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1. 发明授权

US08329688B2 Trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid 失效
标题翻译：反式-4 - [[（5S）-5 - [[[3,5-双（三氟甲基）苯基]甲基]（2-甲基-2H-四唑-5-基）氨基] -2,3,4,5 - 四氢-7,9-二甲基-1H-1-苯并氮杂-1-基]甲基] - 环己烷甲酸
公开(公告)号：US08329688B2
公开(公告)日：2012-12-11
申请号：US12824355
申请日：2010-06-28
申请人： Xinchao Chen
发明人： Xinchao Chen
IPC分类号： A61P9/10 , A61K31/55 , C07D403/12
CPC分类号： C07D403/12
摘要： Compounds of a formula entitled, trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof; and hydrates and other solvates in crystalline form; pharmaceutical formulations; and methods of use are disclosed.
摘要翻译：称为反式-4 - [[（5S）-5 - [[[3,5-双（三氟甲基）苯基]甲基]（2-甲基-2H-四唑-5-基）氨基] -2 ，3,4,5-四氢-7,9-二甲基-1H-1-苯并吖庚因-1-基]甲基] - 环己烷甲酸作为游离酸或其药学上可接受的盐; 和水合物等结晶形式的溶剂合物; 药物制剂; 并且公开了使用方法。

2. 发明授权

US08299060B2 Trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl] (2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid 有权
标题翻译：反式-4 - [[（5S）-5 - [[[3,5-双（三氟甲基）苯基]甲基]（2-甲基-2H-四唑-5-基）氨基] -2,3,4,5 - 四氢-7,9-二甲基-1H-1-苯并氮杂-1-基]甲基] - 环己烷甲酸
公开(公告)号：US08299060B2
公开(公告)日：2012-10-30
申请号：US13318874
申请日：2010-06-28
申请人： Xinchao Chen , Scott Alan Frank , Steven Wayne Pedersen , David Michael Remick
发明人： Xinchao Chen , Scott Alan Frank , Steven Wayne Pedersen , David Michael Remick
IPC分类号： A61P9/10 , A61K31/55 , C07D403/12
CPC分类号： C07D403/12
摘要： Abstract Compounds of a formula entitled, trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof, hydrate, and hydrate in crystalline form; pharmaceutical formulations; and methods of use are disclosed.
摘要翻译：摘要题目为反式-4 - [[（5S）-5 - [[[[3,5-双（三氟甲基）苯基]甲基]（2-甲基-2H-四唑-5-基）氨基] 2,3,4,5-四氢-7,9-二甲基-1H-1-苯并吖庚因-1-基]甲基] - 环己烷甲酸作为游离酸或其药学上可接受的盐，水合物和结晶形式的水合物 ; 药物制剂; 并且公开了使用方法。

3. 发明申请

US20070225302A1 2-Amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents 有权
标题翻译： 2-氨基-9 - [（2-羟甲基）环丙基亚甲基]嘌呤作为抗病毒剂
公开(公告)号：US20070225302A1
公开(公告)日：2007-09-27
申请号：US11707248
申请日：2007-02-15
申请人： Jiri Zemlicka , John Drach , Xinchao Chen
发明人： Jiri Zemlicka , John Drach , Xinchao Chen
IPC分类号： A61K31/52
CPC分类号： C07D473/00 , C07F9/65616
摘要： Compounds which are active against viruses have the following Formulas: wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3; R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R2 is selected from the group consisting of C2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.
摘要翻译：对病毒有活性的化合物具有下式：其中B是2-氨基嘌呤-9-基，其可以是未取代的或在6位被NHR 1或OR 2取代， SUB>或SR 3; R 1选自烷基，烯基，炔基和C 4-18环烷基，其中任何一个可以任选地被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基组成的基团; R 2选自C 2-18烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选地被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基组成的组中的更多成员; 和R 3 3选自烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选被一个或多个由羟基，卤代，氨基，酰基，环烷基，杂环基和芳基。

