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1. 发明授权

US07141611B2 High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof 有权
标题翻译：由天然产物获得的高分子量伯脂肪醇及其用途
公开(公告)号：US07141611B2
公开(公告)日：2006-11-28
申请号：US10622249
申请日：2003-07-18
申请人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
发明人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
IPC分类号： A61K31/045 , C07C29/76 , C07C29/28 , C07C29/86
CPC分类号： C07C29/76 , C07C29/86 , C07C31/125 , C07C33/025
摘要： This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.
摘要翻译：本发明提供了具有20,22,24,26,27,28,30,32和34个碳原子的较高分子量伯脂肪醇的分离混合物，并且具有增强的纯度。本发明还提供了一种通过在天然产物皂化或不皂化的情况下用有机溶剂萃取天然产物来获得醇混合物的方法。酒精混合物可用于药物组合物，食品和膳食补充剂中，并有效降低总胆固醇和低密度脂蛋白胆固醇并增加HDL-胆固醇水平，因此有效治疗高胆固醇血症。该组合物可用于降低冠心病的风险，抑制动脉粥样硬化过程（血小板超聚集，缺血和血栓形成），并可用作抗炎和抗血栓形成剂。该组合物还具有神经营养性质，可用于改善男性的性活动。

2. 发明授权

US06596776B2 High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof 有权
公开(公告)号：US06596776B2
公开(公告)日：2003-07-22
申请号：US10133986
申请日：2002-04-25
申请人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
发明人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
IPC分类号： A61K31045
CPC分类号： C07C29/76 , C07C29/86 , C07C31/125 , C07C33/025
摘要： The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia. Consequently the composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis) and also to act as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.

3. 发明授权

US6132726A Process for removing impurities from natural product extracts 失效
标题翻译：从天然产物提取物中除去杂质的方法
公开(公告)号：US6132726A
公开(公告)日：2000-10-17
申请号：US176348
申请日：1998-10-21
申请人： Randall J. Daughenbaugh , David T. Bailey , William R. Gamble , Dennis D. Gertenbach
发明人： Randall J. Daughenbaugh , David T. Bailey , William R. Gamble , Dennis D. Gertenbach
IPC分类号： A61K36/00 , A61K35/78
CPC分类号： A61K36/00
摘要： In general the present invention relates to a process for the removal of undesireable compounds or residues from an extract which are more polar or less polar than the desired target compound. The preferred embodiment of the present invention is a three step process and is described in detail below. The first step includes contacting a plant material that contains the desired target compound(s) with a solvent, thus producing a crude extract containing a mixture of compounds that includes, in addition to the undesireable residues, the desired target compound(s). The second step involves passing the crude extract through a series of columns containing an absorbent that retards the movement of the undesireable compounds, while allowing the desired compounds to pass. The third and final step involves drying the eluant product to achieve a final product.
摘要翻译：一般来说，本发明涉及一种从提取物中除去不希望的化合物或残留物的方法，其比所需目标化合物更极性或极性低。本发明的优选实施方案是三步法并在下面详细描述。第一步包括使含有所需目标化合物的植物材料与溶剂接触，从而产生含有化合物混合物的粗提取物，除了不期望的残留物之外，还包括所需的目标化合物。第二步涉及将粗提取物通过一系列含有吸收剂的色谱柱，该吸收剂阻止不需要的化合物的运动，同时允许期望的化合物通过。第三步和最后一步涉及干燥洗脱剂产品以获得最终产品。

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