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1. 发明专利

CA2816040A1 CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 未知
公开(公告)号：CA2816040A1
公开(公告)日：2012-05-10
申请号：CA2816040
申请日：2011-10-25
申请人： MAUCH KEVIN , ALVARADO MARIO , BEETEL ROBERT J , COLE JUANITA SANCHEZ , CHANG WILLIAM , GOSHGARIAN JUSTIN , RIVERA LEONILA , SHIN SUKYOUNG , SILVER MICHELE , WU ANDREW , ZARINS DENISE , ABOYTES MARIA G , SOM SINA
发明人： MAUCH KEVIN , ALVARADO MARIO , BEETEL ROBERT J , COLE JUANITA SANCHEZ , CHANG WILLIAM , GOSHGARIAN JUSTIN , RIVERA LEONILA , SHIN SUKYOUNG , SILVER MICHELE , WU ANDREW , ZARINS DENISE , ABOYTES MARIA G , SOM SINA
IPC分类号： A61B18/14
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfused the neural fibers.

2. 发明专利

AU2011239313A1 Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods 未知
公开(公告)号：AU2011239313A1
公开(公告)日：2012-05-10
申请号：AU2011239313
申请日：2011-10-25
申请人： ABOYTES MARIA G , ALVARADO MARIO , BEETEL ROBERT J , CHANG WILLIAM , COLE JAUNITA SANCHEZ , GOSHGARIAN JUSTIN , MAUCH KEVIN , RIVERA LEONILA , SHIN SUKYOUNG , SILVER MICHELE , SOM SINA , WU ANDREW , ZARINS DENISE
发明人： MAUCH KEVIN , ALVARADO MARIO , BEETEL ROBERT J , COLE JAUNITA SANCHEZ , CHANG WILLIAM , GOSHGARIAN JUSTIN , RIVERA LEONILA , SHIN SUKYOUNG , SILVER MICHELE , SOM SINA , WU ANDREW , ZARINS DENISE , ABOYTES MARIA
IPC分类号： A61F7/12 , A61N1/00
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers. -135- FEEDBACK 31 38 10 i NEUTRAL RO 30 ELECTRODE[ 33 fi

3. 发明专利

CA1284692C MULTILAYER INTERCONNECTION SYSTEM FOR MULTICHIP HIGH PERFORMANCE SEMICONDUCTOR PACKAGING 未知
公开(公告)号：CA1284692C
公开(公告)日：1991-06-04
申请号：CA566024
申请日：1988-05-05
申请人： WU ANDREW L
发明人： WU ANDREW L
IPC分类号： H05K3/46 , H01L21/31 , H01L21/48 , H01L23/52 , H01L23/538 , H05K3/14 , H05K3/18 , H01L21/90
摘要： : A method for fabricating a multilayer interconnection system that is fully planar with completely sealed and corrosion resistant conductors separated by dielectric material. The method involves forming a dielectric sub-layer overlying a base layer, the sub-layer being non-soluble after it is cured. A sacrificial sub-layer is then formed over the dielectric sublayer, the sacrificial sub-layer being insoluble after it is cured. A portion of the sacrificial sub-layer is removed to expose a portion of the dielectric sub-layer. The exposed portion of the dielectric sub-layer and a selected portion surrounding the exposed portion is removed to expose a portion of the base layer with an exposed portion of the sacrificial sublayer overhanging the exposed portion of the base layer. A first conductive adhesive sub-layer is deposited overlying the dielectric and sacrificial sub-layers and the exposed area of the base layer without overlaying the exposed overhanging portion facing the base layer of the sacrificial sub-layer. A conductive seeding sub-layer is deposited overlaying the first conductive adhesive sub-layer. The sacrificial sub-layer and the first conductive adhesive sub-layer and the conductive seeding sublayer in contact with the sacrificial sub-layer are removed, a conductor sub-layer is formed by electrolessly plating a conductor sub-layer onto the seeding sub-layer, and then a second conductive adhesive sub-layer is formed by electrolessly plating the second adhesive sub-layer onto the conductor sub-layer to form a surface which is planar with the dielectric sub-layer. The resulting structures are useful, for example, as VLSI and ULSI devices.

