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1. 发明专利

AU2003275421A8 Three-dimensional peripheral lymphoid organ cell cultures 未知
公开(公告)号：AU2003275421A8
公开(公告)日：2008-03-13
申请号：AU2003275421
申请日：2003-10-03
申请人： UNIV ROCHESTER , BOTTARO ANDREA , WU J H DAVID
发明人： WU J H DAVID , BOTTARO ANDREA
IPC分类号： C12Q1/68 , A01N63/00 , A61K35/26 , A61K39/395 , C12N5/00 , C12N5/071 , C12N5/078

2. 发明专利

AU2003275421A1 THREE-DIMENSIONAL PERIPHERAL LYMPHOID ORGAN CELL CULTURES 未知
公开(公告)号：AU2003275421A1
公开(公告)日：2004-04-23
申请号：AU2003275421
申请日：2003-10-03
申请人： WU J H DAVID , BOTTARO ANDREA , UNIV ROCHESTER
发明人： BOTTARO ANDREA , WU J H DAVID
IPC分类号： A61K39/395 , C12N5/071 , C12N5/078

3. 发明申请

WO2014028509A3 THROMBOPOIETIN MIMETICS FOR THE TREATMENT OF RADIATION OR CHEMICAL INDUCED BONE MARROW INJURY 审中-公开
标题翻译：用于治疗放射性或化学诱导性骨髓损伤的血小板生成素
公开(公告)号：WO2014028509A3
公开(公告)日：2014-05-08
申请号：PCT/US2013054758
申请日：2013-08-13
申请人： UNIV ROCHESTER , CHEN YUHCHYAU , WU J H DAVID , LIESVELD JANE L , GAN LIN
发明人： CHEN YUHCHYAU , WU J H DAVID , LIESVELD JANE L , GAN LIN
IPC分类号： C12N15/63 , A61K38/57 , C07K16/18
CPC分类号： A61K31/4152 , A01K2207/15 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A61K38/196 , A61K39/3955 , A61K45/06 , C07K14/715 , C07K16/2866 , G01N33/5008 , G01N33/5094 , G01N2333/524
摘要： Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non- human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor.
摘要翻译：公开了可用于筛选对血小板生成素受体有活性的血小板生成素模拟物，血小板生成素受体激动剂或血小板生成素受体拮抗剂的转基因非人哺乳动物。转基因非人哺乳动物具有包含稳定整合的转基因构建体的基因组，其包含编码人源化血小板生成素受体的多核苷酸序列，其中所述转基因非人哺乳动物具有对应于匹配非血管生成素受体的生理血小板计数的基线血小板计数，转基因非人哺乳动物。嵌合血小板生成素受体包括人类血小板生成素受体的跨膜结构域或人血小板生成素受体的细胞外和跨膜结构域，其可操作地偶联至非人血小板生成素受体的细胞质结构域。

4. 发明申请

WO2004031361A3 THREE-DIMENSIONAL PERIPHERAL LYMPHOID ORGAN CELL CULTURES 审中-公开
标题翻译：三维外周淋巴组织细胞培养
公开(公告)号：WO2004031361A3
公开(公告)日：2008-01-24
申请号：PCT/US0331394
申请日：2003-10-03
申请人： UNIV ROCHESTER , WU J H DAVID , BOTTARO ANDREA
发明人： WU J H DAVID , BOTTARO ANDREA
IPC分类号： C12Q1/68 , A01N63/00 , A61K35/26 , A61K39/395 , C12N5/00 , C12N5/071 , C12N5/078
CPC分类号： C12N5/0648 , C12N5/0651 , C12N2531/00 , C12N2533/78
摘要： The present invention relates to a method of culturing peripheral lymphoid organ cells on a three-dimensional scaffolding which is covered or surrounded with culture medium, under conditions effective to generate and maintain mature and functional lymphoid cells, where the three-dimensional scaffolding allows cells in the culture medium to have cell to cell contact in three dimensions. The present invention also provides methods of screening for vaccine candidates for efficacy in eliciting an immune response, identifying genes or proteins which are related to peripheral lymphoid organ cell formation or function, screening for drugs effecting peripheral lymphoid organ cell maturation, treating a patient for a disease condition using antigen-specific lymphoid cells, and effecting gene expression of peripheral lymphoid organ cells.
摘要翻译：本发明涉及一种在有效产生和维持成熟和功能性淋巴样细胞的条件下在培养基上覆盖或包围的三维支架上培养外周淋巴器官细胞的方法，其中三维支架允许细胞在细胞与细胞在三维接触的培养基。本发明还提供了筛选疫苗候选物的方法，其用于引发免疫应答，识别与外周淋巴器官细胞形成或功能相关的基因或蛋白质，筛选影响外周淋巴器官细胞成熟的药物，治疗患者的使用抗原特异性淋巴细胞的疾病状况，以及影响外周淋巴器官细胞的基因表达。

