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1. 发明申请

US20060188453A1 Use of substitute 2,4-bis (alkylamino)pyrimidines 失效
公开(公告)号：US20060188453A1
公开(公告)日：2006-08-24
申请号：US10565545
申请日：2004-07-16
申请人： Sophie Marquais-Bienewald , Werner Holzl , Andrea Preuss , Andreas Mehlin
发明人： Sophie Marquais-Bienewald , Werner Holzl , Andrea Preuss , Andreas Mehlin
IPC分类号： A61K31/517 , A61K31/505 , A61K8/49
CPC分类号： A61Q17/005 , A01N43/54 , A61K8/4953 , A61L2/16 , A61L2/18 , A61Q11/00 , C11D3/28 , C11D3/48 , D06M13/355 , Y10T442/2525
摘要： The use of 2,4—bis(alkylamino)pyrimidines of formula (1) R1 is C1-C12alkyl or C6-C10laryl; R2 is hydrogen or C1-C12alkyl; or R1 and R2 together form a radical of formula (1a) R′ and R″ are each independently of the other hydrogen, C1-C6alkyl or C1-C6alkoxy, R3 and R5 are each independently of the other hydrogen or C1-C8alkyl; R4 is C1-C20alkyl, unsubstituted phenyl, C6-C10aryl, C6-C10aryl—C1-C6alkyl, hydroxy—C1-C6alkyl, di—C1-C6al—ky—lamino—C 1-C6alkyl, mono—C1-C6alkylamino—C1-C6alkyl,—(CH2)2—(O—(CH2)2)1—4-OH or —(CH2)2-(O—(CH2)2)1—4-NH2; R6 is C1-C20alkyl, C6-C10aryl, C6-C10aryl—C1-C6alkyl, hydroxy—C1-C6alkyl, di—C1C6alkylamino—C1-C6alkyl, mono—C1-C6alkylamino—C1-C 6alkyl, —(CH2)2-(O—(CH2)2)1—4-OH or —(CH2)2-(O—(CH2)2)1—4-NH2; or R3 and R 4 and/or R5 and R6, together form a pyrrolidine, piperidine, hexamethyleneimine or morpholine ring; in the antimicrobial treatment of surfaces.

2. 发明申请

US20090286878A1 POLYOL DERIVED ANTI-MICROBIAL AGENTS AND COMPOSITIONS 审中-公开
标题翻译：聚氨酯衍生的抗微生物剂和组合物
公开(公告)号：US20090286878A1
公开(公告)日：2009-11-19
申请号：US12465799
申请日：2009-05-14
申请人： Stewart Todd Elder , Fadi Khawam , Xinyu Huang , Werner Holzl
发明人： Stewart Todd Elder , Fadi Khawam , Xinyu Huang , Werner Holzl
IPC分类号： A01N37/12 , A01P1/00
CPC分类号： A01N37/36 , A01N37/44 , C07C229/12
摘要： Anti-microbial compositions are provided which comprise as an antimicrobial agent at least one compound derived from a select polyol containing at least 3 hydroxy groups wherein one or more, and often two or more, of the hydroxyls are derivitized to form certain ether, ester, carbonate or carbamate groups which groups may bear additional functionality. Novel antimicrobial compounds of this class are also provided. The compositions are effective against a variety of pathogens including fungi, Gram positive bacteria and Gram negative bacteria and are expected to have low human toxicity. Applications for the polyglycerol anti-microbial agents and compositions include those involving human and plant contact, such as cosmetics, hair care products, textiles and plant protections, as well as in applications with much less human contact, such as plastics, coatings, wood, paper and other materials of construction.
摘要翻译：提供了抗微生物组合物，其包含至少一种衍生自含有至少3个羟基的选择多元醇的化合物作为抗微生物剂，其中一个或多个，并且通常两个或更多个羟基被衍生以形成某些醚，酯，碳酸酯或氨基甲酸酯基，这些基团可以具有附加的功能。还提供了这一类的新型抗菌化合物。该组合物对各种病原体有效，包括真菌，革兰氏阳性菌和革兰氏阴性细菌，预计人体毒性低。聚甘油抗微生物剂和组合物的应用包括涉及人和植物接触的那些，例如化妆品，护发产品，纺织品和植物保护，以及在人类接触少得多的应用中，例如塑料，涂料，木材，纸等施工材料。

