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1. 发明申请

WO9822588A2 AN IMPROVED METHOD FOR THE PRODUCTION AND PURIFICATION OF ADENOVIRAL VECTORS 审中-公开
标题翻译：一种用于生产和纯化腺病毒载体的改进方法
公开(公告)号：WO9822588A2
公开(公告)日：1998-05-28
申请号：PCT/US9721504
申请日：1997-11-20
申请人： INTROGEN THERAPEUTICS INC , ZHANG SHUYUAN , THWIN CAPUCINE , WU ZHANG , CHO TOOHYON
发明人： ZHANG SHUYUAN , THWIN CAPUCINE , WU ZHENG , CHO TOOHYON
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , C07K14/47 , C12N5/02 , C12N7/01 , C12N7/02 , C12N15/86 , C12N15/861 , C12N15/12 , C12N5/08 , C12N15/11
CPC分类号： C12N7/00 , A61K35/761 , A61K38/00 , A61K48/00 , C07K14/4746 , C12N15/86 , C12N2710/10045 , C12N2710/10051 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10351 , C12N2810/6018
摘要： The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsC1 banding using an ultracentrifuge.
摘要翻译：本发明涉及在细胞培养系统中生长时需要提高病毒载体的产量。特别地，已经证明，对于腺病毒，在附着的细胞培养系统中使用低中等灌注速率提供了提高的产量。在其他实施方案中，本发明人已经表明，在无血清条件下，特别是在无血清悬浮培养物中生长的细胞，存在改善的Ad-p53产生。提高产量也很重要的是使用洗涤剂溶解。本发明的这些方面的组合允许通过单个色谱步骤纯化病毒，其导致与使用超速离心机的双CsC1条带制备相同质量的纯化病毒。

2. 发明授权

US09387108B2 Night splint with digital dorsiflexion 有权
标题翻译：夜间夹板与数字背屈
公开(公告)号：US09387108B2
公开(公告)日：2016-07-12
申请号：US13555482
申请日：2012-07-23
申请人： H. Darrel Darby, II , Wu Zhang
发明人： H. Darrel Darby, II , Wu Zhang
IPC分类号： A61F5/01
CPC分类号： A61F5/0111 , A61F5/019
摘要： A night splint for a user's foot having a frame member and a toe retainer that is releasably connected to the frame member. The toe retainer is configured to dorsiflex at least one toe of the user to allow for a dynamic stretch of the plantar fascia and to provide a low load stretch of the Achilles tendon, plantar fascia tendon, deep flexor muscles and calf muscles to relieve symptoms of plantar fasciitis.
摘要翻译：用于使用者脚的夜夹板具有可拆卸地连接到框架构件的框架构件和脚趾保持器。脚趾保持器被配置为使得使用者的至少一个脚趾脱离以允许足底筋膜的动态伸展，并且提供跟腱，足底筋膜腱，深屈肌和小腿肌肉的低负荷拉伸以缓解足底筋膜炎。

3. 发明授权

US08729655B2 Etching narrow, tall dielectric isolation structures from a dielectric layer 有权
标题翻译：从电介质层蚀刻窄而高的介电隔离结构
公开(公告)号：US08729655B2
公开(公告)日：2014-05-20
申请号：US13565675
申请日：2012-08-02
申请人： Chia-Ying Liu , Keh-Chiang Ku , Wu-Zhang Yang
发明人： Chia-Ying Liu , Keh-Chiang Ku , Wu-Zhang Yang
IPC分类号： H01L27/146
CPC分类号： H01L27/1463 , H01L27/14689
摘要： Methods of forming isolation structures are disclosed. A method of forming isolation structures for an image sensor array of one aspect may include forming a dielectric layer over a semiconductor substrate. Narrow, tall dielectric isolation structures may be formed from the dielectric layer. The narrow, tall dielectric isolation structures may have a width that is no more than 0.3 micrometers and a height that is at least 1.5 micrometers. A semiconductor material may be epitaxially grown around the narrow, tall dielectric isolation structures. Other methods and apparatus are also disclosed.
摘要翻译：公开了形成隔离结构的方法。形成一个方面的图像传感器阵列的隔离结构的方法可以包括在半导体衬底上形成电介质层。可以从电介质层形成窄的高介电隔离结构。窄的高介电隔离结构可以具有不超过0.3微米的宽度和至少1.5微米的高度。半导体材料可以围绕窄的高介电隔离结构外延生长。还公开了其它方法和装置。

