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1. 发明专利

IL243699D0 Tricyclic benzoxaborole compound, preparation method therefor, and use thereof 未知
公开(公告)号：IL243699D0
公开(公告)日：2016-04-21
申请号：IL24369916
申请日：2016-01-20
申请人： DONG A ST CO LTD , SOON HOE KIM , WEON BIN IM , SEUNG BUM HA , JUNG SANG PARK , MI YEON KIM , SUNG HAK CHOI , HYUN JUNG SUNG
IPC分类号： C07F20060101
摘要： The present invention relates to a novel tricyclic benzoxaborole derivative, a preparation method thereof, and use of antibiotics pharmaceutical composition including the same as an active ingredient.

2. 发明授权

US07816379B2 Oxazolidinone derivatives 有权
标题翻译：恶唑烷酮衍生物
公开(公告)号：US07816379B2
公开(公告)日：2010-10-19
申请号：US10596412
申请日：2004-12-17
申请人： Jae Keol Rhee , Weon Bin Im , Chong Hwan Cho , Sung Hak Choi , Tae Ho Lee
发明人： Jae Keol Rhee , Weon Bin Im , Chong Hwan Cho , Sung Hak Choi , Tae Ho Lee
IPC分类号： A61K31/4439 , C07D413/14
CPC分类号： A61K31/4439 , A61K31/675 , C07D263/32 , C07D413/14 , C07D417/10 , C07D417/14 , C07F9/653 , C07F9/65583
摘要： The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.
摘要翻译：本发明涉及恶唑烷酮的新衍生物，其方法和药物组合物，其包含用于抗生素的衍生物。本发明的恶唑烷酮衍生物显示出对广谱细菌的抑制活性和较低的毒性。通过使具有羟基的化合物与氨基酸或磷酸酯反应制备的前药在对水的溶解性方面具有优异的效果。此外，本发明的衍生物可以相对于各种人和动物病原体，包括葡萄球菌，肠球菌和链球菌等革兰阳性菌，拟杆菌和梭菌等厌氧菌，耐结核菌如结核分枝杆菌和鸟分枝杆菌。因此，包含恶唑烷酮的组合物用于抗生素中。

3. 发明授权

US09221790B2 Benzamide derivatives 有权
标题翻译：苯甲酰胺衍生物
公开(公告)号：US09221790B2
公开(公告)日：2015-12-29
申请号：US13641867
申请日：2011-04-18
申请人： Soon-Hoe Kim , Weon-Bin Im , Sung-Hak Choi , Sun-Ho Choi , Ju-Hee Sohn , Hyun-Jung Sung , Mi-Yeon Kim , Kang-Hun Cho , Tae-Kyoung Sohn
发明人： Soon-Hoe Kim , Weon-Bin Im , Sung-Hak Choi , Sun-Ho Choi , Ju-Hee Sohn , Hyun-Jung Sung , Mi-Yeon Kim , Kang-Hun Cho , Tae-Kyoung Sohn
IPC分类号： C07D211/26 , C07D401/06
CPC分类号： C07D401/06 , C07D211/26
摘要： The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HT4 receptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HT4 receptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HT4 receptors.
摘要翻译：本发明提供了一种新的苯甲酰胺衍生物或其药学上可接受的盐，其制备方法和含有该活性成分的5-HT 4受体激动剂。本发明的苯甲酰胺衍生物对5-HT 4受体具有优异的亲和力，降低胃排空时间和低毒性的能力，因此对于治疗与5-HT 4受体相关的各种疾病具有治疗上的有效性。

4. 发明授权

US08420676B2 Oxazolidinone derivatives 有权
标题翻译：恶唑烷酮衍生物
公开(公告)号：US08420676B2
公开(公告)日：2013-04-16
申请号：US12211655
申请日：2008-09-16
申请人： Jae Keol Rhee , Weon Bin Im , Chong Hwan Cho , Sung Hak Choi , Tae Ho Lee
发明人： Jae Keol Rhee , Weon Bin Im , Chong Hwan Cho , Sung Hak Choi , Tae Ho Lee
IPC分类号： A61K31/4439 , C07D413/14
CPC分类号： A61K31/4439 , A61K31/675 , C07D263/32 , C07D413/14 , C07D417/10 , C07D417/14 , C07F9/653 , C07F9/65583
摘要： The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as, Staphylococci, Enterococci and Streptococci anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.
摘要翻译：本发明涉及恶唑烷酮的新衍生物，其方法和药物组合物，其包含用于抗生素的衍生物。本发明的恶唑烷酮衍生物显示出对广谱细菌的抑制活性和较低的毒性。通过使具有羟基的化合物与氨基酸或磷酸酯反应制备的前药在对水的溶解性方面具有优异的效果。此外，本发明的衍生物相对于各种人和动物病原体，包括革兰氏阳性菌如葡萄球菌，肠球菌和链球菌厌氧微生物如拟杆菌和梭菌，以及耐酸微生物如结核分枝杆菌和鸟分枝杆菌。因此，包含恶唑烷酮的组合物用于抗生素中。

