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1. 发明专利

IL206959A [({2-sulfonylpyridin-3-yl}methyl)2-methylindol-1-yl]- ethanoates and use thereof in preparing a medicament 未知
公开(公告)号：IL206959A
公开(公告)日：2014-09-30
申请号：IL20695910
申请日：2010-07-12
申请人： PETTIPHER ERIC R , ARMER RICHARD EDWARD , WYNNE GRAHAM MICHAEL , VILE JULIA , SCHROER FRANK , WHITTAKER MARK , ATOPIX THERAPEUTICS LTD , OXAGEN LTD
发明人： PETTIPHER ERIC R , ARMER RICHARD EDWARD , WYNNE GRAHAM MICHAEL , VILE JULIA , SCHROER FRANK , WHITTAKER MARK
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： Compounds of general formula (I) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents selected from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, and -O(CH2)p-O-(CH2)qOR2 wherein each R2 is independently hydrogen, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

2. 发明专利

IL196640D0 COMPOUNDS HAVING CRTH2 ANTAGONIST ACTIVITY 未知
公开(公告)号：IL196640D0
公开(公告)日：2009-11-18
申请号：IL19664009
申请日：2009-01-21
申请人： OXAGEN LTD , ARMER RICHARD EDWARD , WYNNE GRAHAM MICHAEL , DORGAN COLIN RICHARD , JOHNSON PETER DAVID
IPC分类号： C07D20100101
摘要： Compounds of general formula (1) wherein R is phenyl optionally substituted with one or more halo substituents; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

3. 发明专利

IL196640A 2-{5-FLUORO-2-METHYL-3-[2-(PHENYLSULFONYL)BENZYL]-1H-INDOL-1-YL}ACETIC ACID AND DERIVATIVES THEREOF FOR TREATMENT OF DISEASE MEDIATED BY AGONISTS AT THE CRTH2 RECEPTOR 未知
公开(公告)号：IL196640A
公开(公告)日：2013-01-31
申请号：IL19664009
申请日：2009-01-21
申请人： OXAGEN LTD , ARMER RICHARD EDWARD , WYNNE GRAHAM MICHAEL , DORGAN COLIN RICHARD , JOHNSON PETER DAVID
发明人： ARMER RICHARD EDWARD , WYNNE GRAHAM MICHAEL , DORGAN COLIN RICHARD , JOHNSON PETER DAVID
摘要： Compounds of general formula (1) wherein R is phenyl optionally substituted with one or more halo substituents; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

4. 发明专利

IL206959D0 COMPOUNDS HAVING CRTH2 ANTAGONIST ACTIVITY 未知
公开(公告)号：IL206959D0
公开(公告)日：2010-12-30
申请号：IL20695910
申请日：2010-07-12
申请人： OXAGEN LTD , ERIC R PETTIPHER , ARMER RICHARD EDWARD , WYNNE GRAHAM MICHAEL , VILE JULIA , SCHROER FRANK , MARK WHITTAKER
IPC分类号： C07D20060101
摘要： Compounds of general formula (I) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents selected from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, and -O(CH2)p-O-(CH2)qOR2 wherein each R2 is independently hydrogen, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

5. 发明申请

WO2009093026A1 COMPOUNDS HAVING CRTH2 ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有CRTH2拮抗剂活性的化合物
公开(公告)号：WO2009093026A1
公开(公告)日：2009-07-30
申请号：PCT/GB2009/000171
申请日：2009-01-22
申请人： OXAGEN LIMITED , ARMER, Richard, Edward , WYNNE, Graham, Michael
发明人： ARMER, Richard, Edward , WYNNE, Graham, Michael
IPC分类号： C07D209/10 , A61K31/404 , A61P11/06 , A61P17/06
CPC分类号： C07D209/10
摘要： Compounds of general formula (I) W is chloro or fluoro; Z is a -SO 2 YR 1 group wherein R 1 is C 3 -C 8 heterocyclyl, aryl or heteroaryl any of which may optionally be substituted with one or more substituents selected from halo, -CN, -C 1 -C 6 alkyl, -SOR 3 , -SO 2 R 3 , -SO 2 N(R 2 ) 2 , -N(R 2 ) 2 , -NR 2 C(O)R 3 , -CO 2 R 2 , -CONR 2 R 3 , -NO 2 , -OR 2 , -SR 2 , -O(CH 2 ) P OR 2 , and -O(CH 2 ) p O(CH 2 ) q OR 2 wherein each R 2 is independently hydrogen, -C 1 -C 6 alkyl, -C 3 -C 8 cycloalkyl, aryl or heteroaryl; each R 3 is independently, -C 1 -C 6 alkyl, -C 3 -C 8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; Y is a straight or branched C 1 -C 4 alkylene chain; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.
摘要翻译：通式（I）的化合物W是氯或氟; Z是-SO 2 YR1基团，其中R 1是C 3 -C 8杂环基，芳基或杂芳基，其中任何一个可以任选被一个或多个选自卤素，-CN，-C 1 -C 6烷基，-SOR 3，-SO 2 R 3，-SO 2 N （R 2）2，-N（R 2）2，-NR 2 C（O）R 3，-CO 2 R 2，-CONR 2 R 3，-NO 2，-OR 2，-SR 2，-O（CH 2）POR 2和-O（CH 2））qOR 2，其中每个R 2独立地是氢，-C 1 -C 6烷基，-C 3 -C 8环烷基，芳基或杂芳基; 每个R 3独立地是-C 1 -C 6烷基，-C 3 -C 8环烷基，芳基或杂芳基; p和q各自独立地为1至3的整数; Y是直链或支链C 1 -C 4亚烷基链; 其药学上可接受的盐，水合物，溶剂合物，复合物或前药可用于口服给药的组合物中，用于治疗过敏性疾病如哮喘，过敏性鼻炎和特应性皮炎。

