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1. 发明申请

US20120157660A1 NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR 审中-公开
标题翻译：与蛋白激酶受体结合的新肽
公开(公告)号：US20120157660A1
公开(公告)日：2012-06-21
申请号：US12859204
申请日：2010-08-18
申请人： Christopher P. Holmes , Qun Yin , Genet Zemede , Ashok Bhandari , David Tumelty , Guy Lalonde , Palani Balu , Peter J. Schatz , William J. Dower , Anjan Chakrabarti , Yaohua S. Dong , Brian T. Frederick , Nicholas C. Wrighton
发明人： Christopher P. Holmes , Qun Yin , Genet Zemede , Ashok Bhandari , David Tumelty , Guy Lalonde , Palani Balu , Peter J. Schatz , William J. Dower , Anjan Chakrabarti , Yaohua S. Dong , Brian T. Frederick , Nicholas C. Wrighton
IPC分类号： C07K14/00 , C07K7/08
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译：本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞生成相关的疾病的治疗方法。还提供了包含本发明的肽化合物的药物组合物。

2. 发明授权

US07741062B2 Epitope-captured antibody display 失效
标题翻译：表位捕获抗体显示
公开(公告)号：US07741062B2
公开(公告)日：2010-06-22
申请号：US12420001
申请日：2009-04-07
申请人： William J. Dower , Steven E. Cwirla
发明人： William J. Dower , Steven E. Cwirla
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , C07K16/28 , C07K16/2878 , C40B30/04 , G01N33/531 , G01N33/6845 , G01N33/6857 , G01N2035/00158 , G01N2600/00
摘要： Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed protein and which have an open binding site for a target protein. Thus, a segment of the nucleic acid encodes for an epitope that is shared by the expressed polypeptide and the target protein. The reagents can be utilized individually or as part of a library or an array to bind target proteins within protein samples to form one or more complexes. By determining the sequence of the segment of the heterologous nucleic acid of a package within a complex, one can identify the target protein since the segment encodes for an epitope that is shared by the expressed and target proteins.
摘要翻译：提供了用于检测样品中靶蛋白的试剂和方法。试剂包括可复制的遗传包装，显示在由包装所携带的异源核酸表达的包装外表面上的蛋白质，以及与表达的蛋白质复合的一种或多种抗体，并且具有用于靶蛋白。因此，一段核酸编码由表达的多肽和靶蛋白共享的表位。试剂可以单独使用或作为文库或阵列的一部分来结合蛋白质样品中的靶蛋白以形成一种或多种复合物。通过确定复合物内的包装的异源核酸的片段的序列，可以鉴定靶蛋白，因为片段编码由表达的和靶蛋白共享的表位。

3. 发明申请

US20090221442A1 SUBSTRATES AND SCREENING METHODS FOR TRANSPORT PROTEINS 审中-公开
标题翻译：运输蛋白的基质和筛选方法
公开(公告)号：US20090221442A1
公开(公告)日：2009-09-03
申请号：US12172801
申请日：2008-07-14
申请人： William J. Dower , Mark Gallop , Ronald W. Barrett , Kenneth C. Cundy , Tania Chernov-Rogan
发明人： William J. Dower , Mark Gallop , Ronald W. Barrett , Kenneth C. Cundy , Tania Chernov-Rogan
IPC分类号： C40B30/06
CPC分类号： G01N33/5088 , A61K49/0004 , C07C271/22 , C07C2603/18 , C07D271/08 , C07D277/32 , C07D311/16 , C07K1/047 , C12N15/1034 , C12N15/1086 , C40B40/00 , G01N33/5008 , G01N33/533 , G01N33/566 , G01N33/92
摘要： A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
摘要翻译：提供了用于测定测试化合物的文库作为载体蛋白质（包括载体型和受体型转运蛋白）的转运蛋白质的配体和/或底物的多种方法。公开了体外和体内筛选方法。还提供了筛选DNA文库以鉴定编码转运蛋白的成员的方法。还提供了包括通过筛选方法鉴定的化合物的药物组合物。

4. 发明申请

US20090137419A1 Sequencing of surface immobilized polymers utilizing microfluorescence detection 审中-公开
标题翻译：利用微荧光检测法测定表面固定化聚合物
公开(公告)号：US20090137419A1
公开(公告)日：2009-05-28
申请号：US12325799
申请日：2008-12-01
申请人： William J. Dower , Stephen P.A. Fodor
发明人： William J. Dower , Stephen P.A. Fodor
IPC分类号： C40B30/04
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6823 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2537/157 , C12Q2533/101 , C12Q2565/537 , C12Q2563/107 , C12Q2565/513 , C12Q2537/143 , C12Q2565/518
摘要： Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid substrate.
摘要翻译：用于同时并行序列分析大量生物聚合物大分子的方法。装置和方法可以在重复化学中使用荧光标记来测定固相固定化聚合物上的末端单体。专门识别末端单体的试剂用于在固体基质上的限定位置上标记聚合物。

