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1. 发明专利

IL191718D0 BINDING PROTEINS SPECIFIC FOR INSULIN-LIKE GROWTH FACTORS AND USES THEREOF 未知
公开(公告)号：IL191718D0
公开(公告)日：2009-02-11
申请号：IL19171808
申请日：2008-05-26
申请人： ASTRAZENECA AB , TONGE DAVID WILLIAM , RAEBER OLIVIA , GAZIT BORNSTEIN GADI , YANG XIAODONG , CARTLIDGE SUSAN ANN
IPC分类号： A61K20100101
摘要： Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3.

2. 发明专利

IL196209D0 TARGETED BINDING AGENTS DIRECTED TO PDGFR-ALPHA AND USES THEREOF 未知
公开(公告)号：IL196209D0
公开(公告)日：2011-08-01
申请号：IL19620908
申请日：2008-12-25
申请人： ASTRAZENECA AB , BLAKEY DAVID CHARLES , GAZIT BORNSTEIN GADI , YANG XIAODONG , CARTLIDGE SUSAN ANN , LAING NAOMI , KANG JASPAL SINGH , FOLTZ IAN , TAYLOR LAURA
IPC分类号： A61K20060101
摘要： Targeted binding agents directed to the antigen PDGFR-alpha and uses of such agents are disclosed herein. More specifically the invention relates to fully human monoclonal antibodies directed to the antigen PDGFR-alpha and uses of these antibodies. Aspects of the invention also relate to hybridomas or other cell lines expressing such antibodies. The described targeted binding agents and antibodies are useful as diagnostics and for the treatment of diseases associated with the activity and/or overexpression of PDGFR-alpha.

3. 发明专利

AU2020100888A4 COMPUTER NUMERICAL CONTROL (CNC) LATHE FOR RETRACTABLE BIT TOOL 未知
公开(公告)号：AU2020100888A4
公开(公告)日：2020-07-09
申请号：AU2020100888
申请日：2020-05-29
申请人： YANG XIAODONG
发明人： YANG XIAODONG
IPC分类号： B23B3/00
摘要： The utility model discloses a computer numerical control (CNC) lathe for retractable bit tool, including a machine body, a first transmission assembly, a sliding frame, a second 5 transmission assembly, a guide rod, a sliding cover, a third transmission assembly, a drill bit, a control panel, a power cord, a clamping mechanism and a dustproof device. Through the provision of the clamping mechanism, when a position of the bit tool needs to be adjusted to be retracted or disassembled, it can be retracted into the sliding cover by pressing down the clamping blocks on both sides while the drill bit being in a movable state, then release the 0 clamping blocks to reset a spring and fixation is completed again by pushing out the clamping blocks, so that the problems of being not easy to retract the bit tool and complexity in disassembly and mounting during the use of the existing CNC lathe are solved. Through the provision of the dustproof device, a pulling block can be used to drive a pulling plate to move to the left when the lathe is not in use, so that a dustproof cover covers an upper end of the 5 machine body to prevent dust, thereby solving the problem of floating dust into cutting grooves or drilling hole and causing cutting positions to be deviated in drilling holes next time due to adhesion of dust after the CNC lathe is placed and not used for a long time. 3 8i Fig. 1 9i Fig. 2

4. 发明申请

WO2009143372A3 COMPOSITIONS COMPRISING A-RAF, B-RAF, AND C-RAF SIRNA AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含A-RAF，B-RAF和C-RAF SIRNA的组合物及其使用方法
公开(公告)号：WO2009143372A3
公开(公告)日：2010-03-11
申请号：PCT/US2009044893
申请日：2009-05-21
申请人： INTRADIGM CORP , XIE FRANK Y , YANG XIAODONG
发明人： XIE FRANK Y , YANG XIAODONG
IPC分类号： A61K31/713 , A61P35/00 , C12N15/113
CPC分类号： C12N15/1135 , C12N2310/14
摘要： The present invention provides nucleic acid molecules that inhibit A-Raf, B-Raf, and/or C-Raf expression. Methods of using the nucleic acid molecules are also provided.
摘要翻译：本发明提供抑制A-Raf，B-Raf和/或C-Raf表达的核酸分子。还提供了使用核酸分子的方法。

5. 发明申请

WO2009143372A2 COMPOSITIONS COMPRISING A-RAF, B-RAF, AND C-RAF SIRNA AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含A-RAF，B-RAF和C-RAF SIRNA的组合物及其使用方法
公开(公告)号：WO2009143372A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044893
申请日：2009-05-21
申请人： INTRADIGM CORPORATION , XIE, Frank, Y. , YANG, Xiaodong
发明人： XIE, Frank, Y. , YANG, Xiaodong
IPC分类号： C12N15/11 , A61K31/713 , A61P35/00
CPC分类号： C12N15/1135 , C12N2310/14
摘要： The present invention provides nucleic acid molecules that inhibit A-Raf, B-Raf, and/or C-Raf expression. Methods of using the nucleic acid molecules are also provided.
摘要翻译：本发明提供抑制A-Raf，B-Raf和/或C-Raf表达的核酸分子。还提供了使用核酸分子的方法。

