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1. 发明申请

US20120021111A1 Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture 审中-公开
标题翻译：用于饮料，食品和药物的天然低热量甜味剂组合物及其制造方法
公开(公告)号：US20120021111A1
公开(公告)日：2012-01-26
申请号：US13189501
申请日：2011-07-23
申请人： William R. Pfister , Sanjay Sehgal
发明人： William R. Pfister , Sanjay Sehgal
IPC分类号： A23L1/236
CPC分类号： A23L2/60 , A23L27/33 , A23L27/34 , A23L27/36
摘要： Natural sweetener compositions, comprising a highly purified steviol extract of rebaudioside A (Reb A) of about 80 to 99% purity, other steviol glycosides of about 3% or less, and sterebins of 1% or less, and one or more bulking agents, where the natural sweetener compositions are suitable for use as an ingredient in orally administered pharmaceuticals, foods, beverages, and other orally administered products, for humans and animals. A method of preparing naturally sweetened orally administered products, comprising the step of mixing natural sweetener compositions, having a highly purified steviol extract and one or more bulking agents, with other ingredients commonly used in manufacturing orally administered products. A process to prepare natural sweetener compositions, comprising the steps of combining a highly purified Stevia extract, having a pure primary steviol glycoside, and one or more bulking agents, with optional additives, and mixing, dissolving, drying, granulating and sieving the resulting composition.
摘要翻译：天然甜味剂组合物，其包含纯度为约80-99％的莱鲍迪甙A（Reb A）的高度纯化的甜菊醇提取物，约3％或更少的其它甜菊糖苷和1％或更少的立体异构体，以及一种或多种填充剂，其中天然甜味剂组合物适合用作人和动物的口服药物，食品，饮料和其它口服制剂中的成分。一种制备天然甜味口服产品的方法，包括将具有高度纯化的甜菊醇提取物和一种或多种填充剂的天然甜味剂组合物与通常用于制备口服产品的其它成分混合的步骤。一种制备天然甜味剂组合物的方法，包括以下步骤：将具有纯的初级甜菊醇糖苷的高度纯化的甜叶菊提取物与一种或多种填充剂与任选的添加剂混合，混合，溶解，干燥，造粒和筛分所得组合物。

2. 发明申请

US20090099266A1 Antifungal nail coat and method of use 审中-公开
标题翻译：抗真菌指甲外套及使用方法
公开(公告)号：US20090099266A1
公开(公告)日：2009-04-16
申请号：US12316009
申请日：2008-12-09
申请人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
发明人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
IPC分类号： A01N33/04 , A01P3/00
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.
摘要翻译：含有烯丙胺，N，N-二（C1-C8）烷基氨基取代的（C4-C18）烷基（C2-C18）羧酸酯或其药学上可接受的酸加成盐的抗真菌指甲油组合物，亲水性聚合物和公开了药学上可接受的挥发性有机载体。当与真菌感染或感染的指甲接触时，组合物提供基本上水溶性的杀真菌涂层。

3. 发明授权

US4874129A Multi-laminate fragrance release device 失效
标题翻译：多层次的香水释放装置
公开(公告)号：US4874129A
公开(公告)日：1989-10-17
申请号：US213738
申请日：1988-06-30
申请人： Alfred J. DiSapio , William R. Pfister , Mary A. Sheeran
发明人： Alfred J. DiSapio , William R. Pfister , Mary A. Sheeran
IPC分类号： A45D40/00 , A61L9/12 , B32B25/20
CPC分类号： A45D40/0087 , A61L9/12
摘要： A multi-layered multi-laminate sustained release device capable of releasing fragrances, colognes, and perfumes, at a controlled rate for a prolonged period of time and having a first layer of a pressure sensitive adhesive release liner for providing a protective peel strip for the device, a second layer of a silicone pressure sensitive adhesive for adhering the device to a substrate to which it is applied including human skin, a third layer of a fragrance oil impregnated matrix of a silicone material selected from the group consisting of silicone elastomers, silicone elastomers having adhesive characteristics, and elastomeric silicone pressure sensitive adhesives, and a fourth layer of a permeable facestock backing member on the surface of the device for controlling the rate of release of the fragrance oil from the impregnated matrix.

