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1. 发明申请

WO2009091372A1 ACTIVE TRANSDERMAL MEDICAMENT PATCH 审中-公开
标题翻译：主动变态药物贴
公开(公告)号：WO2009091372A1
公开(公告)日：2009-07-23
申请号：PCT/US2008/009452
申请日：2008-08-06
申请人： ActuvaTek, Inc. , YANAKI, Jamal S.
发明人： YANAKI, Jamal S.
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： An active transdermal medicament patch (16) includes a planar substrate (18) with a therapeutic face (20) releasably retainable against the skin (112) of a patient (10). A return electrode (42) and a medicament matrix (30) susceptible to permeation by medicament (M + , M - ) are secured at separated locations on the therapeutic face (20). Each electrically conductively engages the skin (112), when the substrate (18) is retained thereon. A power source (62) carried on the substrate (18) is electrically coupled between the medicament matrix (30) and a programmed microprocessor (122) also carried on the substrate (18). A substantially invariant voltage presented at an output contact (P4) of the microprocessor (122) is applied during a predetermined therapy period (T M ) across the skin (112) between the medicament matrix (30) and the return electrode (42), inducing transcutaneous migration of medicament (M + , M - ) into the skin (112)at a substantially constant rate. A light-emitting diode (67) carried on the substrate (18) and coupled to the microprocessor (122) communicates that the patch (16) is operating.
摘要翻译：活性透皮药物贴片（16）包括具有可释放地保持抵靠患者（10）的皮肤（112）的治疗面（20）的平面基底（18）。在治疗面（20）上的分离位置处固定有易于被药物（M +，M-）渗透的返回电极（42）和药物基质（30）。当衬底（18）保持在其上时，每个电导电地接合皮肤（112）。承载在基板（18）上的电源（62）电耦合在药物矩阵（30）和也承载在基板（18）上的编程的微处理器（122）之间。在处理药物矩阵（30）和返回电极（42）之间的皮肤（112）的预定治疗期间（TM）期间，施加在微处理器（122）的输出触点（P4）处呈现的基本上不变的电压，药物（M +，M-）以基本恒定的速率经皮迁移到皮肤（112）中。携带在基板（18）上并耦合到微处理器（122）的发光二极管（67）传送补片（16）正在操作。

2. 发明申请

WO2010002363A1 COSMETIC IONTOPHORESIS SYSTEM 审中-公开
标题翻译：化妆品IOPOPHORESIS系统
公开(公告)号：WO2010002363A1
公开(公告)日：2010-01-07
申请号：PCT/US2008/008215
申请日：2008-07-02
申请人： ACTIVATEK, INC. , YANAKI, Jamal, S.
发明人： YANAKI, Jamal, S.
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/044 , A61N1/0448
摘要： Iontophoretically administering a cosmetic agent requires an active electrode and a return electrode secured to the skin (150). The active electrode includes a flexible biocompatible substrate (20, 170) having a therapeutic face (106, 206) configured for disposition toward the skin (150) and an exterior periphery (32, 182) shaped to facilitate conformance of the substrate (20, 170) to the skin (150) over an intended treatment region. A flexible electrically conductive layer (110, 210) is disposed on the therapeutic face (106, 206). The side of the conductive layer (110, 210) opposite from the substrate (20, 170) defines a driving face (120, 220) to which is affixed an electrically conductive adhesive matrix (82, 192) comprised of a material capable of repeatedly releasably securing the active electrode to the skin (150) through an applied solution (156, 158) of the cosmetic agent. A power source (76, 186) electrically connectable to the return electrode and to the conductive layer (110, 210) of the active electrode causes migration of the cosmetic agent away from the adhesive matrix (82, 192) into the skin (150).
摘要翻译：离子电渗施用化妆品需要固定在皮肤上的活性电极和返回电极（150）。活性电极包括柔性生物相容性基底（20,170），其具有被配置成朝向皮肤（150）配置的治疗面（106,206）和外周边（32,182），外周边（32,182）成形为促进基底 170）穿过预期治疗区域到皮肤（150）。柔性导电层（110,210）设置在治疗面（106,206）上。与衬底（20,170）相对的导电层（110,210）的一侧限定了驱动面（120,220），所述驱动面（120,220）固定有导电粘合剂基体（82,192），所述导电粘合剂基质由能够重复地通过化妆品的施加溶液（156,158）可释放地将活性电极固定到皮肤（150）上。可电连接到返回电极和活性电极的导电层（110,210）的电源（76,186）导致化妆剂从粘合剂基质（82,192）远离皮肤（150）的迁移，。

