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1. 发明申请

US20050032115A1 Taxonomic identification of pathogenic microorganisms and their toxic proteins 审中-公开
公开(公告)号：US20050032115A1
公开(公告)日：2005-02-10
申请号：US10706543
申请日：2003-11-12
申请人： Linda Powers , Walther Ellis , Christopher Lloyd
发明人： Linda Powers , Walther Ellis , Christopher Lloyd
IPC分类号： G01N33/566 , B01J20/32 , C12Q1/04 , C12Q1/70 , G01N21/76 , G01N21/78 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/547 , G01N33/569
CPC分类号： B01J20/3242 , B01J20/3217 , B01J20/3219 , C12Q1/04 , G01N33/54333 , Y02A50/52
摘要： The present invention describes a method for the binding of pathogenic microorganisms and their toxic proteins with ligands that have been covalently tethered at some distance from the surface of a substrate: distances of at least fifteen Å are required for microorganism binding ligand tethers and at least six Å are required for protein binding ligand tethers. The ligands described herein include heme compounds, siderophores, polysaccharides, and peptides specific for toxic proteins, outer membrane proteins and conjugated lipids. Non-binding components of the solution to be analyzed are separated from the bound fraction and binding is confirmed by detection of the analyte via microscopy, fluorescence, epifluorescence, luminescence, phosphorescence, radioactivity, or optical absorbance. By patterning numerous ligands in an array on a substrate surface it is possible to taxonomically identify the microorganism by analysis of the binding pattern of the sample to the array.

2. 发明授权

US08834687B2 Multilayer self-decontaminating coatings 有权
标题翻译：多层自净化涂料
公开(公告)号：US08834687B2
公开(公告)日：2014-09-16
申请号：US11529787
申请日：2006-09-28
申请人： Martin W. Kendig , Young J. Chung , Alan B. Harker , Dennis R. Strauss , Walther Ellis , Linda S. Powers
发明人： Martin W. Kendig , Young J. Chung , Alan B. Harker , Dennis R. Strauss , Walther Ellis , Linda S. Powers
IPC分类号： C25B9/00 , A61L2/00 , A61L2/03 , A61L2/20 , A61L2/235 , C02F1/467
CPC分类号： A61L2/0011 , A61L2/0094 , A61L2/035 , A61L2/20 , A61L2/235 , A61L2202/26 , C02F1/4674
摘要： A layered construction for use in decontaminating a surface or enclosed space is described. The construction is an electrochemical cell which includes a cathode, an electrolyte layer, an anode and a protective surface layer. A precursor compound that can be electrically decomposed to release an oxidant, on demand and over an extended period of time, is included in the layered structure, preferably in the electrolyte layer. The oxidant compounds react with various different chemical or biological contaminants in contact the protective layer, thereby deactivating, destroying or devitalizing the contaminants. The layered construction is suitable for application to a device or substrate, or placement in an enclosed space, and can be used on sensitive surfaces such as electronic components and human skin.
摘要翻译：描述了用于净化表面或封闭空间的分层结构。该结构是包括阴极，电解质层，阳极和保护表面层的电化学电池。优选在电解质层中，层状结构中包含能够电分解以释放氧化剂的前体化合物，并且在需要时间内延长时间。氧化剂化合物与保护层接触的各种不同的化学或生物污染物反应，从而使污染物失活，破坏或失活。分层结构适用于设备或基板，或放置在封闭空间中，可用于敏感表面，如电子部件和人体皮肤。

3. 发明申请

US20050026141A1 Taxonomic identification of pathogenic microorganisms and their toxic proteins 审中-公开
标题翻译：病原微生物及其毒性蛋白质的分类鉴定
公开(公告)号：US20050026141A1
公开(公告)日：2005-02-03
申请号：US10706544
申请日：2003-11-12
申请人： Linda Powers , Walther Ellis , Christopher Lloyd
发明人： Linda Powers , Walther Ellis , Christopher Lloyd
IPC分类号： G01N33/566 , B01J20/32 , C12Q1/04 , C12Q1/70 , G01N21/76 , G01N21/78 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/547 , G01N33/569 , C12Q1/68 , G01N33/554
CPC分类号： B01J20/3242 , B01J20/3217 , B01J20/3219 , C12Q1/04 , G01N33/54333 , Y02A50/52
摘要： The present invention describes a method for the binding of pathogenic microorganisms and their toxic proteins with ligands that have been covalently tethered at some distance from the surface of a substrate: distances of at least fifteen Å are required for microorganism binding ligand tethers and at least six Å are required for protein binding ligand tethers. The ligands described herein include heme compounds, siderophores, polysaccharides, and peptides specific for toxic proteins, outer membrane proteins and conjugated lipids. Non-binding components of the solution to be analyzed are separated from the bound fraction and binding is confirmed by detection of the analyte via microscopy, fluorescence, epifluorescence, luminescence, phosphorescence, radioactivity, or optical absorbance. By patterning numerous ligands in an array on a substrate surface it is possible to taxonomically identify the microorganism by analysis of the binding pattern of the sample to the array.
摘要翻译：本发明描述了一种用于将病原微生物及其毒性蛋白质与已经在基底表面一定距离共价连接的配体结合的方法：微生物结合配体系链需要至少15埃的距离和至少6 Å是蛋白质结合配体系链所必需的。本文所述的配体包括血红素化合物，铁载体，多糖和对毒性蛋白质，外膜蛋白质和缀合脂质有特异性的肽。要分析的溶液的非结合组分与结合部分分离，通过显微镜，荧光，落射荧光，发光，磷光，放射性或光吸收检测分析物来确认结合。通过在基板表面上阵列中的许多配体图案，可以通过分析样品与阵列的结合模式来分类学地鉴定微生物。

