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1. 发明专利

AU2018355462A1 Recombinant immune cells, methods of making, and methods of use 未知
公开(公告)号：AU2018355462A1
公开(公告)日：2020-05-14
申请号：AU2018355462
申请日：2018-10-26
申请人： HULLSIEK ROBERT HARRISON , MISHRA HEMANT KUMAR , UNIV MINNESOTA , WALCHECK BRUCE , WU JIANMING , YUNGFANG LI
发明人： WU JIANMING , WALCHECK BRUCE , HULLSIEK ROBERT HARRISON , LI YUNGFANG , MISHRA HEMANT KUMAR
IPC分类号： C07K19/00 , A61K35/17 , C07K14/735 , C12N5/0783 , C12N5/10 , C12N15/62
摘要： A recombinant immune cell expresses a heterologous IgG Fc receptor. In some embodiments, the heterologous IgG Fc receptor can be a chimeric IgG Fc receptor. Generally, the chimeric IgG Fc receptor includes an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain generally includes a sufficient portion of CD64 to bind to an IgG Fc region. The intracellular domain of the chimeric IgG Fc receptor includes a sufficient portion of an Fc receptor allowing immunoreceptor tyrosine-based activation motif (ITAM) to initiate cell signaling when an IgG Fc region binds to the extracellular domain.

2. 发明专利

AU2018355462B2 Recombinant immune cells, methods of making, and methods of use 未知
公开(公告)号：AU2018355462B2
公开(公告)日：2022-04-14
申请号：AU2018355462
申请日：2018-10-26
申请人： HULLSIEK ROBERT HARRISON , MISHRA HEMANT KUMAR , UNIV MINNESOTA , WALCHECK BRUCE , WU JIANMING , YUNGFANG LI
发明人： WU JIANMING , WALCHECK BRUCE , HULLSIEK ROBERT HARRISON , LI YUNGFANG , MISHRA HEMANT KUMAR
IPC分类号： C07K19/00 , A61K35/17 , C07K14/735 , C12N5/0783 , C12N5/10 , C12N15/62
摘要： A recombinant immune cell expresses a heterologous IgG Fc receptor. In some embodiments, the heterologous IgG Fc receptor can be a chimeric IgG Fc receptor. Generally, the chimeric IgG Fc receptor includes an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain generally includes a sufficient portion of CD64 to bind to an IgG Fc region. The intracellular domain of the chimeric IgG Fc receptor includes a sufficient portion of an Fc receptor allowing immunoreceptor tyrosine-based activation motif (ITAM) to initiate cell signaling when an IgG Fc region binds to the extracellular domain.

3. 发明申请

WO2012082920A3 SYSTEM AND METHOD FOR CONTENT-ORIENTED NETWORK INTERWORKING 审中-公开
标题翻译：用于面向内容的网络交互的系统和方法
公开(公告)号：WO2012082920A3
公开(公告)日：2014-04-10
申请号：PCT/US2011064947
申请日：2011-12-14
申请人： HUAWEI TECH CO LTD , XIE HAIYONG , WU JIANMING , SHI GUANGYU , WANG GUO QIANG
发明人： XIE HAIYONG , WU JIANMING , SHI GUANGYU , WANG GUO QIANG
IPC分类号： H04L12/28
CPC分类号： H04L12/66 , H04L67/2823
摘要： A content-oriented communications network includes an ingress gateway (220) in communication with a legacy client (205) of a first legacy communications network, and an egress gateway (225) in communication with the ingress gateway (220) and a legacy server (210) of a second legacy communications network. The ingress gateway (220) translates a content request of the legacy client (205) from a first legacy protocol to a content-oriented protocol and translates a content reply received in response to the content request from the content-oriented protocol to the first legacy protocol. The egress gateway (225) translates the content request from the content-oriented protocol to a second legacy protocol and translates the content reply received in response to the content request from the second legacy protocol to the content-oriented protocol.
摘要翻译：面向内容的通信网络包括与第一传统通信网络的传统客户端（205）通信的入口网关（220）和与入口网关（220）和传统服务器（220）通信的出口网关（225） 210）的第二传统通信网络。入口网关（220）将传统客户端（205）的内容请求从第一传统协议转换为面向内容的协议，并将响应于内容请求而接收的内容响应从面向内容的协议转换为第一传统协议。出口网关（225）将内容请求从面向内容的协议转换为第二传统协议，并将响应于内容请求而接收到的内容响应从第二传统协议翻译成面向内容的协议。

