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1. 发明申请

US20140206788A1 ADDITION-FRAGMENTATION AGENTS 有权
标题翻译：附加分类代理
公开(公告)号：US20140206788A1
公开(公告)日：2014-07-24
申请号：US14239160
申请日：2012-08-14
申请人： Guy D. Joly , Ahmed S. Abuelyaman , Bradley D. Craig , Afshin Falsafi , Joel D. Oxman , Larry R. Krepski , William H. Moser , Serkan Yurt , Ann R. Fornof
发明人： Guy D. Joly , Ahmed S. Abuelyaman , Bradley D. Craig , Afshin Falsafi , Joel D. Oxman , Larry R. Krepski , William H. Moser , Serkan Yurt , Ann R. Fornof
IPC分类号： C09D133/08 , C08F30/08 , C08F22/10 , C09D133/04 , C08F30/02
CPC分类号： C09D133/08 , C08F2/38 , C08F22/10 , C08F30/02 , C08F30/08 , C08F222/10 , C08F2438/03 , C09D133/04 , C08F220/20 , C08F2222/102 , C08F230/02 , C08F265/06 , C08F220/34 , C08F2222/1013
摘要： Addition-fragmentation agents of the formula are disclosed having the following functional groups: 1) a labile addition-fragmentation group that can cleave and reform to relieve strain, 2) a free-radically polymerizable group, and 3) a surface-modifying functional group that associates with the surface of a substrate.
摘要翻译：公开了具有以下官能团的式的加成裂解剂：1）可以切割和改性以减轻应变的不稳定加成断裂基团，2）可自由基聚合的基团，和3）表面改性官能团其与基底的表面相关联。

2. 发明授权

US08697873B2 Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines 有权
标题翻译：酰胺取代的咪唑并吡啶，咪唑并喹啉和咪唑并吡啶
公开(公告)号：US08697873B2
公开(公告)日：2014-04-15
申请号：US10599159
申请日：2005-03-24
申请人： Larry R. Krepski , Joseph F. Dellaria, Jr. , Daniel E. Duffy , David T. Amos , Bernhard M. Zimmermann , William H. Moser
发明人： Larry R. Krepski , Joseph F. Dellaria, Jr. , Daniel E. Duffy , David T. Amos , Bernhard M. Zimmermann , William H. Moser
IPC分类号： C07D401/02 , A61K31/437
CPC分类号： C07D471/04 , C07D413/14 , C07D471/02 , C07D471/12 , C07D471/14
摘要： Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，其在1-位具有酰胺基取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗公开了包括病毒和肿瘤疾病在内的疾病。

3. 发明申请

US20120035209A1 Hydroxy Substituted 1H-Imidazopyridines and Methods 审中-公开
标题翻译：羟基取代的1H-咪唑并吡啶及其方法
公开(公告)号：US20120035209A1
公开(公告)日：2012-02-09
申请号：US13277619
申请日：2011-10-20
申请人： Joseph F. Dellaria, JR. , William H. Moser , Matthew R. Radmer , George W. Griesgraber
发明人： Joseph F. Dellaria, JR. , William H. Moser , Matthew R. Radmer , George W. Griesgraber
IPC分类号： A61K31/437 , A61P35/00 , A61P31/12 , C07D471/04
CPC分类号： C07D471/04
摘要： Hydroxy substituted 1H-imidazo[4,5-c]pyridin-4-amines, with a hydroxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在2-位羟基取代的1H-咪唑并[4,5-c]吡啶-4-胺，含有这些化合物的药物组合物，制备化合物的方法，中间体和这些化合物的使用方法如公开了用于在动物中诱导细胞因子生物合成和用于治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。

