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1. 发明专利

IL250498A Modified nucleotide linkers 未知
公开(公告)号：IL250498A
公开(公告)日：2021-03-25
申请号：IL25049817
申请日：2017-02-07
申请人： ILLUMINA CAMBRIDGE LTD , WU XIAOLIN , LIU XIAOHAI
发明人： WU XIAOLIN , LIU XIAOHAI
IPC分类号： C07H1/00 , C07H19/14 , C12Q1/6869 , G01N21/64
摘要： Some embodiments of the present application relate to novel modified nucleotide linkers for increasing the efficiency of nucleotide incorporation in Sequencing by Synthesis applications. Methods of preparing these modified nucleotide linkers are also provided herewith.

2. 发明专利

IL279562D0 Nucleosides and nucleotides with 3ʹ-hydroxy blocking groups 未知
公开(公告)号：IL279562D0
公开(公告)日：2021-01-31
申请号：IL27956220
申请日：2020-12-17
申请人： ILLUMINA CAMBRIDGE LTD , FRANCAIS ANTOINE , CRESSINA ELENA , CULLEY ADAM , MARIANI ANGELICA , WU XIAOLIN , LIU XIAOHA
发明人： FRANCAIS ANTOINE , CRESSINA ELENA , CULLEY ADAM , MARIANI ANGELICA , WU XIAOLIN , LIU XIAOHA
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869
摘要： Embodiments of the present disclosure relate to sequencing methods using nucleotide molecules with a 3′ AOM blocking group, which can provide reduced phasing and pre-phasing values. Also provided herein are kits related to such sequencing methods.

3. 发明专利

IL292961A Cyclooctatetraene containing dyes and compositions 未知
公开(公告)号：IL292961A
公开(公告)日：2022-07-01
申请号：IL29296122
申请日：2022-05-11
申请人： ILLUMINA CAMBRIDGE LTD , WU XIAOLIN , LIU XIAOHAI , ROMANOV NIKOLAI NIKOLAEVICH , FRANCAIS ANTOINE , MCCAULEY PATRICK , CALLINGHAM MICHAEL , ANASTASI CAROLE
发明人： WU XIAOLIN , LIU XIAOHAI , ROMANOV NIKOLAI NIKOLAEVICH , FRANCAIS ANTOINE , MCCAULEY PATRICK , CALLINGHAM MICHAEL , ANASTASI CAROLE
IPC分类号： C07H19/06 , C07H19/16 , C07H21/04 , C09B57/02
摘要： Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.

4. 发明专利

IL271613D0 Secondary amine-substituted coumarin compounds and their uses as fluorescent labels 未知
公开(公告)号：IL271613D0
公开(公告)日：2020-02-27
申请号：IL27161319
申请日：2019-12-19
申请人： ILLUMINA CAMBRIDGE LTD , ROMANOV NIKOLAI , WU XIAOLIN , MCCAULEY PATRICK , ANASTASI CAROLE , HYNES NIALL
发明人： ROMANOV NIKOLAI , WU XIAOLIN , MCCAULEY PATRICK , ANASTASI CAROLE , HYNES NIALL
IPC分类号： C07D20060101
摘要： The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

5. 发明专利

IL250498D0 Modified nucleotide linkers 未知
公开(公告)号：IL250498D0
公开(公告)日：2017-03-30
申请号：IL25049817
申请日：2017-02-07
申请人： ILLUMINA CAMBRIDGE LTD , WU XIAOLIN , LIU XIAOHAI
发明人： WU XIAOLIN , LIU XIAOHAI
IPC分类号： C12Q20060101
摘要： Some embodiments of the present application relate to novel modified nucleotide linkers for increasing the efficiency of nucleotide incorporation in Sequencing by Synthesis applications. Methods of preparing these modified nucleotide linkers are also provided herewith.

6. 发明专利

IL279644D0 Nucleosides and nucleotides with 3'-hydroxy blocking groups and their use in polynucleotide sequencing methods 未知
公开(公告)号：IL279644D0
公开(公告)日：2021-03-01
申请号：IL27964420
申请日：2020-12-21
申请人： ILLUMINA CAMBRIDGE LTD , CRESSINA ELENA , FRANCAIS ANTOINE , LIU XIAOHAI , WU XIAOLIN , CULLEY ADAM , MARIANI ANGELICA
发明人： CRESSINA ELENA , FRANCAIS ANTOINE , LIU XIAOHAI , WU XIAOLIN , CULLEY ADAM , MARIANI ANGELICA
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869
摘要： Embodiments of the present disclosure relate to sequencing methods using nucleotide molecules with a 3′ AOM blocking group, which can provide reduced phasing and pre-phasing values. Also provided herein are kits related to such sequencing methods.

7. 发明专利

IL271446D0 Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides 未知
公开(公告)号：IL271446D0
公开(公告)日：2020-01-30
申请号：IL27144619
申请日：2019-12-15
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD , GEORGE WAYNE N , BEIERLE JOHN M , SHIEH PEYTON , SMITH RANDALL , LIU XIAOHAI , WU XIAOLIN , LAWRENCE ELLIOT JOHN , MAO JIE
发明人： GEORGE WAYNE N , BEIERLE JOHN M , SHIEH PEYTON , SMITH RANDALL , LIU XIAOHAI , WU XIAOLIN , LAWRENCE ELLIOT JOHN , MAO JIE
IPC分类号： C07H20060101
摘要： Embodiments of the present disclosure relate to methods of preparation of templates for polynucleotide sequencing. In particular, the disclosure relates to linearization of clustered polynucleotides in preparation for sequencing by cleavage of one or more first strands of double-stranded polynucleotides immobilized on a solid support by a transition metal complex, for example, a palladium complex or a nickel complex. Further disclosure relate to linearization of clustered polynucleotides by cleaving one or more second strands of double double-stranded polynucleotides immobilized on a solid support comprising azobenzene linker by Na2S2O4. Nucleotides and oligonucleotides comprising a 3′ phosphate moiety blocking group, and methods of removing the same using a fluoride reagent are also disclosed.

