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1. 发明申请

US20010033931A1 Porous inorganic/organic hybrid particles for chromatographic separations and process for its preparation 审中-公开
标题翻译：用于色谱分离的多孔无机/有机杂化颗粒及其制备方法
公开(公告)号：US20010033931A1
公开(公告)日：2001-10-25
申请号：US09858087
申请日：2001-05-14
申请人： Waters Investments Limited
发明人： Zhiping Jiang , Raymond P. Fisk
IPC分类号： B32B005/16 , B05D007/00
CPC分类号： B01J20/3204 , B01J20/103 , B01J20/28057 , B01J20/28083 , B01J20/28095 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3227 , B01J20/3259 , B01J20/3261 , B01J39/26 , B01J41/20 , Y10T428/2982 , Y10T428/2995
摘要： Novel material for chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material. In particular, the disclosure describes porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, which desirably may be surface modified, and which offer more efficient chromatographic separations than that known in the art.
摘要翻译：用于色谱分离的新型材料，其制备方法和含有色谱材料的分离装置。特别地，本公开描述了具有色谱增强孔几何形状的多孔无机/有机杂化颗粒，其理想地可以被表面改性，并且提供比本领域已知的更有效的色谱分离。

2. 发明申请

US20040048067A1 Porous hybrid particles with organic groups removed from the surface 有权
标题翻译：从表面除去有机基团的多孔杂化颗粒
公开(公告)号：US20040048067A1
公开(公告)日：2004-03-11
申请号：US10352582
申请日：2003-01-28
申请人： Waters Investments Limited
发明人： John E. O'Gara
IPC分类号： B32B027/04
CPC分类号： B01J20/283 , B01J20/103 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/285 , B01J20/286 , B01J20/287 , B01J20/3204 , B01J20/3212 , B01J20/3217 , B01J20/3227 , B01J20/3246 , B01J20/3272 , B01J2220/46 , B01J2220/54 , B01J2220/58 , C08G77/18 , C08K9/10 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995
摘要： A material for chromatographic separations, processes for its preparation, and separation devices containing the chromatographic material. In particular, porous inorganic/organic hybrid materials are provided with a decreased concentration of surface organic groups. These particles may be surface modified and have enhanced stability at low pH.
摘要翻译：用于色谱分离的材料，其制备方法和含有色谱材料的分离装置。特别地，多孔无机/有机杂化材料具有降低的表面有机基团浓度。这些颗粒可以被表面改性，并且在低pH下具有增强的稳定性。

3. 发明申请

US20030150811A1 Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation 有权
标题翻译：用于色谱分离的多孔无机/有机混合整料材料及其制备方法
公开(公告)号：US20030150811A1
公开(公告)日：2003-08-14
申请号：US10216674
申请日：2002-08-08
申请人： Waters Investments Limited
发明人： Thomas H. Walter , Julia Ding , Marianna Kele , John E. O'Gara , Pamela C. Iraneta
IPC分类号： C02F001/28 , B01J020/26 , B01J021/04 , B01D015/08
CPC分类号： B01J20/286 , B01J20/103 , B01J20/262 , B01J20/264 , B01J20/28033 , B01J20/28042 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28095 , B01J20/3204 , B01J20/3212 , B01J20/3217 , B01J20/3227 , B01J20/3242 , B01J20/3246 , B01J20/3272 , B01J2220/46 , B01J2220/54 , B01J2220/58 , B01J2220/82 , D04H1/42 , Y10T428/2982 , Y10T428/2993 , Y10T428/2995
摘要： Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, the novel materials are porous inorganic/organic hybrid monolith materials, which desirably may be surface modified, and which offer more efficient chromatographic separations than that known in the art.
摘要翻译：用于色谱分离的新型材料，其制备方法和含有色谱材料的分离装置。特别地，新型材料是多孔无机/有机混合整料材料，其理想地可以被表面改性，并且提供比本领域已知的更有效的色谱分离。