4. 发明申请

WO2012155065A2 METHOD AND SYSTEM FOR LONGEST PREFIX MATCHING OF VARIABLE-SIZED HIERARCHICAL NAMES BY TREELETS 审中-公开
标题翻译：通过TREELETS可变尺度分层名称的最大前缀匹配的方法和系统
公开(公告)号：WO2012155065A2
公开(公告)日：2012-11-15
申请号：PCT/US2012/037568
申请日：2012-05-11
申请人： HUAWEI TECHNOLOGIES, CO., LTD. , WU, Jianming , SHI, Guangyu , LI, Fu
发明人： WU, Jianming , SHI, Guangyu , LI, Fu
IPC分类号： G06F17/30
CPC分类号： G06F17/30091 , G06F17/30197
摘要： A method for determining a location of a requested resource, comprising receiving a request for a resource, wherein the resource is identified by a hierarchically structured name, decomposing the hierarchically structured name into a plurality of segments, comparing each of the plurality of segments to parent nodes of a plurality of two-level treelets, wherein the comparing of at least two of the plurality of segments to parent nodes of the plurality of two-level treelets is performed in a parallel manner, wherein combinations of two-level treelets comprise a hierarchical name of a network resource, and determining a longest prefix match of the hierarchically structured name.
摘要翻译：一种用于确定所请求资源的位置的方法，包括接收对资源的请求，其中所述资源由分层结构的名称标识，将所述分层结构的名称分解为多个段，将所述多个段中的每一个段与父多个二级小树的节点，其中以并行方式执行所述多个片段中的至少两个片段与所述多个两层小树枝中的父节点的比较，其中所述两层小树的组合包括层级网络资源的名称，以及确定分层结构名称的最长前缀匹配。

5. 发明申请

WO2009074880A3 RANK ADAPTATION FOR AN OPEN LOOP MULTI-ANTENNA MODE OF WIRELESS COMMUNICATION 审中-公开
标题翻译：用于无线通信的开环多天线模式的RANK适配
公开(公告)号：WO2009074880A3
公开(公告)日：2011-04-28
申请号：PCT/IB2008003841
申请日：2008-10-02
申请人： NORTEL NETWORKS LTD , XU HUA , WU JIANMING , MA JIANGLEI , JIA MING , BALIGH MOHAMMADHADI , ZHU PEIYING , TONG WEN
发明人： XU HUA , WU JIANMING , MA JIANGLEI , JIA MING , BALIGH MOHAMMADHADI , ZHU PEIYING , TONG WEN
IPC分类号： H04W28/18 , H04W72/06
CPC分类号： H04B7/0689 , H04B7/063 , H04B7/0632
摘要： To perform rank adaptation for a mobile station in a wireless network, it is determined whether the mobile station is fast moving. In response to determining that the mobile station is fast moving, an open loop multi-antenna mode is selected to perform wireless communication between the mobile station and a base station. Also, selection is made from among plural ranks for the wireless communication according to the open loop multi-antenna mode between the mobile station and the base station.
摘要翻译：为了对无线网络中的移动台执行秩调整，确定移动站是否快速移动。响应于确定移动台正在快速移动，选择开环多天线模式来执行移动台和基站之间的无线通信。此外，根据移动台和基站之间的开环多天线模式，从用于无线通信的多个等级中进行选择。