6. 发明申请

WO2007091107A1 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY 审中-公开
标题翻译：杜氏肌肉晶状体的治疗
公开(公告)号：WO2007091107A1
公开(公告)日：2007-08-16
申请号：PCT/GB2007/050056
申请日：2007-02-09
申请人： VASTOX Plc , WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Paul Damien , DE MOOR, Olivier , NUGENT, Gary , DORGAN, Colin Richard , TINSLEY, Jonathon Mark , STORER, Richard , MULVANEY, Andrew , PYE, Richard
发明人： WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Paul Damien , DE MOOR, Olivier , NUGENT, Gary , DORGAN, Colin Richard , TINSLEY, Jonathon Mark , STORER, Richard , MULVANEY, Andrew , PYE, Richard
IPC分类号： A61K31/416 , A61K31/4192 , A61P21/00
CPC分类号： A61K31/416 , A61K31/4192
摘要： There are disclosed compound of Formula (I) or (II) wherein A 1 , A 2 , A 3 , A 4 and A 5 , which may be the same or different, represent N or CR 1 , R 9 represents - L -R 3 , in which L is a single bond or a linker group and R 3 represents hydrogen or a substituent and in addition, when an adjacent pair of A 1 - A 4 each represent CR 1 , then the adjacent carbon atoms, together with their substituents may form a ring B, when A 5 represents CR 1 , then A 5 and N - R 9 , together with their substituents may form a ring C, or a harmaceutically acceptable salt thereof, in the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia.
摘要翻译：公开了式（I）或（II）的化合物，其中A 1，A 2，A 3，A 4， / SUP>和A <5>可以相同或不同，表示N或CR 1，R 9表示-L-R，其中L是单键或连接基，R 3表示氢或取代基，此外，当相邻的一对A 1，各自代表CR 1，则相邻的碳原子连同它们的取代基可以形成环B，当A 5 < 表示CR 1，则A 5和N-R 9以及它们的取代基可以形成环C或其药学上可接受的盐在制备用于治疗和/或预防性治疗杜氏肌营养不良症，贝克肌营养不良症或恶病质的药物中的用途。

7. 发明申请

WO2007091106A3 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY 审中-公开
公开(公告)号：WO2007091106A3
公开(公告)日：2007-08-16
申请号：PCT/GB2007/050055
申请日：2007-02-09
申请人： SUMMIT CORPORATION PLC , WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Damien , DE MOOR, Olivier , NUGENT, Gary , TINSLEY, Jonathan Mark , STORER, Richard , MULVANEY, Andrew , PYE, Richard Joseph , DORGAN, Colin Richard
发明人： WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Damien , DE MOOR, Olivier , NUGENT, Gary , TINSLEY, Jonathan Mark , STORER, Richard , MULVANEY, Andrew , PYE, Richard Joseph , DORGAN, Colin Richard
IPC分类号： A61K31/343 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/423 , A61K31/4245 , A61K31/426 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/4709 , A61K31/404
摘要： There are disclosed compound of Formula (1): A 1 , A 2 , A 3 and A 4 which may be the same or different, represent N or CR 1 , X is a divalent group selected from O, S(O) n , C=W, NR 4 , NC(=O)R 5 and CR 6 R 7 , W is O, S, NR 20 , Y is N or CR 8 , one of R 4 , R 5 , R 6 , R 8 , R 9 and NR 20 represents - L -R 3 , in which L is a single bond or a linker group, additionally, R 1 , R 3 - R 9 , which may be the same or different, independently represent hydrogen or a substituent and R 20 represents hydrogen, hydroxyl, alkyl optionally substituted by aryl, alkoxy optionally substituted by aryl, aryl, CN, optionally substituted alkoxy, optionally substituted aryloxy, optionally substitute alkanoyl, optionally substituted aroyl, NO 2 , NR 30 R 31 , in which R 30 and R 31 , which may be the same or different, represent hydrogen, optionally substituted alkyl or optionally substituted aryl; additionally, one of R 30 and R 31 may represent optionally substituted alkanoyl or optionally substituted aroyl, n represents an integer from 0 to 2, in addition, when an adjacent pair of A 1 - A 4 each represent CR 1 , then the adjacent carbon atoms, together with their substituents may form a ring B, when X is CR 6 R 7 , R 6 and R 7 , together with the carbon atom to which they are attached may form a ring C, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia.

