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1. 外观设计

USD924671S1 Curtain clip 有权
公开(公告)号：USD924671S1
公开(公告)日：2021-07-13
申请号：US29719789
申请日：2020-01-07
申请人： Xinjian Yan
设计人： Xinjian Yan

2. 发明授权

US06177280B1 Ricin inhibitors and methods for use thereof 失效
标题翻译：蓖麻毒素抑制剂及其使用方法
公开(公告)号：US06177280B1
公开(公告)日：2001-01-23
申请号：US09118535
申请日：1998-07-17
申请人： Xinjian Yan , Sean Kerwin , Jon D. Robertus
发明人： Xinjian Yan , Sean Kerwin , Jon D. Robertus
IPC分类号： G01N33566
CPC分类号： C07D285/22 , C07D285/24 , C07D473/18 , C07D475/04 , C07D487/04 , C12Q1/34 , G01N33/5308 , G01N33/56916
摘要： Ricin A-chain is an N-glycosidase that attacks ribosomal RNA at a highly conserved adenine residue. Crystallographic studies show that not only adenine and formycin, but also pterin-based rings can bind in the ricin active site. For a better understanding of the recognition mode between ricin, and adenine-like rings, the interaction energies and geometries were calculated for a number of complexes. Shiga toxin, a compound essentially identical to the protein originally isolated from Shigella dysenteriae, has an active protein chain that is a homologue of the ricin active chain, and catalyzes the same depurination reaction. The present invention is drawn to identifying inhibitors of ricin and Shiga toxin, using methods molecular mechanics and ab initio methods and using the identified inhibitors as antidotes to ricin or Shiga toxin, or to facilitate immunotoxin treatment by controlling non-specific cytotoxicity.
摘要翻译：蓖麻毒素A链是一种在高度保守的腺嘌呤残基下攻击核糖体RNA的N-糖苷酶。晶体学研究表明，不仅腺嘌呤和霉素，而且基于蝶呤的环可以在蓖麻毒素活性位点结合。为了更好地了解蓖麻毒蛋白和腺嘌呤样环之间的识别模式，计算了多种复合物的相互作用能和几何形状。志贺毒素是一种基本上与痢疾志贺氏菌分离的蛋白质基本相同的化合物，具有活性蛋白链，是蓖麻毒素活性链的同源物，并催化相同的去血反应。本发明涉及鉴定蓖麻毒素和志贺毒素的抑制剂，使用分子力学和从头法，并使用鉴定的抑制剂作为蓖麻毒素或志贺毒素的解毒剂，或通过控制非特异性细胞毒性促进免疫毒素治疗。

3. 发明授权

US5688992A O-malonyltryrosyl compounds, O-malonyltryrosyl compound-containing peptides, and use thereof 失效
标题翻译： O-丙二酰基酪酰基化合物，含有O-丙二酰基特异性基化合物的肽及其用途
公开(公告)号：US5688992A
公开(公告)日：1997-11-18
申请号：US414520
申请日：1995-03-31
申请人： Terrence R. Burke, Jr. , Bin Ye , Miki Akamatsu , Hemanta K. Kole , Xinjian Yan , Peter R. Roller
发明人： Terrence R. Burke, Jr. , Bin Ye , Miki Akamatsu , Hemanta K. Kole , Xinjian Yan , Peter R. Roller
IPC分类号： A61K38/00 , A61K31/195 , A61K31/215 , A61P3/08 , A61P3/10 , A61P35/00 , A61P37/04 , A61P43/00 , C07C229/36 , C07C237/20 , C07C271/22 , C07K5/065 , C07K7/06 , C07K14/47 , C07K14/705 , C07C57/145 , A61K31/19
CPC分类号： C07C271/22 , C07C229/36 , C07C237/20 , C07K14/705 , C07K5/06078 , A61K38/00 , C07C2103/18
摘要： The present invention relates to non-phosphorus containing O-malonyltryrosyl compounds, derivatives thereof, uses of the O-malonyltryrosyl compounds in the synthesis of peptides, and O-malonyltryrosyl compound-containing peptides. The O-malonyltyrosyl malonyltyrosyl compounds and O-malonyltryrosyl compound-containing peptides of the present invention are uniquely stable to phosphotases, capable of crossing cell membranes, suitable for application to peptide synthesis of O-malonyltryrosyl compound-containing peptides, and amenable to prodrag defivatization for delivery into cells. The present invention also provides for O-malonyltryrosyl compound-containing peptides which exhibit inhibitory potency against binding interactions of receptor domains with phosphotyrosyl-containing peptide ligands.
摘要翻译：本发明涉及不含磷的O-壬二酰基特异性基团的化合物，其衍生物，O-丙二酰基二辛基化合物在肽的合成中的应用，以及含有O-丙二酰基二酰基化合物的肽。本发明的O-丙二酰基特异酰基丙二酰基酪氨酸化合物和含O-丙二酰基酪酰基化合物的肽对于能够与细胞膜交叉的磷酸酶是独特稳定的，适用于肽合成含有O-丙二酰基二酰基化合物的肽，并且适于产生衍生化用于送入细胞。本发明还提供了对具有含磷酰基的肽配体的受体结构域的结合相互作用具有抑制效力的含有O-丙二酰基二酰基化合物的肽。

4. 发明授权

US06562969B1 Ricin inhibitors and methods for use thereof 失效
标题翻译：蓖麻毒素抑制剂及其使用方法
公开(公告)号：US06562969B1
公开(公告)日：2003-05-13
申请号：US09535460
申请日：2000-03-24
申请人： Jon Robertus , Sean Kerwin , Xinjian Yan
发明人： Jon Robertus , Sean Kerwin , Xinjian Yan
IPC分类号： C07D48702
CPC分类号： C07D239/47 , C07D239/48 , C07D239/545 , C07D285/22 , C07D285/24 , C07D473/18 , C07D475/04 , C07D487/04 , C07D513/04 , C12Q1/34 , G01N33/5308 , G01N33/56916
摘要： Ricin A-chain is an N-glycosidase that attacks ribosomal RNA at a highly conserved adenine residue. Crystallographic studies show that not only adenine and formycin, but also pterin-based rings can bind in the ricin active site. For a better understanding of the recognition mode between ricin, and adenine-like rings, the interaction energies and geometries were calculated for a number of complexes. Shiga toxin, a compound essentially identical to the protein originally isolated from Shigella dysenteniae, has an active protein chain that is a homologue of the ricin active chain, and catalyzes the same depurination reaction. The present invention is drawn to identifying inhibitors of ricin and Shiga toxin, using methods molecular mechanics and ab initio methods and using the identified inhibitors as antidotes to ricin or Shiga toxin, or to facilitate immunotoxin treatment by controlling non-specific cytotoxicity.
摘要翻译：蓖麻毒素A链是一种在高度保守的腺嘌呤残基下攻击核糖体RNA的N-糖苷酶。晶体学研究表明，不仅腺嘌呤和霉素，而且基于蝶呤的环可以在蓖麻毒素活性位点结合。为了更好地了解蓖麻毒蛋白和腺嘌呤样环之间的识别模式，计算了多种复合物的相互作用能和几何形状。志贺毒素，一种与最初从志贺氏菌志愿菌中分离的蛋白质基本相同的化合物，具有活性蛋白质链，其是蓖麻毒素活性链的同系物，并催化相同的去血反应。本发明涉及鉴定蓖麻毒素和志贺毒素的抑制剂，使用分子力学和从头法，并使用鉴定的抑制剂作为蓖麻毒素或志贺毒素的解毒剂，或通过控制非特异性细胞毒性促进免疫毒素治疗。

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