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1. 发明申请

US20080020994A1 G proteins in tumor growth and angiogenesis 有权
标题翻译： G蛋白在肿瘤生长和血管生成中的作用
公开(公告)号：US20080020994A1
公开(公告)日：2008-01-24
申请号：US11805715
申请日：2007-05-24
申请人： Xin-Yun Huang
发明人： Xin-Yun Huang
IPC分类号： A61K31/70 , A61P7/00 , C07H21/04 , C12N15/00 , C12N5/00 , C12P21/06 , G01N33/567
CPC分类号： G01N33/5023 , G01N2333/515
摘要： The invention provides an agent that reduces the expression of Gα12 or Gα13 polypeptide, as well as an agent that enhances G protein Gα12 or Gα13 expression and/or activity. An agent of the invention may be used to decrease or increase G protein Gα12 or Gα13 expression and/or activity thereby to treat or prevent the onset of a disease or condition associated with Gα12 or Gα13 expression and/or activity. The invention also provides a method for screening for an anti-cancer or anti-angiogenesis agent, as well as an agent that promotes angiogenesis.
摘要翻译：本发明提供了减少Galpha 12或Gal 13 13多肽的表达的试剂，以及增强G蛋白Galpha 12或/ Galpha 13表达和/或活性。本发明的药剂可用于降低或增加G蛋白Galpha 12或Gal 13 13表达和/或活性，从而治疗或预防疾病或病症的发作与Galpha 12或Galpha 13表达和/或活性相关。本发明还提供了用于筛选抗癌或抗血管生成剂的方法，以及促进血管发生的药剂。

2. 发明申请

US20130259857A1 METHODS FOR INHIBITING FASCIN 审中-公开
标题翻译：抑制FASCIN的方法
公开(公告)号：US20130259857A1
公开(公告)日：2013-10-03
申请号：US13840287
申请日：2013-03-15
申请人： Xin-Yun Huang
发明人： Xin-Yun Huang
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/16
CPC分类号： A61K39/395 , A61K31/35 , A61K31/39 , A61K31/7088 , A61K38/16 , A61K48/00 , C07K2299/00 , C12N15/113 , C12N2310/14
摘要： The invention relates to compositions and methods useful for inhibiting fascin. These compositions and methods can be used to inhibit fascin-related diseases. For example, according to the invention inhibition of fascin inhibits metastasis of tumor cells in mammals.
摘要翻译：本发明涉及用于抑制肌成束蛋白的组合物和方法。这些组合物和方法可用于抑制肌成束相关疾病。例如，根据本发明，肌成肌抑制抑制哺乳动物肿瘤细胞的转移。

3. 发明申请

US20070037783A1 Migrastatin analogs and uses thereof 审中-公开
标题翻译： Migrastatin类似物及其用途
公开(公告)号：US20070037783A1
公开(公告)日：2007-02-15
申请号：US10551152
申请日：2004-03-26
申请人： Xin-Yun Huang , Samuel Danishefsky , Christoph Gaul , Jon Njardarson
发明人： Xin-Yun Huang , Samuel Danishefsky , Christoph Gaul , Jon Njardarson
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/452 , A61K31/427 , A61K31/422 , A61K31/395 , A61K31/4025
CPC分类号： A61K31/395 , A61K31/4025 , A61K31/422 , A61K31/427 , A61K31/452 , A61K31/496 , A61K31/5377 , A61K31/541
摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1—R6, Ra—RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译：一方面，本发明提供药物组合物，其包含治疗有效量的通式（I）的化合物，其中R 1 -R 6，R 6， Q 1，Y 1，Y 2和n如本文所定义，由此将组合物配制成施用于剂量为约0.1mg / kg至约50mg / kg体重的受试者。另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。

4. 发明授权

US06979547B2 Methods for designing specific ion channel blockers 有权
标题翻译：设计特定离子通道阻滞剂的方法
公开(公告)号：US06979547B2
公开(公告)日：2005-12-27
申请号：US09273217
申请日：1999-03-19
申请人： Xin-Yun Huang
发明人： Xin-Yun Huang
IPC分类号： C07K14/705 , C07K16/28 , G01N33/53 , A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K14/705
摘要： The present invention relates to a method of designing an ion channel blocker for an ion channel which includes providing an ion channel having an external vestibule portion and raising an antibody, binding portion, probe, or ligand specific to the external vestibule portion of the ion channel, where the antibody, binding portion, probe, or ligand inhibits ion transport through the ion channel. The present invention further relates to a method of inhibiting ion transport through an ion channel, a method for screening a drug for effectiveness as an ion channel blocker, and an antibody, binding portion, probe, or ligand.
摘要翻译：本发明涉及设计用于离子通道的离子通道阻断剂的方法，该方法包括提供具有外部前庭部分的离子通道，并提供对离子通道的外部前庭部分特异的抗体，结合部分，探针或配体其中抗体，结合部分，探针或配体抑制离子通过离子通道的离子传递。本发明还涉及通过离子通道抑制离子转运的方法，用于筛选药物作为离子通道阻断剂的有效性的方法，以及抗体，结合部分，探针或配体。

