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1. 发明授权

US09056909B2 Mycoplasma hyopneumoniae avirulent adjuvanted live vaccine 有权
标题翻译：猪肺炎支原体无毒佐剂活疫苗
公开(公告)号：US09056909B2
公开(公告)日：2015-06-16
申请号：US12265274
申请日：2008-11-05
申请人： Hsien-Jue Chu , Zhichang Xu , Wumin Li , Nicole Rae Gibson
发明人： Hsien-Jue Chu , Zhichang Xu , Wumin Li , Nicole Rae Gibson
IPC分类号： A61K39/02 , C12N1/02 , C07K14/30 , A61K39/116 , A61K39/00
CPC分类号： C07K14/30 , A61K39/0241 , A61K39/116 , A61K2039/522 , A61K2039/55566 , A61K2039/70
摘要： Provided are immunogenic and vaccine compositions and methods for their preparation and use, which compositions are effective in protecting against, minimizing the severity of, preventing, and/or ameliorating M. hyopneumoniae infection. Administration to an animal of one or two doses of an adjuvanted live avirulent M. hyopneumoniae composition disclosed herein is effective in providing immunity to the animal and protection from infection with a virulent strain of M. hyopneumoniae thereby reducing the severity of and/or preventing disease caused by one or more virulent strain of M. hyopneumoniae. Also provided are compositions, which further comprise one or more antigen such as, for example, one or more live bacteria, bacterin, toxoid, and/or virus and/or viral antigen. Exemplified are immunogenic compositions, comprising an adjuvanted live avirulent M. hyopneumoniae and compositions, comprising Porcine Circovirus Type 1-Type 2 chimera modified live vaccine (cPCV1-2) in further combination with an adjuvanted live avirulent M. hyopneumoniae.
摘要翻译：提供免疫原性和疫苗组合物及其制备和使用的方法，该组合物有效地防止，最小化预防和/或改善猪肺炎支原体感染的严重性。向一种或两种剂量的动物给药一种或两种剂量的本文公开的佐剂化的无毒无毒性猪肺炎支原体组合物有效地提供对动物的免疫并且防止感染猪肺炎支原体毒性菌株，从而降低疾病的严重性和/或预防疾病由一种或多种毒性猪肺炎支原体毒株引起。还提供了还包含一种或多种抗原例如一种或多种活细菌，菌苗，类毒素和/或病毒和/或病毒抗原的组合物。示例是免疫原性组合物，其包含佐剂化的无毒力无毒环境的猪肺炎支原体和包含猪佐氮病毒1型2嵌合体修饰的活疫苗（cPCV1-2）的进一步组合的组合物，其与佐剂化的无毒力无毒性猪肺炎支原体组合。

2. 发明授权

US07169394B2 Mycoplasma hyopneumoniae bacterin vaccine 有权
标题翻译：肺炎支原体疫苗疫苗
公开(公告)号：US07169394B2
公开(公告)日：2007-01-30
申请号：US11318983
申请日：2005-12-27
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K39/295
CPC分类号： A61K9/0024 , A61K39/0241 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2039/521 , A61K2039/525 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2760/16134 , Y02A50/48
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA. In another embodiment, the invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration, and comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant or adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity, in combination with other vaccine components.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选的是CARBOPOL，以及可代谢的油如一种或多种不饱和萜烯烃，优选角鲨烯或角鲨烷的混合物，以及聚氧乙烯 - 聚氧丙烯嵌段共聚物作为PLURONIC（R）。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。在另一个实施方案中，本发明提供了改进的猪肺炎支原体疫苗组合物，其有利地在单次施用后提供免疫感染，并且包含灭活的猪肺炎支原体菌苗和佐剂或佐剂混合物，其组合提供猪肺炎支原体单次给药后感染，并引起特异于猪肺炎支原体菌的免疫应答，并与其他疫苗组分结合使用，包括细胞介导的免疫和局部（分泌型IgA）免疫。

3. 发明申请

US20100119471A1 MYCOPLASMA HYOPNEUMONIAE BACTERIN VACCINE 有权
公开(公告)号：US20100119471A1
公开(公告)日：2010-05-13
申请号：US12692275
申请日：2010-01-22
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K31/765 , A61P31/04 , A61P37/04
CPC分类号： A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , Y10S424/825 , A61K2300/00
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选的是CARBOPOL，以及可代谢的油如一种或多种不饱和萜烯烃，优选角鲨烯或角鲨烷和聚氧乙烯 - 聚氧丙烯嵌段共聚物如PLURONIC ®。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。