3. 发明申请

US20060052375A1 Bis-alkylbenzylamines 审中-公开
标题翻译：双烷基苄胺
公开(公告)号：US20060052375A1
公开(公告)日：2006-03-09
申请号：US10531232
申请日：2003-10-14
申请人： Sophie Marquais-Bienewald , Werner Holzl , Andrea Preuss , Andreas Mehlin , Frederic Brunner
发明人： Sophie Marquais-Bienewald , Werner Holzl , Andrea Preuss , Andreas Mehlin , Frederic Brunner
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/4178 , C07D413/02 , C07D401/02 , C07D403/02
CPC分类号： C07C211/27 , A01N33/04 , A01N33/08 , A01N43/16 , A01N43/46 , A01N43/60 , A01N43/84 , A61K8/41 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/005 , C07C211/35 , C07C215/14 , C07C217/08 , C07C2601/14 , C07D295/02 , C07D295/023 , C07D295/185 , C07D307/52
摘要： Compounds of Formula (1), wherein R1 is hydrogen; C1-C18alkyl; trifluoromethyl; C3-C8cycloalkyl; phenylC1-C5alkyl; phenyl-C1-C5alkoxy; mono- or di-N-C1-C5alkamino-C1-C5alkyl; amino-di-N-C1-C5alkylamino-C1-C5alkyl; C1-C5alkoxy-C1-C5alkyl; R2 is C2-C20alkyl; hydroxy-C1-C20alkyl; phenyl; phenyl-C1-C5alkyl; phenyl-C1-C5alkoxy; mono- or di-N-C1-C5alkylamino-C1-C5alkyl; amino-di-N-C1-C5alkylamino-C1-C5alkyl; or heteroaryl-C1-C5alkyl; or R1 and R2 together with the nitrogen atom bonding them form a 5- to 7-membered monocyclic heterocyclic ring; are described. They are suitable for the antimicrobial treatment of surfaces, especially as antimicrobial active ingredients against gram-positive and gram-negative bacteria.
摘要翻译：式（1）的化合物，其中R 1是氢; C 1 -C 18烷基; 三氟甲基 C 3 -C 8环烷基; 苯基C 1 -C 5烷基; 苯基-C 1 -C 5烷氧基; 单或二-N- C 1 -C 5烷基氨基-C 1 -C 5烷基; 氨基 - 二-N-C 1 -C 5烷基氨基-C 1 -C 5烷基; C 1 -C 5烷氧基-C 1 -C 5烷基; C 1 -C 5烷基; R 2是C 2 -C 20烷基; 羟基-C 1 -C 20烷基; 苯基; 苯基-C 1 -C 5烷基; 苯基-C 1 -C 5烷氧基; 单或二-N- C 1 -C 5烷基氨基-C 1 -C 5烷基; 氨基 - 二-N-C 1 -C 5烷基氨基-C 1 -C 5烷基; 或杂芳基-C 1 -C 5烷基; 或R 1和R 2与与它们键合的氮原子一起形成5-至7-元单环杂环; 被描述。它们适用于表面的抗微生物处理，特别是抗革兰氏阳性和革兰氏阴性菌的抗微生物活性成分

4. 发明申请

US20050267109A1 Pyridyl-triazine derivatives as microbiocidal active substances 失效
标题翻译：吡啶基 - 三嗪衍生物作为杀微生物活性物质
公开(公告)号：US20050267109A1
公开(公告)日：2005-12-01
申请号：US10522925
申请日：2003-07-22
申请人： Werner Holzl , Gabriele Eichacker , Andrea Preuss
发明人： Werner Holzl , Gabriele Eichacker , Andrea Preuss
IPC分类号： A01N43/66 , A61K8/49 , A61Q11/00 , C07D401/04 , A61K31/53 , C07D43/02
CPC分类号： C07D401/04 , A01N43/66 , A61K8/4966 , A61Q11/00
摘要： Triazine derivatives of formula (1) wherein R1 is C1-C20alkyl; C3-C7cycloalkyl; or C1-C20perfl C1-C20alkyl; or C3-C7cycloalkyl; and R3 is hydrogen; C1-C20alkyl; C3-C7cycloalkyl; C1-C20perfluoroalky; C1-C20alkyl-carbonyl; C3-C7cycloalkyl-carbonyl; C1-C20perfluoroalkyl-carbonyl; or phenylcarbonyl; are described. The compounds exhibit pronounced action against gram-positive and gram-negative bacteria and also against yeasts and moulds. They are also suitable for treating or preventing biofilms on human tooth surfaces and oral mucosa.
摘要翻译：式（1）的三嗪衍生物，其中R 1是C 1 -C 20烷基; C 3 -C 7环烷基; 或C 1 -C 20烷基;或C 1至C 20 -C 20烷基; 或C 3 -C 7环烷基; 和R 3是氢; C 1 -C 20烷基; C 1 -C 20烷基; C 3 -C 7环烷基; C 1 -C 20全氟烷基; C 1 -C 20烷基 - 羰基; C 3 -C 7环烷基 - 羰基; C 1 -C 20 -C 20全氟烷基 - 羰基; 或苯基羰基; 被描述。化合物对革兰氏阳性和革兰氏阴性细菌以及酵母和霉菌都表现出明显的作用。它们也适用于治疗或预防人牙齿表面和口腔粘膜上的生物膜。

