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1. 发明申请

US20120045812A1 PRODUCTION OF ISOPRENE UNDER NEUTRAL pH CONDITIONS 审中-公开
标题翻译：在中性pH条件下生产异丙苯
公开(公告)号：US20120045812A1
公开(公告)日：2012-02-23
申请号：US13204612
申请日：2011-08-05
申请人： Martien H. Bergsma , Anthony R. Calabria , Gopal K. Chotani , William A. Cuevas , Gang Duan , Sung H. Lee , Ying Qian , Vivek Sharma , Jayarama K. Shetty , Bruce A. Strohm , Paula Johanna Maria Teunissen , Hongxian Xu
发明人： Martien H. Bergsma , Anthony R. Calabria , Gopal K. Chotani , William A. Cuevas , Gang Duan , Sung H. Lee , Ying Qian , Vivek Sharma , Jayarama K. Shetty , Bruce A. Strohm , Paula Johanna Maria Teunissen , Hongxian Xu
IPC分类号： C12P5/02 , C12M1/00
CPC分类号： C12P5/007 , C12N9/2428 , C12P5/026 , C12P19/02 , C12P19/14 , C12Y302/01003
摘要： Embodiments of the present disclosure relate to a process for producing isoprene from a starch substrate by saccharification and/or fermentation. The saccharification is effectively catalyzed by a glucoamylase at a pH in the range of 5.0 to 8.0. At a pH of 6.0 or above, the glucoamylase possesses at least 50% activity relative to its maximum activity. The saccharification and fermentation may be performed as a simultaneous saccharification and fermentation (SSF) process.
摘要翻译：本公开的实施方案涉及通过糖化和/或发酵从淀粉底物生产异戊二烯的方法。糖化在pH为5.0至8.0的范围内由葡糖淀粉酶有效地催化。在6.0或更高的pH下，葡糖淀粉酶相对于其最大活性具有至少50％的活性。糖化和发酵可以作为同时糖化和发酵（SSF）方法进行。

2. 发明授权

US08048859B2 Use of repeat sequence protein polymers in personal care compositions 失效
标题翻译：在个人护理组合物中使用重复序列蛋白聚合物
公开(公告)号：US08048859B2
公开(公告)日：2011-11-01
申请号：US11860911
申请日：2007-09-25
申请人： Manoj Kumar , William A. Cuevas
发明人： Manoj Kumar , William A. Cuevas
IPC分类号： A61K38/19 , A61K38/17
CPC分类号： A61K8/0212 , A61K8/0229 , A61K8/64 , A61K38/1709 , A61K2800/28 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q3/00 , A61Q3/02 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/002 , A61Q19/10
摘要： A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.
摘要翻译：提供个人护理组合物并且包括有效量的重复序列蛋白质聚合物。个人护理组合物可以是护发组合物，护肤组合物，指甲护理组合物，化妆品组合物或非处方药物组合物。

3. 发明申请

US20090314286A1 Geobacillus Stearothermophilus Alpha-Amylase (AmyS) Variants with Improved Properties 有权
标题翻译：具有改善性质的嗜热脂肪芽孢杆菌α-淀粉酶（AmyS）变体
公开(公告)号：US20090314286A1
公开(公告)日：2009-12-24
申请号：US12477028
申请日：2009-06-02
申请人： William A. Cuevas , Sang-Kyu Lee , Sandra W. Ramer , Andrew Shaw , Amr R. Toppozada , David E. Estell , Sura H. Hadi , Walter Weyler
发明人： William A. Cuevas , Sang-Kyu Lee , Sandra W. Ramer , Andrew Shaw , Amr R. Toppozada , David E. Estell , Sura H. Hadi , Walter Weyler
IPC分类号： C08B31/00 , C12N9/28
CPC分类号： D06M16/003 , C11D3/38609 , C11D3/38618 , C11D3/3869 , C12N9/2417 , C12Y302/01001 , D06L4/40
摘要： Described are variants of a parent α-amylase that exhibits an alteration in at least one of the following properties relative to said parent α-amylase: specific activity, substrate specificity, substrate binding, substrate cleavage, thermal stability, pH-dependent activity, pH-dependent stability, oxidative stability, Ca2+ dependency, pI, and wash performance. The variants are suitable for starch conversion, ethanol production, laundry washing, dish washing, hard surface cleaning, textile desizing, and/or sweetener production.
摘要翻译：描述了相对于所述亲本α-淀粉酶在下列性质中的至少一个表现出改变的母体α-淀粉酶的变体：比活性，底物特异性，底物结合，底物切割，热稳定性，pH依赖性活性，pH 依赖稳定性，氧化稳定性，Ca2 +依赖性，pI和洗涤性能。这些变体适用于淀粉转化，乙醇生产，洗衣，洗碗，硬表面清洗，纺织品退浆和/或甜味剂生产。