4. 发明申请

US20050124582A1 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents 失效
标题翻译： 2-氨基-9 - [（2-羟甲基）环丙基亚甲基]嘌呤抗病毒剂
公开(公告)号：US20050124582A1
公开(公告)日：2005-06-09
申请号：US10942314
申请日：2004-09-15
申请人： Jiri Zemlicka , John Drach , Xinchao Chen
发明人： Jiri Zemlicka , John Drach , Xinchao Chen
IPC分类号： C07D473/16 , A61K31/52 , A61P31/12 , A61P31/18 , A61P31/20 , A61P31/22 , C07D473/00 , C07D473/18 , C07D473/24 , C07D473/32 , C07F9/6561 , A61K31/675 , C07D473/12
CPC分类号： C07D473/00 , C07F9/65616
摘要： Compounds which are active against viruses have the following Formulas: wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3; R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R2 is selected from the group consisting of C2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.
摘要翻译：对病毒有活性的化合物具有下式：其中B是2-氨基嘌呤-9-基，其可以是未取代的或在6位被NHR 1或OR 2取代， SUB>或SR 3; R 1选自烷基，烯基，炔基和C 4-18环烷基，其中任何一个可以任选地被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基组成的基团; R 2选自C 2-18烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选地被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基组成的组中的更多成员; 和R 3 3选自烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选被一个或多个由羟基，卤代，氨基，酰基，环烷基，杂环基和芳基。

5. 发明申请

US20120058990A1 Trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl] (2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid 有权
公开(公告)号：US20120058990A1
公开(公告)日：2012-03-08
申请号：US13318874
申请日：2010-06-28
申请人： Xinchao Chen , Scott Alan Frank , Steven Wayne Pedersen , David Michael Remick
发明人： Xinchao Chen , Scott Alan Frank , Steven Wayne Pedersen , David Michael Remick
IPC分类号： A61K31/55 , A61P9/10 , C07D403/12
CPC分类号： C07D403/12
摘要： Abstract Compounds of a formula entitled, trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof, hydrate, and hydrate in crystalline form; pharmaceutical formulations; and methods of use are disclosed.

6. 发明申请

US20100331309A1 Trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid 失效
标题翻译：反式-4 - [[（5S）-5 - [[[3,5-双（三氟甲基）苯基]甲基]（2-甲基-2H-四唑-5-基）氨基] -2,3,4,5 - 四氢-7,9-二甲基-1H-1-苯并氮杂-1-基]甲基] - 环己烷甲酸
公开(公告)号：US20100331309A1
公开(公告)日：2010-12-30
申请号：US12824355
申请日：2010-06-28
申请人： Xinchao Chen , Scott Alan Frank , David Michael Remick , Steven Wayne Pedersen
发明人： Xinchao Chen , Scott Alan Frank , David Michael Remick , Steven Wayne Pedersen
IPC分类号： A61K31/55 , C07D403/12 , A61P9/10
CPC分类号： C07D403/12
摘要： Compounds of a formula entitled, trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof; and hydrates and other solvates in crystalline form; pharmaceutical formulations; and methods of use are disclosed.
摘要翻译：称为反式-4 - [[（5S）-5 - [[[3,5-双（三氟甲基）苯基]甲基]（2-甲基-2H-四唑-5-基）氨基] -2 ，3,4,5-四氢-7,9-二甲基-1H-1-苯并吖庚因-1-基]甲基] - 环己烷甲酸作为游离酸或其药学上可接受的盐; 和水合物等结晶形式的溶剂合物; 药物制剂; 并且公开了使用方法。