5. 发明申请

US20050143387A1 4-Aminopyrimidines and their use for the antimicrobial treatment of surfaces 失效
标题翻译： 4-氨基嘧啶及其用于抗菌处理的表面
公开(公告)号：US20050143387A1
公开(公告)日：2005-06-30
申请号：US10507800
申请日：2003-03-10
申请人： Sophie Marquais-Bienewald , Werner Holzl , Wolfgang Haap , Andrea Preuss , Andreas Mehlin
发明人： Sophie Marquais-Bienewald , Werner Holzl , Wolfgang Haap , Andrea Preuss , Andreas Mehlin
IPC分类号： A01N43/54 , A01N43/60 , A01N43/62 , A01N43/78 , A01N43/84 , A61K8/49 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61P31/02 , A61P31/04 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/04 , C09D5/14 , C09D7/12 , C09D11/00 , C09D201/00 , C11D3/28 , C11D3/48 , C07D43/02
CPC分类号： C07D239/42 , A01N43/54 , A01N43/78 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/04
摘要： Use of 4-aminopyrimidines of formula (1), wherein R1, R2, R3, R4 and R5 are as described in the description in the antimicrobial treatment of surfaces.
摘要翻译：使用式（1）的4-氨基嘧啶，其中R 1，R 2，R 3，R 4，/ SO 3 >和R 5>如在表面的抗微生物处理中的描述中所描述的。

6. 发明申请

US20050124579A1 Benzyl alcohol derivatives 审中-公开
标题翻译：苄醇衍生物
公开(公告)号：US20050124579A1
公开(公告)日：2005-06-09
申请号：US10507965
申请日：2003-03-13
申请人： Werner Holzl , Jurgen Koppold , Sophie Marquais-Bienewald , Andrea Preuss
发明人： Werner Holzl , Jurgen Koppold , Sophie Marquais-Bienewald , Andrea Preuss
IPC分类号： A61K8/30 , A01N31/14 , A01N31/16 , A01N55/00 , A01N55/10 , A61K8/00 , A61K8/34 , A61K8/55 , A61K8/58 , A61K31/085 , A61K31/09 , A61K31/695 , A61P31/02 , A61Q5/00 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q19/10 , C07C43/23 , C07C43/253 , C07F7/08 , C07F7/04 , A61K31/075
CPC分类号： A61Q17/005 , A01N31/14 , A01N31/16 , A01N55/00 , A61K8/34 , A61Q5/00 , A61Q11/00 , A61Q15/00 , C07C43/23 , C07C43/253 , C07F7/081
摘要： The use of benzyl alcohol derivatives of the formula CH2OH in which R, R2, R3, n and m have the meanings given in claim 1, as microbicidal active substances is described. The compounds exhibit a marked effect against pathogenic Gram-positive and Gram-negative bacteria. They are therefore suitable for the antimicrobial treatment, in particular preservation and disinfection, of surfaces.
摘要翻译：描述了其中R，R2，R3，n和m具有权利要求1中给出的含义的式CH 2 OH的苄醇衍生物用作杀微生物活性物质。该化合物对致病性革兰氏阳性和革兰氏阴性细菌表现出显着的作用。因此，它们适用于表面的抗菌处理，特别是保存和消毒。

7. 发明申请

US20070196407A1 Alkoxyphenylcarboxylic acid derivatives 审中-公开
标题翻译：烷氧基苯基羧酸衍生物
公开(公告)号：US20070196407A1
公开(公告)日：2007-08-23
申请号：US10589383
申请日：2005-02-11
申请人： Werner Holzl , Andrea Preuss
发明人： Werner Holzl , Andrea Preuss
IPC分类号： A61K31/265
CPC分类号： A61K8/368 , A61K8/39 , A61Q11/00 , A61Q15/00 , A61Q17/005
摘要： Use of compounds of formula (I) wherein R1 is substituted or unsubstituted C8-C30alkyl or substituted or unsubstituted C3-C7cyclo-alkyl, and R2 is H, COOH or substituted or unsubstituted O-C1-C30alkyl, in the antimicrobial treatment of surfaces, in the preservation of cosmetics, household products, textiles and plastics, and for use in disinfectants.
摘要翻译：使用式（I）的化合物，其中R 1是取代或未取代的C 8 -C 30烷基或取代或未取代的C 1 -C 10烷基， 3个C 7 - 环烷基，R 2是H，COOH或取代或未取代的OC 1 -C 3 在表面的抗微生物处理中，在化妆品，家用产品，纺织品和塑料的保存中并用于消毒剂中。