4. 发明申请

US20110269965A1 Ring Closing and Related Methods and Intermediates 失效
标题翻译：闭环及其相关方法和中间体
公开(公告)号：US20110269965A1
公开(公告)日：2011-11-03
申请号：US11887525
申请日：2006-03-31
申请人： David S. Hays , Sonja S. Mackey , William H. Moser , Doris D. Stoermer , Matthew R. Radmer , Shri Niwas
发明人： David S. Hays , Sonja S. Mackey , William H. Moser , Doris D. Stoermer , Matthew R. Radmer , Shri Niwas
IPC分类号： C07D233/90 , C07D471/04
CPC分类号： C07D471/04 , C07D233/90 , C07D471/14
摘要： Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:
摘要翻译：可用于制备下式化合物的方法和中间体：和式I化合物的制备，优选包括形成下式的中间体化合物：

5. 发明申请

US20090318435A1 PYRAZOLOPYRIDINES AND ANALOGS THEREOF 有权
标题翻译：吡咯并吡啶及其类似物
公开(公告)号：US20090318435A1
公开(公告)日：2009-12-24
申请号：US12480471
申请日：2009-06-08
申请人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
发明人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
IPC分类号： A61K31/5377 , C07D413/14 , C07D471/14 , C07D471/04 , A61K31/437 , A61P37/04
CPC分类号： C07D471/04 , C07D471/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译：吡唑并吡啶-4-胺，吡唑并喹啉-4-胺，吡唑啉酮-4-胺和6,7,8,9-四氢吡唑并喹啉-4-胺，含有化合物，中间体，制备方法和使用方法的药物组合物这些化合物作为用于在动物中诱导或抑制细胞因子生物合成以及治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。

6. 发明申请

US20090075980A1 Pyrazolopyridines and Analogs Thereof 审中-公开
标题翻译：吡唑并吡啶类及其类似物
公开(公告)号：US20090075980A1
公开(公告)日：2009-03-19
申请号：US11887496
申请日：2006-03-31
申请人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
发明人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
IPC分类号： A61K31/473 , C07D471/04 , C07D403/14 , C07D413/14 , A61K31/5377 , A61K31/55 , A61P35/00 , A61K31/5513 , A61K31/541 , A61K31/496 , C07D417/14 , C07D243/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译：吡唑并吡啶-4-胺，吡唑啉-4-胺，吡唑啉-4-基胺，6,7,8,9-四氢吡唑并喹啉-4-胺及其前药，含有这些化合物的药物组合物，中间体，制备方法和方法这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

7. 发明授权

US07220758B2 Ether substituted imidazopyridines 失效
标题翻译：醚取代的咪唑并吡啶
公开(公告)号：US07220758B2
公开(公告)日：2007-05-22
申请号：US11459489
申请日：2006-07-24
申请人： Joseph F. Dellaria , Kyle J. Lindstrom , Luke T. Dressel , Philip D. Heppner , John R. Jacobsen , Joan T. Moseman , William H. Moser , Matthew R. Radmer , Doris Stoermer
发明人： Joseph F. Dellaria , Kyle J. Lindstrom , Luke T. Dressel , Philip D. Heppner , John R. Jacobsen , Joan T. Moseman , William H. Moser , Matthew R. Radmer , Doris Stoermer
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译：在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。还公开了制备可用于制备化合物的化合物和中间体的方法。

