种简单,坚固和低成本的扭转灵活的密封驱动器,允许外部驱动器在容器内提供搅动。 扭转柔性管被密封到容器的扭转刚性部分。 管的第二端被密封到容器内的从动元件。 被驱动元件联接到部分地包含在管内的驱动轴。 驱动轴的突出端的运动给驱动元件施加相应的运动,同时保持容器和驱动轴之间的水密密封。 一个有用的运动是旋转振荡。 步进马达可以经由这样的驱动器操作,以将旋转振荡给予生物反应器或混合容器中的叶轮,该混合容器适于搅拌营养培养基中的细胞培养物或将粉末状介质水合在水中。 该驱动器适用于一次性生物反应器和混合器。