4. 发明授权

US07297678B2 Use of repeat sequence protein polymers in personal care compositions 失效
标题翻译：在个人护理组合物中使用重复序列蛋白聚合物
公开(公告)号：US07297678B2
公开(公告)日：2007-11-20
申请号：US10800179
申请日：2004-03-12
申请人： Manoj Kumar , William A. Cuevas
发明人： Manoj Kumar , William A. Cuevas
IPC分类号： A61K38/00 , C07K2/00
CPC分类号： A61K8/0212 , A61K8/0229 , A61K8/64 , A61K38/1709 , A61K2800/28 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q3/00 , A61Q3/02 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/002 , A61Q19/10
摘要： A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.
摘要翻译：提供个人护理组合物并且包括有效量的重复序列蛋白质聚合物。个人护理组合物可以是护发组合物，护肤组合物，指甲护理组合物，化妆品组合物或非处方药物组合物。

5. 发明授权

US5683911A Method of enhancing the delignification and/or bleaching of pulp 失效
标题翻译：增加纸浆脱木质素和/或漂白的方法
公开(公告)号：US5683911A
公开(公告)日：1997-11-04
申请号：US426505
申请日：1995-04-21
申请人： Elizabeth A. Bodie , William A. Cuevas , Marja Koljonen
发明人： Elizabeth A. Bodie , William A. Cuevas , Marja Koljonen
IPC分类号： A23K1/165 , C12N9/24 , C12P21/00 , C12R1/00 , C12R1/645 , C12S3/08 , D21C5/00 , D21C9/10 , C12N9/26
CPC分类号： C12Y302/01032 , C12N9/248 , C12Y302/01008 , D21C5/005 , Y10S426/807 , Y10S435/822
摘要： The present invention relates to novel xylanases purified from the microorganism, Microtetraspora flexuosa. Each biochemically unique xylanase is thermostable and has optimal activity in alkaline conditions. The present invention is also directed to methods that utilize either the whole enzyme system or one or more of the above purified thermostable xylanases obtained from Microtetraspora flexuosa. These enzymes are excellent candidates for enhancing the delignification and bleaching of pulp. Furthermore, treating the pulp with the above enzymes prior to bleaching may reduce the amount of chlorine containing and/or peroxide chemicals required in the bleaching process.
摘要翻译：本发明涉及从微生物Microtetraspora flexuosa中纯化的新型木聚糖酶。每种生物化学独特的木聚糖酶是耐热的，并且在碱性条件下具有最佳的活性。本发明还涉及利用从Microtetraspora flexuosa获得的整个酶系统或一种或多种上述纯化的热稳定性木聚糖酶的方法。这些酶是增强纸浆脱木质素和脱色的极好候选物。此外，在漂白之前用上述酶处理纸浆可以减少漂白过程中所需的含氯和/或过氧化物的量。