4. 发明申请

US20060228373A1 MYCOPLASMA HYOPNEUMONIAE BACTERIN VACCINE 有权
公开(公告)号：US20060228373A1
公开(公告)日：2006-10-12
申请号：US11318983
申请日：2005-12-27
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K39/295 , A61K9/14
CPC分类号： A61K9/0024 , A61K39/0241 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2039/521 , A61K2039/525 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2760/16134 , Y02A50/48
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably Carbopol, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polypropylene block copolymer such as Pluronic®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA. In another emodiment, the invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration, and comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant or adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity, in combination with other vaccine components.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选Carbopol，以及可代谢的油，例如一种或多种不饱和萜烯烃，优选角鲨烯或角鲨烷和聚氧乙烯 - 聚丙烯嵌段共聚物如Pluronic（ R）。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。另一个实例中，本发明提供了一种改进的猪肺炎支原体疫苗组合物，其有利地在单次给药后提供免疫感染，并且包含灭活的猪肺炎支原体菌苗和佐剂或佐剂混合物，其组合提供了猪肺炎支原体单次给药后感染，并引起特异于猪肺炎支原体菌的免疫应答，并与其他疫苗组分结合使用，包括细胞介导的免疫和局部（分泌型IgA）免疫。

5. 发明申请

US20120213816A1 MYCOPLASMA HYOPNEUMONIAE BACTERIN VACCINE 有权
公开(公告)号：US20120213816A1
公开(公告)日：2012-08-23
申请号：US13458541
申请日：2012-04-27
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K39/39 , A61P31/04
CPC分类号： A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , Y10S424/825 , A61K2300/00
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选的是CARBOPOL，以及可代谢的油如一种或多种不饱和萜烯烃，优选角鲨烯或角鲨烷和聚氧乙烯 - 聚氧丙烯嵌段共聚物如PLURONIC ®。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。

6. 发明授权

US07959927B2 Mycoplasma hyopneumoniae bacterin vaccine 有权
标题翻译：肺炎支原体疫苗疫苗
公开(公告)号：US07959927B2
公开(公告)日：2011-06-14
申请号：US12618842
申请日：2009-11-16
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K39/295
CPC分类号： A61K9/0024 , A61K39/0241 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2039/521 , A61K2039/525 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2760/16134 , Y02A50/48
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosal and/or EDTA. In another embodiment, the invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration, and comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant or adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity, in combination with other vaccine components.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选CARBOPOL，以及可代谢的油，例如一种或多种不饱和萜烯烃，优选角鲨烯或角鲨烷和聚氧乙烯 - 聚丙烯嵌段共聚物如PLURONIC ®。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。在另一个实施方案中，本发明提供了改进的猪肺炎支原体疫苗组合物，其有利地在单次施用后提供免疫感染，并且包含灭活的猪肺炎支原体菌苗和佐剂或佐剂混合物，其组合提供猪肺炎支原体单次给药后感染，并引起特异于猪肺炎支原体菌的免疫应答，并与其他疫苗组分结合使用，包括细胞介导的免疫和局部（分泌型IgA）免疫。

7. 发明授权

US07622124B2 Mycoplasma hyopneumoniae bacterin vaccine 有权
标题翻译：肺炎支原体疫苗疫苗
公开(公告)号：US07622124B2
公开(公告)日：2009-11-24
申请号：US11652306
申请日：2007-01-11
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K39/295
CPC分类号： A61K9/0024 , A61K39/0241 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2039/521 , A61K2039/525 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2760/16134 , Y02A50/48
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA. In another embodiment, the invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration, and comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant or adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity, in combination with other vaccine components.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选的是CARBOPOL，以及可代谢的油如一种或多种不饱和萜烯烃（优选角鲨烯或角鲨烷）和聚氧乙烯 - 聚丙烯嵌段共聚物作为PLURONIC（R）。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。在另一个实施方案中，本发明提供了改进的猪肺炎支原体疫苗组合物，其有利地在单次施用后提供免疫感染，并且包含灭活的猪肺炎支原体菌苗和佐剂或佐剂混合物，其组合提供猪肺炎支原体单次给药后感染，并引起特异于猪肺炎支原体菌的免疫应答，并与其他疫苗组分结合使用，包括细胞介导的免疫和局部（分泌型IgA）免疫。

