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    • 9. 发明授权
    • Compounds and methods for controlling fungi
    • 用于控制真菌的化合物和方法
    • US08759356B2
    • 2014-06-24
    • US12772248
    • 2010-05-03
    • Francis E. TisdellJames M. RengaWilliam C. LoMaurice C. H. YapDavid H. YoungGeorge E. Davis
    • Francis E. TisdellJames M. RengaWilliam C. LoMaurice C. H. YapDavid H. YoungGeorge E. Davis
    • A01N43/54C07D239/42C07D401/04A61K31/505C07D239/30
    • A61K31/505A01N43/54C07D239/30
    • Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula 1: wherein, X1 is N or C—R3; X2 is N or C—R4 provided that X1 and X2 are not both N; R1-R7 are H, CN, CHO, —SCN, NO2, F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-amino, C1-C4-alkyl-S(O)═NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO2, CHO, —SCN, S(O)n-C1-C4-alkyl (where n=0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-thioalkyl, halo-C1-C4-thioalkyl, C1-C4-alkylacyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-imino, hydroxy-imino; C1-C4-alkyl-S(O)═NH; and Q is a substituted or unsubstituted aryl, substituted or unsubstituted heterocycle wherein the substituents of Q are taken from R1-R7.
    • 本文公开的各个方面涉及式1的芳基取代的氨基嘧啶:其中,X 1是N或C-R 3; X2是N或C-R4,条件是X1和X2不同时为N; R 1 -R 7是H,CN,CHO,-SCN,NO 2,F,Cl,Br,I,取代或未取代的C 1 -C 4 - 烷基,取代或未取代的卤代-C 1 -C 4烷基,取代或未取代的C 1 -C 4 - 烷氧基,取代或未取代的卤代-C 1 -C 4 - 烷氧基,取代或未取代的C 1 -C 4 - 硫代烷基,取代或未取代的卤代-C 1 -C 4 - 硫代烷基,取代或未取代的C 3 -C 7 - 环烷基,取代或未取代的C 2 -C 4 烯基,C 2 -C 4 - 炔基,取代或未取代的C 1 -C 4酰基烷基,C 1 -C 4酰氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基 - 氨基,C 1 -C 4烷基-S(O) 取代或未取代的芳基,取代或未取代的杂环,其中取代基是以下F,Cl,Br,OH,CN,NO 2,CHO,-SCN,S(O)n-C 1 -C 4烷基中的一种或多种 n = 0-2),C 1 -C 4 - 烷基,卤代-C 1 -C 4 - 烷基,C 1 -C 4烷基胺,C 1 -C 4 - 烷氧基,卤代-C 1 -C 4 - 烷氧基,C 1 -C 4 - C 1 -C 4烷氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基亚氨基,羟基亚氨基, C 1 -C 4烷基-S(O)= NH; 并且Q是取代或未取代的芳基,取代或未取代的杂环,其中Q的取代基取自R 1 -R 7。