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1. 发明授权

US09409222B2 Reducing waste in metal stamping processes and systems therefor 有权
标题翻译：减少金属冲压工艺和系统的浪费
公开(公告)号：US09409222B2
公开(公告)日：2016-08-09
申请号：US13581662
申请日：2011-02-25
申请人： William R. Moore , Kevin P. Glenn
发明人： William R. Moore , Kevin P. Glenn
IPC分类号： B21D22/06 , B21D22/22 , B21D24/04
CPC分类号： B21D22/06 , B21D22/22 , B21D24/04
摘要： Disclosed herein is a sheet metal stamping device and methods for reducing the size of a blank required for producing a stamped part therefrom than is conventionally possible. The device utilizes an intermediate clamp section with projections having clamping formations located thereon which complement clamping formations located on a first die section. The intermediate clamp section projections allow for the use of a smaller blank size as less addendum material is required to secure the blank during the stamping process. The blank is secured using the intermediate clamp section and the first die section prior to the second die section engaging the blank to stamp the part. In some embodiments, retention beads resultant from the clamping process may remain in the stamped part, that being inside a trim line. Furthermore, in some embodiments, a blank shifter may be provided to locate the blank between the die sections prior to clamping. In other embodiments, more than one complementary pair of clamping formations may be provided. Furthermore, in some embodiments a trim line cutter may be provided.
摘要翻译：本文公开了一种金属冲压装置以及用于从传统可能的方式减小制造冲压部件所需的坯料尺寸的方法。该装置利用具有位于其上的夹持结构的突起的中间夹具部分，其对位于第一模具部分上的夹紧结构进行补充。中间夹具部分突起允许使用较小的坯料尺寸，因为在冲压过程中需要更少的齿顶材料来固定坯件。在第二模具部分接合坯件之前，使用中间夹紧部分和第一模具部分来固定坯件以压印该零件。在一些实施例中，由夹紧过程产生的保留珠可以保留在冲压部分中，即在修剪线内。此外，在一些实施例中，可以提供空白移位器以在夹紧之前将坯料定位在模具部分之间。在其它实施例中，可以提供多于一对的互补的夹持结构对。此外，在一些实施例中，可以提供修剪线切割器。

2. 发明授权

US5278171A Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis 失效
标题翻译：十八烷酰胺和硫代酰胺作为胆固醇生物合成的抑制剂
公开(公告)号：US5278171A
公开(公告)日：1994-01-11
申请号：US776143
申请日：1991-10-15
申请人： Marion W. Wannamaker , William A. Van Sickle , William R. Moore
发明人： Marion W. Wannamaker , William A. Van Sickle , William R. Moore
IPC分类号： A61K31/47 , A61K31/472 , A61P3/06 , A61P31/04 , A61P31/10 , C07D217/06 , C07D217/04
CPC分类号： C07D217/06
摘要： The present invention provides certain novel azadecalin amides and thioamides which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.
摘要翻译：本发明提供了一些可用作胆固醇生物合成抑制剂的新型十八烷酰胺和硫代酰胺，以及降低有需要的患者的总血清胆固醇的试剂。

3. 发明授权

US5084461A Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis 失效
标题翻译：十八烷酰胺和硫代酰胺作为胆固醇生物合成的抑制剂
公开(公告)号：US5084461A
公开(公告)日：1992-01-28
申请号：US676149
申请日：1991-03-27
申请人： Marion W. Wannamaker , William A. Van Sickle , William R. Moore
发明人： Marion W. Wannamaker , William A. Van Sickle , William R. Moore
IPC分类号： A61K31/47 , A61K31/472 , A61P3/06 , A61P31/04 , A61P31/10 , C07D217/06
CPC分类号： C07D217/06
摘要： The present invention provides certain novel azadecalin amides and thioamides which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.

