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1. 发明公开

EP0136111A3 Real time seismic telemetry system 失效
标题翻译：实时地震电报系统
公开(公告)号：EP0136111A3
公开(公告)日：1987-01-21
申请号：EP84305935
申请日：1984-08-30
申请人： Russell, William Franklin , Bryce, William Wilson
发明人： Russell, William Franklin
IPC分类号： G01V01/22 , H04L25/49
CPC分类号： G01V1/22
摘要： A real time seismic telemetry system includes a central station (10) for communication with a plurality of remote data acquisition units (14). The command station (10) has a command unit (34) for controlling the operation of a transmitter (40) for providing instructions to the data acquisition units (14). The data acquisition units (14) receive the data on a receiver (80) and process the data in a logic control circuit (88). Remote data is picked up with a hydrophone (30) and converted to digital data for transmission through a transmitter (78) which is tuned to a discrete channel for each data acquisition unit (14). The command station (10) has a PCM receiver (62) tuned to each of the channels for demodulating the data stream therefrom. A digital receiver (66) is provided for synchronizing and processing the data. The digital receiver (66) synchronizes both to the bit rate and to the beginning and ending of the digital word such that data contained in the digital word can be multiplexed onto a data bus (68). The data bus (68) is controlled by an external storage/control (70) for storage of the data from all of the digital receivers (66) for all of the discrete channels.
摘要翻译：实时地震遥测系统包括用于与多个远程数据采集单元（14）通信的中心站（10）。指令台（10）具有用于控制用于向数据采集单元（14）提供指令的发送器（40）的操作的命令单元（34）。数据采集单元（14）在接收器（80）上接收数据并处理逻辑控制电路（88）中的数据。用水听器（30）拾取远程数据，并将其转换成数字数据，以通过发射器（78）传输，该发射器被调谐到每个数据采集单元（14）的离散通道。命令站（10）具有调谐到每个通道的PCM接收器（62），用于解调来自其的数据流。提供数字接收机（66）用于同步和处理数据。数字接收机（66）同时将比特率与数字字的开始和结束同步，使得包含在数字字中的数据可以复用到数据总线（68）上。数据总线（68）由外部存储/控制（70）控制，用于存储来自用于所有离散通道的所有数字接收器（66）的数据。

2. 发明公开

EP0136111A2 Real time seismic telemetry system 失效
标题翻译： Seismische Echtzeitfernmessanordnung。
公开(公告)号：EP0136111A2
公开(公告)日：1985-04-03
申请号：EP84305935.3
申请日：1984-08-30
申请人： Russell, William Franklin , Bryce, William Wilson
发明人： Russell, William Franklin , Bryce, William Wilson
IPC分类号： G01V1/22 , H04L25/49
CPC分类号： G01V1/22
摘要： A real time seismic telemetry system includes a central station (10) for communication with a plurality of remote data acquisition units (14). The command station (10) has a command unit (34) for controlling the operation of a transmitter (40) for providing instructions to the data acquisition units (14). The data acquisition units (14) receive the data on a receiver (80) and process the data in a logic control circuit (88). Remote data is picked up with a hydrophone (30) and converted to digital data for transmission through a transmitter (78) which is tuned to a discrete channel for each data acquisition unit (14). The command station (10) has a PCM receiver (62) tuned to each of the channels for demodulating the data stream therefrom. A digital receiver (66) is provided for synchronizing and processing the data. The digital receiver (66) synchronizes both to the bit rate and to the beginning and ending of the digital word such that data contained in the digital word can be multiplexed onto a data bus (68). The data bus (68) is controlled by an external storage/control (70) for storage of the data from all of the digital receivers (66) for all of the discrete channels.
摘要翻译：实时地震遥测系统包括用于与多个远程数据采集单元（14）通信的中心站（10）。指令台（10）具有用于控制用于向数据采集单元（14）提供指令的发送器（40）的操作的命令单元（34）。数据采集单元（14）在接收器（80）上接收数据并处理逻辑控制电路（88）中的数据。用水听器（30）拾取远程数据，并将其转换成数字数据，以通过发射器（78）传输，该发射器被调谐到每个数据采集单元（14）的离散通道。命令站（10）具有调谐到每个通道的PCM接收器（62），用于解调来自其的数据流。提供数字接收机（66）用于同步和处理数据。数字接收机（66）同时将比特率与数字字的开始和结束同步，使得包含在数字字中的数据可以复用到数据总线（68）上。数据总线（68）由外部存储/控制（70）控制，用于存储来自用于所有离散通道的所有数字接收器（66）的数据。

