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1. 发明申请

US20130039972A1 COMPOSITIONS AND METHODS OF USE OF TARGETING PEPTIDES AGAINST PLACENTA AND ADIPOSE TISSUES 有权
标题翻译：使用针对PLACENTA和ADIPOSE TISSUES的靶向肽的组合物和方法
公开(公告)号：US20130039972A1
公开(公告)日：2013-02-14
申请号：US13559222
申请日：2012-07-26
申请人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
发明人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
IPC分类号： C07K1/107 , C12N1/20 , A61K38/10 , A61K9/127 , A61K38/08 , A61K38/16 , C12N7/00 , C12N15/63
CPC分类号： A61K38/08 , A61K31/70
摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 or SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens.
摘要翻译：本发明涉及包含鉴定和使用用于胎盘或脂肪组织的靶向肽的组合物。在某些实施方案中，靶向肽包含SEQ ID NO：5-11，SEQ ID NO：13-22或SEQ ID NO：144的部分或全部。肽可以连接到各种用于靶向递送的治疗剂。脂肪酸靶向肽可用于体重控制，诱导体重减轻和脂肪营养不良综合症的治疗方法。脂肪靶向也可以使用选择性靶向脂肪受体的其它结合部分来实现，例如抗蛋白受体蛋白复合物。胎盘靶向肽可用于干扰妊娠，诱导劳动和/或用于靶向递送治疗剂至胎盘和/或胎儿。在其它实施方案中，通过结合胎盘靶向肽鉴定的受体可用于筛选化合物以产生潜在的致畸性。示例性的胎盘受体是FcRn / bgr; 2M，并且与FcRn / bgr2M2结合的化合物是潜在的致畸因子。

2. 发明申请

US20120028880A1 VEGFR-1/NRP-1 TARGETING PEPTIDES 审中-公开
标题翻译： VEGFR-1 / NRP-1靶向肽
公开(公告)号：US20120028880A1
公开(公告)日：2012-02-02
申请号：US12672647
申请日：2008-08-08
申请人： Renata Pasqualini , Wadih Arap , Ricardo Giordano , Marina Cardó-Vila , Ana Paula Valente , Fabio Ceneviva Lacerda De Almeida
发明人： Renata Pasqualini , Wadih Arap , Ricardo Giordano , Marina Cardó-Vila , Ana Paula Valente , Fabio Ceneviva Lacerda De Almeida
IPC分类号： A61K38/02 , C07K7/06 , C07K7/64 , C07K19/00 , C07K5/083 , C12N7/00 , C12N1/20 , C12N1/16 , C12N5/071 , C07K17/00 , C12N9/96 , A61P11/06 , A61P35/02 , A61P35/00 , A61P19/02 , A61P3/04 , A61P3/10 , A61P27/02 , A61P19/08 , A61P9/10 , A61P17/06 , A61P27/06 , C12Q1/02 , C07K4/00
CPC分类号： C12N15/62 , A61K47/66 , B82Y5/00 , C07K5/0806 , C07K5/0808 , C07K5/0817 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-I and NRP-I expressing cells. Targeted molecules in accor-dance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
摘要翻译：本发明涉及治疗剂的分子药物和靶向递送领域。更具体地，本发明涉及结合选择性靶向VEGFR-1和NRP-1表达细胞的氨基酸Leu-Pro-Arg（LPR），特别是D（LPR）的新肽序列的鉴定。本发明的靶向分子可用于治疗和检测新生血管或血管生成VEGF相关疾病，包括但不限于癌症，肥胖症，糖尿病，哮喘，关节炎，肝硬化和眼部疾病。