8. 发明授权

US5316133A Movable floor mechanism 失效
标题翻译：可移动地板机构
公开(公告)号：US5316133A
公开(公告)日：1994-05-31
申请号：US72175
申请日：1993-06-03
申请人： William H. Moser
发明人： William H. Moser
IPC分类号： B60P1/38 , B65G17/08 , B65G17/06
CPC分类号： B65G17/08 , B60P1/38 , B65G2201/02
摘要： A movable floor mechanism (10) is adapted for placement in the bed of a truck. The mechanism includes a frame (12, 14, 16), a movable floor (26) encircling the frame, a motor (24) attached to the frame, and at least one sprocket (22) attached to the motor, the sprocket engaging the movable floor. The frame is made from a pair of longitudinal beams (12), a plurality of lateral beams (14) attached between the longitudinal beams, and at least one guide rail (16) attached to the lateral beams. The movable floor (26) is made from a plurality of interengaged floor elements (26a, 26b). Each of the floor elements is made from a central portion, a connector, and a receptor, wherein the receptor is configured to accept the connector of an adjacent floor element. The receptor contains an axial slot (52) and the connector contains a pin receiving hole (56). When two floor elements are engaged the axial slot of the first floor element and pin receiving hole of the second floor element align to receive a pin (54).
摘要翻译：可动地板机构（10）适于放置在卡车的床中。该机构包括框架（12,14,16），围绕框架的可动底板（26），附接到框架的电动机（24）和附接到电动机的至少一个链轮（22），链轮接合活动地板框架由一对纵向梁（12），附接在纵向梁之间的多个横向梁（14）和连接到横向梁的至少一个导轨（16）制成。活动地板（26）由多个互相接合的地板元件（26a，26b）制成。每个地板元件由中心部分，连接器和接收器制成，其中接收器被配置为接受相邻地板元件的连接器。所述接收器包含轴向槽（52），并且所述连接器包含销接收孔（56）。当两个地板元件接合时，第一楼层元件的轴向槽和第二楼层元件的销接收孔对齐以接收销（54）。

9. 发明授权

US4518303A Movable floor self-unloading trailer 失效
标题翻译：活动地板自卸拖车
公开(公告)号：US4518303A
公开(公告)日：1985-05-21
申请号：US482423
申请日：1983-04-06
申请人： William H. Moser
发明人： William H. Moser
IPC分类号： B60P1/38
CPC分类号： B60P1/38
摘要： A movable floor self-unloading trailer has a frame with rotatable sprocket shafts supported at each end and engaged with an endless conveyor type floor comprising a series of side-by-side floor plates which are interconnected by hinge pins and are each provided with a plurality of laterally spaced bearing shoes which slide in elongated longitudinally extending channel shaped bearing rails. The movable floor includes a drive sprocket assembly characterized by a series of sprocket segments which are configured to engage the floor plates along the bearing hinge portions. The movable floor is particularly adapted for use in conjunction with a modified general cargo type truck trailer which is adapted to handle containerized as well as bulk material loads.
摘要翻译：可移动地板自卸式拖车具有框架，该框架具有可旋转的链轮轴，每个端部都支撑着可动链轮轴，并与环形输送机地板接合，该地板包括一系列并排的底板，它们通过铰链销相互连接并分别设有多个的横向间隔的轴承滑块，其在细长的纵向延伸的通道形状的轴承轨道中滑动。活动地板包括驱动链轮组件，其特征在于一系列链轮段，其构造成沿轴承铰链部分接合底板。可移动地板特别适用于改装的通用货物型卡车拖车，适用于处理集装箱和散装物料的装载。

10. 发明申请

US20160008234A1 DENTAL COMPOSITIONS COMPRISING ADDITION-FRAGMENTATION AGENTS 有权
公开(公告)号：US20160008234A1
公开(公告)日：2016-01-14
申请号：US14239566
申请日：2012-08-14
申请人： Guy D. Joly , Ahmed S. Abuelyaman , Bradley D. Craig , Afshin Falsafi , Joel D. Oxman , Larry R. Krepski , William H. Moser , Serkan Yurt
发明人： Guy D. Joly , Ahmed S. Abuelyaman , Bradley D. Craig , Afshin Falsafi , Joel D. Oxman , Larry R. Krepski , William H. Moser , Serkan Yurt
IPC分类号： A61K6/083 , A61C13/15 , C08L33/08
CPC分类号： A61K6/083 , A61C19/003 , A61K6/0023 , A61K6/0835 , C08L33/08 , C08L33/10
摘要： A curable dental composition comprising an addition-fragmentation agent and a curable dental resin is disclosed.

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