6. 发明申请

WO2009143281A2 COMPOSITIONS COMPRISING C-MET SIRNA AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含C-MET SIRNA的组合物及其使用方法
公开(公告)号：WO2009143281A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044723
申请日：2009-05-20
申请人： INTRADIGM CORPORATION , XIE, Frank, Y. , YANG, Xiaodong
发明人： XIE, Frank, Y. , YANG, Xiaodong
IPC分类号： C12N15/11
CPC分类号： C12N15/1135 , C12N2310/14
摘要： The present invention provides nucleic acid molecules that inhibit c-Met expression. Methods of using the nucleic acid molecules are also provided.
摘要翻译：本发明提供抑制c-Met表达的核酸分子。还提供了使用核酸分子的方法。

7. 发明申请

WO2009114726A1 COMPOSITIONS COMPRISING NOTCH1 SIRNA AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含NOTCH1 SIRNA的组合物及其使用方法
公开(公告)号：WO2009114726A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/037014
申请日：2009-03-12
申请人： INTRADIGM CORPORATION , XIE, Frank, Y. , YANG, Xiaodong , LIU, Ying
发明人： XIE, Frank, Y. , YANG, Xiaodong , LIU, Ying
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： C12N15/1138 , C12N2310/14
摘要： The present invention provides siRNA nucleic acid molecules that inhibit Notch1 expression. Methods of using the nucleic acid molecules are also provided.
摘要翻译：本发明提供抑制Notch1表达的siRNA核酸分子。还提供了使用核酸分子的方法。

8. 发明申请

WO2009108217A3 COMPOSITIONS COMPRISING K-RAS SIRNA AND METHODS OF USE 审中-公开
公开(公告)号：WO2009108217A3
公开(公告)日：2009-09-03
申请号：PCT/US2008/076889
申请日：2008-09-18
申请人： INTRADIGM CORPORATION , XIE, Frank, Y. , YANG, Xiaodong , LIU, Ying
发明人： XIE, Frank, Y. , YANG, Xiaodong , LIU, Ying
IPC分类号： C12N15/11 , A61K48/00
摘要： The present invention provides nucleic acid molecules that inhibit K-ras expression. Methods of using the nucleic acid molecules are also provided.

9. 发明申请

WO2009039189A2 COMPOSITIONS COMPRISING STAT3 SIRNA AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含STAT3 SIRNA的组合物及其使用方法
公开(公告)号：WO2009039189A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/076700
申请日：2008-09-17
申请人： INTRADIGM CORPORATION , XIE, Frank, Y. , YANG, Xiaodong , LIU, Ying
发明人： XIE, Frank, Y. , YANG, Xiaodong , LIU, Ying
IPC分类号： C12N15/11 , A61K31/713 , A61P35/00
CPC分类号： A61K31/713 , C12N15/113 , C12N2310/14
摘要： The present invention provides nucleic acid molecules that inhibit STAT3 expression. Methods of using the nucleic acid molecules are also provided.
摘要翻译：本发明提供了抑制STAT3表达的核酸分子。还提供了使用核酸分子的方法。

10. 发明申请

WO2021155531A1 METHOD AND APPARATUS FOR TUNING FILM PROPERTIES DURING THIN FILM DEPOSITION 审中-公开
公开(公告)号：WO2021155531A1
公开(公告)日：2021-08-12
申请号：PCT/CN2020/074419
申请日：2020-02-06
申请人： APPLIED MATERIALS, INC. , YANG, Xiaodong
发明人： SUN, Lizhong , YANG, Xiao Dong
IPC分类号： C23C14/34 , C23C14/54 , C23C14/56
摘要： Disclosed herein is an apparatus and method for fine tuning properties of a thin film. The method of forming a piezoelectric film includes (a) depositing a first piezoelectric film layer (408 (1)) on a surface of a substrate by a first physical vapor deposition (PVD) process. The method includes (b) depositing a second piezoelectric film layer (408 (2)), on top of and in contact with the first piezoelectric film layer (408 (1)), by a second PVD process. A temperature of the substrate is (c) reduced after forming the first piezoelectric film layer (408 (1)) and before forming the second piezoelectric film layer (408 (2)). The temperature is reduced by performing a process for a first period of time. Processes (a), (b) and (c) are additionally performed one or more times. Process (c) is performed for a second period of time. The second period of time is different than the first period of time.

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