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3. 发明公开

EP0869792A2 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS 失效
标题翻译：模拟4-取代NMDA SUBTYPREZEPTONS的哌啶和DEREM使用AS选择性拮抗剂
公开(公告)号：EP0869792A2
公开(公告)日：1998-10-14
申请号：EP96945682.0
申请日：1996-12-20
申请人： WARNER-LAMBERT COMPANY , Cocensys, Inc. , Bigge, Christopher F. , Cai, Sui Xiong , Weber, Eckhard , Woodward, Richard , KEANA, John F.W. , Lan, Nancy C. , Guzikowski, Anthony P. , Zhou, Zhang-Lin , Yeun, Po-Wai
发明人： BIGGE, Christopher, F. , CAI, Sui, Xiong , WEBER, Eckard , WOODWARD, Richard , KEANA, John, F., W. , LAN, Nancy, C. , GUZIKOWSKI, Anthony, P. , ZHOU, Zhang-Lin , YEUN, Po-Wai
IPC分类号： C07D211 , C07D401 , C07D405 , C07D413 , C07D417 , C07D487
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04
摘要： Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

4. 发明专利

AT290380T 未知
公开(公告)号：AT290380T
公开(公告)日：2005-03-15
申请号：AT96945682
申请日：1996-12-20
申请人： WARNER LAMBERT CO , COCENSYS INC , BIGGE CHRISTOPHER F , CAI SUI XIONG , WEBER ECKHARD , WOODWARD RICHARD , KEANA JOHN F W , LAN NANCY C , GUZIKOWSKI ANTHONY P , ZHOU ZHANG-LIN , YEUN PO-WAI
发明人： BIGGE CHRISTOPHER F , CAI SUI XIONG , WEBER ECKARD , WOODWARD RICHARD , KEANA JOHN F W , LAN NANCY C , GUZIKOWSKI ANTHONY P , ZHOU ZHANG-LIN , YEUN PO-WAI
IPC分类号： C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04 , A61K31/445
摘要： PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

5. 发明专利

AU1689997A 4-substituted piperidine analogs and their use as subtype selective nmda receptor antagonists 未知
公开(公告)号：AU1689997A
公开(公告)日：1997-07-17
申请号：AU1689997
申请日：1996-12-20
申请人： WARNER LAMBERT CO , COCENSYS INC , BIGGE CHRISTOPHER F , CAI SUI XIONG , WEBER ECKHARD , WOODWARD RICHARD , KEANA JOHN F W , LAN NANCY C , GUZIKOWSKI ANTHONY P , ZHOU ZHANG LIN , YEUN WAI
发明人： BIGGE CHRISTOPHER F , CAI SUI X , WEBER ECKARD , WOODWARD RICHARD , KEANA JOHN F , LAN NANCY C , GUZIKOWSKI ANTHONY P , ZHOU ZHANG-LIN , YUEN PO-WAI
IPC分类号： C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04 , A61K31/445
摘要： PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

6. 发明专利

AU1354597A 2-substituted piperidine analogs and their use as subtype-selective nmda receptor antagonists 未知
公开(公告)号：AU1354597A
公开(公告)日：1997-07-17
申请号：AU1354597
申请日：1996-12-20
申请人： BIGGE CHRISTOPHER F , CAI SUI XIONG , COCENSYS INC , GUZIKOWSKI ANTHONY P , KEANA JOHN F W , LAN NANCY C , WARNER LAMBERT CO , WEBER ECKARD , WOODWARD RICHARD
发明人： BIGGE CHRISTOPHER F , CAI SUI XIONG , WEBER ECKARD , WOODWARD RICHARD , LAN NANCY C , KEANA JOHN F W , GUZIKOWSKI ANTHONY P
IPC分类号： A61K31/445 , A61K31/454 , C07D211/14 , C07D401/12
摘要： PCT No. PCT/US96/20767 Sec. 371 Date Nov. 18, 1998 Sec. 102(e) Date Nov. 18, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23215 PCT Pub. Date Jul. 3, 1997Novel 2-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 2-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartatc (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, amioglycoside antibiotics-induced hearing loss, migraine headaches, chronic pain, glaucoma, CMV retinitis, psychosis, urinary incontinence, opioid tolerance or withdrawal, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