3. 发明申请

US20100172864A1 COMPOSITIONS AND METHODS OF USE OF TARGETING PEPTIDES FOR DIAGNOSIS AND THERAPY OF HUMAN CANCER 有权
标题翻译：靶向肽用于诊断和治疗癌症的组合物和方法
公开(公告)号：US20100172864A1
公开(公告)日：2010-07-08
申请号：US12714147
申请日：2010-02-26
申请人： Wadih Arap , Mikhail G. Kolonin , Paul J. Mintz , Renata Pasqualini , Amado J. Zurita
发明人： Wadih Arap , Mikhail G. Kolonin , Paul J. Mintz , Renata Pasqualini , Amado J. Zurita
IPC分类号： A61K38/20 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C12N9/96 , C07K9/00 , C12N7/00 , C12N1/20 , C12N1/16 , C12N5/00 , C12N15/63
CPC分类号： C07K5/0806 , A61K38/00 , A61K45/06 , A61K47/64 , A61K47/642 , A61K48/00 , C07K5/0819 , C07K16/2866 , C07K16/3069 , C07K2317/34 , C07K2317/77 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2795/00032 , C12N2795/00043 , C12N2795/00045 , C12N2795/00062 , C12N2795/00071 , C12N2810/40 , C12N2830/60
摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides selective for cancer tissue, particularly prostate or ovarian cancer tissue. The method may comprise identifying endogenous mimeotopes of such peptides, such as GRP78, IL-11Rα and hsp90. Antibodies against such targeting peptides or their mimeotopes may be used for detection, diagnosis and/or staging of prostate or ovarian cancer. In other embodiments, the compositions and methods concern a novel type of gene therapy vector, known as adeno-associated phage (AAP). AAP are of use for targeted delivery of therapeutic agents to particular tissues, organs or cell types, such as prostate or ovarian cancer. In still other embodiments, targeting peptides selective for low-grade lipomas may be used for detection, diagnosis and targeted delivery of therapeutic agents.
摘要翻译：本发明涉及包含对于癌组织，特别是前列腺或卵巢癌组织有选择性的靶向肽的鉴定和使用方法。该方法可以包括鉴定此类肽的内源性mimeotopes，例如GRP78，IL-11Rα和hsp90。针对这些靶向肽或其肌炎组织的抗体可用于前列腺癌或卵巢癌的检测，诊断和/或分期。在其它实施方案中，组合物和方法涉及称为腺相关噬菌体（AAP）的新型基因治疗载体。 AAP可用于将特定组织，器官或细胞类型如前列腺或卵巢癌的治疗剂靶向递送。在其它实施方案中，对低级脂肪瘤有选择性的靶向肽可用于治疗剂的检测，诊断和靶向递送。

4. 发明授权

US07452964B2 Compositions and methods of use of targeting peptides against placenta and adipose tissues 失效
标题翻译：使用针对胎盘和脂肪组织的肽的组合物和方法
公开(公告)号：US07452964B2
公开(公告)日：2008-11-18
申请号：US10489071
申请日：2002-08-30
申请人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
发明人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
IPC分类号： C07K5/00 , A61K48/00
CPC分类号： A61K38/08 , A61K31/70
摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 OR SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens.
摘要翻译：本发明涉及包含鉴定和使用用于胎盘或脂肪组织的靶向肽的组合物。在某些实施方案中，靶向肽包含SEQ ID NO：5-11，SEQ ID NO：13-22或SEQ ID NO：144的部分或全部。肽可以连接到各种用于靶向递送的治疗剂。脂肪酸靶向肽可用于体重控制，诱导体重减轻和脂肪营养不良综合症的治疗方法。脂肪靶向也可以使用选择性靶向脂肪受体的其它结合部分来实现，例如抗蛋白受体蛋白复合物。胎盘靶向肽可用于干扰妊娠，诱导劳动和/或用于靶向递送治疗剂至胎盘和/或胎儿。在其他实施方案中，通过结合胎盘靶向肽鉴定的受体可用于筛选化合物以产生潜在的致畸性。示例性的胎盘受体是FcRn /β2M，并且结合FcRn /β2M的化合物是潜在的致畸因子。

