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1. 发明专利

GB371897A Improvements in attemperators for the regulation of the temperature of the wort during fermentation in brewing or distilling 未知
公开(公告)号：GB371897A
公开(公告)日：1932-04-25
申请号：GB815132
申请日：1931-01-24
申请人： WILLIAM JOHN WATKINS , ALUMIMIUM PLANT & VESSEL COMPA
IPC分类号： C12M1/02
摘要： 371,897. Straight and loop tube heat exchangers. WATKINS, W. J., Brenda Lodge, The Avenue, Harlestone Road, Northampton, and ALUMINIUM PLANT & VESSEL CO., Ltd., Point Pleasant, Wandsworth, London. Jan. 24, 1931, No. 8151/32. Divided on 371,862. Drawings to Specification. [Class 64 (iii).] Attemperators for use in brewing &c. consist of a group of pipes mounted in transverse frame members or connected by tie members so as to form a structure of the nature of an arched or trussed beam or a tied girder. The constructions described are the same as those described with reference to Figs. 1-14 of Specification 371,862.

2. 发明专利

GB371862A Improvements in attemperators or like devices 未知
公开(公告)号：GB371862A
公开(公告)日：1932-04-25
申请号：GB239931
申请日：1931-01-24
申请人： WILLIAM JOHN WATKINS , ALUMINIUM PLANT & VESSEL CO
IPC分类号： C12M1/02
摘要： 371,862. Cooling wort &c. ; straight and loop tube heat exchangers. WATKINS, W. J., Brenda Lodge, The Avenue, Harlestone Road, Northampton, and ALUMINIUM PLANT & VESSEL CO., Ltd., Point Pleasant, Wandsworth, London. Jan. 24, 1931, No. 2399. [Classes 29 and 64 (iii).] Attemperators for fermenting vessels are mounted so that they may be positioned at different operative levels according to the amount of wort &c. to be treated, without extensive alteration of the inlet and outlet pipe connections. As shown in Figs. 1 and 2, the vat 1 is fitted with brackets 2 for supporting an attemperator comprising straight tubes 3 connected by return bends 8, or by headers, the tubes being mounted in a frame or bar 7 having a fitting 10 at each end provided with holes for turning pins 9 and positioning-pins 11 passed into the brackets. For the higher level of liquid B the attemperator occupies the higher position shown in full lines, while for the lower level A the attemperator is reversed and occupies the lower position X. Inlet and outlet pipes 4, 5 are connected at unions 6 in the ends of the pipe system. Another construction consists of a group of oval tubes 21, Figs. 7 and 9, passing through girder-like frames 17, having end brackets 19 formed with trunnions 20 about which the whole can be reversed. In another construction the tubes pass through a frame supported from a point above the centre or at one side, with a counterpoise such as a tube filled with lead. Other forms comprise bent tubes 43, Fig. 14, connected by a straight tube 44 and a post 45 to provide a girder-like assemblage, and curved tubes, Fig. 15, movable as a grid about a point 43 at one side. Specification 371,897 is referred to.

3. 发明授权

US10144736B2 Substituted pteridines useful for the treatment and prevention of viral infections 有权
公开(公告)号：US10144736B2
公开(公告)日：2018-12-04
申请号：US12374457
申请日：2007-07-20
申请人： Piet AndréMaurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
发明人： Piet AndréMaurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
IPC分类号： C07D487/00 , C07D475/02 , C07D475/00 , C07D475/04 , C07D475/06 , C07D475/08
摘要： The invention provides 4,6-di- and 2,4,6-tri-substituted pteridine derivatives with a specific substitution pattern which exhibit a significant and selective activity against certain types of viral infections, in particular selectively inhibit replication of Flaviridae such as the hepatitis C virus, and are useful for the prevention and treatment of such viral infections.

4. 发明授权

US08143394B2 Pyrido(3,2-d)pyrimidines useful for treating viral infections 有权
标题翻译：吡啶（3,2-d）嘧啶可用于治疗病毒感染
公开(公告)号：US08143394B2
公开(公告)日：2012-03-27
申请号：US12519496
申请日：2007-12-24
申请人： William John Watkins , Lee Shun Chong , Jennifer R. Zhang
发明人： William John Watkins , Lee Shun Chong , Jennifer R. Zhang
IPC分类号： C07D471/00 , C07D487/00
CPC分类号： C07D471/04
摘要： 2-amino-pyrido(3,2-d)pyrimidine derivatives with a specific substitution pattern on positions 4 and 6 of the core structure are useful in the treatment or prevention of an infection due to a virus from the Flaviviridae family, especially HCV, when administered to a patient in a therapeutically effective amount.
摘要翻译：具有核心结构位置4和6上特定取代模式的2-氨基 - 吡啶并（3,2-d）嘧啶衍生物可用于治疗或预防由于来自黄病毒科的病毒感染，特别是HCV，当以治疗有效量施用于患者时。