3. 发明申请

WO2004094363A1 MUSCARINIC AGONISTS 审中-公开
公开(公告)号：WO2004094363A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/005234
申请日：2004-03-12
申请人： ELI LILLY AND COMPANY , ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , TURNER, William, Wilson, Junior , LIU, Bin
发明人： ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , TURNER, William, Wilson, Junior , LIU, Bin
IPC分类号： C07C251/08
CPC分类号： C07C323/41 , C07B2200/07 , C07C257/14 , C07C257/18 , C07C271/24 , C07C2601/02 , C07C2602/08 , C07D213/64 , C07D213/70 , C07D295/125 , C07D295/13
摘要： The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.
摘要翻译：本发明涉及式（I）的化合物：其为M-1毒蕈碱性受体的激动剂。

4. 发明申请

WO03027061A3 MUSCARINIC AGONISTS 审中-公开
标题翻译：肌肉激素
公开(公告)号：WO03027061A3
公开(公告)日：2003-07-31
申请号：PCT/US0225969
申请日：2002-09-09
申请人： LILLY CO ELI , ALLEN JENNIFER REBECCA , HITCHCOCK STEPHEN ANDREW , LIU BIN , TURNER WILLIAM WILSON JR , JAMISON JAMES ANDREW
发明人： ALLEN JENNIFER REBECCA , HITCHCOCK STEPHEN ANDREW , LIU BIN , TURNER WILLIAM WILSON JR , JAMISON JAMES ANDREW
IPC分类号： C07D333/38 , A61K31/166 , A61K31/341 , A61K31/381 , A61K31/44 , A61K31/4436 , A61K31/4965 , A61P25/18 , A61P25/28 , A61P43/00 , C07C257/14 , C07D207/32 , C07D207/325 , C07D213/54 , C07D213/56 , C07D213/81 , C07D213/82 , C07D213/84 , C07D241/24 , C07D307/52 , C07D317/28 , C07D333/24 , C07D409/04 , C07C251/00
CPC分类号： C07D207/325 , C07C257/14 , C07C2602/08 , C07D213/54 , C07D213/56 , C07D213/81 , C07D213/82 , C07D213/84 , C07D241/24 , C07D307/52 , C07D317/28 , C07D333/24 , C07D409/04 , Y02P20/582
摘要： The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor.
摘要翻译：本发明涉及作为M-1毒蕈碱受体的激动剂的式I化合物：式I。

5. 发明申请

WO0011023A3 RING MODIFIED CYCLIC PEPTIDE ANALOGS 审中-公开
标题翻译：环修饰的环状肽类似物
公开(公告)号：WO0011023A3
公开(公告)日：2000-06-15
申请号：PCT/US9918908
申请日：1999-08-18
申请人： LILLY CO ELI , BORROMEO PETER STANLEY , COHEN JEFFREY DANIEL , GREGORY GEORGE STUART , HENLE STACY KAY , HITCHCOCK STEPHEN ANDREW , JUNGHEIM LOUIS NICKOLAUS , MAYHUGH DANIEL RAY , SHEPHERD TIMOTHY ALAN , TURNER WILLIAM WILSON JR
发明人： BORROMEO PETER STANLEY , COHEN JEFFREY DANIEL , GREGORY GEORGE STUART , HENLE STACY KAY , HITCHCOCK STEPHEN ANDREW , JUNGHEIM LOUIS NICKOLAUS , MAYHUGH DANIEL RAY , SHEPHERD TIMOTHY ALAN , TURNER WILLIAM WILSON JR
IPC分类号： A61K9/08 , A61K9/72 , A61K38/00 , A61P31/10 , A61P33/00 , C07K1/06 , C07K7/50 , C07K7/54 , C07K7/56 , C07K7/64 , A61K38/12
CPC分类号： C07K7/50 , A61K38/00 , C07K7/56
摘要： A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.
摘要翻译：提供了用于修饰棘白菌素型化合物的环肽环体系以产生具有抗真菌活性的新型类似物的方法。本发明的方法包括打开环肽环，切割末端鸟氨酸单元，插入至少一个新氨基酸或其他合成单元并闭合环以产生新的环肽环结构。该方法允许将诸如水溶性的特征结合到环肽环核中，进一步修饰的位点，增加或减少环核内氨基酸或肽单元的数目，以及增加或减少环内肽的总数戒指。本发明还提供了新型棘白菌素类化合物及其作为抗真菌剂或抗寄生虫剂的用途。

