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1. 发明申请

WO2013006020A3 COMPOSITION COMPRISING PYRUVIC ACIDS FOR PROTECTING NERVE CELLS 审中-公开
标题翻译：包含用于保护神经细胞的吡喃酸的组合物
公开(公告)号：WO2013006020A3
公开(公告)日：2013-04-11
申请号：PCT/KR2012005417
申请日：2012-07-09
申请人： NAT UNIV GYEONGSANG IACF , KIM MYEONG OK , KIM TAE HYUN , YANG BYOUNG CHUL
发明人： KIM MYEONG OK , KIM TAE HYUN , YANG BYOUNG CHUL
IPC分类号： A61K31/19 , A61K31/21 , A61K31/22 , A61P25/00
CPC分类号： A61K31/19 , A23L33/10 , A23V2002/00 , A23V2200/322 , A23V2250/052
摘要： The present invention relates to a composition for protecting nerve cells, and to a functional health food, which comprise pyruvic acids or pharmaceutically acceptable salts thereof so as to inhibit nerve cell apoptosis caused by ethanol. The present invention further relates to a method for protecting nerve cells from the nerve cell apoptosis caused by ethanol, and to a method for treating neurological disorders, which involve injecting the composition into an individual. The composition for protecting nerve cells of the present invention may inhibit apoptosis induced by ethanol, and therefore may be widely used in the prevention and treatment of nerve damage caused by chemicals such as ethanol.
摘要翻译：本发明涉及用于保护神经细胞的组合物，并且涉及包含丙酮酸或其药学上可接受的盐以抑制由乙醇引起的神经细胞凋亡的功能性保健食品。本发明进一步涉及保护由乙醇引起的神经细胞凋亡的神经细胞的方法，以及治疗神经病症的方法，其涉及将组合物注射到个体中。本发明的用于保护神经细胞的组合物可以抑制乙醇诱导的凋亡，因此可以广泛用于预防和治疗由乙醇等化学物质引起的神经损伤。

2. 发明申请

WO2011145905A3 METHOD FOR SCREENING, USING GABA RECEPTORS, FOR PREPARATIONS FOR PREVENTING FETAL NEURAL DISEASE CAUSED BY ALCOHOL EXPOSURE DURING PREGNANCY 审中-公开
标题翻译：使用GABA受体进行筛选的方法，用于预防由酒精暴露引起的宫颈神经疾病的准备
公开(公告)号：WO2011145905A3
公开(公告)日：2012-05-03
申请号：PCT/KR2011003725
申请日：2011-05-19
申请人： NAT UNIV GYEONGSANG IACF , KIM MYEONG OK , PARK MOON SEOK , PARK TAE JU , YANG BYOUNG CHUL
发明人： KIM MYEONG OK , PARK MOON SEOK , PARK TAE JU , YANG BYOUNG CHUL
IPC分类号： G01N33/68 , G01N33/15
CPC分类号： G01N33/9426 , G01N2500/04 , G01N2800/385
摘要： The present invention relates to a method for screening for preparations for preventing fetal neural disease caused by alcohol exposure during pregnancy, comprising: a step of treating a fetus-derived specimen with ethanol to inhibit the expression of GABAB1 receptors; and a step of treating the specimen with a candidate material, and checking the increase in the expression of one or more selected from a group consisting of GABAB1 receptors, p-CREB and PKA. The present invention also relates to a method for predicting the probability of the onset of fetal neural disease caused by alcohol exposure during pregnancy, comprising measuring the decrease in the expression of GABAB1 receptors in the fetus-derived specimen exposed to alcohol. The present invention also relates to a method for preparing compositions for preventing fetal neural disease caused by alcohol exposure during pregnancy, comprising: a step of treating a fetus-derived specimen exposed to alcohol with a candidate material, and checking the increase in the expression of one or more selected from a group consisting of GABAB1 receptors, p-CREB and PKA; and a step of adding the candidate material that exhibits said increase in expression.
摘要翻译：本发明涉及一种筛选用于预防妊娠期酒精暴露引起的胎儿神经疾病的制剂的方法，包括：用乙醇处理胎儿来源的标本以抑制GABAB1受体的表达的步骤; 以及用候选材料处理标本的步骤，检查从由GABAB1受体，p-CREB和PKA组成的组中选出的一种或多种的表达增加。本发明还涉及一种用于预测妊娠期酒精暴露引起的胎儿神经疾病发作概率的方法，包括测量暴露于酒精的胎儿来源标本中GABAB1受体表达的降低。本发明还涉及一种制备用于预防由怀孕期间的酒精暴露引起的胎儿神经疾病的组合物的方法，其包括：用候选物质处理暴露于酒精的胎儿来源的标本的步骤，以及检查表达的增加选自由GABAB1受体，p-CREB和PKA组成的组中的一种或多种; 以及添加表现出所述表达增加的候选材料的步骤。

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