5. 发明申请

US20130085160A1 NOVEL BENZAMIDE DERIVATIVES 有权
标题翻译：新的苯甲酸衍生物
公开(公告)号：US20130085160A1
公开(公告)日：2013-04-04
申请号：US13641867
申请日：2011-04-18
申请人： Soon-Hoe Kim , Weon-Bin Im , Sung-Hak Choi , Sun-Ho Choi , Ju-Hee Sohn , Hyun-Jung Sung , Mi-Yeon Kim , Kang-Hun Cho , Tae-Kyoung Sohn
发明人： Soon-Hoe Kim , Weon-Bin Im , Sung-Hak Choi , Sun-Ho Choi , Ju-Hee Sohn , Hyun-Jung Sung , Mi-Yeon Kim , Kang-Hun Cho , Tae-Kyoung Sohn
IPC分类号： C07D401/06 , C07D211/26
CPC分类号： C07D401/06 , C07D211/26
摘要： The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HT4 receptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HT4 receptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HT4 receptors.
摘要翻译：本发明提供了一种新的苯甲酰胺衍生物或其药学上可接受的盐，其制备方法和含有该活性成分的5-HT 4受体激动剂。本发明的苯甲酰胺衍生物对5-HT 4受体具有优异的亲和力，降低胃排空时间和低毒性的能力，因此对于治疗与5-HT 4受体相关的各种疾病具有治疗上的有效性。

6. 发明申请

US20100105727A1 NOVEL BENZAMIDE DERIVATIVES AND PROCESS FOR THE PREPARTION THEREOF 审中-公开
标题翻译：新的苯甲酸衍生物及其制备方法
公开(公告)号：US20100105727A1
公开(公告)日：2010-04-29
申请号：US12531677
申请日：2008-03-14
申请人： Moo-Hi Yoo , Jae-Keol Rhee , Weon-Bin Im , Sung-Hak Choi , Eun-Jung Kim , Jung-Sang Park , Sun-Ho Choi , Tae-Kyoung Shon , Hyun-Jung Sung , Ja-Young Kim , Ju-Hee Shon
发明人： Moo-Hi Yoo , Jae-Keol Rhee , Weon-Bin Im , Sung-Hak Choi , Eun-Jung Kim , Jung-Sang Park , Sun-Ho Choi , Tae-Kyoung Shon , Hyun-Jung Sung , Ja-Young Kim , Ju-Hee Shon
IPC分类号： A61K31/47 , C07D401/02 , A61K31/4545 , A61K31/454 , C07D405/02 , A61K31/4525 , C07D215/00 , A61P1/00 , A61P25/00 , A61P9/00 , A61P3/10
CPC分类号： C07D401/12 , C07D211/58 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/12
摘要： The present invention provides a novel benzamide derivative represented by formula 1 and an isomer, a pharmaceutically acceptable salt or hydrate thereof, and a composition for activating a 5-HT 4 receptor comprising the same, as an active ingredient. Benzamide derivatives of the present invention has superior affinity for 5-HT 4 receptors, capability to reduce the gastric evacuation time, capability to alleviate ventricular tachycardia, ventricular fibrillation, torsades de pointes and QT prolongation, and low toxicity. Therefore, benzamide derivatives of the present invention are therapeutically effective for digestive system diseases.
摘要翻译：本发明提供了一种由式1表示的新型苯甲酰胺衍生物及其异构体，药学上可接受的盐或水合物，以及用于活化含有其的作为活性成分的5-HT 4 S受体的组合物。本发明的苯甲酰胺衍生物对5-HT4α受体具有优异的亲和力，降低胃抽空时间，减轻室性心动过速，心室颤动，尖端扭转型室性心动过速和QT延长的能力以及低毒性。因此，本发明的苯甲酰胺衍生物对于消化系统疾病是治疗有效的。

7. 发明申请

US20090192197A1 NOVEL OXAZOLIDINONE DERIVATIVES 有权
标题翻译：新型氧杂环丁酮衍生物
公开(公告)号：US20090192197A1
公开(公告)日：2009-07-30
申请号：US12211655
申请日：2008-09-16
申请人： Jae Keol Rhee , Weon Bin Im , Chong Hwan Cho , Sung Hak Choi , Tae Ho Lee
发明人： Jae Keol Rhee , Weon Bin Im , Chong Hwan Cho , Sung Hak Choi , Tae Ho Lee
IPC分类号： A61K31/4439 , C07D413/14 , A61P3/04
CPC分类号： A61K31/4439 , A61K31/675 , C07D263/32 , C07D413/14 , C07D417/10 , C07D417/14 , C07F9/653 , C07F9/65583
摘要： The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.
摘要翻译：本发明涉及恶唑烷酮的新衍生物，其方法和药物组合物，其包含用于抗生素的衍生物。本发明的恶唑烷酮衍生物显示出对广谱细菌的抑制活性和较低的毒性。通过使具有羟基的化合物与氨基酸或磷酸酯反应制备的前药在对水的溶解性方面具有优异的效果。此外，本发明的衍生物可以相对于各种人和动物病原体，包括葡萄球菌，肠球菌和链球菌等革兰阳性菌，拟杆菌和梭菌等厌氧菌，耐结核菌如结核分枝杆菌和鸟分枝杆菌。因此，包含恶唑烷酮的组合物用于抗生素中。

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