5. 发明授权

US07459275B2 Sequencing of surface immobilized polymers utilizing microfluorescence detection 失效
标题翻译：利用微荧光检测法测定表面固定化聚合物
公开(公告)号：US07459275B2
公开(公告)日：2008-12-02
申请号：US11446575
申请日：2006-06-02
申请人： William J. Dower , Stephen P. A. Fodor
发明人： William J. Dower , Stephen P. A. Fodor
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6823 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2537/157 , C12Q2533/101 , C12Q2565/537 , C12Q2563/107 , C12Q2565/513 , C12Q2537/143 , C12Q2565/518
摘要： Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid substrate.
摘要翻译：用于同时并行序列分析大量生物聚合物大分子的方法。装置和方法可以在重复化学中使用荧光标记物来测定固相固定化聚合物上的末端单体。专门识别末端单体的试剂用于在固体基质上的限定位置上标记聚合物。

6. 发明授权

US07413536B1 Substrates and screening methods for transport proteins 失效
标题翻译：转运蛋白的底物和筛选方法
公开(公告)号：US07413536B1
公开(公告)日：2008-08-19
申请号：US09661927
申请日：2000-09-14
申请人： William J. Dower , Mark A. Gallop , Ronald W. Barrett , Kenneth C. Cundy , Tania Chernov-Rogan
发明人： William J. Dower , Mark A. Gallop , Ronald W. Barrett , Kenneth C. Cundy , Tania Chernov-Rogan
IPC分类号： C40B30/04
CPC分类号： G01N33/5088 , A61K49/0004 , C07C271/22 , C07C2603/18 , C07D271/08 , C07D277/32 , C07D311/16 , C07K1/047 , C12N15/1034 , C12N15/1086 , C40B40/00 , G01N33/5008 , G01N33/533 , G01N33/566 , G01N33/92
摘要： A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
摘要翻译：提供了用于测定测试化合物的文库作为载体蛋白质（包括载体型和受体型转运蛋白）的转运蛋白质的配体和/或底物的多种方法。公开了体外和体内筛选方法。还提供了筛选DNA文库以鉴定编码转运蛋白的成员的方法。还提供了包括通过筛选方法鉴定的化合物的药物组合物。

7. 发明申请

US20070281910A1 Salicyl alcohol creatine phosphate prodrugs, compositions and uses thereof 审中-公开
标题翻译：水杨酸肌酸磷酸酯前药，组合物和用途
公开(公告)号：US20070281910A1
公开(公告)日：2007-12-06
申请号：US11810985
申请日：2007-06-06
申请人： Noa Zerangue , Qingzhi Gao , William J. Dower
发明人： Noa Zerangue , Qingzhi Gao , William J. Dower
IPC分类号： C07F9/02 , A61K31/66
CPC分类号： C07F9/657154
摘要： Membrane permeable prodrugs of creatine phosphate, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate or pharmaceutical compositions thereof are disclosed.
摘要翻译：本发明公开了磷酸肌酸的可渗透膜的前体药物，包含可渗透磷酸肌酸前药的药物组合物，以及治疗疾病如缺血，心力衰竭和神经变性疾病的方法，包括施用磷酸肌酸前药或其药物组合物。

8. 发明授权

US06582908B2 Oligonucleotides 失效
标题翻译：寡核苷酸
公开(公告)号：US06582908B2
公开(公告)日：2003-06-24
申请号：US09519090
申请日：2000-03-06
申请人： Stephen P.A. Fodor , Dennis W. Solas , William J. Dower , Xiaohua C. Huang
发明人： Stephen P.A. Fodor , Dennis W. Solas , William J. Dower , Xiaohua C. Huang
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6827 , C12Q1/6837 , C12Q3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/00 , G03F7/265 , G11C13/0014 , C12Q2565/519 , C12Q2545/114 , C12Q2535/131
摘要： The present invention provides a number of oligonucleotide sequences which can be used for a wide variety of analyses applicable to the diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics. In certain embodiments these oligonucleotides may be used as probes to be used in, for example, gene expression analysis.
摘要翻译：本发明提供了许多寡核苷酸序列，其可用于广泛分析，适用于受分子相互作用性质（包括化学，生物学，医学和医学诊断）影响的各种领域。在某些实施方案中，这些寡核苷酸可以用作例如基因表达分析中使用的探针。

9. 发明授权

US06576424B2 Arrays and methods for detecting nucleic acids 失效
标题翻译：用于检测核酸的数组和方法
公开(公告)号：US06576424B2
公开(公告)日：2003-06-10
申请号：US09768626
申请日：2001-01-25
申请人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
发明人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
IPC分类号： C12Q168
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2565/513 , C12Q2565/507 , C12Q2545/101 , C12Q2525/185 , C12Q2565/514 , C12Q2563/173 , C12Q2563/119 , C12Q2563/149 , C12Q2525/151 , C12Q2525/179 , C12Q2525/204
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
摘要翻译：本发明提供了用于测序，指纹和绘制生物大分子（通常为生物聚合物）的方法和装置。该方法利用多种序列特异性识别试剂，其也可用于生物样品的分类和表征其来源。

10. 发明授权

US06506362B1 Labeled compounds that bind to a thrombopoietin receptor 有权
标题翻译：与血小板生成素受体结合的标记化合物
公开(公告)号：US06506362B1
公开(公告)日：2003-01-14
申请号：US09832230
申请日：2001-04-10
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3819
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译：描述了结合并激活血小板生成素受体的肽和肽模拟物。这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

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