8. 发明授权

US09458380B2 5H-furan-2-one derivatives for stabilization of organic material 有权
标题翻译： 5H-呋喃-2-酮衍生物用于有机材料的稳定化
公开(公告)号：US09458380B2
公开(公告)日：2016-10-04
申请号：US14114538
申请日：2012-04-25
申请人： Walter Fischer , Abdel-Ilah Basbas , Kai-Uwe Schoning , Cinzia Tartarini , Werner Holzl , Bruno Rotzinger
发明人： Walter Fischer , Abdel-Ilah Basbas , Kai-Uwe Schoning , Cinzia Tartarini , Werner Holzl , Bruno Rotzinger
IPC分类号： C09K15/06 , C08K5/1535 , C08K5/52 , C07D307/58 , C07D307/64 , C07D405/12
CPC分类号： C08K5/1535 , C07D307/58 , C07D307/64 , C07D307/68 , C07D405/12 , C08K5/13 , C08K5/1345 , C08K5/3435 , C08K5/357 , C08K5/52 , C08K5/526 , C09K15/06 , C09K15/12 , C09K15/20 , C09K15/22 , C09K15/30
摘要： A composition, which comprises a) an organic material susceptible to oxidative, thermal or light-induced degradation; and b) a compound of formula I (Formula I) (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently from each other H, C1-C8-alkyl, C4-C8-cycloalkyl, phenyl, C1-C4-alkoxy or halogen; n is 1, 2, 3, or 4; and when n is 1 A is —C(=0)-OR′1, —C(=0)-N(R′2)(R′3), —CN, phenyl, which is unsubstituted or substituted by one or more C1-C8-alkyl, C4-C8-alkoxy, C5-C7-cycloalkyl or halogen, —H or —S02-phenyl; when n is 2 A is —C(=0)-O—Z1—O—C(=0)-, —C(=0)-N(R″1)—Z2—N(R″2)—C(=0)- or piperazine-N,N′-biscarbonyl.

9. 发明申请

US20090036543A1 Preservatives 审中-公开
标题翻译：防腐剂
公开(公告)号：US20090036543A1
公开(公告)日：2009-02-05
申请号：US11988589
申请日：2006-07-05
申请人： Werner Holzl , Andrea Preuss
发明人： Werner Holzl , Andrea Preuss
IPC分类号： A01N31/08 , A01N31/16 , A01P1/00
CPC分类号： A61Q17/005 , A61K8/347 , A61K2800/524
摘要： The present invention relates to the use of compounds of the formula (1) wherein all substitutents have the meanings as defined in claim 1 as preservatives in personal care, pharmaceutical and household; the preservatives can also be used as in-can preservatives.
摘要翻译：本发明涉及式（1）化合物的用途，其中所有取代基具有权利要求1中定义的含义作为个人护理，制药和家庭中的防腐剂; 防腐剂也可以作为罐内防腐剂使用。

10. 发明申请

US20070258912A1 Use of Fluorescent Whitening Agents as Antimicrobials 审中-公开
标题翻译：使用荧光增白剂作为抗菌剂
公开(公告)号：US20070258912A1
公开(公告)日：2007-11-08
申请号：US11659549
申请日：2005-08-03
申请人： Werner Holzl , Andrea Preuss , Olof Wallquist
发明人： Werner Holzl , Andrea Preuss , Olof Wallquist
IPC分类号： A61K8/00 , A61K31/10 , A61K31/135 , A61K31/41 , A61Q11/00 , A61K31/465 , A61K31/53
CPC分类号： A61K8/41 , A01N61/00 , A61K8/40 , A61K8/46 , A61K8/466 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4966 , A61K8/498 , A61Q11/00 , A61Q11/02 , C11D3/42 , C11D3/48 , D21H21/36
摘要： Use of fluorescent whitening agents for whitening and the antimicrobial treatment of surfaces, and preservation of cosmetics, household products, personal care products, textiles, paper and starting materials of paper, plastics and disinfectants.
摘要翻译：使用荧光增白剂进行美白和表面的抗微生物处理，以及化妆品，家用产品，个人护理产品，纺织品，纸张和纸张，塑料和消毒剂原料的保存。

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