8. 发明专利

IL293913A Systems and methods for detecting multiple analytes 未知
公开(公告)号：IL293913A
公开(公告)日：2022-08-01
申请号：IL29391322
申请日：2022-06-14
申请人： ILLUMINA CAMBRIDGE LTD , ILLUMINA INC , ILLUMINA SINGAPORE PTE LTD , SHULTZABERGER SARAH , BRODIN JEFFREY , TEO YIN NAH , ROHRBACK SUZANNE , MACLEOD REBECCA , PANTOJA RIGO , ECKHARDT ALLEN , FISHER JEFFREY S , YANG XIANGYUAN , PUGLIESE KAITLIN , GOLYNSKIY MISHA , WU XIAOLIN , MCDONALD SETH
发明人： SHULTZABERGER SARAH , BRODIN JEFFREY , TEO YIN NAH , ROHRBACK SUZANNE , MACLEOD REBECCA , PANTOJA RIGO , ECKHARDT ALLEN , FISHER JEFFREY S , YANG XIANGYUAN , PUGLIESE KAITLIN , GOLYNSKIY MISHA , WU XIAOLIN , MCDONALD SETH
摘要： A method for detecting different analytes includes mixing different analytes with sensing probes, wherein at least some of the sensing probes are specific to respective ones of the analytes. The analytes respectively are captured by the sensing probes that are specific to those analytes. Fluorophores respectively are coupled to sensing probes that captured respective analytes. The sensing probes are mixed with beads, wherein the beads are specific to respective ones of the sensing probes, and wherein the beads include different codes identifying the analytes to which those sensing probes are specific. The sensing probes respectively are coupled to beads that are specific to those sensing probes. The beads are identified that are coupled to the sensing probes that captured analytes using at least fluorescence from the fluorophores coupled to those sensing probes. The analytes that are captured are identified.

9. 发明申请

WO2007130519A3 VIRAL NUCLEIC ACID MICROARRAY AND METHOD OF USE 审中-公开
标题翻译：病毒核酸微量元素及其使用方法
公开(公告)号：WO2007130519A3
公开(公告)日：2008-07-10
申请号：PCT/US2007010742
申请日：2007-05-02
申请人： US GOV HEALTH & HUMAN SERV , BAPTISTA CASSIO S , WU XIAOLIN , MUNROE DAVID J
发明人： BAPTISTA CASSIO S , WU XIAOLIN , MUNROE DAVID J
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/70 , C12Q1/6837
摘要： The present invention relates generally to methods of detecting and identifying known and unknown viruses using hybridization microarrays to known conserved and non-conserved viral nucleotide sequences, the sequencing of nucleotides which hybridize to the microarrays and analysis of the hybridized sequences with existing databases, thus identifying existing or new subtypes of viruses.
摘要翻译：本发明一般涉及使用已知的保守和非保守的病毒核苷酸序列的杂交微阵列检测和鉴定已知和未知病毒的方法，与微阵列杂交的核苷酸的测序以及与现有数据库的杂交序列的分析，从而鉴定现有或新的病毒亚型。

10. 发明申请

WO1996015620A1 CONTEXT-BASED, ADAPTIVE, LOSSLESS IMAGE CODEC 审中-公开
标题翻译：基于语境，自适应，无损图像编解码器
公开(公告)号：WO1996015620A1
公开(公告)日：1996-05-23
申请号：PCT/CA1995000635
申请日：1995-11-08
申请人： THE CHINESE UNIVERSITY OF HONG KONG , WU, Xiaolin , MEMON, Nasir
发明人： THE CHINESE UNIVERSITY OF HONG KONG
IPC分类号： H04N01/41
CPC分类号： H04N1/41 , G06T9/004
摘要： An encoding/decoding method is provided for lossless (reversible) compression of digital pictures of all types, including continuous-tone images, graphics, multimedia images of mixed text, graphics and photographs, binary documents and drawings. Continuous-tone mode and binary mode are identified on a pixel-by-pixel basis (12). In continuous-tone mode, context modeling and prediction (20, 22, 26) are employed involving mostly integer arithmetic and simple logic in a conceptually sophisticated scheme. Both the encoding and decoding techniques are suitable for sequential and progressive transmission, although different specific algorithms may be employed for the different specific cases. The system is symmetric, meaning that the encoder and decoder have the same time and space complexities.
摘要翻译：提供了一种编码/解码方法，用于所有类型的数字图像的无损（可逆）压缩，包括连续色调图像，图形，混合文本的多媒体图像，图形和照片，二进制文件和图形。逐像素地识别连续色调模式和二进制模式（12）。在连续色调模式中，上下文建模和预测（20,22,26）在概念上复杂的方案中主要涉及整数运算和简单逻辑。编码和解码技术都适用于顺序和逐行传输，尽管不同的具体算法可以用于不同的具体情况。系统是对称的，这意味着编码器和解码器具有相同的时间和空间复杂性。

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