5. 发明授权

US09592238B2 Anti-ceramide monoclonal antibody 2A2 有权
标题翻译：抗神经酰胺单克隆抗体2A2
公开(公告)号：US09592238B2
公开(公告)日：2017-03-14
申请号：US13974405
申请日：2013-08-23
申请人： Jimmy Andrew Rotolo , Richard N. Kolesnick , Renata Pasqualini , Wadih Arap
发明人： Jimmy Andrew Rotolo , Richard N. Kolesnick , Renata Pasqualini , Wadih Arap
IPC分类号： A61K39/295 , A61K31/55 , C07K16/40 , C07K16/44 , A61K39/00
CPC分类号： A61K31/55 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K16/44
摘要： We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.
摘要翻译：我们已经发现，施用抗神经酰胺抗体治疗并预防由细胞溶解性T淋巴细胞（CTL）介导的一系列疾病 - 诱导的杀伤和内皮微血管的损伤，包括放射诱导的GI综合征，移植物抗宿主病，炎性疾病和自身免疫性疾病我们还发现了新的抗神经酰胺单克隆抗体，其优选以人源化形式治疗或预防这些疾病。

6. 发明授权

US08710017B2 Human and mouse targeting peptides identified by phage display 失效
标题翻译：通过噬菌体展示鉴定的人和小鼠靶向肽
公开(公告)号：US08710017B2
公开(公告)日：2014-04-29
申请号：US13286887
申请日：2011-11-01
申请人： Wadih Arap , Renata Pasqualini
发明人： Wadih Arap , Renata Pasqualini
IPC分类号： A61K38/08 , A61K38/16 , A61P3/10 , A61P7/12
CPC分类号： C40B40/02 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/1037 , C12N2810/40
摘要： The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, including but not limited to gene therapy vectors. A novel class of gene therapy vectors is disclosed. Certain of the disclosed peptides have therapeutic use for inhibiting angiogenesis, inhibiting tumor growth, inducing apoptosis, inhibiting pregnancy or inducing weight loss. Methods of identifying novel targeting peptides in humans, as well as identifying endogenous receptor-ligand pairs are disclosed. Methods of identifying novel infectious agents that are causal for human disease states are also disclosed. A novel mechanism for inducing apoptosis is further disclosed.
摘要翻译：本发明涉及用于体内和体外靶向的方法和组合物。公开了大量针对人器官，组织或细胞类型的靶向肽。肽可用于靶向递送治疗剂，包括但不限于基因治疗载体。公开了一类新型的基因治疗载体。某些所公开的肽具有抑制血管发生，抑制肿瘤生长，诱导凋亡，抑制妊娠或引起体重减轻的治疗用途。公开了鉴定人中新靶向肽的方法，以及鉴定内源性受体 - 配体对。还公开了鉴定对人类疾病状态有影响的新型感染因子的方法。进一步公开了诱导细胞凋亡的新机制。

7. 发明授权

US08562993B2 Methods for treating GI syndrome and graft versus host disease 有权
标题翻译：治疗GI综合征和移植物抗宿主病的方法
公开(公告)号：US08562993B2
公开(公告)日：2013-10-22
申请号：US12599280
申请日：2008-05-06
申请人： Jimmy Andrew Rotolo , Richard Kolesnick , Renata Pasqualini , Wadih Arap
发明人： Jimmy Andrew Rotolo , Richard Kolesnick , Renata Pasqualini , Wadih Arap
IPC分类号： A61K39/395
CPC分类号： A61K31/55 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K16/44
摘要： We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.
摘要翻译：我们已经发现，施用抗神经酰胺抗体治疗并预防由细胞溶解性T淋巴细胞（CTL）介导的一系列疾病 - 诱导的杀伤和内皮微血管的损伤，包括放射诱导的GI综合征，移植物抗宿主病，炎性疾病和自身免疫性疾病我们还发现了新的抗神经酰胺单克隆抗体，其优选以人源化形式治疗或预防这些疾病。