7. 发明申请

US20100204207A1 Compounds and Methods for Treating Dyslipidemia 审中-公开
标题翻译：治疗血脂异常的化合物和方法
公开(公告)号：US20100204207A1
公开(公告)日：2010-08-12
申请号：US12763344
申请日：2010-04-20
申请人： Xinchao Chen , Christopher Lawrence Cioffi , Sean Richard Dinn , Ana Maria Escribano , Maria Carmen Fernandez , Todd Fields , Robert Jason Herr , Nathan Bryan Mantlo , Eva Maria Martin De La Nava , Ana Isabel Mateo Herranz , Saravanan Parthasarathy , Xiaodong Wang
发明人： Xinchao Chen , Christopher Lawrence Cioffi , Sean Richard Dinn , Ana Maria Escribano , Maria Carmen Fernandez , Todd Fields , Robert Jason Herr , Nathan Bryan Mantlo , Eva Maria Martin De La Nava , Ana Isabel Mateo Herranz , Saravanan Parthasarathy , Xiaodong Wang
IPC分类号： A61K31/55 , C07D403/12 , C07D417/12 , C07D491/048 , C07D405/14 , C07D413/12 , C07D401/14 , A61P3/00 , A61P9/10
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D491/04
摘要： Compounds of Formula (I): wherein n, m, p, q, Y, R1, R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed.
摘要翻译：式（I）化合物：其中n，m，p，q，Y，R 1，R 2，R 3a，R 3b，R 4，R 5和R 6如本文所定义，并公开了其药物组合物和使用方法。

8. 发明申请

US20070244095A1 Compounds and Method for Treating Dyslipidemia 有权
标题翻译：化合物和治疗血脂异常的方法
公开(公告)号：US20070244095A1
公开(公告)日：2007-10-18
申请号：US11570542
申请日：2005-06-23
申请人： Xinchao Chen , Christopher Cioffi , Sean Dinn , Ana Escribano , Maria Fernandez , Todd Fields , Robert Herr , Nathan Mantlo , Eva Martin De La Nava , Ana Mateo-Herranz , Saravanan Parthasarathy , Xiaodong Wang
发明人： Xinchao Chen , Christopher Cioffi , Sean Dinn , Ana Escribano , Maria Fernandez , Todd Fields , Robert Herr , Nathan Mantlo , Eva Martin De La Nava , Ana Mateo-Herranz , Saravanan Parthasarathy , Xiaodong Wang
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D491/04
摘要： Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed.
摘要翻译：其中n，m，p，q，Y，R 1，R 2，R 3a，R 3b， R 4，R 5，R 5和R 6如本文所定义，并且公开了它们的药物组合物和使用方法。

9. 发明授权

US09174990B2 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents 有权
标题翻译： 2-氨基-9 - [（2-羟甲基）环丙基亚甲基]嘌呤作为抗病毒剂
公开(公告)号：US09174990B2
公开(公告)日：2015-11-03
申请号：US11707248
申请日：2007-02-15
申请人： Jiri Zemlicka , John C. Drach , Xinchao Chen
发明人： Jiri Zemlicka , John C. Drach , Xinchao Chen
IPC分类号： C07D473/00 , C07F9/6561
CPC分类号： C07D473/00 , C07F9/65616
摘要： Compounds which are active against viruses have the following Formulas: wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3; R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R2 is selected from the group consisting of C2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.
摘要翻译：对病毒有活性的化合物具有下式：其中B是2-氨基嘌呤-9-基，其可以是未被取代的或在6位被NHR1，OR2或SR3取代; R 1选自烷基，烯基，炔基和C 4-18环烷基，其中任何一个可以任选地被羟基，卤素，氨基，酰基，环烷基，杂环基和芳基中的一个或多个成员取代 ; R2选自C2-18烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基; 并且R 3选自烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基。

10. 发明授权

US07786108B2 Compounds and method for treating dyslipidemia 有权
标题翻译：治疗血脂异常的化合物和方法
公开(公告)号：US07786108B2
公开(公告)日：2010-08-31
申请号：US11570542
申请日：2005-06-23
申请人： Xinchao Chen , Todd Fields , Nathan Bryan Mantlo , Xiaodong Wang
发明人： Xinchao Chen , Todd Fields , Nathan Bryan Mantlo , Xiaodong Wang
IPC分类号： A61P9/10 , A61P3/06 , A61K31/55 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D491/04
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D491/04
摘要： Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed.
摘要翻译：其中n，m，p，q，Y，R 1，R 2，R 3a，R 3b，R 4，R 5和R 6如本文所定义的式I化合物及其药物组合物和使用方法。

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