4. 发明专利

AU2011239316A1 Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and method 未知
公开(公告)号：AU2011239316A1
公开(公告)日：2012-05-10
申请号：AU2011239316
申请日：2011-10-25
申请人： ABOYTES MARIA G , BEETEL ROBERT J , KU VINCENT , WU ANDREW , ZARINS DENISE
发明人： KU VINCENT , BEETEL ROBERT J , WU ANDREW , ZARINS DENISE , ABOYTES MARIA
IPC分类号： A61F7/12 , A61N1/00
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

5. 发明申请

WO2013134133A1 GENERATOR ASSEMBLIES FOR NEUROMODULATION THERAPY AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于神经修复治疗的发生器组件及相关系统和方法
公开(公告)号：WO2013134133A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/028886
申请日：2013-03-04
申请人： MEDTRONIC ARDIAN LUXEMBOURG SARL , BALLAKUR, Sowmya , WU, Andrew , GEORGE, William, R. , LEWIS, Charles, Richard, Jr. , MINAMI, Don, S.
发明人： BALLAKUR, Sowmya , WU, Andrew , GEORGE, William, R. , LEWIS, Charles, Richard, Jr. , MINAMI, Don, S. , CADOURI, Hadar , FRIEDRICHS, Paul , SHAH, JignesH , TRUDEL, Julie , DOERKSEN, Kyle , HARBOUN, Michael , KING, Simon , VONDLE, Dave
IPC分类号： A61B18/12 , A61B18/14
CPC分类号： A61B18/1206 , A61B18/1492 , A61B50/10 , A61B50/13 , A61B90/98 , A61B2017/00115 , A61B2017/00199 , A61B2017/00212 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577
摘要： Generator assemblies and systems for neuromodulation therapies are disclosed herein. A generator system configured in accordance with a particular embodiment of the present technology can include, for example, a generator console and a stand assembly configured to releasably carry the generator console. The generator console can include a plurality of radiofrequency (RF) channels configured to deliver energy to a plurality of electrodes of a neuromodulation device. The generator console can also include a display configured to indicate operating conditions of the RF channels during energy delivery. The stand assembly can include a recessed portion having a plurality of spring-loaded locking members and a release mechanism operably coupled to the locking members. The release mechanism can be configured to move the locking members from a locked arrangement to an unlocked arrangement to disengage the generator console from the stand assembly.
摘要翻译：用于神经调节治疗的发生器组件和系统在本文中公开。根据本技术的特定实施例配置的发电机系统可以包括例如发电机控制台和配置成可释放地携带发电机控制台的支架组件。发电机控制台可以包括被配置为向神经调节装置的多个电极输送能量的多个射频（RF）通道。发电机控制台还可以包括配置为在能量传递期间指示RF信道的操作条件的显示器。支架组件可以包括具有多个弹簧加载的锁定构件的凹部和可操作地联接到锁定构件的释放机构。释放机构可以被配置为将锁定构件从锁定装置移动到解锁装置，以将发生器控制台与支架组件分离。

6. 发明申请

WO2011139589A3 CATHETER APPARATUSES, SYSTEMS, AND METHODS FOR RENAL NEUROMODULATION 审中-公开
标题翻译：用于肾神经调节的导管装置，系统和方法
公开(公告)号：WO2011139589A3
公开(公告)日：2012-03-15
申请号：PCT/US2011033491
申请日：2011-04-21
申请人： MEDTRONIC ARDIAN LLC , LEUNG MARK S , CLARK BENJAMIN J , MICHLITSCH KENNETH , THAI ERIK , WU ANDREW , ZARINS DENISE
发明人： LEUNG MARK S , CLARK BENJAMIN J , MICHLITSCH KENNETH , THAI ERIK , WU ANDREW , ZARINS DENISE
IPC分类号： A61B18/14
CPC分类号： A61B18/082 , A61B17/320068 , A61B18/02 , A61B18/0206 , A61B18/10 , A61B18/1492 , A61B18/1815 , A61B18/20 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B2018/1861 , H04L29/12066 , H04L61/1511
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.
摘要翻译：本文公开了用于通过血管内通路实现肾神经调节的导管设备，系统和方法。例如，本申请的一个方面涉及结合包括细长轴的导管治疗装置的装置，系统和方法。细长轴的尺寸和构造被设定为经由血管内路径将能量输送元件输送到肾动脉。可以通过直接和/或通过间接应用热和/或电能来加热或冷却或以其他方式电调节有助于肾功能的神经纤维，或者通过给予或灌注神经纤维。

7. 发明申请

WO2011130005A2 HANDLE ASSEMBLIES FOR INTRAVASCULAR TREATMENT DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于静脉内治疗装置和相关系统和方法的手柄组件
公开(公告)号：WO2011130005A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/030496
申请日：2011-03-30
申请人： MEDTRONIC ARDIAN LLC , CLARK, Benjamin, C. , GEORGE, William, R. , MICHLITSCH, Kenneth, J. , SAM, John, Paul , THAI, Erik , WU, Andrew
发明人： CLARK, Benjamin, C. , GEORGE, William, R. , MICHLITSCH, Kenneth, J. , SAM, John, Paul , THAI, Erik , WU, Andrew
IPC分类号： A61B18/14 , A61B19/00 , A61B17/00
CPC分类号： A61B18/08 , A61B34/74 , A61B2017/003 , A61B2018/00916
摘要： The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.
摘要翻译：本公开包括用于血管内治疗装置的手柄组件。在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。在一个实施例中，手柄组件包括旋转限制元件，用于限制血管内治疗装置相对于手柄组件的独立旋转。还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