3. 发明申请

WO2008153931A3 TRANSDERMAL MEDICAMENT PATCH AND ACTIVE ELECTRODE FOR SAME 审中-公开
标题翻译：用于同种异体的药物传递物质和活性电极
公开(公告)号：WO2008153931A3
公开(公告)日：2009-03-12
申请号：PCT/US2008007109
申请日：2008-06-06
申请人： ACTIVATEK INC , YANAKI JAMAL S
发明人： YANAKI JAMAL S
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61F13/00051 , A61F13/02 , A61F2013/00285 , A61F2013/00417 , A61F2013/00442 , A61F2013/00489 , A61F2013/00646 , A61F2013/00906 , A61F2013/00919 , A61F2013/00948 , A61F2013/00961
摘要： A transdermal medicament patch (18,0168) includes a substrate(32, 172) having a therapeutic face (40, 180) configured for disposition against the skin (102), an adhesive on the therapeutic face (40, 180), a planar medicament matrix (46, 188) covering a portion of the therapeutic face (46,188), and a release liner (41, 182) covering the portion of therapeutic face (40, 180) not obscured by the medicament matrix (46, 188) An aperture (44, 186) through the release liner (41, 182) affords access to the medicament matnx (46, 188) An active electrode (54, 110, 120, 130, 140, 150, 210, 230, 250,270, 290) positioned between the medicament matrix (46,188) and the therapeutic face (40, 180) includes an electpcally conductive backing layer (56, 142, 152,212,232,252,272, 292) positioned against the therapeutic face (40, 180) and a pH-control layer (58, 132, 146, 156,216, 236, 256, 276, 296) that moderates changes in hydrogen-ion concentration covering
摘要翻译：透皮药物贴剂（18,0168）包括具有配置用于处置皮肤（102）的治疗面（40,180）的基底（32,172），治疗面（40,180）上的粘合剂，平面覆盖治疗面（46,188）的一部分的药物基质（46,188）和覆盖治疗面（40,180）部分的释放衬垫（41,182），其不被药物基质（46,188）遮蔽。通过释放衬垫（41,182）的孔径（44,186）可以进入药物基质（46,188）。有效电极（54,110,120,130,140,150,210,230,250,270,290）位于药物基质（46,188）和治疗面（40,180）之间的电极包括位于治疗面（40,180）和pH控制层（58）上的电导电背衬层（56,142,152,212,232,252,272,292），132,146,156,216,236,256,276,296），其缓和了氢离子浓度的变化