8. 发明申请

US20070020296A1 Mycoplasma hyopneumoniae bacterin vaccine 有权
标题翻译：肺炎支原体疫苗疫苗
公开(公告)号：US20070020296A1
公开(公告)日：2007-01-25
申请号：US11507231
申请日：2006-08-21
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K39/116 , A61K39/02
CPC分类号： A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , Y10S424/825 , A61K2300/00
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选的是CARBOPOL，以及可代谢的油如一种或多种不饱和萜烯烃，优选角鲨烯或角鲨烷的混合物，以及聚氧乙烯 - 聚氧丙烯嵌段共聚物作为PLURONIC（R）。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。

9. 发明申请

US20060171960A1 Methods and composition for oral vaccination 审中-公开
公开(公告)号：US20060171960A1
公开(公告)日：2006-08-03
申请号：US11321389
申请日：2005-12-29
申请人： Hsien-Jue Chu , Wumin Li
发明人： Hsien-Jue Chu , Wumin Li
IPC分类号： A61K39/295
CPC分类号： A61K39/0241 , A61K9/0095 , A61K2039/522 , A61K2039/542 , A61K2039/552
摘要： The present invention encompasses methods and compositions both for providing protection against disease in an animal and for inducing increased intake of an orally administered vaccine by an animal. The methods of the invention are directed to admixing a bacterial or viral antigen with a water soluble palatable flavorant, further admixing the antigen and flavorant mixture with a water soluble vehicle for oral administration of the vaccine to an animal in order to provide protection against disease associated with infection by the admixed antigen and to induce the increased intake of the vaccine with the flavorant. The present invention thus encompasses methods and compositions for the oral vaccination of healthy animals through drinking water or syrups as an aid in the prevention of disease. The admixing of the palatable flavorant provides for a vaccine formulation with a desirable taste in order to promote self-administration of the vaccine formulation and/or to prevent rejection of the formulation when administered by an animal handler.

10. 发明授权

US07018638B2 Mycoplasma hyopneumoniae bacterin vaccine 有权
标题翻译：肺炎支原体疫苗疫苗
公开(公告)号：US07018638B2
公开(公告)日：2006-03-28
申请号：US10150597
申请日：2002-05-17
申请人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
发明人： Hsien-Jue Chu , Wumin Li , Zhichang Xu
IPC分类号： A61K39/295
CPC分类号： A61K9/0024 , A61K39/0241 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2039/521 , A61K2039/525 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2760/16134 , Y02A50/48
摘要： The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA. In another embodiment, the invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration, and comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant or adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity, in combination with other vaccine components.
摘要翻译：本发明提供了一种改良的猪肺炎支原体疫苗组合物，其在单次给药后有利地提供免疫感染。组合物包含灭活的猪肺炎支原体疫苗和佐剂混合物，其组合在单次施用后提供对猪肺炎支原体感染的免疫，并引起对猪肺炎支原体菌苗特异性的免疫应答，并且包括细胞介导的免疫和局部（分泌型IgA ）免疫力。在优选的实施方案中，佐剂混合物包含丙烯酸聚合物，最优选的是CARBOPOL，以及可代谢的油如一种或多种不饱和萜烯烃，优选角鲨烯或角鲨烷的混合物，以及聚氧乙烯 - 聚氧丙烯嵌段共聚物作为PLURONIC（R）。疫苗组合物可以任选地包括防腐剂，优选硫柳汞和/或EDTA。在另一个实施方案中，本发明提供了改进的猪肺炎支原体疫苗组合物，其有利地在单次施用后提供免疫感染，并且包含灭活的猪肺炎支原体菌苗和佐剂或佐剂混合物，其组合提供猪肺炎支原体单次给药后感染，并引起特异于猪肺炎支原体菌的免疫应答，并与其他疫苗组分结合使用，包括细胞介导的免疫和局部（分泌型IgA）免疫。

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