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1. 发明申请

WO2006110768A2 SYSTEM, METHOD AND SOFTWARE ARRANGEMENT FOR ANALYZING AND CORRELATING MOLECULAR PROFILES ASSOCIATED WITH ANATOMICAL STRUCTURES 审中-公开
标题翻译：用于分析和分析与分析结构相关的分子谱的系统，方法和软件安排
公开(公告)号：WO2006110768A2
公开(公告)日：2006-10-19
申请号：PCT/US2006013517
申请日：2006-04-11
申请人： GEN HOSPITAL CORP , CHENG LEO L , JENKINS BRUCE , WU CHIN-LEE , DAI GUANGPING , HALPERN ELKAN F
发明人： CHENG LEO L , JENKINS BRUCE , WU CHIN-LEE , DAI GUANGPING , HALPERN ELKAN F
CPC分类号： G01R33/485
摘要： A system, method and software arrangement according to exemplary embodiments of the present invention are provided which can use molecular profiles obtained from unaltered human tissue specimens for clinical purposes including disease diagnoses and treatment evaluations. For example, spatial distributions of chemical species including metabolites within the tissue may be obtained using radiological techniques such as magnetic resonance spectroscopy imaging. Disease-specific profiles may be obtained by comparing the distributions of chemical species obtained in ex vivo tissues with pathological observations made on them using statistical analysis. The disease-specific profiles may then be correlated with in vivo or ex vivo molecular profiles to obtain spatial maps that can provide a more sensitive and accurate detection of diseased tissue. Thus, such exemplary systems, methods and software arrangements can include the ability to receive information relating to the distribution of at least three chemical species in the tissue of interest, compare this information statistically to a predetermined profile and, based on the statistical correlation between the information and the profile, determine certain characteristics of the tissue of interest such as, e.g., the presence or absence of diseased tissue.
摘要翻译：提供了根据本发明的示例性实施例的系统，方法和软件装置，其可以使用从未改变的人组织标本获得的分子轮廓用于临床目的，包括疾病诊断和治疗评估。例如，可以使用诸如磁共振光谱成像的放射技术获得组织内包括代谢物的化学物质的空间分布。通过使用统计学分析比较离体组织中获得的化学物质的分布与对其进行的病理观察，可以获得疾病特异性谱。然后可以将疾病特异性谱与体内或离体分子谱相关，以获得可以提供对病变组织更灵敏和更准确的检测的空间图。因此，这样的示例性系统，方法和软件安排可以包括接收关于感兴趣组织中至少三种化学物质的分布的信息的能力，将该信息与统计学上的比较将其与预定的分布进行比较，并且基于信息和简档，确定感兴趣的组织的某些特征，例如患病组织的存在或不存在。

2. 发明申请

WO2007048076A3 METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF CANCER 审中-公开
公开(公告)号：WO2007048076A3
公开(公告)日：2007-04-26
申请号：PCT/US2006/041655
申请日：2006-10-23
申请人： THE GENERAL HOSPITAL CORPORATION , CHENG, Leo, L. , POHL, Ute , WU, Chin-lee , CORTEZ-RETAMOZO, Virna Fatima
发明人： CHENG, Leo, L. , POHL, Ute , WU, Chin-lee , CORTEZ-RETAMOZO, Virna Fatima
IPC分类号： C12Q1/68
摘要： Disclosed are methods for prognostic evaluation, and diagnosis of cancers. The methods of the present invention allow for the diagnosis and prognosis of cancers by analyzing the levels of expression of an enzyme that is involved in the biosynthetic pathway of spermine within tissue samples containing cancerous tissues. In particular, the amount of enzyme mRNA detected in tissue sample correlates with disease status such that enzyme levels can be used to predict the presence of, as well as the metastatic potential of cancer. Thus, measuring the level of spermine pathway enzymes in biological samples provides a quick, easy, and safe screen that can be used to both diagnose and prognose cancer in a patient thus leading to more effective treatments and cures.