4. 发明授权

US08201346B2 Medical shoe system 有权
标题翻译：医疗鞋系统
公开(公告)号：US08201346B2
公开(公告)日：2012-06-19
申请号：US12164430
申请日：2008-06-30
申请人： H. Darrel Darby, II , Wu Zhang
发明人： H. Darrel Darby, II , Wu Zhang
IPC分类号： A43B13/42 , A43B13/38 , A43C11/00
CPC分类号： A61F5/0195 , A43B7/00 , A43B7/28 , A61F5/14
摘要： A system, method, and apparatus for treating a foot using a medical shoe and interchangeable insoles. A plurality of interchangeable insoles is provided, including a surgical insole and a wound care insole. The surgical insole provides rigidity for a patient's foot. The surgical insole comprises a first upper layer and a rigid second lower layer. The wound care insole offloads weight from a wound region on the foot. The wound care insole comprises a first upper layer of stretchy, thin film, a second, middle, layer that is moldable, and a third, lower layer that is spongy and provides support.
摘要翻译：一种用于使用医用鞋和可互换的鞋垫处理足部的系统，方法和装置。提供了多个可互换的鞋垫，包括手术内底和伤口护理内底。手术内底为患者的脚提供刚性。手术内底包括第一上层和刚性第二下层。伤口护理鞋垫从脚上的伤口区域卸载重物。伤口护理鞋垫包括可塑性的第一上层的弹性薄膜，第二中层，以及海绵状并提供支撑的第三下层。

5. 发明申请

US20110178110A1 Genotype and Expression Analysis for Use in Predicting Outcome and Therapy Selection 审中-公开
标题翻译：用于预测结果和治疗选择的基因型和表达分析
公开(公告)号：US20110178110A1
公开(公告)日：2011-07-21
申请号：US12992584
申请日：2009-05-14
申请人： Heinz-Josef Lenz , Wu Zhang
发明人： Heinz-Josef Lenz , Wu Zhang
IPC分类号： A61K31/513 , C12Q1/68 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156
摘要： The invention provides compositions and methods for determining the likelihood of successful treatment with a various treatment regimens available to gastrointestinal cancer patients. After determining if a patient is likely to be successfully treated, the invention also provides methods for treating these patients.
摘要翻译：本发明提供了用于确定胃肠癌患者可获得的各种治疗方案成功治疗的可能性的组合物和方法。在确定患者是否可能被成功治疗之后，本发明还提供了治疗这些患者的方法。

6. 发明申请

US20120283612A1 NIGHT SPLINT WITH DIGITAL DORSIFLEXION 审中-公开
标题翻译：与数字脱落的夜间分支
公开(公告)号：US20120283612A1
公开(公告)日：2012-11-08
申请号：US13555482
申请日：2012-07-23
申请人： H. Darrel DARBY, II , Wu ZHANG
发明人： H. Darrel DARBY, II , Wu ZHANG
IPC分类号： A61F5/00
CPC分类号： A61F5/0111 , A61F5/019
摘要： A night splint for a user's foot having a frame member and a toe retainer that is releasably connected to the frame member. The toe retainer is configured to dorsiflex at least one toe of the user to allow for a dynamic stretch of the plantar fascia and to provide a low load stretch of the Achilles tendon, plantar fascia tendon, deep flexor muscles and calf muscles to relieve symptoms of plantar fasciitis.
摘要翻译：用于使用者脚的夜夹板具有可拆卸地连接到框架构件的框架构件和脚趾保持器。脚趾保持器被配置为使得使用者的至少一个脚趾脱离以允许足底筋膜的动态伸展，并且提供跟腱，足底筋膜腱，深屈肌和小腿肌肉的低负荷拉伸以缓解足底筋膜炎。