4. 发明申请

US20120111719A1 Multilayer self-decontaminating coatings 有权
标题翻译：多层自净化涂料
公开(公告)号：US20120111719A1
公开(公告)日：2012-05-10
申请号：US11529787
申请日：2006-09-28
申请人： Martin W. Kendig , Young J. Chung , Alan B. Harker , Dennis R. Strauss , Walther Ellis , Linda S. Powers
发明人： Martin W. Kendig , Young J. Chung , Alan B. Harker , Dennis R. Strauss , Walther Ellis , Linda S. Powers
IPC分类号： C25D17/00 , C25D9/04
CPC分类号： A61L2/0011 , A61L2/0094 , A61L2/035 , A61L2/20 , A61L2/235 , A61L2202/26 , C02F1/4674
摘要： A layered construction for use in decontaminating a surface or enclosed space is described. The construction is an electrochemical cell which includes a cathode, an electrolyte layer, an anode and a protective surface layer. A precursor compound that can be electrically decomposed to release an oxidant, on demand and over an extended period of time, is included in the layered structure, preferably in the electrolyte layer. The oxidant compounds react with various different chemical or biological contaminants in contact the protective layer, thereby deactivating, destroying or devitalizing the contaminants. The layered construction is suitable for application to a device or substrate, or placement in an enclosed space, and can be used on sensitive surfaces such as electronic components and human skin.
摘要翻译：描述了用于净化表面或封闭空间的分层结构。该结构是包括阴极，电解质层，阳极和保护表面层的电化学电池。优选在电解质层中，层状结构中包含能够电分解以释放氧化剂的前体化合物，并且在需要时间内延长时间。氧化剂化合物与保护层接触的各种不同的化学或生物污染物反应，从而使污染物失活，破坏或失活。分层结构适用于设备或基板，或放置在封闭空间中，可用于敏感表面，如电子部件和人体皮肤。

5. 发明申请

US20060257929A1 Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins 审中-公开
标题翻译：用于快速分类鉴定病原微生物及其有毒蛋白质的方法
公开(公告)号：US20060257929A1
公开(公告)日：2006-11-16
申请号：US11273356
申请日：2005-11-14
申请人： Linda Powers , Walther Ellis , Christopher Lloyd
发明人： Linda Powers , Walther Ellis , Christopher Lloyd
IPC分类号： G01N33/53
CPC分类号： G01N33/54353
摘要： The present invention describes a method for the rapid binding of pathogenic microorganisms and their toxic proteins with ligands that have been covalently tethered at some distance from the surface of a substrate. Ligands directed to microbes are covalently attached to the substrate surface by tethers that are between 35 Å and 50 Å in length for optimal binding efficacy. Ligands directed to capture and concentrate proteinaceous materials are covalently attached to the substrate surface by tethers that are between 35 Å and 50 Å in length for optimum assay kinetics. The ligands described herein include heme compounds, siderophores, polysaccharides, and peptides specific for toxic proteins, outer membrane proteins and conjugated lipids. Non-binding components of the solution to be analyzed are separated from the bound fraction and binding is confirmed by detection of the analyte via microscopy, fluorescence, epifluorescence, luminescence, phosphorescence, radioactivity, or optical absorbance. By patterning numerous ligands in an array on a substrate surface it is possible to taxonomically identify the microorganism by analysis of the binding pattern of the sample to the array.
摘要翻译：本发明描述了一种用于将病原微生物及其毒性蛋白质与已经在与基底表面一定距离共价连接的配体快速结合的方法。针对微生物的配体通过长度在35埃和50埃之间的系链共价连接到基质表面，以获得最佳的结合效力。用于捕获和浓缩蛋白质材料的配体通过长度在35Å和50之间的系链共价连接到基底表面，以获得最佳的测定动力学。本文所述的配体包括血红素化合物，铁载体，多糖和对毒性蛋白质，外膜蛋白质和缀合脂质有特异性的肽。要分析的溶液的非结合组分与结合部分分离，通过显微镜，荧光，落射荧光，发光，磷光，放射性或光吸收检测分析物来确认结合。通过在基板表面上阵列中的许多配体图案，可以通过分析样品与阵列的结合模式来分类学地鉴定微生物。

6. 发明申请

US20050026140A1 Taxonomic identification of pathogenic microorganisms and their toxic proteins 审中-公开
公开(公告)号：US20050026140A1
公开(公告)日：2005-02-03
申请号：US10706542
申请日：2003-11-12
申请人： Linda Powers , Walther Ellis , Christopher Lloyd
发明人： Linda Powers , Walther Ellis , Christopher Lloyd
IPC分类号： G01N33/566 , B01J20/32 , C12Q1/04 , C12Q1/70 , G01N21/76 , G01N21/78 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/547 , G01N33/569 , C12Q1/68 , G01N33/554
CPC分类号： B01J20/3242 , B01J20/3217 , B01J20/3219 , C12Q1/04 , G01N33/54333 , Y02A50/52
摘要： The present invention describes a method for the binding of pathogenic microorganisms and their toxic proteins with ligands that have been covalently tethered at some distance from the surface of a substrate: distances of at least fifteen Å are required for microorganism binding ligand tethers and at least six Å are required for protein binding ligand tethers. The ligands described herein include heme compounds, siderophores, polysaccharides, and peptides specific for toxic proteins, outer membrane proteins and conjugated lipids. Non-binding components of the solution to be analyzed are separated from the bound fraction and binding is confirmed by detection of the analyte via microscopy, fluorescence, epifluorescence, luminescence, phosphorescence, radioactivity, or optical absorbance. By patterning numerous ligands in an array on a substrate surface it is possible to taxonomically identify the microorganism by analysis of the binding pattern of the sample to the array.

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