4. 发明授权

US07462362B2 Antifungal nail coat and method of use 失效
标题翻译：抗真菌指甲外套及使用方法
公开(公告)号：US07462362B2
公开(公告)日：2008-12-09
申请号：US10514190
申请日：2004-03-22
申请人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
发明人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
IPC分类号： A61K8/00 , A61K8/18
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.
摘要翻译：公开了一种双作用抗真菌指甲油组合物和用于改善或预防指甲真菌感染和甲真菌病的用途的方法。公开了适用于日常杀真菌方案的单涂层型和双层型形式的组合物实施方案。优选的抗真菌指甲涂层组合物包含有效杀真菌量的抗真菌剂，渗透促进量的基本上不挥发的渗透促进剂，成膜量的亲水性聚合物和药学上可接受的挥发性载体。组合物在接触真菌感染或感染的指甲时提供基本上水溶性的杀真菌涂层。

5. 发明授权

US5613958A Transdermal delivery systems for the modulated administration of drugs 失效
标题翻译：用于调节药物给药的透皮递送系统
公开(公告)号：US5613958A
公开(公告)日：1997-03-25
申请号：US469178
申请日：1995-06-06
申请人： Frank Kochinke , William R. Pfister , Jenny Louie , Dan Arenson
发明人： Frank Kochinke , William R. Pfister , Jenny Louie , Dan Arenson
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7084 , Y10S514/947
摘要： A transdermal delivery system for the modulated administration of drugs is described. The drug delivery device comprises a backing; a drug reservoir containing the drug, a plasticizer-type enhancer, a solvent-type enhancer, and optionally, a gelling agent; a non-rate-controlling membrane; and an adhesive layer containing a plasticizer-type enhancer. This drug delivery system is particularly useful for the administration of tolerance-inducing drugs, for example, vasodilators, such as isosorbide dinitrate.
摘要翻译：描述了用于调节药物给药的透皮递送系统。药物递送装置包括背衬; 含有药物的药物储存器，增塑剂型增强剂，溶剂型增强剂和任选的胶凝剂; 非速率控制膜; 和含有增塑剂型增强剂的粘合剂层。该药物递送系统特别可用于施用耐受诱导药物，例如血管扩张剂，例如硝酸异山梨酯。

6. 发明授权

US4951657A Heat sealable membrane for transdermal drug release 失效
标题翻译：用于透皮药物释放的可热封膜
公开(公告)号：US4951657A
公开(公告)日：1990-08-28
申请号：US184750
申请日：1988-04-22
申请人： William R. Pfister , Chi-Long Lee , Gerald A. Gornowicz
发明人： William R. Pfister , Chi-Long Lee , Gerald A. Gornowicz
IPC分类号： A61K9/70 , A61M35/00 , C08G18/61 , C08G77/42 , C08G77/458 , C09J7/02
CPC分类号： A61K9/7084 , A61M35/00 , C08G18/61
摘要： A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a release rate controlling membrane, and, a reservoir containing a medicinally active ingredient; the improvement in such system is based on the fact that said membrane is heat and pressure sealed to said backing without the use of a separate adhesive and is formed of a substantially linear block copolymer which is a reaction product of an amino functional polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 50.degree. C. and 200.degree. C. said soft segments comprising from 60 to 90 percent by weight, based on the weight of said copolymer.

