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1. 发明申请

WO2007009058A3 CONTRAST AGENTS AND METHODS FOR PREPARING CONTRAST AGENTS 审中-公开
标题翻译：对比剂和制备对比剂的方法
公开(公告)号：WO2007009058A3
公开(公告)日：2007-04-19
申请号：PCT/US2006027327
申请日：2006-07-13
申请人： UNIV GEORGIA STATE RES FOUND , YANG JENNY J , LIU ZHI-REN
发明人： YANG JENNY J , LIU ZHI-REN
IPC分类号： A61B8/00
CPC分类号： A61K49/0002 , A61K49/0019 , A61K49/0056 , A61K49/14
摘要： Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.
摘要翻译：造影剂包含具有至少一个可操作的整合的金属离子结合位点的支架蛋白。

2. 发明申请

WO2006119337A2 FLUORESCENT PROTEINS AND USES THEREOF 审中-公开
标题翻译：荧光蛋白及其用途
公开(公告)号：WO2006119337A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016926
申请日：2006-05-03
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , YANG, Jenny J.
发明人： YANG, Jenny J.
IPC分类号： C07K14/435
CPC分类号： C07K14/43595 , G01N33/533 , G01N33/582
摘要： A fluorescent sensor and methods for producing and using the fluorescent sensor. Such fluorescent sensors have broad applicability in characterizing cells and organisms, in detecting or measuring various cellular parameters, and in detecting or measuring protein-protein/peptide interactions.
摘要翻译：一种荧光传感器及其生产和使用荧光传感器的方法。这种荧光传感器在表征细胞和生物体，检测或测量各种细胞参数以及检测或测量蛋白质/蛋白质/肽相互作用方面具有广泛的应用。

3. 发明申请

WO2008019123A2 ENZYME SENSORS, METHODS FOR PREPARING AND USING SUCH SENSORS, AND METHODS OF DETECTING PROTEASE ACTIVITY 审中-公开
标题翻译：酶传感器，用于制备和使用这种传感器的方法以及检测蛋白酶活性的方法
公开(公告)号：WO2008019123A2
公开(公告)日：2008-02-14
申请号：PCT/US2007017462
申请日：2007-08-06
申请人： UNIV GEORGIA STATE RES FOUND , YANG JENNY J , CHEN NING
发明人： YANG JENNY J , CHEN NING
IPC分类号： C12Q1/37
CPC分类号： G01N33/573 , C07K19/00 , C12Q1/00 , C12Q1/37 , G01N2333/9015 , G01N2333/95 , G01N2333/96466 , G01N2333/974 , G01N2333/976
摘要： Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods fo characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.
摘要翻译：本发明的实施方案提供酶传感器，蛋白酶传感器，用于生产和使用酶和蛋白酶传感器的方法，检测和/或测定蛋白酶活性的方法，表征蛋白酶细胞活性的方法，融合蛋白，多核苷酸和对应于酶和蛋白酶传感器，试剂盒等。

4. 发明申请

WO2006119337A8 FLUORESCENT PROTEINS AND USES THEREOF 审中-公开
标题翻译：荧光蛋白及其用途
公开(公告)号：WO2006119337A8
公开(公告)日：2007-08-16
申请号：PCT/US2006016926
申请日：2006-05-03
申请人： UNIV GEORGIA STATE RES FOUND , YANG JENNY J
发明人： YANG JENNY J
IPC分类号： C07K14/00 , C12P21/06
CPC分类号： C07K14/43595 , G01N33/533 , G01N33/582

5. 发明申请

WO2007030802A3 TARGETED CONTRAST AGENTS AND METHODS FOR TARGETING CONTRAST AGENTS 审中-公开
公开(公告)号：WO2007030802A3
公开(公告)日：2007-03-15
申请号：PCT/US2006/035221
申请日：2006-09-08
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , YANG, Jenny, J. , LIU, Zhi-Ren
发明人： YANG, Jenny, J. , LIU, Zhi-Ren
IPC分类号： A61K49/14
摘要： A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included.

6. 发明申请

WO2007030802A2 TARGETED CONTRAST AGENTS AND METHODS FOR TARGETING CONTRAST AGENTS 审中-公开
标题翻译：针对对象代理的目标对象代理和方法
公开(公告)号：WO2007030802A2
公开(公告)日：2007-03-15
申请号：PCT/US2006035221
申请日：2006-09-08
申请人： UNIV GEORGIA STATE RES FOUND , YANG JENNY J , LIU ZHI-REN
发明人： YANG JENNY J , LIU ZHI-REN
IPC分类号： A61K49/16
CPC分类号： A61K49/14 , A61K49/085
摘要： A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included.
摘要翻译：具有对比度蛋白质的造影剂具有对比性质和至少一种靶向部分，其中所述至少一种靶向部分可操作地连接或引入对比蛋白。包括靶向造影剂和制备这些药剂的方法。