5. 发明授权

US08202911B2 Migrastatin analog compositions and uses thereof 有权
标题翻译：米舍他汀类似物组合物及其用途
公开(公告)号：US08202911B2
公开(公告)日：2012-06-19
申请号：US13053161
申请日：2011-03-21
申请人： Xin-Yun Huang , Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson
发明人： Xin-Yun Huang , Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson
IPC分类号： A61K31/12 , C07C49/587
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译：一方面，本发明提供包含治疗有效量的通式（I）化合物的药物组合物，其中R 1 -R 6，R a -R c，Q，Y 1，Y 2和n如本文所定义，其中组合物为配制成以约0.1mg / kg至约50mg / kg体重的剂量施用于受试者。另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。

6. 发明申请

US20050271656A1 Methods for designing specific ion channel blockers 审中-公开
公开(公告)号：US20050271656A1
公开(公告)日：2005-12-08
申请号：US11187558
申请日：2005-07-22
申请人： Xin-Yun Huang
发明人： Xin-Yun Huang
IPC分类号： C07K14/705 , C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K14/705
摘要： The present invention relates to a method of designing an ion channel blocker for an ion channel which includes providing an ion channel having an external vestibule portion and raising an antibody, binding portion, probe, or ligand specific to the external vestibule portion of the ion channel, where the antibody, binding portion, probe, or ligand inhibits ion transport through the ion channel. The present invention further relates to a method of inhibiting ion transport through an ion channel, a method for screening a drug for effectiveness as an ion channel blocker, and an antibody, binding portion, probe, or ligand.

7. 发明授权

US08383597B2 G proteins in tumor growth and angiogenesis 有权
标题翻译： G蛋白在肿瘤生长和血管生成中的作用
公开(公告)号：US08383597B2
公开(公告)日：2013-02-26
申请号：US11805715
申请日：2007-05-24
申请人： Xin-Yun Huang
发明人： Xin-Yun Huang
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： G01N33/5023 , G01N2333/515
摘要： The invention provides an agent that reduces the expression of Gα12 or Gα13 polypeptide, as well as an agent that enhances G protein Gα12 or Gα13 expression and/or activity. An agent of the invention may be used to decrease or increase G protein Gα12 or Gα13 expression and/or activity thereby to treat or prevent the onset of a disease or condition associated with Gα12 or Gα13 expression and/or activity. The invention also provides a method for screening for an anti-cancer or anti-angiogenesis agent, as well as an agent that promotes angiogenesis.
摘要翻译：本发明提供减少Gα12或Gα13多肽的表达的试剂，以及增强G蛋白Gα12或Gα13表达和/或活性的药剂。本发明的药剂可用于降低或增加G蛋白Gα12或Gα13的表达和/或活性，从而治疗或预防与Gα12或Gα13表达和/或活性相关的疾病或病症的发作。本发明还提供了用于筛选抗癌或抗血管生成剂的方法，以及促进血管发生的药剂。

8. 发明申请

US20110263653A1 MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF 有权
标题翻译：莫替沙星类似物组合物及其用途
公开(公告)号：US20110263653A1
公开(公告)日：2011-10-27
申请号：US13053161
申请日：2011-03-21
申请人： Xin-Yun Huang , Samuel J. Danishefsky , Christoph Gaul , Jön T. Njardarson
发明人： Xin-Yun Huang , Samuel J. Danishefsky , Christoph Gaul , Jön T. Njardarson
IPC分类号： A61K31/4427 , A61P35/00 , A61K31/365
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译：一方面，本发明提供包含治疗有效量的通式（I）化合物的药物组合物，其中R 1 -R 6，R a -R c，Q，Y 1，Y 2和n如本文所定义，其中组合物为配制成以约0.1mg / kg至约50mg / kg体重的剂量施用于受试者。另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。

9. 发明申请

US20100297109A1 METHODS FOR INHIBITING FASCIN 审中-公开
标题翻译：抑制FASCIN的方法
公开(公告)号：US20100297109A1
公开(公告)日：2010-11-25
申请号：US12743962
申请日：2008-11-21
申请人： Xin-Yun Huang
发明人： Xin-Yun Huang
IPC分类号： A61K39/395 , C12N5/02 , A61K31/7088 , A61K38/16 , A61P35/00 , A61P25/00 , A61P31/12 , A61P31/04 , G01N33/566 , C07H21/04 , C12N15/63 , C07K16/00 , C07K14/435
CPC分类号： A61K39/395 , A61K31/35 , A61K31/39 , A61K31/7088 , A61K38/16 , A61K48/00 , C07K2299/00 , C12N15/113 , C12N2310/14
摘要： The invention relates to compositions and methods useful for inhibiting fascin. These compositions and methods can be used to inhibit fascin-related diseases. For example, according to the invention inhibition of fascin inhibits metastasis of tumor cells in mammals.
摘要翻译：本发明涉及用于抑制肌成束蛋白的组合物和方法。这些组合物和方法可用于抑制肌成束相关疾病。例如，根据本发明，肌成肌抑制抑制哺乳动物肿瘤细胞的转移。

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