7. 发明授权

US06831688B2 Multispectral or hyperspectral imaging system and method for tactical reconnaissance 有权
标题翻译：多光谱或高光谱成像系统和战术侦察方法
公开(公告)号：US06831688B2
公开(公告)日：2004-12-14
申请号：US10118534
申请日：2002-04-08
申请人： Andre G. Lareau , Bradford Speer , William R. Pfister , Stephen R. Beran , Barry Swartz , James P. Karins , Robert J. Lintell , Christopher P. Warren
发明人： Andre G. Lareau , Bradford Speer , William R. Pfister , Stephen R. Beran , Barry Swartz , James P. Karins , Robert J. Lintell , Christopher P. Warren
IPC分类号： H04N5335
CPC分类号： H04N5/37206 , G01J3/02 , G01J3/0256 , G01J3/2803 , G01J3/2823 , G01J3/51 , H04N5/353 , H04N5/3743
摘要： A two-dimensional focal plane array (FPA) is divided into sub-arrays of rows and columns of pixels, each sub-array being responsive to light energy from a target object which has been separated by a spectral filter or other spectrum dividing element into a predetermined number of spectral bands. There is preferably one sub-array on the FPA for each predetermined spectral band. Each sub-array has its own read out channel to allow parallel and simultaneous readout of all sub-arrays of the array. The scene is scanned onto the array for simultaneous imaging of the terrain in many spectral bands. Time Delay and Integrate (TDI) techniques are used as a clocking mechanism within the sub-arrays to increase the signal to noise ratio (SNR) of the detected image. Additionally, the TDI length (i.e., number of rows of integration during the exposure) within each sub-array is adjustable to optimize and normalize the response of the photosensitive substrate to each spectral band. The array provides for parallel and simultaneous readout of each sub-array to increase the collection rate of the spectral imagery. All of these features serve to provide a substantial improvement in the area coverage of a hyperspectral imaging system while at the same time increasing the SNR of the detected spectral image.
摘要翻译：二维焦平面阵列（FPA）被划分为行和列的像素的子阵列，每个子阵列响应于已经被光谱滤波器或其他频谱分割元件分离的目标对象的光能预定数量的光谱带。对于每个预定的光谱带，FPA上最好有一个子阵列。每个子阵列都有自己的读出通道，以允许并行和同时读出阵列的所有子阵列。将场景扫描到阵列上，以便在许多光谱带中同时成像地形。时间延迟和积分（TDI）技术被用作子阵列内的时钟机制，以增加检测到的图像的信噪比（SNR）。此外，每个子阵列内的TDI长度（即，曝光期间的积分行数）是可调整的，以使感光基片对每个光谱带的响应进行优化和归一化。该阵列提供并行和同时读取每个子阵列以增加光谱图像的采集速率。所有这些特征用于提供高光谱成像系统的面积覆盖的显着改进，同时增加检测到的光谱图像的SNR。

8. 发明授权

US06552024B1 Compositions and methods for mucosal delivery 失效
标题翻译：粘膜递送的组成和方法
公开(公告)号：US06552024B1
公开(公告)日：2003-04-22
申请号：US09434878
申请日：1999-11-05
申请人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
发明人： Li-Lan H. Chen , William R. Pfister , Donald W. Renn , Thitiwan Buranachokpaisan , James Osborne , Hock Seng Tan , Li Tao
IPC分类号： A61K31495
CPC分类号： A61K9/0007 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0056 , A61K9/006 , A61K9/145 , A61K9/1623 , A61K9/7007 , A61K9/7015 , A61K31/495 , A61K31/505
摘要： Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface.
摘要翻译：含有水溶性水胶体的粘膜表面涂膜形成膜剂量单位，有效剂量的活性剂和粘膜粘附增强剂; 其中所述活性剂包封在化学或物理上不同于所述液体胶体的聚合物内; 其中粘膜粘附增强剂是淀粉接枝共聚物; 其中所述膜的干粘度值小于3.5g，湿粘性大于35g，对于2％聚合物溶液的凝胶化温度大于70℃，干膜厚度小于20密耳，水含量为0.5〜10％，拉伸强度大于1500psi，模量为35,000〜300,000psi，％伸长率小于20％，耐撕裂概率为0.001〜1N，施用于口腔粘膜表面后的溶出时间为1至600秒。