4. 发明申请

US20040262513A1 Parallel concentration, desalting and deposition onto MALDI targets 失效
标题翻译：平行浓缩，脱盐和沉积到MALDI靶上
公开(公告)号：US20040262513A1
公开(公告)日：2004-12-30
申请号：US10834780
申请日：2004-04-29
申请人： WATERS INVESTMENTS LIMITED
发明人： Robert Karol , Jeffrey Finch , Daniel Wall
IPC分类号： H01J049/00
CPC分类号： G01N30/466 , G01N30/468 , G01N30/724 , G01N30/84 , G01N2030/027 , G01N2030/324 , G01N2030/8417 , H01J49/00 , H01J49/0418 , H01J49/165
摘要： A method and apparatus for the continuous deposition of RP HPLC eluent, from isocratic or gradient elutions, on to a MALDI target using a parallel sample desalting method, allows increased sensitivity of the MALDI sample by pre-concentration of the analyte, separation of interfering contaminants from the analyte and increased dynamic range of peptide abundance that can be analyzed. The parallel processing of sample material allows greater throughput than that of manual methods.
摘要翻译：使用平行样品脱盐方法从等度或梯度洗脱液将RP HPLC洗脱液连续沉积到MALDI靶上的方法和装置允许通过预浓缩分析物来增加MALDI样品的敏感性，分离干扰污染物从分析物和增加的肽丰度的动态范围可以分析。样品材料的并行处理能够提供比手工方法更高的产量。

5. 发明申请

US20040118201A1 System and method of measuring convection induced impedance gradients to determine liquid flow rates 有权
标题翻译：测量对流感应阻抗梯度以确定液体流速的系统和方法
公开(公告)号：US20040118201A1
公开(公告)日：2004-06-24
申请号：US10328986
申请日：2002-12-23
申请人： Waters Investments Limited
发明人： Geoff C. Gerhardt , Keith Fadgen
IPC分类号： G01F001/68
CPC分类号： G01F1/6847 , G01N30/64 , G01N2030/324
摘要： A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensor means. Said excitation means is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensor means, at least one of said sensors is located in a position upstream of the excitation source location, and additionally a second of said plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to said sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.
摘要翻译：一种用于利用位于中心的激励源和多个传感器装置来测量流动通道内的液体或气体的流量的方法和系统。所述激励装置包括与交流发电机耦合的加热元件。在多个传感器装置中，至少一个所述传感器位于激励源位置的上游位置，并且所述多个传感器中的另一个位于激发源的下游位置。利用电耦合到所述传感器的高增益差分放大器来计算瞬时流体流速，其中流动流体的对流感应感应梯度与对称零流感应梯度进行比较。在进行这样的比较之后，导出与通道内的流体流量成比例的电压信号。

6. 发明申请

US20040166589A1 Device for solid phase extraction and method for purifying samples prior to analysis 有权
标题翻译：固相萃取装置和分析前样品的纯化方法
公开(公告)号：US20040166589A1
公开(公告)日：2004-08-26
申请号：US10785754
申请日：2004-02-24
申请人： WATERS INVESTMENTS LIMITED
发明人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： G01N001/18
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent particles within the well below the first filter; and a second filter having a diameter smaller than the first filter within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.
摘要翻译：固相萃取（SPE）装置，其具有带有开口的储存器; 一个包括内部锥形壁的井，该井在最靠近开口的一端具有比在出口处出口处更宽的内径; 井内的第一个过滤器; 在第一过滤器下面的井内的吸附剂颗粒床; 并且提供具有小于第一过滤器的第二过滤器，该第二过滤器位于吸附剂颗粒床之下的井内以及排出口上方。还提供了使用该装置执行SPE的方法。

7. 发明申请

US20040108273A1 Backflow prevention for high pressure gradient systems 失效
公开(公告)号：US20040108273A1
公开(公告)日：2004-06-10
申请号：US10314725
申请日：2002-12-09
申请人： Waters Investments Limited
发明人： Hal Richardson , Richard W. Andrews
IPC分类号： B01D015/08
CPC分类号： G01N30/32 , G01N30/10 , G01N30/36 , G01N2030/322 , G01N2030/328 , Y10T137/7838 , Y10T137/87684 , G01N30/34
摘要： Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance.