4. 发明授权

US09415433B2 Scrap shape retention 有权
标题翻译：废料形状保持
公开(公告)号：US09415433B2
公开(公告)日：2016-08-16
申请号：US13504895
申请日：2010-06-29
申请人： William R. Moore
发明人： William R. Moore
IPC分类号： B21D22/22 , B21D24/16 , B21D53/88
CPC分类号： B21D22/22 , B21D24/16 , B21D53/88
摘要： Disclosed herein is a sheet metal stamping device and method for substantially inhibiting recoil from a neutral stamped position of a scrap part region. A sheet metal stamping device for stamping a sheet metal part comprising a first die body and a second is provided wherein the first die body and the second die body are in operable communication for forming the sheet metal part from a sheet metal blank. The sheet metal part includes at least one scrap region formed therein which is prone to recoil from a neutral stamped position. The first die body and the second die body have complementary elongate bead-forming regions located for forming an elongate bead region in the scrap region. And, the elongate bead-forming regions are configured such that the elongate bead substantially inhibits recoil or springback of the scrap region from the neutral stamped position when the scrap region is severed from the part. A method of stamping a sheet metal part having at least one scrap region prone to recoil formed therein utilizing the device and severing the scrap region is also disclosed.
摘要翻译：本文公开了一种用于从废料部分区域的中立冲压位置基本上抑制反冲的钣金冲压装置和方法。提供了一种用于冲压包括第一模具本体和第二模具的金属片的金属板冲压装置，其中，第一模具主体和第二模具主体可操作地连接，用于从金属板坯形成金属片。钣金件包括形成在其中的至少一个废料区域，其易于从中立的冲压位置反冲。第一模具体和第二模具体具有互补的细长的胎圈形成区域，用于在废料区域中形成细长的胎圈区域。并且，细长的胎圈形成区域被构造成使得当废料区域从该零件切断时，细长的胎圈基本上阻止废料区域从中立的冲压位置的后退或回弹。还公开了一种使用该装置冲压具有至少一个容易发生反冲的废料区域的金属片部件的方法，并且切断废料区域。

5. 发明申请

US20120210764A1 SCRAP SHAPE RETENTION 有权
标题翻译： SCRAP形状保持
公开(公告)号：US20120210764A1
公开(公告)日：2012-08-23
申请号：US13504895
申请日：2010-06-29
申请人： William R. MOORE
发明人： William R. MOORE
IPC分类号： B21D37/10 , B21D22/02 , B21D43/28 , B21D53/88
CPC分类号： B21D22/22 , B21D24/16 , B21D53/88
摘要： Disclosed herein is a sheet metal stamping device and method for substantially inhibiting recoil from a neutral stamped position of a scrap part region. A sheet metal stamping device for stamping a sheet metal part comprising a first die body and a second is provided wherein the first die body and the second die body are in operable communication for forming the sheet metal part from a sheet metal blank. The sheet metal part includes at least one scrap region formed therein which is prone to recoil from a neutral stamped position. The first die body and the second die body have complementary elongate bead-forming regions located for forming an elongate bead region in the scrap region. And, the elongate bead-forming regions are configured such that the elongate bead substantially inhibits recoil or springback of the scrap region from the neutral stamped position when the scrap region is severed from the part. A method of stamping a sheet metal part having at least one scrap region prone to recoil formed therein utilizing the device and severing the scrap region is also disclosed.
摘要翻译：本文公开了一种用于从废料部分区域的中立冲压位置基本上抑制反冲的钣金冲压装置和方法。提供了一种用于冲压包括第一模具本体和第二模具的金属片的金属板冲压装置，其中，第一模具主体和第二模具主体可操作地连接，用于从金属板坯形成金属片。钣金件包括形成在其中的至少一个废料区域，其易于从中立的冲压位置反冲。第一模具体和第二模具体具有互补的细长的胎圈形成区域，用于在废料区域中形成细长的胎圈区域。并且，细长的胎圈形成区域被构造成使得当废料区域从该零件切断时，细长的胎圈基本上阻止废料区域从中立的冲压位置的后退或回弹。还公开了一种使用该装置冲压具有至少一个容易发生反冲的废料区域的金属片部件的方法，并且切断废料区域。

6. 发明申请

US20120318034A1 REDUCING WASTE IN METAL STAMPING PROCESSES AND SYSTEMS THEREFOR 有权
标题翻译：减少金属冲压工艺和系统中的废物
公开(公告)号：US20120318034A1
公开(公告)日：2012-12-20
申请号：US13581662
申请日：2011-02-25
申请人： William R. Moore , Kevin P. Glenn
发明人： William R. Moore , Kevin P. Glenn
IPC分类号： B21D22/06 , B21D28/14
CPC分类号： B21D22/06 , B21D22/22 , B21D24/04
摘要： Disclosed herein is a sheet metal stamping device and methods for reducing the size of a blank required for producing a stamped part therefrom than is conventionally possible. The device utilizes an intermediate clamp section with projections having clamping formations located thereon which complement clamping formations located on a first die section. The intermediate clamp section projections allow for the use of a smaller blank size as less addendum material is required to secure the blank during the stamping process. The blank is secured using the intermediate clamp section and the first die section prior to the second die section engaging the blank to stamp the part. In some embodiments, retention beads resultant from the clamping process may remain in the stamped part, that being inside a trim line. Furthermore, in some embodiments, a blank shifter may be provided to locate the blank between the die sections prior to clamping. In other embodiments, more than one complementary pair of clamping formations may be provided. Furthermore, in some embodiments a trim line cutter may be provided.
摘要翻译：本文公开了一种金属冲压装置以及用于从传统可能的方式减小制造冲压部件所需的坯料尺寸的方法。该装置利用具有位于其上的夹持结构的突起的中间夹具部分，其对位于第一模具部分上的夹紧结构进行补充。中间夹具部分突起允许使用较小的坯料尺寸，因为在冲压过程中需要更少的齿顶材料来固定坯件。在第二模具部分接合坯件之前，使用中间夹紧部分和第一模具部分来固定坯件以压印该零件。在一些实施例中，由夹紧过程产生的保留珠可以保留在冲压部分中，即在修剪线内。此外，在一些实施例中，可以提供空白移位器以在夹紧之前将坯料定位在模具部分之间。在其它实施例中，可以提供多于一对的互补的夹持结构对。此外，在一些实施例中，可以提供修剪线切割器。

