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1. 发明申请

US20120074066A1 Microchip Capillary Electrophoresis Absent Electrokinetic Injection 有权
标题翻译：微毛细管电泳缺少电动注射
公开(公告)号：US20120074066A1
公开(公告)日：2012-03-29
申请号：US12889108
申请日：2010-09-23
申请人： Xuefei Sun , Ryan T. Kelly , Keqi Tang , Richard D. Smith
发明人： Xuefei Sun , Ryan T. Kelly , Keqi Tang , Richard D. Smith
IPC分类号： G01N27/416 , B01D15/08 , G01N30/02 , B01D17/06
CPC分类号： G01N27/44743 , G01N27/44791 , G01N30/461
摘要： Microchip capillary electrophoresis (CE) utilizing a sample injector based on a mechanical valve rather than electrokinetic injection can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. In one instance CE electrodes continuously apply an electric field for CE separation along a separation channel. A sample channel is connected to the separation channel at an intersection and has a sample pressure that is greater than that which is present in the separation channel near the intersection. The sample channel does not have electrodes that apply voltages for electrokinetic injection. A sample injector in the sample channel or at the intersection comprises a mechanical valve to control sample injection from the sample channel to the separation channel.
摘要翻译：使用基于机械阀而不是电动注射的样品注射器的微芯片毛细管电泳（CE）可以提供改进的样品注射，增强的能力，并且可以消除改变分离通道中的电场以诱导注射样品的需要。在一个实例中，CE电极沿着分离通道连续地施加用于CE分离的电场。样品通道在交叉口处连接到分离通道，并且具有大于在交叉口附近的分离通道中存在的样品压力的样品压力。样品通道不具有施加电动注射电压的电极。样品通道或交叉口处的样品注射器包括一个机械阀，用于控制从样品通道到分离通道的样品注射。

2. 发明申请

US20140194304A1 PROCESS FOR ULTRA-SENSITIVE QUANTIFICATION OF TARGET ANALYTES IN COMPLEX BIOLOGICAL SYSTEMS 审中-公开
标题翻译：复杂生物系统中目标分析的超敏感量化方法
公开(公告)号：US20140194304A1
公开(公告)日：2014-07-10
申请号：US13736279
申请日：2013-01-08
申请人： Tujin Shi , Weijun Qian , Thomas L. Fillmore , Xuefei Sun , Richard D. Smith
发明人： Tujin Shi , Weijun Qian , Thomas L. Fillmore , Xuefei Sun , Richard D. Smith
IPC分类号： G01N30/00 , G01N27/447 , G01N33/50
CPC分类号： G01N33/6848 , G01N30/72 , G01N30/8631 , G01N33/50 , G01N33/6842 , G01N2030/8831 , G01N2458/15 , G01N2560/00
摘要： Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.
摘要翻译：公开了无抗体方法，其提供复杂样品中各种低丰度目标分析物的准确定量。该方法可以采用高压，高分辨率色谱分离来进行分析物富集。目标分数的智能选择可以通过在线选择反应监测（SRM）或离线快速筛选内部标准进行。可以对单个或多个分数进行定量。应用包括例如血浆，细胞或组织样品中非常低丰度蛋白或候选生物标志物的分析，而不需要亲和特异性试剂。

3. 发明申请

US20120318672A1 Systems for Microchip Capillary Electrophoresis Absent Electrokinetic Injection 审中-公开
标题翻译：微毛细管电泳系统缺少电动注射
公开(公告)号：US20120318672A1
公开(公告)日：2012-12-20
申请号：US13596360
申请日：2012-08-28
申请人： Xuefei Sun , Ryan T. Kelly , Keqi Tang , Richard D. Smith
发明人： Xuefei Sun , Ryan T. Kelly , Keqi Tang , Richard D. Smith
IPC分类号： G01N27/447
CPC分类号： G01N27/44743 , G01N27/44791 , G01N30/461
摘要： Microchip capillary electrophoresis (CE) utilizing a sample injector based on a mechanical valve rather than electrokinetic injection can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. In one instance CE electrodes continuously apply an electric field for CE separation along a separation channel. A sample channel is connected to the separation channel at an intersection and has a sample pressure that is greater than that which is present in the separation channel near the intersection. The sample channel does not have electrodes that apply voltages for electrokinetic injection. A sample injector in the sample channel or at the intersection comprises a mechanical valve to control sample injection from the sample channel to the separation channel.
摘要翻译：使用基于机械阀而不是电动注射的样品注射器的微芯片毛细管电泳（CE）可以提供改进的样品注射，增强的能力，并且可以消除改变分离通道中的电场以诱导注射样品的需要。在一个实例中，CE电极沿着分离通道连续地施加用于CE分离的电场。样品通道在交叉口处连接到分离通道，并且具有大于在交叉口附近的分离通道中存在的样品压力的样品压力。样品通道不具有施加电动注射电压的电极。样品通道或交叉口处的样品注射器包括一个机械阀，用于控制从样品通道到分离通道的样品注射。

