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1. 发明授权

US09244082B2 Detection and treatment of LRP4-associated neurotransmission disorders 有权
标题翻译：检测和治疗LRP4相关的神经传递障碍
公开(公告)号：US09244082B2
公开(公告)日：2016-01-26
申请号：US13452018
申请日：2012-04-20
申请人： Lin Mei , Wen-Cheng Xiong , Bin Zhang , Chengyong Shen
发明人： Lin Mei , Wen-Cheng Xiong , Bin Zhang , Chengyong Shen
IPC分类号： A61K39/395 , A61K38/00 , C07K1/00 , G01N33/68 , C12Q1/68 , G01N33/564 , G01N33/92
CPC分类号： G01N33/6896 , C07K16/28 , C07K2317/76 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/564 , G01N33/6893 , G01N33/92 , G01N2333/705 , G01N2500/04 , G01N2800/28 , G01N2800/38
摘要： The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.
摘要翻译：本发明包括用于检测神经传递或发育障碍的方法，包括但不限于对乙酰胆碱受体（AChR）和/或肌肉特异性酪氨酸激酶（MuSK）的自身抗体血清阴性的重症肌无力，所述方法包括检测与LRP4结合的自身抗体或其表位。还包括用于治疗患有神经传递障碍的个体的方法，所述方法包括在体液中检测结合LRP4的单个自身抗体或其表位，并向患者施用有效量的免疫抑制剂和/ 或另一适当的治疗方式。还包括与LRP4自身抗体结合的抗体和用于检测神经传递或发育障碍的试剂盒。

2. 发明申请

US20100136004A1 COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗神经疾病的组合物和方法
公开(公告)号：US20100136004A1
公开(公告)日：2010-06-03
申请号：US12624035
申请日：2009-11-23
申请人： LIN MEI , WEN-CHENG XIONG , RAN-SOOK WOO , XIAOMING LI
发明人： LIN MEI , WEN-CHENG XIONG , RAN-SOOK WOO , XIAOMING LI
IPC分类号： A61K39/395 , A61K33/14 , A61K33/00 , A61K31/7088 , C07H21/04 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24
CPC分类号： A61K39/3955 , A61K38/177 , A61K38/1883 , A61K38/45
摘要： Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote GABA release, i.e., GABAergic transmission. The ErbB4 ligand can be an agonist ligand or an antagonist ligand depending on the disorder to be treated. Methods for treating neurological disorders are also provided. Representative disorders that can be treated include, but are not limited to schizophrenia, epilepsy, depression and anxiety, insomnia, stroke, pain, bipolar, autism, or a combination thereof. By increasing GABA release a sedative effective can be induced in the subject. Methods for inducing a stimulatory effect in a subject are also provided. In these methods, an effective amount of an ErbB4 antagonist ligand is administered to the subject to reduce or inhibit GABA release in the subject.
摘要翻译：提供了用于调节受试者中GABA释放的方法和组合物。优选的实施方案提供含有有效量的ErbB4配体的组合物以增强或促进GABA释放，即GABA能传递。根据待治疗的病症，ErbB4配体可以是激动剂配体或拮抗剂配体。还提供了治疗神经障碍的方法。可以治疗的代表性疾病包括但不限于精神分裂症，癫痫，抑郁和焦虑，失眠，中风，疼痛，双相，孤独症或其组合。通过增加GABA释放可以在受试者中诱导镇静作用。还提供了在受试者中诱导刺激作用的方法。在这些方法中，向受试者施用有效量的ErbB4拮抗剂配体以减少或抑制受试者中的GABA释放。

3. 发明申请

US20100260774A1 Netrin-1 Compositions and Methods of Use Thereof 有权
标题翻译： Netrin-1组合物及其使用方法
公开(公告)号：US20100260774A1
公开(公告)日：2010-10-14
申请号：US12740594
申请日：2008-11-03
申请人： Wen-Cheng Xiong , Jae-Ho Lee , Lin Mei
发明人： Wen-Cheng Xiong , Jae-Ho Lee , Lin Mei
IPC分类号： A61K38/02 , C07K16/18 , A61K39/395 , A61K31/7088 , A61K31/713 , A61K31/711 , A61K31/7105 , C07H21/04 , C07H21/02 , A61P15/18 , A61P15/16 , A61P15/08 , C12Q1/02
CPC分类号： A61K38/18 , G01N33/689 , G01N2333/475 , G01N2800/367
摘要： Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to inhibit or reduce fusion of male gametes with female gametes in a female subject Still another embodiment provides a method for diagnosing male infertility by determining the amount of netrin-1 in a sample of epididymal fluid or semen from a male subject, comparing the amount of netting-1 in the sample to levels of netrin-1 in samples of epididymal fluid or semen from fertile males, wherein levels of netrin-1 in the sample from the male subject that are higher or lower than levels of netrin-1 in samples from fertile males are indicative of male infertility in the male subject.
摘要翻译：提供男性或女性避孕方法和组合物。组合物包括有效量的netrin-1以减少或抑制雄性精液中的精子浓度或抑制或减少雄性配子与女性受试者的雌性配子的融合。另一个实施方案提供了一种通过确定雌性不育症的量来确定男性不育症的量的netrin-1在附睾液或精液样本中的比较，将来自可能的男性的附睾液或精液样品中的netting-1与netrin-1的水平进行比较，其中netrin-1 在男性受试者的样本中，来自可育男性样本中的netrin-1水平高于或低于男性受试者的男性不育症。