7. 发明申请

WO2006020550A2 ANALYTE SENSORS AND METHOD FOR CONSTRUCTING ANALYTE BINDING MOTIFS 审中-公开
标题翻译：分析传感器和建立分析仪绑定运动的方法
公开(公告)号：WO2006020550A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028079
申请日：2005-08-08
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , YANG, Jenny, J.
发明人： YANG, Jenny, J.
IPC分类号： G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/84 , G01N33/542 , G01N2458/40
摘要： An analyte sensor with a tailored analyte binding motif that binds an analyte and a host protein in which the analyte binding motif is operatively linked or integrated therein and in which the binding of the analyte to the analyte binding motif produces a detectable change and manipulation of the analyte binding motif manipulates the responsiveness of the sensor. Also, a method for constructing an analyte sensor by constructing a tailored analyte binding motif capable of responding to an analyte and operatively inserting the analyte binding motif into a host protein. Included is a method for quantifying an analyte by introducing a nucleotide sequence for a protein having an analyte sensor with a tailored analyte binding motif that is able to produce a detectable change upon excitation, expressing the protein, providing excitement to the analyte sensor, and quantifying the detectable change.
摘要翻译：分析物传感器，具有定制的分析物结合基序，其结合分析物和宿主蛋白，其中分析物结合基序可操作地连接或整合在其中，并且其中分析物与分析物结合基序的结合产生可检测的变化和操纵分析物结合基序操纵传感器的响应性。另外，一种构建分析物传感器的方法，该方法通过构建能够对分析物作出响应并且将分析物结合基序可操作地插入宿主蛋白质的定制的分析物结合基序。包括通过为具有分析物传感器的蛋白质的核苷酸序列引入定制的分析物结合基序来定量分析物的方法，所述分析物结合基序在激发时能够产生可检测的变化，表达蛋白质，向分析物传感器提供兴奋并量化可检测的变化。

8. 发明申请

WO2008019123A3 ENZYME SENSORS, METHODS FOR PREPARING AND USING SUCH SENSORS, AND METHODS OF DETECTING PROTEASE ACTIVITY 审中-公开
公开(公告)号：WO2008019123A3
公开(公告)日：2008-02-14
申请号：PCT/US2007/017462
申请日：2007-08-06
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , YANG, Jenny, J. , CHEN, Ning
发明人： YANG, Jenny, J. , CHEN, Ning
IPC分类号： C12N9/64
摘要： Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods fo characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.

9. 发明申请

WO2012009471A1 ANTI-ANGIOGENIC AGENT AND METHOD OF USING SUCH AGENT 审中-公开
标题翻译：抗发生代谢物及其使用方法
公开(公告)号：WO2012009471A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/043907
申请日：2011-07-13
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION , LIU, Zhi-Ren , YANG, Jenny J. , LU, Yin
发明人： LIU, Zhi-Ren , YANG, Jenny J. , LU, Yin
IPC分类号： A61K38/17 , C07K14/705 , A61P35/00 , A61P27/00 , A61P9/10
CPC分类号： C07K14/70507 , A61K38/1774 , A61K45/06
摘要： Anti-angiogenic agents or polypeptides comprising an amino acid segment substantially similar to domain one of CD2 wherein the polypeptide has a β-sheet formed by two segments. Methods of using such agents and polypeptide are also included.
摘要翻译：抗血管生成剂或多肽，其包含基本上与CD2的结构域1相似的氨基酸区段，其中所述多肽具有由两个区段形成的β片段。还包括使用这些试剂和多肽的方法。

10. 发明申请

WO2006020550A3 ANALYTE SENSORS AND METHOD FOR CONSTRUCTING ANALYTE BINDING MOTIFS 审中-公开
标题翻译：分析传感器和构建分析结合运动的方法
公开(公告)号：WO2006020550A3
公开(公告)日：2009-04-09
申请号：PCT/US2005028079
申请日：2005-08-08
申请人： UNIV GEORGIA STATE RES FOUND , YANG JENNY J
发明人： YANG JENNY J
IPC分类号： G01N21/00 , G01N21/01 , G01N21/76 , G01N33/44 , G01N33/53
CPC分类号： G01N33/84 , G01N33/542 , G01N2458/40
摘要： An analyte sensor with a tailored analyte binding motif that binds an analyte and a host protein in which the analyte binding motif is operatively linked or integrated therein and in which the binding of the analyte to the analyte binding motif produces a detectable change and manipulation of the analyte binding motif manipulates the responsiveness of the sensor. Also, a method for constructing an analyte sensor by constructing a tailored analyte binding motif capable of responding to an analyte and operatively inserting the analyte binding motif into a host protein. Included is a method for quantifying an analyte by introducing a nucleotide sequence for a protein having an analyte sensor with a tailored analyte binding motif that is able to produce a detectable change upon excitation, expressing the protein, providing excitement to the analyte sensor, and quantifying the detectable change.
摘要翻译：具有定制的分析物结合基序的分析物传感器，其结合分析物和宿主蛋白，其中分析物结合基序可操作地连接或整合在其中，并且其中分析物与分析物结合基序的结合产生可检测的变化和操纵分析物结合基序操纵传感器的响应性。另外，一种构建分析物传感器的方法，该方法通过构建能够对分析物作出响应并且将分析物结合基序可操作地插入宿主蛋白质的定制的分析物结合基序。包括一种通过为具有分析物传感器的蛋白质的核苷酸序列引入定制的分析物结合基序来定量分析物的方法，其能够在激发时产生可检测的变化，表达蛋白质，向分析物传感器提供兴奋，并量化可检测的变化。

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