7. 发明申请

US20120126419A1 Substrate Arrangement and a Method of Manufacturing a Substrate Arrangement 审中-公开
标题翻译：基板布置和基板布置方法
公开(公告)号：US20120126419A1
公开(公告)日：2012-05-24
申请号：US13055525
申请日：2008-07-24
申请人： Vaidyanathan Kripesh , Navas Khan Orattikalandar , Srinivasa Rao Vempati , Yak Long Samuel Lim , Yee Mong Khoo , Chee Houe Khong , Xiao Wu Zhang , Tai Chong Chai , Hon-Shing John Lau
发明人： Vaidyanathan Kripesh , Navas Khan Orattikalandar , Srinivasa Rao Vempati , Yak Long Samuel Lim , Yee Mong Khoo , Chee Houe Khong , Xiao Wu Zhang , Tai Chong Chai , Hon-Shing John Lau
IPC分类号： H01L23/522 , H01L21/768
CPC分类号： H01L29/0657 , H01L24/11 , H01L24/13 , H01L24/14 , H01L24/16 , H01L24/81 , H01L25/0657 , H01L2224/0554 , H01L2224/05548 , H01L2224/05573 , H01L2224/05647 , H01L2224/1132 , H01L2224/1146 , H01L2224/1147 , H01L2224/11472 , H01L2224/11849 , H01L2224/11902 , H01L2224/13009 , H01L2224/13025 , H01L2224/131 , H01L2224/13147 , H01L2224/1403 , H01L2224/14051 , H01L2224/14181 , H01L2224/14505 , H01L2224/161 , H01L2224/16145 , H01L2224/16146 , H01L2224/16225 , H01L2224/1624 , H01L2224/8114 , H01L2224/81141 , H01L2225/06513 , H01L2225/06517 , H01L2225/06541 , H01L2225/06555 , H01L2924/00014 , H01L2924/01006 , H01L2924/01011 , H01L2924/01022 , H01L2924/01029 , H01L2924/01032 , H01L2924/01033 , H01L2924/01059 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/10329 , H01L2924/14 , H01L2924/15787 , H01L2924/3025 , H01L2924/35 , H01L2924/01014 , H01L2924/00 , H01L2224/05599 , H01L2224/0555 , H01L2224/0556
摘要： According to one embodiment of the present invention, a substrate arrangement is provided. The substrate arrangement includes a first substrate; a second substrate positioned above the first substrate, the second substrate comprising a first through hole; a third substrate positioned above the second substrate, the third substrate comprising a second through hole; a first electrically conductive interconnect pillar positioned on the first substrate and extending from the first substrate through the first through hole to electrically contact the third substrate; and a second electrically conductive interconnect pillar positioned on the second substrate and extending from the second substrate through the second through hole. A method of manufacturing a substrate arrangement is also provided.
摘要翻译：根据本发明的一个实施例，提供了一种衬底布置。衬底布置包括第一衬底; 位于所述第一基板上方的第二基板，所述第二基板包括第一通孔; 位于所述第二基板上方的第三基板，所述第三基板包括第二通孔; 位于所述第一基板上并且从所述第一基板延伸穿过所述第一通孔的第一导电互连柱，以与所述第三基板电接触; 以及第二导电互连柱，其定位在所述第二基板上并且从所述第二基板延伸穿过所述第二通孔。还提供了一种制造衬底布置的方法。