9. 发明授权

US5231502A Image information processing techniques for improving the resolution of scanned imaging systems 失效
标题翻译：用于提高扫描成像系统分辨率的图像信息处理技术
公开(公告)号：US5231502A
公开(公告)日：1993-07-27
申请号：US699000
申请日：1991-05-13
申请人： William R. Pfister
发明人： William R. Pfister
IPC分类号： F02B75/02 , H04N5/372
CPC分类号： H04N3/1525 , F02B2075/027
摘要： Improved apparatus and methods of image information processing are disclosed which extend the operational coverage of an image system to higher velocity to height ratio scenarios while optimizing image resolution. The invention typically is implemented by a time delay and integrate charge-coupled device. In conjunction with an image variable row scan rate, a novel method of clocking the device is used to adjust the number of cycles of clocking performed in one row read out time, and to simultaneously transfer pixel information located in a plurality of rows of an imaging array having a predetermined row relationship. The relationship between the variable row scan rate, the predetermined row relationship and the number of cycles of clocking is adjusted so that the scan rate can increase above a maximum base scan rate by a factor of (AB)/(B-1), where A is the number of cycles of clocking performed and B is an integer corresponding to the predetermined row relationship. This increased scan rate and clocking optimizes resolution in the extended operational coverage scenario at (B-1)/(AB). In some non-scanning applications, the velocity to height ratio will determine the rate of image movement across the array, and the row relationship and the number of cycles of clocking will be the chosen parameters to optimize resolution.
摘要翻译：公开了改进的图像信息处理的装置和方法，其在优化图像分辨率的同时将图像系统的操作覆盖范围扩展到更高的速度与高度比方案。本发明通常通过时间延迟来实现并且集成电荷耦合器件。结合图像可变行扫描速率，使用时钟设备的新颖方法来调整在一行读出时间中执行的时钟的周期数，并且同时传送位于成像的多行中的像素信息阵列具有预定的行关系。调整可变行扫描速率，预定行关系和时钟周期数之间的关系，使得扫描速率可以增加到高于最大基扫描速率乘以（AB）/（B-1）因子，其中 A是执行时钟的周期数，B是对应于预定行关系的整数。在（B-1）/（AB）的扩展操作覆盖情况下，这种增加的扫描速率和时钟优化了分辨率。在某些非扫描应用中，速度与高度之比决定了阵列上的图像移动速率，并且行关系和时钟周期数将成为选择的参数以优化分辨率。

10. 发明授权

US5155597A Electro-optical imaging array with motion compensation 失效
标题翻译：具有运动补偿的电光成像阵列
公开(公告)号：US5155597A
公开(公告)日：1992-10-13
申请号：US619219
申请日：1990-11-28
申请人： Andre G. Lareau , Stephen R. Beran , John A. Lund , William R. Pfister
发明人： Andre G. Lareau , Stephen R. Beran , John A. Lund , William R. Pfister
IPC分类号： G01C11/02 , H04N5/33 , H04N5/335
CPC分类号： G01C11/02 , H04N3/1525 , H04N3/1568 , H04N5/33 , H04N5/335
摘要： An electro-optical area array reconnaissance detector is disclosed which accomplishes forward motion compensation electronically and without moving parts. The array is made of photo-sensitive cells arranged in rows and columns, the columns being organized into one or more column groups. Charge packets collected in the cells representing scene information are transferred down the columns at the same rate as the image motion in the plane of the array. In a side oblique reconnaissance scenario, the columns may be organized into 16 column groups, each column group having its own charge transfer rate corresponding to the image motion rate in that column group.
摘要翻译：公开了一种电光区域阵列侦察探测器，其通过电子方式实现向前运动补偿，而不需要移动部件。阵列由以行和列排列的感光细胞组成，列被组织成一个或多个列组。在表示场景信息的单元格中收集的收费分组以与阵列的平面中的图像运动相同的速率向下传送。在侧面倾斜侦察场景中，列可以被组织成16列组，每个列组具有与该列组中的图像运动速率相对应的其自己的电荷传送速率。

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