6. 发明授权

US09040278B2 Production of glucose from starch using alpha-amylases from Bacillus subtilis 有权
标题翻译：使用来自枯草芽孢杆菌的α-淀粉酶从淀粉生产葡萄糖
公开(公告)号：US09040278B2
公开(公告)日：2015-05-26
申请号：US12478266
申请日：2009-06-04
申请人： Luis G. Cascao-Pereira , Regina Chin , William A. Cuevas , David A. Estell , Sang-Kyu Lee , Michael J. Pepsin , Scott D. Power , Sandra W. Ramer , Carol A. Requadt , Andrew Shaw , Amr R. Toppozada , Louise Wallace
发明人： Luis G. Cascao-Pereira , Regina Chin , William A. Cuevas , David A. Estell , Sang-Kyu Lee , Michael J. Pepsin , Scott D. Power , Sandra W. Ramer , Carol A. Requadt , Andrew Shaw , Amr R. Toppozada , Louise Wallace
IPC分类号： C12N9/28 , C12P19/14 , C12P7/06 , C08B37/00 , C07H21/04 , C12P19/02 , C11D3/22 , D06L1/14 , C11D3/386
CPC分类号： C12P19/02 , C11D3/221 , C11D3/386 , C12N9/2417 , D06L1/14 , Y02E50/17
摘要： An α-amylase from Bacillus subtilis (AmyE) produces significant amounts of glucose from various carbohydrate substrates, including vegetable starch, maltoheptaose, and maltotriose. Among other things, this advantageous property allows AmyE or variants thereof to be used in a saccharification reaction having a reduced or eliminated requirement for glucoamylase. The reduction or elimination of the glucoamylase requirement significantly improves the efficiency of the production of ethanol or high fructose corn syrup, for example.
摘要翻译：来自枯草芽孢杆菌（AmyE）的α-淀粉酶从各种碳水化合物底物（包括植物淀粉，麦芽庚糖和麦芽三糖）产生显着量的葡萄糖。除此之外，这种有利的性质允许AmyE或其变体用于具有葡糖淀粉酶降低或消除的糖化反应中。葡糖淀粉酶需求的减少或消除显着提高了乙醇或高果糖玉米糖浆的生产效率。

7. 发明授权

US08323945B2 Variant alpha-amylases from Bacillus subtilis and methods of uses, thereof 有权
标题翻译：来自枯草芽孢杆菌的变体α-淀粉酶及其使用方法
公开(公告)号：US08323945B2
公开(公告)日：2012-12-04
申请号：US12479427
申请日：2009-06-05
申请人： Luis G. Cascao-Pereira , William A. Cuevas , David A. Estell , Sang-Kyu Lee , Scott D. Power , Sandra W. Ramer , Amr Toppozada , Louise Wallace
发明人： Luis G. Cascao-Pereira , William A. Cuevas , David A. Estell , Sang-Kyu Lee , Scott D. Power , Sandra W. Ramer , Amr Toppozada , Louise Wallace
IPC分类号： C12N9/28 , C12N9/34 , C12P19/14 , C12P19/20 , C07H21/04 , C07K1/00 , C11D3/386 , C11D3/00 , C11D1/00
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2408 , C12P7/14 , C12P19/02 , C12P19/14 , G01N11/00 , Y02E50/17
摘要： Alpha-amylases from Bacillus subtilis (AmyE), variants thereof, nucleic acids encoding the same, and host cells comprising the nucleic acids are provided. Methods of using AmyE or variants thereof are disclosed, including liquefaction and/or saccharification of starch. Such methods may yield sugars useful for ethanol production or high fructose corn syrup production. In some cases, the amylases can be used at low pH, in the absence of calcium, and/or in the absence of a glucoamylase.
摘要翻译：提供了来自枯草芽孢杆菌（AmyE）的α-淀粉酶，其变体，编码它们的核酸和包含核酸的宿主细胞。公开了使用AmyE或其变体的方法，包括淀粉的液化和/或糖化。这样的方法可能产生可用于乙醇生产或高果糖玉米糖浆生产的糖。在一些情况下，淀粉酶可以在低pH，不存在钙的情况下和/或不存在葡糖淀粉酶的情况下使用。