6. 发明申请

WO2010080994A2 PROCESS FOR REGULATING IMMUNE RESPONSE 审中-公开
标题翻译：调节免疫应答的方法
公开(公告)号：WO2010080994A2
公开(公告)日：2010-07-15
申请号：PCT/US2010020493
申请日：2010-01-08
申请人： UAB RESEARCH FOUNDATION , KIMBERLY ROBERT P , EDBERG JEFFREY C , WU JIANMING , SU KAILHONG
发明人： KIMBERLY ROBERT P , EDBERG JEFFREY C , WU JIANMING , SU KAILHONG
IPC分类号： C07K14/735 , C12N15/63 , G01N33/15 , G01N33/53
CPC分类号： C07K14/70535 , G01N33/564 , G01N2333/70535 , G01N2800/52
摘要： The discovery of Fc?RIIc expression on B-cells allows several new methods of prediction or regulation of immune responses. A process of altering an immune response in a subject is provided by altering the expression level or activity of Fc?RIIc on a cell. The relative ratio of activating Fc?RIIc to inhibitory Fc?RIIb levels in an immune cell allows prediction of the presence or absence of immune disease or abnormality such as rheumatoid arthritis or systemic lupus erythematosus. Inventive processes are provided whereby the relative levels of activating to inhibitory receptor expression in a subject is compared to an established inventive classification system to predict an immune response to a therapeutic, the presence or absence of disease, or the magnitude, duration, or timing of an immune response in the subject.
摘要翻译：在B细胞上发现FcγRIIc表达允许几种预测或调节免疫应答的新方法。通过改变FcαRIIc在细胞上的表达水平或活性来提供改变受试者中免疫应答的方法。免疫细胞中活化FcγRIIc与抑制性FcγRIIb水平的相对比例允许预测有无免疫疾病或异常如类风湿性关节炎或系统性红斑狼疮。提供本发明的方法，其中将受试者中的活化与抑制性受体表达的相对水平与已建立的本发明分类系统进行比较以预测对治疗的免疫应答，疾病的存在或不存在，或其持续时间或时间受试者的免疫反应。

7. 发明申请

WO2007036031A1 ADAPTIVE POWER CONTROL DATA TRANSMISSION SYSTEMS AND METHODS 审中-公开
标题翻译：自适应功率控制数据传输系统和方法
公开(公告)号：WO2007036031A1
公开(公告)日：2007-04-05
申请号：PCT/CA2006/001587
申请日：2006-09-27
申请人： NORTEL NETWORKS LIMITED , WU, Jianming , TONG, Wen , ZHU, Peiying
发明人： WU, Jianming , TONG, Wen , ZHU, Peiying
IPC分类号： H04B7/005 , H04B1/69 , H04Q7/30 , H04Q7/32 , H04Q7/36
CPC分类号： H04W52/262
摘要： Systems and methods of performing power control in combination with AMC are provided. AMC is performed on the basis of an AMC parameter such as CINR. Once the AMC is set to a highest available AMC for transmission to a given receiver, if the CINR indicates that the highest AMC could be transmitted with less transmit power, the power is reduced. For receivers that are not receiving the highest available AMC for that receiver, they may have their transmit power increased.
摘要翻译：提供了与AMC结合进行功率控制的系统和方法。基于AMC参数（如CINR）执行AMC。一旦将AMC设置为最高可用AMC以传输给给定的接收机，如果CINR指示可以以更少的发射功率传输最高的AMC，则功率被减小。对于没有接收到该接收机的最高可用AMC的接收机，它们可能具有增加的发射功率。

8. 发明申请

WO2015148926A1 POLYPEPTIDES, CELLS, AND METHODS INVOLVING ENGINEERED CD16 审中-公开
标题翻译：涉及工程CD16的聚合物，细胞和方法
公开(公告)号：WO2015148926A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/022998
申请日：2015-03-27
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , WALCHECK, Bruce, Kenneth , KAUFMAN, Dan, Samuel , WU, Jianming , JING, Yawu , NI, Zhenya
发明人： WALCHECK, Bruce, Kenneth , KAUFMAN, Dan, Samuel , WU, Jianming , JING, Yawu , NI, Zhenya
IPC分类号： C07K14/735
CPC分类号： C07K14/70535 , A61K35/17 , A61K38/1774 , A61K39/39558 , A61K2039/505 , C07K16/32 , C07K2317/76 , C12N5/0642 , C12N5/0645 , C12N5/0646 , C12N2501/599 , C12N2510/00
摘要： This disclosure describes, generally, a modified form of CD 16, genetically-modified cells that express the modified CD 16, and methods that involve the genetically-modified cells. The modified form of CD 16 can exhibit increased anti-tumor and/or anti- viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
摘要翻译：本公开通常描述了修饰形式的CD16，表达修饰的CD16的遗传修饰的细胞，以及涉及遗传修饰的细胞的方法。 CD16的修饰形式可以表现出增加的抗肿瘤和/或抗病毒活性，至少部分地降低了对NK细胞刺激时对ADAM17介导的脱落的易感性。