5. 发明授权

US08338435B2 Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections 有权
标题翻译：取代的吡啶并（3,2-D）嘧啶和用于治疗病毒感染的药物组合物
公开(公告)号：US08338435B2
公开(公告)日：2012-12-25
申请号：US12374223
申请日：2007-06-20
申请人： Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong , Jennifer Zhang
发明人： Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong , Jennifer Zhang
IPC分类号： A61K31/517 , C07D471/00
CPC分类号： C07D471/04
摘要： This invention provides di-, tri- and tetra-substituted pyrido(3,2-d)pyrimidine derivatives with specific substituting patterns, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular being highly active antiviral agents. The invention also provides use of such derivatives in the treatment of viral infections and pathologic conditions associated therewith, including hepatitis C.
摘要翻译：本发明提供了具有特定取代模式的二，三和四取代的吡啶并（3,2-d）嘧啶衍生物，其药学上可接受的盐，N-氧化物，溶剂合物，前药和对映异构体，特别是高活性抗病毒剂。本发明还提供了这样的衍生物在治疗与其相关的病毒感染和病理状况（包括丙型肝炎）中的用途。

6. 发明授权

US08232278B2 Pyrido(3,2-D)pyrimidines and pharmaceutical compositions useful for treating hepatitis C 有权
标题翻译：吡啶（3,2-D）嘧啶和用于治疗丙型肝炎的药物组合物
公开(公告)号：US08232278B2
公开(公告)日：2012-07-31
申请号：US11993832
申请日：2006-06-26
申请人： Steven Cesar Alfons De Jonghe , Piet André Maurits Maria Herdewijn , William A. Lee , William John Watkins
发明人： Steven Cesar Alfons De Jonghe , Piet André Maurits Maria Herdewijn , William A. Lee , William John Watkins
IPC分类号： A01N43/90 , A61K31/519 , C07D475/00
CPC分类号： A61K31/519 , C07D471/04
摘要： Specifically substituted pyrido(3,2-d)pyrimidine derivatives having the structural formula (I) are useful for the treatment of hepatitis C.
摘要翻译：具有结构式（I）的具体取代的吡啶并（3,2-d）嘧啶衍生物可用于治疗丙型肝炎。

7. 发明申请

US20100305117A1 SUBSTITUTED PTERIDINES USEFUL FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS 审中-公开
标题翻译：替代治疗有效的治疗和预防病毒感染的脓疱
公开(公告)号：US20100305117A1
公开(公告)日：2010-12-02
申请号：US12374457
申请日：2007-07-20
申请人： Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
发明人： Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
IPC分类号： A61K31/519 , C07D475/04 , A61K31/5377 , C07D475/08 , A61P31/14
CPC分类号： C07D475/02 , C07D475/00 , C07D475/04 , C07D475/06 , C07D475/08
摘要： The invention provides 4,6-di- and 2,4,6-tri-substituted pteridine derivatives with a specific substitution pattern which exhibit a significant and selective activity against certain types of viral infections, in particular selectively inhibit replication of Flaviridae such as the hepatitis C virus, and are useful for the prevention and treatment of such viral infections.
摘要翻译：本发明提供具有特定取代模式的4,6-二 - 和2,4,6-三取代的蝶啶衍生物，其具有对某些类型的病毒感染的显着和选择性活性，特别是选择性抑制黄病毒科的复制，丙型肝炎病毒，并且可用于预防和治疗这种病毒感染。

8. 发明申请

US20090318456A1 SUBSTITUTED PTERIDINES FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS 审中-公开
标题翻译：替代治疗和预防病毒感染的脓疱
公开(公告)号：US20090318456A1
公开(公告)日：2009-12-24
申请号：US12307727
申请日：2007-07-06
申请人： Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William A. Lee , William John Watkins , Steven S. Bondy , Lee S. Chong
发明人： Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William A. Lee , William John Watkins , Steven S. Bondy , Lee S. Chong
IPC分类号： A61K31/4985 , A61P31/12 , C07D475/08
CPC分类号： A61K31/519 , C07D475/04 , C07D475/08
摘要： Tri-substituted pteridines and tetra-substituted pteridines exhibit a significant and selective activity against certain types of viral infections, in particular they selectively inhibit the replication of the hepatitis C virus, and are useful for the prevention and treatment of such infections.
摘要翻译：三取代的蝶啶和四取代的蝶啶对某些类型的病毒感染表现出显着和选择性的活性，特别是它们选择性地抑制丙型肝炎病毒的复制，并且可用于预防和治疗这种感染。