4. 发明授权

US08277659B2 Microchip capillary electrophoresis absent electrokinetic injection 有权
标题翻译：微丝毛细管电泳缺电动注射
公开(公告)号：US08277659B2
公开(公告)日：2012-10-02
申请号：US12889108
申请日：2010-09-23
申请人： Xuefei Sun , Ryan T. Kelly , Keqi Tang , Richard D. Smith
发明人： Xuefei Sun , Ryan T. Kelly , Keqi Tang , Richard D. Smith
IPC分类号： B01D15/08
CPC分类号： G01N27/44743 , G01N27/44791 , G01N30/461
摘要： Microchip capillary electrophoresis (CE) utilizing a sample injector based on a mechanical valve rather than electrokinetic injection can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. In one instance CE electrodes continuously apply an electric field for CE separation along a separation channel. A sample channel is connected to the separation channel at an intersection and has a sample pressure that is greater than that which is present in the separation channel near the intersection. The sample channel does not have electrodes that apply voltages for electrokinetic injection. A sample injector in the sample channel or at the intersection comprises a mechanical valve to control sample injection from the sample channel to the separation channel.
摘要翻译：使用基于机械阀而不是电动注射的样品注射器的微芯片毛细管电泳（CE）可以提供改进的样品注射，增强的能力，并且可以消除改变分离通道中的电场以诱导注射样品的需要。在一个实例中，CE电极沿着分离通道连续地施加用于CE分离的电场。样品通道在交叉口处连接到分离通道，并且样品压力大于在交叉口附近的分离通道中存在的样品压力。样品通道不具有施加电动注射电压的电极。样品通道或交叉口处的样品注射器包括一个机械阀，用于控制从样品通道到分离通道的样品注射。

5. 发明申请

US20070095528A1 Method of Monitoring Fluid Placement During Stimulation Treatments 失效
标题翻译：在刺激治疗期间监测液体放置的方法
公开(公告)号：US20070095528A1
公开(公告)日：2007-05-03
申请号：US11551310
申请日：2006-10-20
申请人： Murtaza Ziauddin , Bhavani Raghuraman , Li Jiang , Xuefei Sun , Sebastien Fremont , Ballard Andrews , Robert Schroeder , Stephen Hill , Mahmuda Afroz , Frank Espinosa , Michael Orlet , John Lovell , Steve Davies
发明人： Murtaza Ziauddin , Bhavani Raghuraman , Li Jiang , Xuefei Sun , Sebastien Fremont , Ballard Andrews , Robert Schroeder , Stephen Hill , Mahmuda Afroz , Frank Espinosa , Michael Orlet , John Lovell , Steve Davies
IPC分类号： E21B47/10 , E21B49/00
CPC分类号： E21B43/25 , E21B47/10 , G01F1/704 , G01F1/7086
摘要： Although the methods have been described here for, and are most typically used for, hydrocarbon production, fluid diversion measurement systems and methods are described. One method includes inserting a tubular tubing having one more fluid injection ports into a wellbore, injecting a treatment fluid through the injection port, and determining differential flow of the treatment fluid at one or more wellbore based on measuring the concentration of at least one particular component of a wellbore fluid located in the annulus formed between the wellbore and tubular; and means for using the measured parameters in realtime to monitor, control, or both monitor and control diversion of the fluid. This abstract allows a searcher or other reader to quickly ascertain the subject matter of the disclosure. It will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).
摘要翻译：虽然这里描述了并且最常用于烃生产的方法，但是描述了流体分流测量系统和方法。一种方法包括将具有一个以上流体注入口的管状管插入井孔中，通过注入口注入处理流体，以及基于测量至少一个特定组分的浓度确定处理流体在一个或多个井筒处的不同流量位于井筒和管状之间形成的环形空间中的井眼流体; 以及实时使用测量参数来监测，控制或监测和控制流体转移的装置。该摘要允许搜索者或其他读者快速确定本公开的主题。它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。