4. 发明申请

US20120039881A1 COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗神经疾病的组合物和方法
公开(公告)号：US20120039881A1
公开(公告)日：2012-02-16
申请号：US13278417
申请日：2011-10-21
申请人： Lin Mei , Wen-Cheng Xiong , Ran-Sook Woo , Xiaoming Li
发明人： Lin Mei , Wen-Cheng Xiong , Ran-Sook Woo , Xiaoming Li
IPC分类号： A61K39/395 , A61K38/18 , A61K39/00 , A61P25/22 , A61P25/18 , A61P25/08 , A61P25/24 , A61K38/45 , A61P25/00
CPC分类号： A61K39/3955 , A61K38/177 , A61K38/1883 , A61K38/45
摘要： Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote GABA release, i.e., GABAergic transmission. The ErbB4 ligand can be an agonist ligand or an antagonist ligand depending on the disorder to be treated. Methods for treating neurological disorders are also provided. Representative disorders that can be treated include, but are not limited to schizophrenia, epilepsy, depression and anxiety, insomnia, stroke, pain, bipolar, autism, or a combination thereof. By increasing GABA release a sedative effective can be induced in the subject. Methods for inducing a stimulatory effect in a subject are also provided. In these methods, an effective amount of an ErbB4 antagonist ligand is administered to the subject to reduce or inhibit GABA release in the subject.
摘要翻译：提供了用于调节受试者中GABA释放的方法和组合物。优选的实施方案提供含有有效量的ErbB4配体的组合物以增强或促进GABA释放，即GABA能传递。根据待治疗的病症，ErbB4配体可以是激动剂配体或拮抗剂配体。还提供了治疗神经障碍的方法。可以治疗的代表性疾病包括但不限于精神分裂症，癫痫，抑郁和焦虑，失眠，中风，疼痛，双相，孤独症或其组合。通过增加GABA释放可以在受试者中诱导镇静作用。还提供了在受试者中诱导刺激作用的方法。在这些方法中，向受试者施用有效量的ErbB4拮抗剂配体以减少或抑制受试者中的GABA释放。

5. 发明授权

US08524228B2 Netrin-1 compositions and methods of use thereof 有权
标题翻译： Netrin-1组合物及其使用方法
公开(公告)号：US08524228B2
公开(公告)日：2013-09-03
申请号：US12740594
申请日：2008-11-03
申请人： Wen-Cheng Xiong , Jae-Ho Lee , Lin Mei
发明人： Wen-Cheng Xiong , Jae-Ho Lee , Lin Mei
IPC分类号： A61K39/395 , A61K39/00 , C07K16/22
CPC分类号： A61K38/18 , G01N33/689 , G01N2333/475 , G01N2800/367
摘要： Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to inhibit or reduce fusion of male gametes with female gametes in a female subject Still another embodiment provides a method for diagnosing male infertility by determining the amount of netrin-1 in a sample of epididymal fluid or semen from a male subject, comparing the amount of netting-1 in the sample to levels of netrin-1 in samples of epididymal fluid or semen from fertile males, wherein levels of netrin-1 in the sample from the male subject that are higher or lower than levels of netrin-1 in samples from fertile males are indicative of male infertility in the male subject.
摘要翻译：提供男性或女性避孕方法和组合物。组合物包括有效量的netrin-1以减少或抑制雄性精液中的精子浓度或抑制或减少雄性配子与女性受试者的雌性配子的融合。另一个实施方案提供了一种通过确定雌性不育症的量来确定男性不育症的量的netrin-1在附睾液或精液样本中的比较，将来自可能的男性的附睾液或精液样品中的netting-1与netrin-1的水平进行比较，其中netrin-1 在男性受试者的样本中，来自可育男性样本中的netrin-1水平高于或低于男性受试者的男性不育症。

6. 发明申请

US20130108616A1 DETECTION AND TREATMENT OF LRP4-ASSOCIATED NEUROTRANSMISSION DISORDERS 有权
标题翻译：检测和治疗LRP4相关的神经递质病变
公开(公告)号：US20130108616A1
公开(公告)日：2013-05-02
申请号：US13452018
申请日：2012-04-20
申请人： Lin Mei , Wen-Cheng Xiong , Bin Zhang , Changyong Shen
发明人： Lin Mei , Wen-Cheng Xiong , Bin Zhang , Changyong Shen
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , C07K16/28 , C07K2317/76 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/564 , G01N33/6893 , G01N33/92 , G01N2333/705 , G01N2500/04 , G01N2800/28 , G01N2800/38
摘要： The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.
摘要翻译：本发明包括用于检测神经传递或发育障碍的方法，包括但不限于对乙酰胆碱受体（AChR）和/或肌肉特异性酪氨酸激酶（MuSK）的自身抗体血清阴性的重症肌无力，所述方法包括检测与LRP4结合的自身抗体或其表位。还包括用于治疗患有神经传递障碍的个体的方法，所述方法包括在体液中检测结合LRP4的单个自身抗体或其表位，并向患者施用有效量的免疫抑制剂和/ 或另一适当的治疗方式。还包括与LRP4自身抗体结合的抗体和用于检测神经传递或发育障碍的试剂盒。

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