8. 发明申请

US20030178370A1 Device for solid phase extraction and method for purifying samples prior to analysis 有权
标题翻译：固相萃取装置和分析前样品的纯化方法
公开(公告)号：US20030178370A1
公开(公告)日：2003-09-25
申请号：US10100762
申请日：2002-03-19
申请人： Waters Investments Limited
发明人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S.P. Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： B01D015/08
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the wall having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter placed within the well; a bed of sorbent particles placed within the well below the first filter; and a second filter having a diameter smaller than the first filter placed within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.
摘要翻译：固相萃取（SPE）装置，其具有带有开口的储存器; 包括内部锥形壁的井，所述壁在最靠近开口的一端处具有比在出口处出口处更宽的内径; 放置在井内的第一过滤器; 放置在第一过滤器下面的井内的吸附剂颗粒床; 并且提供具有小于放置在吸附剂颗粒床之下的孔内的第一过滤器的直径的第二过滤器并且在出口喷嘴上方。还提供了使用该装置执行SPE的方法。

9. 发明申请

US20020017484A1 High pressure capillary liquid chromatography solvent delivery stystem 有权
标题翻译：高压毛细管液相色谱溶剂输送系统
公开(公告)号：US20020017484A1
公开(公告)日：2002-02-14
申请号：US09952934
申请日：2001-09-14
申请人： Waters Investments Limited
发明人： Theodore A. Dourdeville
IPC分类号： B01D015/08
CPC分类号： G01N30/24 , B01D15/166 , G01N30/36 , G01N2030/326
摘要： High pressure capillary liquid chromatography solvent delivery is effected at substantially low volume and atmospheric pressure. The low volume solvent composition is subsequently pressurized and expelled at high pressure into a receiving device such as a column. The solvent composition is expelled from a fluid metering system configured to deliver liquids at low pressures to a storage matrix via an isolation valve. The solvent composition is delivered to the storage matrix in reverse order such that the first volume of liquid delivered into the storage matrix is the last volume of liquid expelled out. Liquid pre-existing within the storage matrix is transferred into a fluid accumulator in fluid communication with the storage matrix. The fluid accumulator is enveloped in a pressure caisson which can be pressurized or depressurized in response to sensor signals obtained from a fluid volume displacement transducer and a pressure sensor, in accordance with solvent composition cycle formation. As the caisson is pressurized, the pressure acting on the fluid accumulator causes the solvent composition within the storage matrix to be expelled out past the isolation valve into a chromatographic column.
摘要翻译：高压毛细管液相色谱溶剂输送在基本上低体积和大气压下进行。随后将低体积溶剂组合物加压并在高压下排出到诸如柱的接收装置中。溶剂组合物从被配置成经由隔离阀将低压液体输送到储存基质的流体计量系统排出。溶剂组合物以相反的顺序输送到储存基质，使得输送到储存基质中的第一体积的液体是排出的最后一液体体积。在存储矩阵内预先存在的液体被转移到与存储矩阵流体连通的流体蓄积器中。流体蓄能器被包围在压力沉箱中，其可以响应于根据溶剂组成循环形成从流体容积位移传感器和压力传感器获得的传感器信号而被加压或减压。当沉箱被加压时，作用在流体蓄液器上的压力导致储存基质中的溶剂组合物被排出通过隔离阀进入色谱柱。

10. 发明申请

US20040191516A1 Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation 有权
公开(公告)号：US20040191516A1
公开(公告)日：2004-09-30
申请号：US10744598
申请日：2003-12-22
申请人： Waters Investments Limited
发明人： Zhiping Jiang , Raymond P. Fisk , John O'Gara , Thomas H. Walter , Kevin D. Wyndham
IPC分类号： B01D015/08
CPC分类号： B01J20/22 , B01D15/08 , B01J20/103 , B01J20/28042 , B01J20/28057 , B01J20/28078 , B01J20/2808 , B01J20/28083 , B01J20/28095 , B01J20/28097 , B01J20/286 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3272 , B01J20/3282 , B01J39/26 , B01J41/20 , B01J2220/46 , B01J2220/52 , B01J2220/54 , B01J2220/58 , G01N2030/525 , Y10T428/249953 , Y10T428/249978 , Y10T428/249979 , Y10T428/249981 , Y10T428/256 , Y10T428/257 , Y10T428/259 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2998
摘要： Novel material for chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material. In particular, the disclosure describes porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, which desirably may be surface modified, and that offer more efficient chromatographic separations than that known in the art.

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