7. 发明申请

US20080280891A1 Anti-cancer agents and uses thereof 审中-公开
标题翻译：抗癌剂及其用途
公开(公告)号：US20080280891A1
公开(公告)日：2008-11-13
申请号：US11819494
申请日：2007-06-27
申请人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce D. Dorsey , Gary A. Flynn , Arifa Husain , William R. Moore, Jr.
发明人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce D. Dorsey , Gary A. Flynn , Arifa Husain , William R. Moore, Jr.
IPC分类号： A61K31/541 , A61K31/404 , C07D209/42 , C07D401/02 , C07D417/14 , A61K31/44 , A61P35/00 , A61K31/4439 , A61K31/5377 , C07D413/14
CPC分类号： A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/5377 , A61K31/541 , C07D213/74 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/12 , C07D498/04
摘要： The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.
摘要翻译：本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。它们对广泛的癌症尤其是白血病，前列腺，非小细胞肺和结肠有效。它们还可用于治疗增殖性视网膜病变，例如糖尿病性神经病变和黄斑变性。

8. 发明授权

US06355460B1 Metal mediated serine protease inhibitors 失效
标题翻译：金属介导的丝氨酸蛋白酶抑制剂
公开(公告)号：US06355460B1
公开(公告)日：2002-03-12
申请号：US09351869
申请日：1999-07-12
申请人： James M. Clark , Kyle Elrod , Thomas E. Jenkins , Bradley A. Katz , William R. Moore , Robert M. Stroud
发明人： James M. Clark , Kyle Elrod , Thomas E. Jenkins , Bradley A. Katz , William R. Moore , Robert M. Stroud
IPC分类号： C12N999
CPC分类号： C07D401/04 , C07D235/18 , C07D235/20 , C07D401/06 , C07D403/06 , C07K14/811 , C12N9/6424 , C12Q1/37 , G01N2333/045 , G01N2333/811 , G01N2333/96433 , G01N2333/976
摘要： The present invention relates to serine protease inhibitors having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s) and methods for identifying and using the inhibitors. The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and are useful in various processes associated with serine protease isolation and inhibition.
摘要翻译：本发明涉及具有P位结合部分和二价阳离子螯合部分的丝氨酸蛋白酶抑制剂，其在二价阳离子存在下预先制备为二价阳离子配合物或与丝氨酸蛋白酶组合，以及用于鉴定和使用抑制剂的方法。所述化合物与二价阳离子络合时显示出高的抑制活性，并且可用于与丝氨酸蛋白酶分离和抑制相关的各种过程。

9. 发明授权

US3689487A Triazinylamino substituted dimethyl ethers 失效
标题翻译：替丁胺取代二甲基醚
公开(公告)号：US3689487A
公开(公告)日：1972-09-05
申请号：US3689487D
申请日：1971-01-27
申请人： MASON PAUL J , WILLIAM R MOORE , HARRY E ULMER
发明人： MASON PAUL J , MOORE WILLIAM R , ULMER HARRY E
IPC分类号： C07D251/50 , C07D55/20
CPC分类号： C07D251/50
摘要： N,N''-bis((2-chloro-4-alkylamino-6-s-triazinyl)amino)-dimethyl ethers are prepared by reacting a 2-alkylamino-4-amino-6-chloros-triazine with formaldehyde in alkaline solution. The products are highly selective herbicides.
摘要翻译：通过使2-烷基氨基-4-氨基-6-氯-s-三嗪与甲醛反应制备N，N'-双[（2-氯-4-烷基氨基-6 -s-三嗪基）氨基]二甲基醚碱性溶液。该产品是高选择性除草剂。

10. 发明授权

US1302457A Combined gaff-hook and fish-rod. 失效
标题翻译：组合果酱和鱼类。
公开(公告)号：US1302457A
公开(公告)日：1919-04-29
申请号：US7933216
申请日：1916-02-19
申请人： WILLIAM R MOORE , URECK HARRY
发明人： URECK HARRY
CPC分类号： F42B6/08 , A01K81/00 , A01K87/007 , A01K97/14

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