9. 发明申请

WO2011120233A9 APPARATUS AND METHOD FOR ORTHOGONAL COVER CODE (OCC) GENERATION, AND APPARATUS AND METHOD FOR OCC MAPPING 审中-公开
标题翻译：正交盖子代码（OCC）生成的装置和方法，以及OCC映射的装置和方法
公开(公告)号：WO2011120233A9
公开(公告)日：2011-12-08
申请号：PCT/CN2010071532
申请日：2010-04-02
申请人： FUJITSU LTD , WANG YI , ZHOU HUA , WU JIANMING
发明人： WANG YI , ZHOU HUA , WU JIANMING
IPC分类号： H04J13/12
CPC分类号： H04J13/0048 , H04B7/0413 , H04J11/00 , H04J13/004 , H04J13/12 , H04J13/18 , H04L5/0007 , H04L5/0016 , H04L5/0017 , H04L5/0048 , H04L27/2602 , H04L27/2613 , H04W72/0466 , H04W88/02 , H04W88/08
摘要： An apparatus and method for Orthogonal Cover Code(OCC) generation, and an apparatus and method for OCC mapping are disclosed in the present invention, wherein the apparatus for OCC generation includes: a means for generating the first group of OCC sequences, which is used to generate the first group of OCC sequences; a means for generating the second group of OCC sequences, which is used to mirror the columns of the first group of OCC sequences to generate the second group of OCC sequences; a means for generating the third group of OCC sequences, which is used to perform cyclic shift on the column vectors of the first group of OCC sequences to generate the third group of OCC sequences; and a means for generating the fourth group of OCC sequences, which is used to mirror the columns of the third group of OCC sequences to generate the fourth group of OCC sequences. According to the above-mentioned technical solution of the present invention, the randomization of the pilot sequence is improved, the problem of data transmission power imbalance is solved, the orthogonality requirements in both time dimension and frequency dimension are satisfied, and more robust channel estimation performance is provided.
摘要翻译：本发明公开了一种用于正交封面（OCC）生成的装置和方法，以及用于OCC映射的装置和方法，其中用于OCC生成的装置包括：用于生成第一组OCC序列的装置，其被使用产生第一组OCC序列; 用于产生第二组OCC序列的装置，其用于镜像第一组OCC序列的列以产生第二组OCC序列; 用于产生第三组OCC序列的装置，其用于对第一组OCC序列的列向量执行循环移位以产生第三组OCC序列; 以及用于产生第四组OCC序列的装置，其用于镜像第三组OCC序列的列以产生第四组OCC序列。根据本发明的上述技术方案，提高了导频序列的随机化，解决了数据传输功率不平衡的问题，满足了时间尺寸和频率尺寸的正交要求，并且更稳健的信道估计提供性能。

10. 发明申请

WO2010080994A3 PROCESS FOR REGULATING IMMUNE RESPONSE 审中-公开
公开(公告)号：WO2010080994A3
公开(公告)日：2010-07-15
申请号：PCT/US2010/020493
申请日：2010-01-08
申请人： THE UAB RESEARCH FOUNDATION , KIMBERLY, Robert, P. , EDBERG, Jeffrey, C. , WU, Jianming , SU, Kailhong
发明人： KIMBERLY, Robert, P. , EDBERG, Jeffrey, C. , WU, Jianming , SU, Kailhong
IPC分类号： C07K14/735 , C12N15/63 , G01N33/53 , G01N33/15
摘要： The discovery of FcγRIIc expression on B-cells allows several new methods of prediction or regulation of immune responses. A process of altering an immune response in a subject is provided by altering the expression level or activity of FcγRIIc on a cell. The relative ratio of activating FcγRIIc to inhibitory FcγRIIb levels in an immune cell allows prediction of the presence or absence of immune disease or abnormality such as rheumatoid arthritis or systemic lupus erythematosus. Inventive processes are provided whereby the relative levels of activating to inhibitory receptor expression in a subject is compared to an established inventive classification system to predict an immune response to a therapeutic, the presence or absence of disease, or the magnitude, duration, or timing of an immune response in the subject.

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