8. 发明授权

US08084240B2 Geobacillus stearothermophilus α-amylase (AmyS) variants with improved properties 有权
标题翻译：具有改善性质的嗜热脂肪芽孢杆菌α-淀粉酶（AmyS）变体
公开(公告)号：US08084240B2
公开(公告)日：2011-12-27
申请号：US12477028
申请日：2009-06-02
申请人： William A Cuevas , Sang-Kyu Lee , Sandra W Ramer , Andrew Shaw , Amr R Toppozada , David E Estell , Sura H Hadi
发明人： William A Cuevas , Sang-Kyu Lee , Sandra W Ramer , Andrew Shaw , Amr R Toppozada , David E Estell , Sura H Hadi
IPC分类号： C12N9/28 , C07K14/00 , C12P21/00 , C12Q1/40
CPC分类号： D06M16/003 , C11D3/38609 , C11D3/38618 , C11D3/3869 , C12N9/2417 , C12Y302/01001 , D06L4/40
摘要： Described are variants of a parent α-amylase that exhibits an alteration in at least one of the following properties relative to said parent α-amylase: specific activity, substrate specificity, substrate binding, substrate cleavage, thermal stability, pH-dependent activity, pH-dependent stability, oxidative stability, Ca2+ dependency, pI, and wash performance. The variants are suitable for starch conversion, ethanol production, laundry washing, dish washing, hard surface cleaning, textile desizing, and/or sweetener production.
摘要翻译：描述了亲本α-淀粉酶的变体，其相对于所述亲本α-淀粉酶在至少一个以下性质中具有改变：比活性，底物特异性，底物结合，底物切割，热稳定性，pH依赖性活性，pH 依赖稳定性，氧化稳定性，Ca2 +依赖性，pI和洗涤性能。这些变体适用于淀粉转化，乙醇生产，洗衣，洗碗，硬表面清洗，纺织品退浆和/或甜味剂生产。

9. 发明申请

US20090305935A1 PRODUCTION OF GLUCOSE FROM STARCH USING ALPHA-AMYLASES FROM BACILLUS SUBTILIS 有权
标题翻译：使用来自BACILLUS SUBTILIS的ALPHA-AMYLASES从淀粉生产葡萄糖
公开(公告)号：US20090305935A1
公开(公告)日：2009-12-10
申请号：US12478266
申请日：2009-06-04
申请人： Luis G. CASCAO-PEREIRA , Regina CHIN , William A. CUEVAS , David A. ESTELL , Sang-Kyu LEE , Michael J. PEPSIN , Scott D. POWER , Sandra W. RAMER , Carol A. REQUADT , Andrew SHAW , Amr R. TOPPOZADA , Louise WALLACE
发明人： Luis G. CASCAO-PEREIRA , Regina CHIN , William A. CUEVAS , David A. ESTELL , Sang-Kyu LEE , Michael J. PEPSIN , Scott D. POWER , Sandra W. RAMER , Carol A. REQUADT , Andrew SHAW , Amr R. TOPPOZADA , Louise WALLACE
IPC分类号： C11D3/386 , C12P19/14 , C12P7/14 , C12P19/24 , D06L1/00
CPC分类号： C12P19/02 , C11D3/221 , C11D3/386 , C12N9/2417 , D06L1/14 , Y02E50/17
摘要： An α-amylase from Bacillus subtilis (AmyE) produces significant amounts of glucose from various carbohydrate substrates, including vegetable starch, maltoheptaose, and maltotriose. Among other things, this advantageous property allows AmyE or variants thereof to be used in a saccharification reaction having a reduced or eliminated requirement for glucoamylase. The reduction or elimination of the glucoamylase requirement significantly improves the efficiency of the production of ethanol or high fructose corn syrup, for example.
摘要翻译：来自枯草芽孢杆菌（AmyE）的α-淀粉酶从各种碳水化合物底物（包括植物淀粉，麦芽七糖和麦芽三糖）产生显着量的葡萄糖。除此之外，这种有利的性质允许AmyE或其变体用于具有葡糖淀粉酶降低或消除的糖化反应中。葡糖淀粉酶需求的减少或消除显着提高了乙醇或高果糖玉米糖浆的生产效率。