8. 发明授权

US08252764B2 Compositions and methods of use of targeting peptides against placenta and adipose tissues 有权
标题翻译：使用针对胎盘和脂肪组织的肽的组合物和方法
公开(公告)号：US08252764B2
公开(公告)日：2012-08-28
申请号：US13084328
申请日：2011-04-11
申请人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
发明人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
IPC分类号： A61K35/00 , A61K38/08
CPC分类号： A61K38/08 , A61K31/70
摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 or SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibition receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens.
摘要翻译：本发明涉及包含鉴定和使用用于胎盘或脂肪组织的靶向肽的组合物。在某些实施方案中，靶向肽包含SEQ ID NO：5-11，SEQ ID NO：13-22或SEQ ID NO：144的部分或全部。肽可以连接到各种用于靶向递送的治疗剂。脂肪酸靶向肽可用于体重控制，诱导体重减轻和脂肪营养不良综合症的治疗方法。脂肪靶向也可以使用选择性靶向脂肪受体的其它结合部分来实现，例如抗蛋白受体蛋白复合物。胎盘靶向肽可用于干扰妊娠，诱导劳动和/或用于靶向递送治疗剂至胎盘和/或胎儿。在其它实施方案中，通过结合胎盘靶向肽鉴定的受体可用于筛选化合物以产生潜在的致畸性。示例性的胎盘受体是FcRn / bgr; 2M，并且与FcRn / bgr2M2结合的化合物是潜在的致畸因子。

9. 发明申请

US20110286975A1 SYSTEMS AND METHODS FOR MAGNETIC GUIDANCE AND PATTERNING OF MATERIALS 有权
标题翻译：用于磁性指导和材料图案的系统和方法
公开(公告)号：US20110286975A1
公开(公告)日：2011-11-24
申请号：US13070873
申请日：2011-03-24
申请人： Glauco R. Souza , Renata Pasqualini , Wadih Arap , Thomas Charles Killian , Robert M. Raphael , Daniel Joshua Stark
发明人： Glauco R. Souza , Renata Pasqualini , Wadih Arap , Thomas Charles Killian , Robert M. Raphael , Daniel Joshua Stark
IPC分类号： A61K35/12 , C12Q1/02 , C12N15/85 , C12N13/00
CPC分类号： C12N13/00 , B82Y5/00 , C12M35/06 , C12N5/0062 , C12N2529/00 , C12N2533/10
摘要： Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.
摘要翻译：讨论了一般在医学，细胞生物学，纳米技术和细胞培养中有用的系统和方法。特别地，至少在一些实施例中，讨论了用于细胞和材料的磁性引导和图案化的系统和方法。这些系统和方法的一些具体应用可以包括将细胞悬浮培养离开表面，制备和操纵悬浮细胞的图案，以及对表面上的细胞进行图案化培养。具体地说，提出培养细胞的方法。该方法可以包括提供多个单元，提供磁场，以及悬浮在磁场中的多个单元中的至少一些单元，其中多个单元包括磁性纳米颗粒。该方法还可以包括将悬浮液维持足以允许细胞生长形成组件的时间。

10. 发明授权

US07951362B2 Compositions and methods of use of targeting peptides against placenta and adipose tissues 有权
标题翻译：使用针对胎盘和脂肪组织的肽的组合物和方法
公开(公告)号：US07951362B2
公开(公告)日：2011-05-31
申请号：US12242427
申请日：2008-09-30
申请人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
发明人： Renata Pasqualini , Wadih Arap , Mikhail G. Kolonin
IPC分类号： A61K48/00 , C07K5/00
CPC分类号： A61K38/08 , A61K31/70
摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 or SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens.
摘要翻译：本发明涉及包含鉴定和使用用于胎盘或脂肪组织的靶向肽的组合物。在某些实施方案中，靶向肽包含SEQ ID NO：5-11，SEQ ID NO：13-22或SEQ ID NO：144的部分或全部。肽可以连接到各种用于靶向递送的治疗剂。脂肪酸靶向肽可用于体重控制，诱导体重减轻和脂肪营养不良综合症的治疗方法。脂肪靶向也可以使用选择性靶向脂肪受体的其它结合部分来实现，例如抗蛋白受体蛋白复合物。胎盘靶向肽可用于干扰妊娠，诱导劳动和/或用于靶向递送治疗剂至胎盘和/或胎儿。在其它实施方案中，通过结合胎盘靶向肽鉴定的受体可用于筛选化合物以产生潜在的致畸性。示例性的胎盘受体是FcRn / bgr; 2M，并且与FcRn / bgr2M2结合的化合物是潜在的致畸因子。

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