6. 发明申请

US20160238614A1 PROCESS FOR ULTRA-SENSITIVE QUANTIFICATION OF TARGET ANALYTES IN COMPLEX BIOLOGICAL SYSTEMS 审中-公开
标题翻译：复杂生物系统中目标分析的超敏感量化方法
公开(公告)号：US20160238614A1
公开(公告)日：2016-08-18
申请号：US14949385
申请日：2015-11-23
申请人： TUJIN SHI , WEIJUN QIAN , THOMAS L. FILLMORE , XUEFEI SUN , RICHARD D. SMITH
发明人： TUJIN SHI , WEIJUN QIAN , THOMAS L. FILLMORE , XUEFEI SUN , RICHARD D. SMITH
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N30/72 , G01N30/8631 , G01N33/50 , G01N33/6842 , G01N2030/8831 , G01N2458/15 , G01N2560/00
摘要： Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.
摘要翻译：公开了无抗体方法，其提供复杂样品中各种低丰度目标分析物的准确定量。该方法可以采用高压，高分辨率色谱分离来进行分析物富集。目标分数的智能选择可以通过在线选择反应监测（SRM）或离线快速筛选内部标准进行。可以对单个或多个分数进行定量。应用包括例如血浆，细胞或组织样品中非常低丰度蛋白或候选生物标志物的分析，而不需要亲和特异性试剂。

7. 发明授权

US07658226B2 Method of monitoring fluid placement during stimulation treatments 失效
标题翻译：在刺激治疗期间监测液体放置的方法
公开(公告)号：US07658226B2
公开(公告)日：2010-02-09
申请号：US11551310
申请日：2006-10-20
申请人： Murtaza Ziauddin , Bhavani Raghuraman , Li Jiang , Xuefei Sun , Sebastien Fremont , Ballard Andrews , Robert Schroeder , Stephen Hill , Mahmuda Afroz , Frank Espinosa , Michael Orlet , John Lovell , Steve Davies
发明人： Murtaza Ziauddin , Bhavani Raghuraman , Li Jiang , Xuefei Sun , Sebastien Fremont , Ballard Andrews , Robert Schroeder , Stephen Hill , Mahmuda Afroz , Frank Espinosa , Michael Orlet , John Lovell , Steve Davies
IPC分类号： E21B43/27 , E21B47/10
CPC分类号： E21B43/25 , E21B47/10 , G01F1/704 , G01F1/7086
摘要： Although the methods have been described here for, and are most typically used for, hydrocarbon production, fluid diversion measurement systems and methods are described. One method includes inserting a tubular tubing having one more fluid injection ports into a wellbore, injecting a treatment fluid through the injection port, and determining differential flow of the treatment fluid at one or more wellbore based on measuring the concentration of at least one particular component of a wellbore fluid located in the annulus formed between the wellbore and tubular; and using the measured parameters in realtime to monitor, control, or both monitor and control diversion of the fluid.
摘要翻译：虽然这里描述了并且最常用于烃生产的方法，但是描述了流体分流测量系统和方法。一种方法包括将具有一个以上流体注入端口的管状管插入井眼中，通过注入端口注入处理流体，以及基于测量至少一个特定组分的浓度确定处理流体在一个或多个井眼处的不同流量位于井筒和管状之间形成的环形空间中的井眼流体; 并且实时使用测量的参数来监测，控制或同时监测和控制流体的转移。

8. 发明申请

US20100056740A1 ADSORPTION-RESISTANT ACRYLIC COPOLYMER FOR FLUIDIC DEVICES 审中-公开
标题翻译：用于流体装置的耐吸附丙烯酸共聚物
公开(公告)号：US20100056740A1
公开(公告)日：2010-03-04
申请号：US12304738
申请日：2007-06-14
申请人： Jikun Liu , Xuefei Sun , Milton L. Lee
发明人： Jikun Liu , Xuefei Sun , Milton L. Lee
IPC分类号： C08F220/26 , B05D3/10 , B05D3/12
CPC分类号： C08F220/26 , C08F222/16
摘要： A copolymer is used for fluidic devices that require surfaces nonreactive with biomolecules. The copolymer is the reaction product of Compound A having the formula: and Compound B having the formula where the R groups are the same or different and are selected from hydrogen, and alkyl groups with 4 carbons or less, where n is the same or different and is greater than 3.
摘要翻译：共聚物用于需要与生物分子无反应的表面的流体装置。共聚物是具有下式的化合物A和具有下式的化合物B的反应产物：其中R基团相同或不同并且选自氢和具有4个碳以下的烷基，其中n相同或不同并且大于3。

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