10. 发明授权

US6132716A Thermostable xylanases from Microtetraspora flexuosa as a feed additive 失效
标题翻译：作为饲料添加剂来自Microtetraspora flexuosa的热稳定性木聚糖酶
公开(公告)号：US6132716A
公开(公告)日：2000-10-17
申请号：US732242
申请日：1997-04-07
申请人： Andrew J. Morgan , Kathleen A. Clarkson , Elizabeth A. Bodie , William A. Cuevas
发明人： Andrew J. Morgan , Kathleen A. Clarkson , Elizabeth A. Bodie , William A. Cuevas
IPC分类号： A23K1/165 , C12N9/24 , C12P21/00 , C12R1/00 , C12R1/645 , C12S3/08 , D21C5/00 , D21C9/10 , A61K38/47 , A23L1/28
CPC分类号： C12Y302/01032 , C12N9/248 , C12Y302/01008 , D21C5/005 , Y10S426/807 , Y10S435/822
摘要： A feed additive that provides increased feed conversion ratio is prepared containing a physiologically acceptable carrier and one or more of five thermostable xylanases from Microtetraspora flexuosa, preferably strain ATCC 35864. The xylanases can tolerate heating for one minute in a water bath at 95.degree. C. without substantial loss of activity, and tolerate alkaline conditions in a pH range of 7.0-10.0. A feed for poultry or pigs contains the xylanases in a feed containing at least 20% by weight cereal. The five xylanases have the following characteristics: (i) a molecular weight of about 33,100 daltons, a pI of about 8.5, and a maximum activity at pH 7.0-7.5 at a temperature of about 70.degree. C.; (ii) a molecular weight of about 33,300 daltons, a pI of about 7.5, and a maximum activity at pH 7.0-7.5 at a temperature of about 65.degree. C.; (iii) a molecular weight of about 31,000 daltons, a pI of about 6.2, and a maximum activity at pH 7.5 at a temperature of about 65.degree. C.; (iv) a molecular weight of about 50,000 daltons, a pI of about 5.8, and a maximum activity at pH 7.5 at a temperature of about 65.degree. C.; and (v) a molecular weight of about 35,000 daltons, a pI of about 5.3, and a maximum activity at pH 7.5 at a temperature of about 70.degree. C.
摘要翻译： PCT No.PCT / EP95 / 01628 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT 1995年4月28日PCT PCT。 WO95 / 29997 PCT出版物日期1995年11月9日制备提供增加的饲料转化率的饲料添加剂，其含有生理学上可接受的载体和来自Microtetraspora flexuosa的五种热稳定性木聚糖酶中的一种或多种，优选菌株ATCC 35864.木聚糖酶可以耐受在水浴中加热1分钟在95℃下没有显着的活性损失，并且在7.0-10.0的pH范围内耐受碱性条件。家禽或猪的饲料在含有至少20重量％谷物的饲料中含有木聚糖酶。五种木聚糖酶具有以下特征：（i）约33,100道尔顿的分子量，约8.5的pI值，在约70℃的温度下在pH 7.0-7.5的最大活性。（ii）约33,300道尔顿的分子量，约7.5的pI，在约65℃的温度下在pH 7.0-7.5的最大活性。（iii）约31,000道尔顿的分子量，约6.2的pI，在约65℃的温度下在7.5的最大活性。（iv）约50,000道尔顿的分子量，约5.8的pI，在约65℃的温度下在pH7.5的最大活性。和（v）约35,000道尔顿的分子量，约5.3的pI，在约70℃的温度下在pH7.5的最大活性。

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