5. 发明申请

WO2004031361A2 THREE-DIMENSIONAL PERIPHERAL LYMPHOID ORGAN CELL CULTURES 审中-公开
标题翻译：三维外周淋巴组织细胞培养
公开(公告)号：WO2004031361A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/031394
申请日：2003-10-03
申请人： UNIVERSITY OF ROCHESTER , WU, J., H., David , BOTTARO, Andrea
发明人： WU, J., H., David , BOTTARO, Andrea
IPC分类号： C12N
CPC分类号： C12N5/0648 , C12N5/0651 , C12N2531/00 , C12N2533/78
摘要： The present invention relates to a method of culturing peripheral lymphoid organ cells on a three-dimensional scaffolding which is covered or surrounded with culture medium, under conditions effective to generate and maintain mature and functional lymphoid cells, where the three-dimensional scaffolding allows cells in the culture medium to have cell to cell contact in three dimensions. The present invention also provides methods of screening for vaccine candidates for efficacy in eliciting an immune response, identifying genes or proteins which are related to peripheral lymphoid organ cell formation or function, screening for drugs effecting peripheral lymphoid organ cell maturation, treating a patient for a disease condition using antigen-specific lymphoid cells, and effecting gene expression of peripheral lymphoid organ cells.
摘要翻译：本发明涉及一种在有效产生和维持成熟和功能性淋巴样细胞的条件下在培养基上覆盖或包围的三维支架上培养外周淋巴器官细胞的方法，其中三维支架允许细胞在细胞与细胞在三维接触的培养基。本发明还提供了筛选疫苗候选物的方法，其用于引发免疫应答，识别与外周淋巴器官细胞形成或功能相关的基因或蛋白质，筛选影响外周淋巴器官细胞成熟的药物，治疗患者的使用抗原特异性淋巴细胞的疾病状况，以及影响外周淋巴器官细胞的基因表达。

6. 发明申请

WO2014028509A2 THROMBOPOIETIN MIMETICS FOR THE TREATMENT OF RADIATION OR CHEMICAL INDUCED BONE MARROW INJURY 审中-公开
标题翻译：用于治疗辐射或化学诱导的骨髓损伤的血栓形成剂模拟物
公开(公告)号：WO2014028509A2
公开(公告)日：2014-02-20
申请号：PCT/US2013/054758
申请日：2013-08-13
申请人： UNIVERSITY OF ROCHESTER , CHEN, Yuhchyau , WU, J.,H., David , LIESVELD, Jane, L. , GAN, Lin
发明人： CHEN, Yuhchyau , WU, J.,H., David , LIESVELD, Jane, L. , GAN, Lin
IPC分类号： A61K31/4152 , A61K45/06 , G01N33/50
CPC分类号： A61K31/4152 , A01K2207/15 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A61K38/196 , A61K39/3955 , A61K45/06 , C07K14/715 , C07K16/2866 , G01N33/5008 , G01N33/5094 , G01N2333/524
摘要： Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non- human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor.
摘要翻译：公开了用于筛选对人血小板生成素受体有活性的血小板生成素模拟物，血小板生成素受体激动剂或血小板生成素受体拮抗剂的转基因非人哺乳动物。转基因非人哺乳动物具有包含稳定整合的转基因构建体的基因组，所述转基因构建体包含编码人源化血小板生成素受体的多核苷酸序列，其中所述转基因非人哺乳动物具有与匹配的非人哺乳动物的生理血小板计数相对应的基线血小板计数，转基因非人哺乳动物。嵌合血小板生成素受体包含人血小板生成素受体的跨膜结构域或人血小板生成素受体的细胞外和跨膜结构域可操作地偶联于非人血小板生成素受体的胞质结构域。

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