3. 发明申请

WO2006110768A3 SYSTEM, METHOD AND SOFTWARE ARRANGEMENT FOR ANALYZING AND CORRELATING MOLECULAR PROFILES ASSOCIATED WITH ANATOMICAL STRUCTURES 审中-公开
公开(公告)号：WO2006110768A3
公开(公告)日：2006-10-19
申请号：PCT/US2006/013517
申请日：2006-04-11
申请人： THE GENERAL HOSPITAL CORPORATION , CHENG, Leo, L. , JENKINS, Bruce , WU, Chin-Lee , DAI, Guangping , HALPERN, Elkan, F.
发明人： CHENG, Leo, L. , JENKINS, Bruce , WU, Chin-Lee , DAI, Guangping , HALPERN, Elkan, F.
IPC分类号： G01R33/485
摘要： A system, method and software arrangement according to exemplary embodiments of the present invention are provided which can use molecular profiles obtained from unaltered human tissue specimens for clinical purposes including disease diagnoses and treatment evaluations. For example, spatial distributions of chemical species including metabolites within the tissue may be obtained using radiological techniques such as magnetic resonance spectroscopy imaging. Disease-specific profiles may be obtained by comparing the distributions of chemical species obtained in ex vivo tissues with pathological observations made on them using statistical analysis. The disease-specific profiles may then be correlated with in vivo or ex vivo molecular profiles to obtain spatial maps that can provide a more sensitive and accurate detection of diseased tissue. Thus, such exemplary systems, methods and software arrangements can include the ability to receive information relating to the distribution of at least three chemical species in the tissue of interest, compare this information statistically to a predetermined profile and, based on the statistical correlation between the information and the profile, determine certain characteristics of the tissue of interest such as, e.g., the presence or absence of diseased tissue.

4. 发明申请

WO2007048076A2 METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF CANCER 审中-公开
标题翻译：癌症诊断和预防方法
公开(公告)号：WO2007048076A2
公开(公告)日：2007-04-26
申请号：PCT/US2006041655
申请日：2006-10-23
申请人： GEN HOSPITAL CORP , CHENG LEO L , POHL UTE , WU CHIN-LEE , CORTEZ-RETAMOZO VIRNA FATIMA
发明人： CHENG LEO L , POHL UTE , WU CHIN-LEE , CORTEZ-RETAMOZO VIRNA FATIMA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： Disclosed are methods for prognostic evaluation, and diagnosis of cancers. The methods of the present invention allow for the diagnosis and prognosis of cancers by analyzing the levels of expression of an enzyme that is involved in the biosynthetic pathway of spermine within tissue samples containing cancerous tissues. In particular, the amount of enzyme mRNA detected in tissue sample correlates with disease status such that enzyme levels can be used to predict the presence of, as well as the metastatic potential of cancer. Thus, measuring the level of spermine pathway enzymes in biological samples provides a quick, easy, and safe screen that can be used to both diagnose and prognose cancer in a patient thus leading to more effective treatments and cures.
摘要翻译：公开了预后评估和癌症诊断的方法。本发明的方法通过分析涉及含有癌组织的组织样品中精胺的生物合成途径的酶的表达水平来允许癌症的诊断和预后。特别地，组织样品中检测到的酶mRNA的量与疾病状态相关，使得酶水平可用于预测癌症的存在和转移潜力。因此，测量生物样品中精胺途径酶的水平提供了一种快速，简单和安全的屏幕，可用于诊断和预测患者的癌症，从而导致更有效的治疗和治愈。

5. 发明申请

WO2014071029A1 METHODS AND ASSAYS FOR TREATMENT OF BLADDER CANCER 审中-公开
标题翻译：用于治疗刮板癌的方法和测定
公开(公告)号：WO2014071029A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067792
申请日：2013-10-31
申请人： THE GENERAL HOSPITAL CORPORATION , LIN, Xuanhui, Sharron , MCDOUGAL, William, Scott , WU, Chin-Lee
发明人： LIN, Xuanhui, Sharron , MCDOUGAL, William, Scott , WU, Chin-Lee
IPC分类号： C12Q1/68 , G01N33/574 , A61K51/00 , A61P35/00 , A61P43/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57407
摘要： The technology described herein relates to methods of prognosing and treating bladder cancer.
摘要翻译：本文所述的技术涉及膀胱癌的预后和治疗方法。

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