8. 发明申请

WO2010020432A3 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY 审中-公开
标题翻译：治疗DUCHENNE肌肉萎缩症的化合物
公开(公告)号：WO2010020432A3
公开(公告)日：2010-04-29
申请号：PCT/EP2009006099
申请日：2009-08-21
申请人： BIOMARIN IGA LTD , WYNNE GRAHAM MICHAEL , WREN STEPHEN , VAN WELL RENATE MARIA , SCHROER FRANK , LECCI CRISTINA , POIGNANT SEVERINE DANIELLE , MA SHUCONG , WILSON FRANCIS
发明人： WYNNE GRAHAM MICHAEL , WREN STEPHEN , VAN WELL RENATE MARIA , SCHROER FRANK , LECCI CRISTINA , POIGNANT SEVERINE DANIELLE , MA SHUCONG , WILSON FRANCIS
IPC分类号： A61K31/505 , A61K31/506 , A61P21/00 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12
摘要： Compounds of formula (I): wherein R1, L2, R2, L3, R3, L4 and R4 are as defined herein, upregulate endogenous utrophin in predictive screens, and thus, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia.
摘要翻译：式（I）化合物：其中R 1，L 2，R 2，L 3，R 3，L 4和R 4如本文所定义，在预测筛选中上调内源性utrophin，并因此可用于治疗或预防诸如杜兴氏肌营养不良，贝克肌营养不良和恶病质。

9. 发明申请

WO2010020432A2 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY 审中-公开
标题翻译：用于治疗杜邦肌肉晶状体的化合物
公开(公告)号：WO2010020432A2
公开(公告)日：2010-02-25
申请号：PCT/EP2009/006099
申请日：2009-08-21
申请人： SUMMIT CORPORATION PLC , WYNNE, Graham, Michael , WREN, Stephen , VAN WELL, Renate, Maria , SCHROËR, Frank , LECCI, Cristina , POIGNANT, Severine, Danielle , MA, Shucong , WILSON, Francis
发明人： WYNNE, Graham, Michael , WREN, Stephen , VAN WELL, Renate, Maria , SCHROËR, Frank , LECCI, Cristina , POIGNANT, Severine, Danielle , MA, Shucong , WILSON, Francis
IPC分类号： A61K31/505 , A61K31/506 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12
摘要： Compounds of formula (I): wherein R 1 , L 2 , R 2 , L 3 , R 3 , L 4 and R 4 are as defined herein, upregulate endogenous utrophin in predictive screens, and thus, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia.
摘要翻译：式（I）化合物：其中R 1，L 2，R 2，L 3，R 3，L 4和R 4如本文所定义，在预测筛选中上调内源性utrophin，因此可用于治疗或预防诸如Duchenne肌营养不良症，贝克肌营养不良症和恶病质。

10. 发明申请

WO2009021748A2 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY 审中-公开
标题翻译：杜氏肌肉晶状体的治疗
公开(公告)号：WO2009021748A2
公开(公告)日：2009-02-19
申请号：PCT/EP2008/006718
申请日：2008-08-14
申请人： SUMMIT CORPORATION PLC , WYNNE, Graham Michael , WEYMOUTH-WILSON, Alexander Charles , CLARKSON, Robert , VAN WELL, Renate , WREN, Stephen Paul , DE MOOR, Olivier
发明人： WYNNE, Graham Michael , WEYMOUTH-WILSON, Alexander Charles , CLARKSON, Robert , VAN WELL, Renate , WREN, Stephen Paul , DE MOOR, Olivier
IPC分类号： C07D263/57
CPC分类号： C07D263/57
摘要： Provided are polymorphic forms of a compound useful in the treatment of Duchenne muscular dystrophy.
摘要翻译：提供了可用于治疗杜氏肌营养不良症的化合物的多晶形式。

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