8. 发明申请

US20120034512A1 LITHIUM ALLOY-CARBON COMPOSITE NANOFIBERS AND METHODS OF FABRICATION 审中-公开
标题翻译：锂合金 - 碳复合材料纳米纤维和制造方法
公开(公告)号：US20120034512A1
公开(公告)日：2012-02-09
申请号：US13231433
申请日：2011-09-13
申请人： Xiang-wu Zhang , Peter S. Fedkiw , Saad A. Khan
发明人： Xiang-wu Zhang , Peter S. Fedkiw , Saad A. Khan
IPC分类号： H01M4/583 , D04H13/00 , D01F9/14 , B29C47/00 , H01M2/02 , D02G3/00 , B82Y40/00
CPC分类号： D04H1/4209 , B32B5/022 , B32B5/22 , B32B5/24 , B32B5/26 , B32B2262/106 , B32B2264/102 , B32B2264/104 , B32B2264/105 , B32B2307/20 , B32B2307/202 , B32B2307/30 , B32B2307/50 , B32B2307/546 , B32B2307/718 , B32B2457/10 , Y10T428/2929 , Y10T442/608
摘要： A carbon/nanoparticle nanofiber includes a carbon base structure and a plurality of nanoparticles that include a lithium alloy or a lithium alloy precursor. One or more nanofibers may be formed into a nonwoven fabric. The fabric may be utilized as an electrode, such as for example in a battery. The carbon/nanoparticle composite nanofiber may be fabricated by forming a polymer/nanoparticle nanofiber, such as for example by a spinning technique, and carbonizing the polymer/nanoparticle nanofiber.
摘要翻译：碳/纳米颗粒纳米纤维包括碳基结构和包括锂合金或锂合金前体的多个纳米颗粒。一个或多个纳米纤维可以形成无纺织物。织物可以用作电极，例如电池中。碳/纳米颗粒复合纳米纤维可以通过形成聚合物/纳米颗粒纳米纤维，例如通过纺丝技术和碳化聚合物/纳米颗粒纳米纤维来制造。

9. 发明申请

US20100324461A1 ADJUSTABLE SPLINTING DEVICE 有权
标题翻译：可调节分离装置
公开(公告)号：US20100324461A1
公开(公告)日：2010-12-23
申请号：US12758518
申请日：2010-04-12
申请人： H. Darrel DARBY, II , Wu ZHANG
发明人： H. Darrel DARBY, II , Wu ZHANG
IPC分类号： A61F5/00
CPC分类号： A61F5/0113
摘要： A splinting device includes a first part for contacting a lower leg and a second part for contacting a foot hingedly connected to the first part. An adjustable attachment includes an elastic part and interconnects the first part and the second part. A method of treating plantar fasciitis includes securing the first part of the splint device to the lower leg, and securing the second part to a foot. The first part is rotated relative to the second part to establish a predetermined angle between the first part and the second part. The elastic part of the adjustable attachment, which is attached to one of the first and second parts, is stretched and attached to the other of the first part of the second part at a position based on the predetermined angle to limit movement of the first part relative to the second part beyond the predetermined angle.
摘要翻译：夹板装置包括用于接触小腿的第一部分和用于接触铰接地连接到第一部分的脚的第二部分。可调附件包括弹性部分并且互连第一部分和第二部分。治疗足底筋膜炎的方法包括将夹板装置的第一部分固定到小腿上，并将第二部分固定到脚上。第一部分相对于第二部分旋转以在第一部分和第二部分之间建立预定角度。附接到第一和第二部分之一的可调节附件的弹性部分在基于预定角度的位置处被拉伸并附接到第二部分的第一部分中的另一部分，以限制第一部分相对于第二部分超过预定角度。

10. 发明申请

US20100099720A1 Gene Polymorphisms as Sex-Specific Predictors in Cancer Therapy 审中-公开
标题翻译：基因多态性作为癌症治疗中的性别特异性预测因子
公开(公告)号：US20100099720A1
公开(公告)日：2010-04-22
申请号：US12523520
申请日：2008-01-18
申请人： Heinz-Josef Lenz , Wu Zhang
发明人： Heinz-Josef Lenz , Wu Zhang
IPC分类号： C12Q1/68 , A61K31/4412 , A61P35/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides compositions and methods for determining the likelihood of gender-specific successful treatment with 5-FU/oxaliplatin or an equivalent of each thereof. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.
摘要翻译：本发明提供用于确定5-FU /奥沙利铂或其各自的等同性别特异性成功治疗的可能性的组合物和方法。所述方法包括确定目标基因的预定区域中存在的基因组多态性，并将该多态性与预测反应相关联。然后用适当的治疗方法治疗患者。

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