8. 发明申请

WO2010068930A1 BUSINESS SOFTWARE APPLICATION SYSTEM AND METHOD 审中-公开
标题翻译：业务软件应用系统和方法
公开(公告)号：WO2010068930A1
公开(公告)日：2010-06-17
申请号：PCT/US2009/067777
申请日：2009-12-11
申请人： SUGARCRM INC. , HSU, Yun-Ping , ITANI, Majed , GUPTA, Ajay , SMITH, Roger , AAGAARD, Rob , WU, Andrew , LEE, Collin , TRETIKOV, Lila
发明人： HSU, Yun-Ping , ITANI, Majed , GUPTA, Ajay , SMITH, Roger , AAGAARD, Rob , WU, Andrew , LEE, Collin , TRETIKOV, Lila
IPC分类号： G06F15/16
CPC分类号： G06Q30/02
摘要： A business software application system and method are provided that include a feed system for distributing changes about the application/module to a group of users and a cloud connector system that links external data sources to the business software application system and method.
摘要翻译：提供了一种商业软件应用系统和方法，其包括用于将关于应用/模块的改变分发给一组用户的馈送系统和将外部数据源连接到商业软件应用系统和方法的云连接器系统。

9. 发明申请

WO2012061164A1 CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：具有多极电极阵列用于肾神经调节和相关系统和方法的导管装置
公开(公告)号：WO2012061164A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/057761
申请日：2011-10-25
申请人： MAUCH, Kevin , ALVARADO, Mario , BEETEL, Robert, J. , COLE, Juanita, Sanchez , CHANG, William , GOSHGARIAN, Justin , RIVERA, Leonila , SHIN, Sukyoung , SILVER, Michele , SOM, Sina , WU, Andrew , ZARINS, Denise , ABOYTES, Maria, G.
发明人： MAUCH, Kevin , ALVARADO, Mario , BEETEL, Robert, J. , COLE, Juanita, Sanchez , CHANG, William , GOSHGARIAN, Justin , RIVERA, Leonila , SHIN, Sukyoung , SILVER, Michele , SOM, Sina , WU, Andrew , ZARINS, Denise , ABOYTES, Maria, G.
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61B2018/1467 , A61M25/0041 , A61M25/0074 , A61M25/0133 , A61M25/0138 , A61M25/0147
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfused the neural fibers.
摘要翻译：本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。例如，本技术的一个方面涉及具有被配置为输送到肾血管的多电极阵列的治疗装置。阵列可以在传送或低轮廓状态（例如，大致直线形状）和展开状态（例如，径向膨胀，大致螺旋形状）之间选择性地变换。多电极阵列的尺寸和形状使得当阵列处于部署（例如螺旋状态）时，电极或能量递送元件接触肾血管的内壁。电极或能量递送元件构造成用于直接和/或间接施加热和/或电能以加热或以其他方式电调制有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构。

10. 发明申请

WO2012061153A1 DEVICES, SYSTEMS AND METHODS FOR EVALUATION AND FEEDBACK OF NEUROMODULATION TREATMENT 审中-公开
标题翻译：神经修复治疗评估与反馈装置，系统及方法
公开(公告)号：WO2012061153A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/057740
申请日：2011-10-25
申请人： BALLAKUR, Sowmya , BEETEL, Robert, J. , FRIEDRICHS, Paul , HERZFELD, David , WU, Andrew , ZARINS, Denise , LEUNG, Mark, S. , MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.
发明人： BALLAKUR, Sowmya , BEETEL, Robert, J. , FRIEDRICHS, Paul , HERZFELD, David , WU, Andrew , ZARINS, Denise , LEUNG, Mark, S.
IPC分类号： A61B18/12 , A61B18/10 , A61F7/12 , A61B18/14 , A61B18/00 , A61B17/00 , A61N1/06 , A61N1/32 , A61B18/08
CPC分类号： A61B18/1206 , A61B18/10 , A61B18/1492 , A61B2017/00075 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00672 , A61B2018/00678 , A61B2018/00702 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00863 , A61B2018/00875 , A61F7/12 , A61F2007/0093 , A61F2007/126
摘要： The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.
摘要翻译：本公开涉及用于评估应用于患者组织的治疗成功的装置，系统和方法，例如用于神经调节与肾动脉相关的神经的射频消融治疗。系统监视在治疗过程中产生的参数或值。提供给运营商的反馈是基于监测值，并且涉及对完成的处理在技术上成功的可能性的评估。在其他实施例中，可以评估在不完全处理过程中产生的参数或值（例如由于高温或高阻抗条件），以向操作者提供额外的指令或反馈。

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