6. 发明申请

WO1991001992A1 NUCLEATION OF ICE 审中-公开
标题翻译：冰的核化
公开(公告)号：WO1991001992A1
公开(公告)日：1991-02-21
申请号：PCT/GB1990001269
申请日：1990-08-13
申请人： CELL SYSTEMS LIMITED , GROUT, Brian, William, Wilson
发明人： CELL SYSTEMS LIMITED
IPC分类号： C07J09/00
CPC分类号： G01N33/5005 , A01N1/02 , A01N1/0221 , G01N33/5014
摘要： The undercooling of an aqueous medium (and therefore damage to a biological sample in the medium) can be minimised by inducing ice nucleation in the medium using cholesterol having a crystal structure which may be obtained by crystallising from methanol and/or acetic acid. Such crystalline cholesterol can be added to the cryopreservation medium (which may also contain a cryoprotectant) or can be coated onto an inner surface of an ampoule, cryopreservation tube or straw. The cholesterol can also be used to induce ice nucleation in the atmosphere to create hail or snow or artificial snow in aerosols of the aqueous medium for use on ski slopes.
摘要翻译：通过使用具有可以通过从甲醇和/或乙酸结晶获得的晶体结构的胆固醇在培养基中诱导冰成核，可以使水性介质的过冷（并因此在培养基中对生物样品的损伤）最小化。可以将这种结晶胆固醇加入到冷冻保存培养基（其也可以含有冷冻保护剂）中，或者可以涂覆在安瓿，冷冻储存管或吸管的内表面上。胆固醇也可用于在大气中诱导冰晶核，以在滑雪场的水性介质的气溶胶中产生冰雹或积雪或人造雪。

7. 发明申请

WO2005009941A1 INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS 审中-公开
标题翻译： INDANE作为MUSCARINIC RECEPTOR AGONISTS衍生
公开(公告)号：WO2005009941A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/019094
申请日：2004-06-23
申请人： ELI LILLY AND COMPANY , ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , LIU, Bin , TURNER, William, Wilson, Jr.
发明人： ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , LIU, Bin , TURNER, William, Wilson, Jr.
IPC分类号： C07C233/79
CPC分类号： C07D207/27 , C07C233/79 , C07C323/25 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07D207/09 , C07D211/26 , C07D213/32 , C07D213/38 , C07D213/70 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D235/14 , C07D263/32 , C07D271/10 , C07D277/28 , C07D307/52 , C07D307/56 , C07D333/20 , C07D333/58
摘要： The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.
摘要翻译：本发明涉及式I化合物：I是M-1毒蕈碱受体的激动剂。

8. 发明申请

WO2003027061A2 MUSCARINIC AGONISTS 审中-公开
公开(公告)号：WO2003027061A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/025969
申请日：2002-09-09
申请人： ELI LILLY AND COMPANY , ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , LIU, Bin , TURNER, William, Wilson, Jr. , JAMISON, James, Andrew
发明人： ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , LIU, Bin , TURNER, William, Wilson, Jr. , JAMISON, James, Andrew
IPC分类号： C07C251/00
CPC分类号： C07D207/325 , C07C257/14 , C07C2602/08 , C07D213/54 , C07D213/56 , C07D213/81 , C07D213/82 , C07D213/84 , C07D241/24 , C07D307/52 , C07D317/28 , C07D333/24 , C07D409/04 , Y02P20/582
摘要： The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor.
摘要翻译：本发明涉及作为M-1毒蕈碱性受体激动剂的式I化合物：

9. 发明申请

WO2004094382A1 MUSCARINIC AGONISTS 审中-公开
标题翻译：肌肉激素
公开(公告)号：WO2004094382A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/005235
申请日：2004-03-12
申请人： ELI LILLY AND COMPANY , ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , TURNER, William, Wilson, Jr. , LIU, Bin
发明人： ALLEN, Jennifer, Rebecca , HITCHCOCK, Stephen, Andrew , TURNER, William, Wilson, Jr. , LIU, Bin
IPC分类号： C07D211/72
CPC分类号： C07D409/12 , C07D207/22 , C07D211/72 , C07D239/14 , C07D263/28 , C07D265/08 , C07D277/18 , C07D279/06
摘要： The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.
摘要翻译：本发明涉及式（I）化合物：它是M-1毒蕈碱受体的激动剂。

10. 发明申请

WO1991001637A1 BIOLOGICAL CRYOPRESERVATION 审中-公开
标题翻译：生物CRYOPRESERVATION
公开(公告)号：WO1991001637A1
公开(公告)日：1991-02-21
申请号：PCT/GB1990001268
申请日：1990-08-13
申请人： CELL SYSTEMS LIMITED , GROUT, Brian, William, Wilson , McFADZEN, Ian, Robert, Bruce
发明人： CELL SYSTEMS LIMITED
IPC分类号： A01N01/02
CPC分类号： G01N33/5014 , A01N1/02 , A01N1/0284 , G01N33/5005
摘要： Bioassays for pollutants or toxicants can be performed at any time of year, even out of season, using cryopreserved unfertilised eggs of the phylum Mollusca, such as oysters and molluscs. The eggs are cryopreserved in an aqueous medium that contains a cryoprotectant such as dimethyl sulphoxide in contact with cholesterol, which may be coated onto an ampoule or cryopreservation straw or tube.
摘要翻译：污染物或毒物的生物测定可以在一年的任何时间，即使在季节之外，也可以使用软体动物门的低温保存的未受精卵，如牡蛎和软体动物。将蛋在含有冷冻保护剂（例如与胆固醇接触的二甲基亚砜）的水性介质中冷冻保存，其可以涂覆在安瓿或冷冻保存的吸管或管上。

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