9. 发明申请

US20090131414A1 PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C 有权
标题翻译： PYRIDO（3,2-D）嘧啶和用于治疗丙型肝炎的药物组合物
公开(公告)号：US20090131414A1
公开(公告)日：2009-05-21
申请号：US11993832
申请日：2006-06-26
申请人： Steven Cesar Alfons De Jonghe , Piet Andre Maurits Maria Herdewijn , William A. Lee , William John Watkins
发明人： Steven Cesar Alfons De Jonghe , Piet Andre Maurits Maria Herdewijn , William A. Lee , William John Watkins
IPC分类号： A61K31/551 , C07D471/04 , A61K31/5377 , A61K31/541 , A61P31/12
CPC分类号： A61K31/519 , C07D471/04
摘要： Specifically substituted pyrido(3,2-d)pyrimidine derivatives having the structural formula (I) are useful for the treatment of hepatitis C.
摘要翻译：具有结构式（I）的具体取代的吡啶并（3,2-d）嘧啶衍生物可用于治疗丙型肝炎。

10. 发明授权

US09259426B2 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections 有权
标题翻译：用于治疗病毒感染的4,6-二 - 和2,4,6-三取代喹唑啉衍生物
公开(公告)号：US09259426B2
公开(公告)日：2016-02-16
申请号：US12374433
申请日：2007-07-20
申请人： Ling-Jie Gao , Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
发明人： Ling-Jie Gao , Piet André Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
IPC分类号： A61K31/517 , A61K31/535 , A61K31/5375 , A61K31/5377 , C07D239/72 , C07D239/78 , C07D239/88 , C07D239/94 , C07D239/95 , C07D401/04 , C07D403/04 , C07D413/04
CPC分类号： C07D413/04 , A61K31/517 , A61K31/5375 , A61K31/5377 , C07D239/72 , C07D239/78 , C07D239/86 , C07D239/88 , C07D239/94 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： This invention provides quinazoline derivatives represented by the structural formula: (I); wherein: R2 is hydrogen, NR′R″, C1-7 alkyl, arylC1-7 alkyl or C3-10 cycloalkyl; R4 is amino, C1-7 alkyl, C2-7 alkenyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, aryl, heterocyclic, arylalkyl, heterocyclic-substituted C1-7 alkyl or C3-10 cycloalkyl-C1-7 alkyl; R5 is hydrogen or C1-7 alkyl, or R5 and R4 together with the nitrogen atom to which they are attached form a heterocyclic ring; Y is a single bond, C1-7 alkylene, C2-7 alkenylene or C2-7 alkynylene; R6 is halogen, heteroaryl or aryl; R′ and R″ are each independently hydrogen, C1-7 alkyl-carbonyl or C1-7 alkyl; provided that R4 is not phenyl substituted with morpholino when R2 is H and R5 is H, and provided that when NR4R5 is piperazinyl, said NR4R5 is either non-substituted or substituted with methyl or acetyl; a pharmaceutically acceptable addition salt, a stereoisomer, a mono- or a di-N-oxide, a solvate or a pro-drug thereof, for the treatment of viral infections.
摘要翻译：本发明提供由结构式（I）表示的喹唑啉衍生物：其中：R 2是氢，NR'R“，C 1-7烷基，芳基C 1-7烷基或C 3-10环烷基; R4是氨基，C1-7烷基，C2-7烯基，C3-10环烷基，C3-10环烯基，芳基，杂环，芳基烷基，杂环取代的C1-7烷基或C3-10环烷基C1-7烷基; R5是氢或C1-7烷基，或R5和R4与它们所连接的氮原子一起形成杂环; Y是单键，C1-7亚烷基，C2-7亚烯基或C2-7亚炔基; R6是卤素，杂芳基或芳基; R'和R“各自独立地为氢，C 1-7烷基 - 羰基或C 1-7烷基; 条件是当R 2为H且R 5为H时，R 4不为被吗啉代取代的苯基，并且条件是当NR 4 R 5为哌嗪基时，所述NR 4 R 5为未取代或被甲基或乙酰基取代的; 用于治疗病毒感染的药学上可接受的加成盐，立体异构体，单或二-N-氧化物，溶剂合物或前体药物。

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