4. 发明申请

WO2008153931A2 TRANSDERMAL MEDICAMENT PATCH AND ACTIVE ELECTRODE FOR SAME 审中-公开
标题翻译：用于同种异体的药物传递物质和活性电极
公开(公告)号：WO2008153931A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/007109
申请日：2008-06-06
申请人： ACTIVATEK, INC. , YANAKI, Jamal, S.
发明人： YANAKI, Jamal, S.
IPC分类号： A61B5/04 , A61F13/00 , A61F13/02
CPC分类号： A61N1/30 , A61F13/00051 , A61F13/02 , A61F2013/00285 , A61F2013/00417 , A61F2013/00442 , A61F2013/00489 , A61F2013/00646 , A61F2013/00906 , A61F2013/00919 , A61F2013/00948 , A61F2013/00961
摘要： A transdermal medicament patch ( 18,0168) includes a substrate(32, 172) having a therapeutic face (40, 180) configured for disposition against the skin (102), an adhesive on the therapeutic face (40, 180), a planar medicament matrix (46, 188) covering a portion of the therapeutic face (46,188), and a release liner (41, 182) covering the portion of therapeutic face (40, 180) not obscured by the medicament matrix (46, 188). An aperture (44, 186) through the release liner (41, 182) affords access to the medicament matrix (46, 188). An active electrode (54, 110, 120, 130, 140, 150, 210, 230, 250, 270, 290) positioned between the medicament matrix (46, 188) and the therapeutic face (40, 180) includes an electrically conductive backing layer (56, 142, 152, 212, 232, 252, 272, 292) positioned against the therapeutic face (40, 180) and a pH-control layer (58, 132, 146, 156, 216, 236, 256, 276, 296) that moderates changes in hydrogen-ion concentration covering less than all of the therapeutic face (40, 180). One active electrode design criterion relates the size of the pH-control layer to the size of the backing layer; another relates the size of the portion of the backing layer not covered by the pH-control layer to the size of the pH-control layer.
摘要翻译：透皮药物贴剂（18,0168）包括具有配置用于处置皮肤（102）的治疗面（40,180）的基底（32,172），治疗面（40,180）上的粘合剂，平面覆盖治疗面（46,188）的一部分的药物基质（46,188）和覆盖治疗面部（40,180）的部分而不被药物基质（46,188）遮蔽的释放衬垫（41,182）。穿过释放衬垫（41,182）的孔（44,186）可以进入药物基质（46,188）。位于药物基质（46,188）和治疗面（40,180）之间的有源电极（54,110,120,130,140,150,210,230,250,270,290）包括导电背衬定位在治疗面（40,180）和pH控制层（58,132,146,156,216,236,256,276）之间的层（56,142,152,212,232,252,272,292），296），其缓和氢离子浓度的变化，其覆盖率小于所有治疗面（40,180）。一个活性电极设计标准将pH控制层的尺寸与背衬层的尺寸相关联; 另一个涉及未被pH控制层覆盖的背衬层的部分的尺寸与pH值控制层的尺寸。

5. 发明申请

WO2006104628A3 MULTILAYER COATING FOR RELEASING BIOLOGICALLY-ACTIVE AGENTS AND METHOD OF MAKING 审中-公开
公开(公告)号：WO2006104628A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/007187
申请日：2006-03-01
申请人： BACTERIN INTERNATIONAL, INC. , MADSEN, Todd, A. , YANAKI, Jamal, S.
发明人： MADSEN, Todd, A. , YANAKI, Jamal, S.
IPC分类号： A61F13/00 , A61F2/00
摘要： A composition for use with healthcare products such as medical device includes one or more biologically-active agents for release into bodily fluids. The composition can be applied to a substrate to form an erodible layer and a polymer layer. Biologically-active agent(s) are releasable from the erodible layer and the polymer layer when exposed to aqueous fluids.

6. 发明申请

WO2006104628A2 MULTILAYER COATING FOR RELEASING BIOLOGICALLY-ACTIVE AGENTS AND METHOD OF MAKING 审中-公开
标题翻译：用于释放生物活性剂的多层涂料及其制备方法
公开(公告)号：WO2006104628A2
公开(公告)日：2006-10-05
申请号：PCT/US2006007187
申请日：2006-03-01
申请人： BACTERIN INT INC , MADSEN TODD A , YANAKI JAMAL S
发明人： MADSEN TODD A , YANAKI JAMAL S
IPC分类号： A61K9/26
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/402 , A61L2300/61
摘要： A composition for use with healthcare products such as medical device includes one or more biologically-active agents for release into bodily fluids. The composition can be applied to a substrate to form an erodible layer and a polymer layer. Biologically-active agent(s) are releasable from the erodible layer and the polymer layer when exposed to aqueous fluids.
摘要翻译：用于医疗保健产品如医疗器械的组合物包括用于释放到体液中的一种或多种生物活性剂。该组合物可以施加到基底上以形成可侵蚀层和聚合物层。当暴露于含水流体时，生物活性剂可从可溶解层和聚合物层释放。

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