7. 发明专利

DE69634447D1 未知
公开(公告)号：DE69634447D1
公开(公告)日：2005-04-14
申请号：DE69634447
申请日：1996-12-20
申请人： WARNER LAMBERT COMPANY LLC MOR , COCENSYS INC , BIGGE CHRISTOPHER F , CAI SUI XIONG , WEBER ECKARD , WOODWARD RICHARD , KEANA JOHN F W , LAN NANCY C , GUZIKOWSKI ANTHONY P , ZHOU ZHANG LIN , YEUN WAI
发明人： BIGGE F , CAI XIONG , WEBER ECKARD , WOODWARD RICHARD , KEANA F , LAN C , GUZIKOWSKI P , ZHOU ZHANG-LIN , YEUN PO-WAI
IPC分类号： C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04 , A61K31/445
摘要： PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

8. 发明申请

WO2012054813A1 NOVEL METHODS FOR TREATING BREATHING DISORDERS OR DISEASES 审中-公开
标题翻译：治疗呼吸系统疾病或疾病的新方法
公开(公告)号：WO2012054813A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057241
申请日：2011-10-21
申请人： GALLEON PHARMACEUTICALS, INC. , MANNION, James, C. , DAX, Scott, L. , WOODWARD, Richard
发明人： MANNION, James, C. , DAX, Scott, L. , WOODWARD, Richard
IPC分类号： A61K31/4015
CPC分类号： A61K31/5377 , A61K31/57 , A61K2300/00
摘要： The present invention includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation comprising (+)-doxapram or a salt thereof, and a pharmaceutically acceptable earner, wherein the formulation is essentially free of (— )-doxapram or a salt thereof.
摘要翻译：本发明包括治疗有需要的受试者的呼吸系统疾病或病症的方法，包括向受试者施用治疗有效量的包含（+） - 多沙普兰或其盐的药物制剂和药学上可接受的进料器，其中所述制剂基本上不含（ - ） - 二吗啉或其盐。

9. 发明申请

WO2011088179A1 AUTHENTICATING A CHIP CARD INTERFACE DEVICE 审中-公开
标题翻译：验证芯片卡接口设备
公开(公告)号：WO2011088179A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021085
申请日：2011-01-13
申请人： BANK OF AMERICA CORPORATION , ADAMS, Amanda, Jane , WOODWARD, Richard, John
发明人： ADAMS, Amanda, Jane , WOODWARD, Richard, John
IPC分类号： G06F7/04 , G06F17/30
CPC分类号： G07F7/00
摘要： A system is configured for authenticating a chip card interface device (CCID) during a transaction with the CCID. The system has a communication device configured for communicating with the CCID over a network and a processing device coupled with the communication device. The processing device is configured for receiving a transaction initiation communication from the CCID and instructing the communication device to communicate a request for authentication information including a random number to the CCID. The CCID encrypts the random number with a unique chip key (UCK) previously created with a master chip key (MCK). Then, the CCID communicates the encrypted random number to the system along with a serial number. The system recalculates the UCK using the serial number, encrypts a copy of the random number using the recalculated UCK and compares the encrypted copy with the encrypted random number received from the CCID to authenticate the CCID.
摘要翻译：系统被配置为在与CCID的交易期间认证芯片卡接口设备（CCID）。该系统具有配置用于通过网络与CCID进行通信的通信设备和与通信设备耦合的处理设备。处理装置被配置为从CCID接收事务发起通信，并且指示通信设备向CCID传送包括随机数的认证信息的请求。 CCID使用先前使用主芯片密钥（MCK）创建的唯一芯片密钥（UCK）对随机数进行加密。然后，CCID将加密的随机数与序列号一起传送到系统。系统使用序列号重新计算UCK，使用重新计算的UCK加密随机数的副本，并将加密的副本与从CCID接收的加密随机数进行比较，以验证CCID。

10. 发明申请

WO2019173352A1 METHODS FOR THE TREATMENT OF THYROID EYE DISEASE 审中-公开
公开(公告)号：WO2019173352A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020770
申请日：2019-03-05
申请人： HZNP LIMITED , MADDEN, David , GABRIEL, Kathleen , MAGNI, Guido , WOODWARD, Richard , LIN, Shao-lee , SHERMAN, Jeffrey
发明人： MADDEN, David , GABRIEL, Kathleen , MAGNI, Guido , WOODWARD, Richard , LIN, Shao-lee , SHERMAN, Jeffrey
IPC分类号： A61K39/395 , C07K16/28 , C12P21/02
摘要： The invention provides a method of treating or reducing the severity of thyroid associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

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