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1. 发明申请

US20090130200A1 GRANULES FOR CONTROLLED RELEASE OF TAMSULOSIN 审中-公开
标题翻译：用于控制释放TAMSULOSIN的颗粒
公开(公告)号：US20090130200A1
公开(公告)日：2009-05-21
申请号：US11632327
申请日：2005-07-07
申请人： Eszter Julianna Biro , Waltraud Bueb
发明人： Eszter Julianna Biro , Waltraud Bueb
IPC分类号： A61K9/48 , A61K31/18
CPC分类号： A61K9/1652 , A61K9/1617 , A61K9/1635 , A61K9/1694 , A61K9/5026
摘要： Granules for controlled release of Tamsulosin, the granules including Tamsulosin and a carrier matrix. The carrier matrix includes a) 2 to 25% by weight of an alginate and b) 30 to 70% by weight of a macromolecular substance selected from the group consisting of: methacrylic acid/ethyl acrylate 1:1 copolymer, methacrylic acid/methyl methacrylate 1:1 or 1:2 copolymers, aminoalkyl methacrylate copolymer, vinyl acetate/crotonic acid copolymer, polyvinyl acetate phthalate, ethylene-vinyl acetate, cellulose acetate phthalate, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, carrageenan, crosslinked chitosan, polyethylene-vinyl acetate, poly-L-lactic acid, xanthan gum, polyvinyl acetate and mixtures thereof. The carrier matrix further includes 10 to 50% by weight of a hydrophobic substance selected from the group consisting of: glycerol behenate, glyceryl monostearate, wax, mono-, di- and trisubstituted glycerides, calcium stearate and mixtures thereof.
摘要翻译：颗粒用于坦洛新的控制释放，颗粒包括坦索罗辛和载体基质。载体基质包括a）2至25重量％的藻酸盐和b）30至70重量％的选自以下的大分子物质：甲基丙烯酸/丙烯酸乙酯1:1共聚物，甲基丙烯酸/甲基丙烯酸甲酯 1：1或1：2共聚物，甲基丙烯酸氨基烷基酯共聚物，乙酸乙烯酯/巴豆酸共聚物，聚乙酸乙烯酯邻苯二甲酸酯，乙烯 - 乙酸乙烯酯，醋酸邻苯二甲酸纤维素，羟丙基甲基纤维素，羧甲基纤维素钠，角叉菜胶，交联壳聚糖，聚乙烯 - 乙酸乙烯酯， L-乳酸，黄原胶，聚乙酸乙烯酯及其混合物。载体基质还包含10至50重量％的选自以下的疏水性物质：山嵛酸甘油酯，单硬脂酸甘油酯，蜡，单取代，二取代和三取代的甘油酯，硬脂酸钙及其混合物。

2. 发明申请

US20080254113A1 Microemulsion Formulations Comprising Particular Substance P Antagonists 审中-公开
标题翻译：包含特定物质P拮抗剂的微乳液制剂
公开(公告)号：US20080254113A1
公开(公告)日：2008-10-16
申请号：US10597313
申请日：2005-02-04
申请人： Waltraud Bueb , Barbara Luckel , Isabel Ottinger , Thomas Reinhart , Angelika Ries
发明人： Waltraud Bueb , Barbara Luckel , Isabel Ottinger , Thomas Reinhart , Angelika Ries
IPC分类号： A61K31/55 , A61K9/48 , A61P11/00
CPC分类号： A61K9/1075 , A61K9/0095 , A61K31/164 , A61K31/55 , A61K47/10
摘要： The present invention relates to dispersible pharmaceutical compositions in which the active agent is a substance P antagonist, in particular a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide, that is useful for the treatment and prevention of respiratory diseases including asthma and chronic obstructive pulmonary disease, bowel disorders including irritable bowel syndrome (IBS), urinary incontinence, and cough.
摘要翻译：本发明涉及可分散药物组合物，其中活性剂是物质P拮抗剂，特别是5-芳基-4（R） - 芳基羰基氨基 - 戊-2-烯酸酰胺，其可用于治疗和预防呼吸系统疾病包括哮喘和慢性阻塞性肺病，肠紊乱，包括肠易激综合征（IBS），尿失禁和咳嗽。

3. 发明申请

US20090208583A1 TABLETS COMPRISING CANDESARTAN CILEXETIL 审中-公开
标题翻译：包含CANDESARTAN CILEXETIL的片剂
公开(公告)号：US20090208583A1
公开(公告)日：2009-08-20
申请号：US12305283
申请日：2007-06-14
申请人： Tillmann Rohrich , Waltraud Bueb , Enno Schweinberger
发明人： Tillmann Rohrich , Waltraud Bueb , Enno Schweinberger
IPC分类号： A61K9/36 , A61K9/28 , A61K31/41 , A61K31/5415 , A61K9/32 , A61P9/12
CPC分类号： A61K9/5073 , A61K9/1623 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K31/4184 , A61K31/54
摘要： Composition in the form of a tablet, comprising candesartan cilexetil and optionally further active agents and usual adjuncts, wherein the surface of at least the active agent candesartan cilexetil in this composition is provided with a coating, made from a compound or a mixture of compounds selected from tri-(C1-C6)alkyl citrate, di-(C1-C6)alkyl phthalate, di-(C1-C6)alkyl sebacate and polydimethysiloxanes and methods for production thereof.
摘要翻译：片剂形式的组合物，其包含坎地沙坦碳酸酯和任选的其它活性剂和通常的助剂，其中在该组合物中至少活性剂坎地沙坦酯的表面具有由选自下列化合物或化合物的混合物制成的涂层柠檬酸三（C1-C6）烷基酯，邻苯二甲酸二（C1-C6）烷基酯，癸二酸二（C1-C6）烷基酯和聚二羟乙基硅烷）及其制备方法。

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